LEF1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description lymphoid enhancer-binding factor 1|This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 51176)
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Genes

302 genes differentially expressed following the LEF1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ARSF arylsulfatase F 2.35925
TBPL2 TATA box binding protein like 2 2.35925
LHX2 LIM homeobox 2 2.35925
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.35925
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.35925
IMPG1 interphotoreceptor matrix proteoglycan 1 2.35925
OPRK1 opioid receptor, kappa 1 2.35925
FMO2 flavin containing monooxygenase 2 (non-functional) 2.35925
EGR2 early growth response 2 2.35925
AKAP14 A kinase (PRKA) anchor protein 14 2.35925
GGN gametogenetin 2.35925
GDF6 growth differentiation factor 6 2.35925
SLC46A1 solute carrier family 46 (folate transporter), member 1 2.35925
PFN4 profilin family, member 4 2.35925
LTF lactotransferrin 2.35925
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.35925
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.35925
LRRC10B leucine rich repeat containing 10B 2.35925
SLC22A14 solute carrier family 22, member 14 2.35925
NDRG1 N-myc downstream regulated 1 2.35925
CD5 CD5 molecule 2.35925
IZUMO4 IZUMO family member 4 2.28443
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.28443
ATP13A5 ATPase type 13A5 2.28443
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.28443
MAGEB16 melanoma antigen family B16 2.28443
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.28443
HLX H2.0-like homeobox 2.28443
HAS1 hyaluronan synthase 1 2.28443
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.28443
NVL nuclear VCP-like 2.28443
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.28443
WEE2 WEE1 homolog 2 (S. pombe) 2.28443
ZACN zinc activated ligand-gated ion channel 2.28443
CD19 CD19 molecule 2.28443
PAX8 paired box 8 2.28443
OLIG3 oligodendrocyte transcription factor 3 2.28443
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.28443
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.28443
SSTR5 somatostatin receptor 5 2.28443
PBOV1 prostate and breast cancer overexpressed 1 2.28443
PLXNB3 plexin B3 2.28443
SP7 Sp7 transcription factor 2.28443
RFPL2 ret finger protein-like 2 2.28443
FAM221B family with sequence similarity 221, member B 2.28443
MUC5B mucin 5B, oligomeric mucus/gel-forming 2.28443
GJB4 gap junction protein, beta 4, 30.3kDa 2.28443
SKOR1 SKI family transcriptional corepressor 1 2.28443
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.28443
HCRTR1 hypocretin (orexin) receptor 1 2.28443
TEX13B testis expressed 13B 2.28443
DDN dendrin 2.28443
CELA3B chymotrypsin-like elastase family, member 3B 2.28443
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 2.28443
TMEM151A transmembrane protein 151A 2.28443
HES3 hes family bHLH transcription factor 3 2.28443
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.28443
C8ORF48 chromosome 8 open reading frame 48 2.28443
ANKRD16 ankyrin repeat domain 16 2.28443
POFUT4 protein O-fucosyltransferase 4 2.28443
ROPN1L rhophilin associated tail protein 1-like 2.28443
HBG2 hemoglobin, gamma G 2.28443
VN1R1 vomeronasal 1 receptor 1 2.28443
DUSP9 dual specificity phosphatase 9 2.28443
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.28443
FRG2C FSHD region gene 2 family, member C 2.28443
STX11 syntaxin 11 2.28443
SPRR2A small proline-rich protein 2A 2.28443
PDF peptide deformylase (mitochondrial) 2.28443
OTOS otospiralin 2.28443
ALPG alkaline phosphatase, germ cell 2.28443
CCN5 cellular communication network factor 5 2.28443
SPMAP2L sperm microtubule associated protein 2 like 2.28443
TEKTL1 tektin like 1 2.28443
EPCIP exosomal polycystin 1 interacting protein 2.28443
CIMIP7 ciliary microtubule inner protein 7 2.28443
SPEGNB SPEG neighbor 2.28443
SPDYE8 speedy/RINGO cell cycle regulator family member E8 2.28443
C20ORF204 chromosome 20 open reading frame 204 2.28443
MYMK myomaker, myoblast fusion factor 2.28443
CFAP157 cilia and flagella associated protein 157 2.28443
ASB9 ankyrin repeat and SOCS box containing 9 2.28443
GRAP GRB2-related adaptor protein 2.28443
GATA3 GATA binding protein 3 2.28443
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.28443
C12ORF54 chromosome 12 open reading frame 54 2.28443
IL6 interleukin 6 2.28443
OR2A12 olfactory receptor, family 2, subfamily A, member 12 2.28443
PTP4A1 protein tyrosine phosphatase type IVA, member 1 2.28443
ANXA10 annexin A10 2.28443
THPO thrombopoietin 2.28443
PCDHB13 protocadherin beta 13 2.28443
PRB4 proline-rich protein BstNI subfamily 4 2.28443
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.28443
SPDYC speedy/RINGO cell cycle regulator family member C 2.28443
CCR8 chemokine (C-C motif) receptor 8 2.28443
HADH hydroxyacyl-CoA dehydrogenase 2.28443
CSAG2 CSAG family, member 2 2.28443
MSGN1 mesogenin 1 2.28443
PCDHGC4 protocadherin gamma subfamily C, 4 2.28443
LGSN lengsin, lens protein with glutamine synthetase domain 2.28443
PLEK2 pleckstrin 2 2.28443
IL1R2 interleukin 1 receptor, type II 2.28443
PGA3 pepsinogen 3, group I (pepsinogen A) 2.28443
RGS21 regulator of G-protein signaling 21 2.28443
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 2.28443
GADL1 glutamate decarboxylase-like 1 2.28443
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 2.28443
CLIC5 chloride intracellular channel 5 2.28443
LRTM2 leucine-rich repeats and transmembrane domains 2 2.28443
CTAGE9 CTAGE family, member 9 2.28443
WFDC8 WAP four-disulfide core domain 8 2.28443
RPL9 ribosomal protein L9 2.28443
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 2.28443
C11ORF16 chromosome 11 open reading frame 16 2.28443
PSKH2 protein serine kinase H2 2.28443
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.28443
MAGEA2B melanoma antigen family A2B 2.28443
PYHIN1 pyrin and HIN domain family, member 1 2.28443
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.28443
RPRD1A regulation of nuclear pre-mRNA domain containing 1A 2.28443
APOL3 apolipoprotein L, 3 2.28443
CARNS1 carnosine synthase 1 2.28443
USHBP1 Usher syndrome 1C binding protein 1 2.28443
AGR3 anterior gradient 3 2.28443
PRSS57 protease, serine, 57 2.28443
PLA2G4E phospholipase A2, group IVE 2.28443
DYTN dystrotelin 2.28443
IFITM5 interferon induced transmembrane protein 5 2.28443
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 2.28443
IL1A interleukin 1, alpha 2.28443
NKX6-3 NK6 homeobox 3 2.28443
FAIM2 Fas apoptotic inhibitory molecule 2 2.28443
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.28443
ADCY10 adenylate cyclase 10 (soluble) 2.28443
PCSK4 proprotein convertase subtilisin/kexin type 4 2.28443
CCDC70 coiled-coil domain containing 70 2.28443
DRC7 dynein regulatory complex subunit 7 2.28443
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.28443
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.28443
MYLK2 myosin light chain kinase 2 2.28443
CLEC1A C-type lectin domain family 1, member A 2.28443
TSPAN1 tetraspanin 1 2.28443
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.28443
SVOP SV2 related protein homolog (rat) 2.28443
SAMD7 sterile alpha motif domain containing 7 2.28443
CTXN2 cortexin 2 2.28443
SYNGR4 synaptogyrin 4 2.28443
VAV2 vav 2 guanine nucleotide exchange factor 2.28443
VAV1 vav 1 guanine nucleotide exchange factor 2.28443
GCGR glucagon receptor 2.28443
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.28443
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 2.28443
TAS2R41 taste receptor, type 2, member 41 2.28443
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 2.28443
BTBD16 BTB (POZ) domain containing 16 2.28443
NPIPA2 nuclear pore complex interacting protein family, member A2 2.28443
AIRE autoimmune regulator 2.28443
RNASE9 ribonuclease, RNase A family, 9 (non-active) 2.28443
FGF6 fibroblast growth factor 6 2.28443
TTLL2 tubulin tyrosine ligase-like family member 2 2.28443
WNT8B wingless-type MMTV integration site family, member 8B 2.28443
FGF4 fibroblast growth factor 4 2.28443
STAP1 signal transducing adaptor family member 1 2.28443
ATOH1 atonal homolog 1 (Drosophila) 2.28443
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.28443
RNF39 ring finger protein 39 2.28443
C2ORF78 chromosome 2 open reading frame 78 2.28443
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.28443
CDCP2 CUB domain containing protein 2 2.28443
ANGPTL5 angiopoietin-like 5 2.28443
TMPRSS15 transmembrane protease, serine 15 2.28443
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.28443
ZNF556 zinc finger protein 556 2.28443
SLX1B SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) 2.28443
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.28443
PADI1 peptidyl arginine deiminase, type I 2.28443
HES2 hes family bHLH transcription factor 2 2.28443
ADAM29 ADAM metallopeptidase domain 29 2.28443
GNAT1 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 2.28443
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.28443
CRH corticotropin releasing hormone 2.28443
F9 coagulation factor IX 2.28443
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.28443
EIF1 eukaryotic translation initiation factor 1 2.28443
ASGR2 asialoglycoprotein receptor 2 2.28443
HDAC1 histone deacetylase 1 2.28392
RNF135 ring finger protein 135 2.27965
SYTL3 synaptotagmin-like 3 2.26632
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 2.24171
PML promyelocytic leukemia 2.237
CHD9 chromodomain helicase DNA binding protein 9 2.23092
MYBPHL myosin binding protein H-like 2.20194
SYS1 Sys1 golgi trafficking protein 2.18777
BTNL9 butyrophilin-like 9 2.17144
EVA1B eva-1 homolog B (C. elegans) 2.16189
PRPF6 pre-mRNA processing factor 6 2.15848
TUFT1 tuftelin 1 2.15807
MMP25 matrix metallopeptidase 25 2.15654
GRIP2 glutamate receptor interacting protein 2 2.1374
NEK11 NIMA-related kinase 11 2.0851
TULP4 tubby like protein 4 2.0851
CRABP1 cellular retinoic acid binding protein 1 2.08247
BOD1 biorientation of chromosomes in cell division 1 2.08247
SP8 Sp8 transcription factor 2.07183
FBXW12 F-box and WD repeat domain containing 12 2.04847
GPR161 G protein-coupled receptor 161 2.04847
GARIN5A golgi associated RAB2 interactor 5A 2.0386
GNPAT glyceronephosphate O-acyltransferase 2.03493
NRIP3 nuclear receptor interacting protein 3 2.026
THAP10 THAP domain containing 10 2.01591
RPS27 ribosomal protein S27 2.01591

decreased expression

Symbol Name Standardized Value
HES4 hes family bHLH transcription factor 4 -2.35925
PDGFRA platelet-derived growth factor receptor, alpha polypeptide -2.35925
SNORC secondary ossification center associated regulator of chondrocyte maturation -2.35925
GLRX2 glutaredoxin 2 -2.35925
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.35925
COBL cordon-bleu WH2 repeat protein -2.35925
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 -2.35925
CCR10 chemokine (C-C motif) receptor 10 -2.35925
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -2.33878
RCCD1 RCC1 domain containing 1 -2.28443
PEAR1 platelet endothelial aggregation receptor 1 -2.28443
ARSD arylsulfatase D -2.28443
C11ORF87 chromosome 11 open reading frame 87 -2.28443
GMFG glia maturation factor, gamma -2.28443
TNS4 tensin 4 -2.28443
CRIP3 cysteine-rich protein 3 -2.28443
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 -2.28443
EMCN endomucin -2.28443
LEP leptin -2.28443
PLAAT1 phospholipase A and acyltransferase 1 -2.28443
PDYN prodynorphin -2.28443
ATP23 ATP23 metallopeptidase and ATP synthase assembly factor homolog -2.28443
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -2.28443
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -2.28443
LDB3 LIM domain binding 3 -2.28443
JADE3 jade family PHD finger 3 -2.28443
TMPRSS6 transmembrane protease, serine 6 -2.28443
MYL10 myosin, light chain 10, regulatory -2.28443
CELA2A chymotrypsin-like elastase family, member 2A -2.28443
ZFP1 ZFP1 zinc finger protein -2.28443
LIX1 Lix1 homolog (chicken) -2.28443
TRIM66 tripartite motif containing 66 -2.28443
PTGDR2 prostaglandin D2 receptor 2 -2.28443
PCDHA7 protocadherin alpha 7 -2.28443
WDR83 WD repeat domain 83 -2.28443
SCGN secretagogin, EF-hand calcium binding protein -2.28443
IRX2 iroquois homeobox 2 -2.28443
TMEM182 transmembrane protein 182 -2.28443
KRT8 keratin 8, type II -2.28443
WNT4 wingless-type MMTV integration site family, member 4 -2.28443
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 -2.28443
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -2.28443
NT5C1B 5'-nucleotidase, cytosolic IB -2.28443
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.28443
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic -2.28443
MLIP muscular LMNA-interacting protein -2.28443
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal) -2.28443
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -2.28443
NTSR1 neurotensin receptor 1 (high affinity) -2.28443
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -2.28443
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -2.28443
EXOSC9 exosome component 9 -2.28443
PTBP2 polypyrimidine tract binding protein 2 -2.28443
AMER2 APC membrane recruitment protein 2 -2.28443
PLGLB1 plasminogen-like B1 -2.28443
MB myoglobin -2.28443
NRK Nik related kinase -2.24171
POMT1 protein-O-mannosyltransferase 1 -2.23726
SLC25A22 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 -2.23092
TC2N tandem C2 domains, nuclear -2.22764
GTPBP6 GTP binding protein 6 (putative) -2.21356
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.20194
SKA1 spindle and kinetochore associated complex subunit 1 -2.20194
EVI2B ecotropic viral integration site 2B -2.20194
RDH16 retinol dehydrogenase 16 (all-trans) -2.20194
SPIN2B spindlin family, member 2B -2.19701
GDAP2 ganglioside induced differentiation associated protein 2 -2.16881
SLC25A40 solute carrier family 25, member 40 -2.15793
AKAP8L A kinase (PRKA) anchor protein 8-like -2.14196
AASS aminoadipate-semialdehyde synthase -2.13046
MAGED1 melanoma antigen family D1 -2.12892
SPDYE3 speedy/RINGO cell cycle regulator family member E3 -2.11994
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit -2.11425
PRTG protogenin -2.10029
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 -2.10029
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -2.08894
LAMA4 laminin, alpha 4 -2.0851
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -2.0851
GLRB glycine receptor, beta -2.0851
RHOBTB2 Rho-related BTB domain containing 2 -2.0851
FSCN3 fascin actin-bundling protein 3, testicular -2.0851
C1ORF116 chromosome 1 open reading frame 116 -2.0851
ZNF628 zinc finger protein 628 -2.0851
PRODH proline dehydrogenase (oxidase) 1 -2.07955
GLDC glycine dehydrogenase (decarboxylating) -2.06788
AK7 adenylate kinase 7 -2.05861
ENO1 enolase 1, (alpha) -2.01591
GNAS GNAS complex locus -2.01591
TAFA5 TAFA chemokine like family member 5 -2.01591
CPQ carboxypeptidase Q -2.00131