LDLR Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description low density lipoprotein receptor|The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010] (NCBI Entrez Gene Database, 3949)
External Link http://www.ncbi.nlm.nih.gov/gene/3949
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Genes

111 interacting proteins for LDLR from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
AP1M1 adaptor-related protein complex 1, mu 1 subunit
AP1M2 adaptor-related protein complex 1, mu 2 subunit
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOB apolipoprotein B
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
ATL3 atlastin GTPase 3
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP2A3 ATPase, Ca++ transporting, ubiquitous
C20ORF24 chromosome 20 open reading frame 24
CALR calreticulin
CALU calumenin
CANX calnexin
CAPN1 calpain 1, (mu/I) large subunit
CASC3 cancer susceptibility candidate 3
CD36 CD36 molecule (thrombospondin receptor)
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHI3L2 chitinase 3-like 2
CKAP4 cytoskeleton-associated protein 4
CLGN calmegin
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
COLGALT1 collagen beta(1-O)galactosyltransferase 1
CREBBP CREB binding protein
CTSD cathepsin D
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHCR24 24-dehydrocholesterol reductase
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ERGIC2 ERGIC and golgi 2
ERGIC3 ERGIC and golgi 3
ERLEC1 endoplasmic reticulum lectin 1
ERP44 endoplasmic reticulum protein 44
EVL Enah/Vasp-like
FAM133B family with sequence similarity 133, member B
FAM195A family with sequence similarity 195, member A
FLT1 fms-related tyrosine kinase 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
G3BP2 GTPase activating protein (SH3 domain) binding protein 2
GANAB glucosidase, alpha; neutral AB
HIST1H3B histone cluster 1, H3b
HLA-A major histocompatibility complex, class I, A
HM13 histocompatibility (minor) 13
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA7 heat shock 70kDa protein 7 (HSP70B)
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
ITM2B integral membrane protein 2B
KIR3DL1 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
LDLRAP1 low density lipoprotein receptor adaptor protein 1
LIPC lipase, hepatic
LMAN1 lectin, mannose-binding, 1
LMAN2 lectin, mannose-binding 2
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LSM12 LSM12 homolog (S. cerevisiae)
MAGT1 magnesium transporter 1
MAP4 microtubule-associated protein 4
MESDC2 mesoderm development candidate 2
MOGS mannosyl-oligosaccharide glucosidase
MYLIP myosin regulatory light chain interacting protein
NGLY1 N-glycanase 1
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PCSK9 proprotein convertase subtilisin/kexin type 9
PDIA3 protein disulfide isomerase family A, member 3
PDIA4 protein disulfide isomerase family A, member 4
PDIA5 protein disulfide isomerase family A, member 5
PF4 platelet factor 4
PGRMC1 progesterone receptor membrane component 1
PHB prohibitin
PRKCSH protein kinase C substrate 80K-H
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RHOC ras homolog family member C
RNF126 ring finger protein 126
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RPN1 ribophorin I
SDF2 stromal cell-derived factor 2
SDF2L1 stromal cell-derived factor 2-like 1
SDF4 stromal cell derived factor 4
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEH1L SEH1-like (S. cerevisiae)
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SNX17 sorting nexin 17
SSR4 signal sequence receptor, delta
SUMF2 sulfatase modifying factor 2
SUN1 Sad1 and UNC84 domain containing 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TMEM38B transmembrane protein 38B
TMEM43 transmembrane protein 43
TOR1A torsin family 1, member A (torsin A)
TOR1AIP2 torsin A interacting protein 2
TRBC1 T cell receptor beta constant 1
TRBV12-3 T cell receptor beta variable 12-3
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UBC ubiquitin C
UGGT1 UDP-glucose glycoprotein glucosyltransferase 1