LEF1 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description lymphoid enhancer-binding factor 1|This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 51176)
External Link https://ncbi.nlm.nih.gov/gene/51176
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Genes

500 genes differentially expressed following the LEF1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
XIC X chromosome inactivation center 0.0129852
KRT14 keratin 14, type I 0.0122395
DEFB1 defensin, beta 1 0.0118209
SSBP2 single-stranded DNA binding protein 2 0.0116137
SOX9 SRY (sex determining region Y)-box 9 0.0112578
SYNGR3 synaptogyrin 3 0.0109962
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 0.0106361
TM4SF1 transmembrane 4 L six family member 1 0.0104411
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00998115
CADM1 cell adhesion molecule 1 0.0098904
SIK1 salt-inducible kinase 1 0.00980555
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D 0.00958729
FGG fibrinogen gamma chain 0.00952495
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00936359
PEG10 paternally expressed 10 0.00916923
KRT23 keratin 23, type I 0.0090526
BASP1 brain abundant, membrane attached signal protein 1 0.00895159
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.00885443
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.00877886
TUBA4A tubulin, alpha 4a 0.00875533
OXA1L oxidase (cytochrome c) assembly 1-like 0.00872821
HSPA1A heat shock 70kDa protein 1A 0.00864594
FOLR1 folate receptor 1 (adult) 0.00854759
KRT17 keratin 17, type I 0.00850824
HMOX1 heme oxygenase 1 0.00845506
ATF3 activating transcription factor 3 0.00844465
GEM GTP binding protein overexpressed in skeletal muscle 0.00828656
EFHD1 EF-hand domain family, member D1 0.0082719
KRT7 keratin 7, type II 0.00825684
ZMAT3 zinc finger, matrin-type 3 0.00804654
S100A7 S100 calcium binding protein A7 0.00801499
HSPH1 heat shock 105kDa/110kDa protein 1 0.00800583
RCAN1 regulator of calcineurin 1 0.00800402
RRAGD Ras-related GTP binding D 0.00796136
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.00786569
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.00782932
MT1X metallothionein 1X 0.00781304
PDZK1IP1 PDZK1 interacting protein 1 0.00779679
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.00778074
FGF13 fibroblast growth factor 13 0.00773312
CLU clusterin 0.00772945
KYNU kynureninase 0.0076733
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 0.00759244
CYB5R1 cytochrome b5 reductase 1 0.00755928
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 0.00750339
CA2 carbonic anhydrase II 0.00747923
HIST1H2BD histone cluster 1, H2bd 0.00743439
OPN3 opsin 3 0.00737503
PLK2 polo-like kinase 2 0.00735885
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.00731958
POU2AF1 POU class 2 associating factor 1 0.0072382
MICB MHC class I polypeptide-related sequence B 0.0070254
ELL2 elongation factor, RNA polymerase II, 2 0.00702434
HSPA6 heat shock 70kDa protein 6 (HSP70B') 0.00701532
AREG amphiregulin 0.00701057
TTR transthyretin 0.00697171
EIF5B eukaryotic translation initiation factor 5B 0.00692202
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.00688935
SCGB2A2 secretoglobin, family 2A, member 2 0.0068649
KRT16 keratin 16, type I 0.00686401
SLPI secretory leukocyte peptidase inhibitor 0.0068299
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 0.00682731
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.00680399
PRPF4 pre-mRNA processing factor 4 0.00680376
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 0.0067995
STEAP3 STEAP family member 3, metalloreductase 0.00678943
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.00674954
CD59 CD59 molecule, complement regulatory protein 0.00673989
SGCE sarcoglycan, epsilon 0.00671025
KRT81 keratin 81, type II 0.00670242
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0066596
GAB2 GRB2-associated binding protein 2 0.00657626
CSRP1 cysteine and glycine-rich protein 1 0.00656459
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 0.00655206
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.00652656
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.00650436
RGCC regulator of cell cycle 0.0065016
BRCA1 breast cancer 1, early onset 0.00649131
STC2 stanniocalcin 2 0.00645238
RBM34 RNA binding motif protein 34 0.00643127
HIST1H2AC histone cluster 1, H2ac 0.00640546
FAM102A family with sequence similarity 102, member A 0.00635119
TRIM22 tripartite motif containing 22 0.00634281
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.00632599
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00631256
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 0.0063091
UNC45A unc-45 homolog A (C. elegans) 0.00629317
NID1 nidogen 1 0.00629164
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 0.00619913
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.00611193
STC1 stanniocalcin 1 0.00607528
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 0.00607198
CALB1 calbindin 1, 28kDa 0.00606372
SLC31A2 solute carrier family 31 (copper transporter), member 2 0.0060634
GPM6B glycoprotein M6B 0.00605842
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.0060528
CRISP3 cysteine-rich secretory protein 3 0.00600114
RBM47 RNA binding motif protein 47 0.005983
DAXX death-domain associated protein 0.0059656
QPRT quinolinate phosphoribosyltransferase 0.00595179
TSC22D1 TSC22 domain family, member 1 0.00594829
PON2 paraoxonase 2 0.0059466
CREB3L2 cAMP responsive element binding protein 3-like 2 0.00594566
THY1 Thy-1 cell surface antigen 0.00593248
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 0.00590375
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 0.00590212
PAWR PRKC, apoptosis, WT1, regulator 0.00587313
L1CAM L1 cell adhesion molecule 0.00586657
NEFM neurofilament, medium polypeptide 0.00585554
KRT6B keratin 6B, type II 0.00585063
KLF7 Kruppel-like factor 7 (ubiquitous) 0.00584871
NCALD neurocalcin delta 0.00584506
TFRC transferrin receptor 0.00583664
HSPA8 heat shock 70kDa protein 8 0.00579668
NEU1 sialidase 1 (lysosomal sialidase) 0.00579362
ELMO1 engulfment and cell motility 1 0.00577481
GADD45A growth arrest and DNA-damage-inducible, alpha 0.00575934
IER5 immediate early response 5 0.00575196
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.00574482
FGA fibrinogen alpha chain 0.00573958
IL1B interleukin 1, beta 0.00568873
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.00568772
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.00568339
CLDN10 claudin 10 0.00566939
PAX5 paired box 5 0.0056627
SLC30A1 solute carrier family 30 (zinc transporter), member 1 0.00564559
PELI1 pellino E3 ubiquitin protein ligase 1 0.00563458
TOB1 transducer of ERBB2, 1 0.00559759
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.00558447
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 0.00556368
FGB fibrinogen beta chain 0.0055317
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.00551857
UQCRH ubiquinol-cytochrome c reductase hinge protein 0.00551502
CCDC6 coiled-coil domain containing 6 0.00550195
BRD4 bromodomain containing 4 0.00545278
TNS3 tensin 3 0.00544571
VSNL1 visinin-like 1 0.00544208
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.00542964
ALDH5A1 aldehyde dehydrogenase 5 family, member A1 0.00542081
RABGGTB Rab geranylgeranyltransferase, beta subunit 0.00541657
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase) 0.00541086
EPB41L4B erythrocyte membrane protein band 4.1 like 4B 0.00539393
ZNF185 zinc finger protein 185 (LIM domain) 0.00539353
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.00537199
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.00536567
SERTAD2 SERTA domain containing 2 0.00535977
AIM2 absent in melanoma 2 0.00535867
SEPP1 selenoprotein P, plasma, 1 0.00535104
PRSS23 protease, serine, 23 0.0053465
RHOB ras homolog family member B 0.00529779
SERINC5 serine incorporator 5 0.00529246
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.00529149
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.00527386
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.00527013
BLNK B-cell linker 0.00526522
METRN meteorin, glial cell differentiation regulator 0.00526302
OLFML2B olfactomedin-like 2B 0.00525765
CRYAB crystallin, alpha B 0.0052569
IL6 interleukin 6 0.00525185
FLNA filamin A, alpha 0.0052497
CCN2 cellular communication network factor 2 0.00524789
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 0.00524559
PTGES prostaglandin E synthase 0.00523893
ALCAM activated leukocyte cell adhesion molecule 0.0052385
RIPK2 receptor-interacting serine-threonine kinase 2 0.00523404
CTTN cortactin 0.00522361
TRIM29 tripartite motif containing 29 0.00522144
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.00521623
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 0.00521461
LAMC2 laminin, gamma 2 0.0052061
OSMR oncostatin M receptor 0.00519496
PGBD5 piggyBac transposable element derived 5 0.00519108
PIP prolactin-induced protein 0.00517862
HIST1H2BH histone cluster 1, H2bh 0.00517243
JUNB jun B proto-oncogene 0.00516954
MMD monocyte to macrophage differentiation-associated 0.00516801
RTL8C retrotransposon Gag like 8C 0.00516211
HBD hemoglobin, delta 0.0051566
HSPA4L heat shock 70kDa protein 4-like 0.00513951
MZB1 marginal zone B and B1 cell-specific protein 0.0051389
AZIN1 antizyme inhibitor 1 0.00512487
SPRR2B small proline-rich protein 2B 0.00510656
TICAM1 toll-like receptor adaptor molecule 1 0.00509562
VAMP8 vesicle-associated membrane protein 8 0.00508344
HTRA2 HtrA serine peptidase 2 0.00508309
MGLL monoglyceride lipase 0.00507305
KDM6A lysine (K)-specific demethylase 6A 0.00505795
RSL1D1 ribosomal L1 domain containing 1 0.00504964
RAB9A RAB9A, member RAS oncogene family 0.00503024
LAMA3 laminin, alpha 3 0.00500916
LBH limb bud and heart development 0.00500901
INHBB inhibin, beta B 0.00500401
BATF basic leucine zipper transcription factor, ATF-like 0.00499828
ABHD5 abhydrolase domain containing 5 0.00499471
MT1HL1 metallothionein 1H-like 1 0.00498589
HCCS holocytochrome c synthase 0.00498541
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.00498425
OSBPL9 oxysterol binding protein-like 9 0.00498224
WIPI1 WD repeat domain, phosphoinositide interacting 1 0.00497855
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.00497529
MAGEA1 melanoma antigen family A1 0.00497374
COL5A2 collagen, type V, alpha 2 0.00496819
INA internexin neuronal intermediate filament protein, alpha 0.00496534
KLK5 kallikrein-related peptidase 5 0.00493082
ADCY9 adenylate cyclase 9 0.00492869
HP haptoglobin 0.00490348
COX7A2L cytochrome c oxidase subunit VIIa polypeptide 2 like 0.00489638
MT1H metallothionein 1H 0.00489209
LRRC8D leucine rich repeat containing 8 family, member D 0.00489006
S100A12 S100 calcium binding protein A12 0.00488373
SOCS1 suppressor of cytokine signaling 1 0.00487926
LMCD1 LIM and cysteine-rich domains 1 0.00487065
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 0.00486377
RUNX1 runt-related transcription factor 1 0.00485816
LY75 lymphocyte antigen 75 0.00485425
TRIB3 tribbles pseudokinase 3 0.00485174
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.00484681
LEF1 lymphoid enhancer-binding factor 1 0.00484358
CALML5 calmodulin-like 5 0.00484188
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor) 0.0048417
SPTLC2 serine palmitoyltransferase, long chain base subunit 2 0.00483019
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 0.00482379
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.00481375
XK X-linked Kx blood group 0.00481261
VTN vitronectin 0.00480889
SH3YL1 SH3 and SYLF domain containing 1 0.00480554
MUC16 mucin 16, cell surface associated 0.0047951
RNASE3 ribonuclease, RNase A family, 3 0.00479304
NCF2 neutrophil cytosolic factor 2 0.00479195
EGF epidermal growth factor 0.00479111
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00478045
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0047731
SIK3 SIK family kinase 3 0.00476657
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.00474846
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.00473727
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.00473416
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.00473406
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.00472425
PRPF3 pre-mRNA processing factor 3 0.0047218
WNK1 WNK lysine deficient protein kinase 1 0.0047211
ZBED2 zinc finger, BED-type containing 2 0.00471534
BTK Bruton agammaglobulinemia tyrosine kinase 0.0047134
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 0.00470962
CLC Charcot-Leyden crystal galectin 0.00470472
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.00470271
CD79A CD79a molecule, immunoglobulin-associated alpha 0.00468589
PPIF peptidylprolyl isomerase F 0.00466988
RHCG Rh family, C glycoprotein 0.00466255
EIF1B eukaryotic translation initiation factor 1B 0.00465555
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.00465341

decreased expression

Symbol Name Standardized Value
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.0140711
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -0.0132916
ZDHHC6 zinc finger, DHHC-type containing 6 -0.0116922
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0113502
FHL1 four and a half LIM domains 1 -0.0110794
GNAS GNAS complex locus -0.0102992
FBN2 fibrillin 2 -0.0100047
LGALS1 lectin, galactoside-binding, soluble, 1 -0.00965504
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.00957076
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0093329
PLN phospholamban -0.00866307
DES desmin -0.00860738
OLFM4 olfactomedin 4 -0.00846369
BCHE butyrylcholinesterase -0.00840107
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 -0.00835509
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.00833078
CASP10 caspase 10, apoptosis-related cysteine peptidase -0.00832067
KDM5D lysine (K)-specific demethylase 5D -0.00822039
COG7 component of oligomeric golgi complex 7 -0.00806413
EIF1AY eukaryotic translation initiation factor 1A, Y-linked -0.00783157
CHEK2 checkpoint kinase 2 -0.00759935
GINS1 GINS complex subunit 1 (Psf1 homolog) -0.0075989
COLEC12 collectin sub-family member 12 -0.00754949
EMP3 epithelial membrane protein 3 -0.00754518
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0075375
CD2 CD2 molecule -0.00743885
SRC SRC proto-oncogene, non-receptor tyrosine kinase -0.00737271
LYZ lysozyme -0.00735535
PDLIM3 PDZ and LIM domain 3 -0.00734684
TFF1 trefoil factor 1 -0.00732298
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.00721845
DACH1 dachshund family transcription factor 1 -0.00716421
REG3A regenerating islet-derived 3 alpha -0.00715495
ADAMDEC1 ADAM-like, decysin 1 -0.0071358
CASP1 caspase 1, apoptosis-related cysteine peptidase -0.00701072
ANXA10 annexin A10 -0.00700382
MAOA monoamine oxidase A -0.00700014
PTTG1 pituitary tumor-transforming 1 -0.00693006
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -0.00687422
LGALS13 lectin, galactoside-binding, soluble, 13 -0.00683704
HOPX HOP homeobox -0.00679782
CXCL11 chemokine (C-X-C motif) ligand 11 -0.00661499
INSM1 insulinoma-associated 1 -0.00659941
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00657644
REG1B regenerating islet-derived 1 beta -0.00657061
KLK3 kallikrein-related peptidase 3 -0.00651716
MYBPC1 myosin binding protein C, slow type -0.00647429
PTGIS prostaglandin I2 (prostacyclin) synthase -0.00644673
CXCL14 chemokine (C-X-C motif) ligand 14 -0.00642754
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0064045
PRUNE2 prune homolog 2 (Drosophila) -0.00637376
LGALS4 lectin, galactoside-binding, soluble, 4 -0.00631161
PNKP polynucleotide kinase 3'-phosphatase -0.00631064
BIRC5 baculoviral IAP repeat containing 5 -0.00626104
SCD5 stearoyl-CoA desaturase 5 -0.00622508
ACTN2 actinin, alpha 2 -0.00622152
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) -0.00620202
POSTN periostin, osteoblast specific factor -0.00618783
TYROBP TYRO protein tyrosine kinase binding protein -0.0061798
IFI6 interferon, alpha-inducible protein 6 -0.00617425
GBP1 guanylate binding protein 1, interferon-inducible -0.00614314
SSPN sarcospan -0.006128
FXYD1 FXYD domain containing ion transport regulator 1 -0.0061073
THAP12 THAP domain containing 12 -0.00610208
NPM3 nucleophosmin/nucleoplasmin 3 -0.0060793
FAR2 fatty acyl CoA reductase 2 -0.00607328
MEIS2 Meis homeobox 2 -0.00606869
CASP2 caspase 2, apoptosis-related cysteine peptidase -0.00605014
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -0.00601629
SLC2A4RG SLC2A4 regulator -0.00596195
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) -0.00595653
ELOVL6 ELOVL fatty acid elongase 6 -0.00595575
STON1 stonin 1 -0.00593139
FSTL1 follistatin-like 1 -0.00590443
MMP12 matrix metallopeptidase 12 -0.00590249
GIMAP4 GTPase, IMAP family member 4 -0.00586997
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.00580911
LPAR6 lysophosphatidic acid receptor 6 -0.00580621
CSTA cystatin A (stefin A) -0.00578682
ZNF22 zinc finger protein 22 -0.00578678
NPY neuropeptide Y -0.00572663
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 -0.00572421
STK39 serine threonine kinase 39 -0.00571033
TIMP3 TIMP metallopeptidase inhibitor 3 -0.00569495
CALR calreticulin -0.00569103
FXYD6 FXYD domain containing ion transport regulator 6 -0.00567707
DEFA6 defensin, alpha 6, Paneth cell-specific -0.00567623
FOXM1 forkhead box M1 -0.00560716
SELENOW selenoprotein W -0.00560213
SIVA1 SIVA1, apoptosis-inducing factor -0.0055897
CRY1 cryptochrome circadian clock 1 -0.00558885
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 -0.00558575
TRIP13 thyroid hormone receptor interactor 13 -0.00557747
DEFA5 defensin, alpha 5, Paneth cell-specific -0.00556418
NCAPD3 non-SMC condensin II complex, subunit D3 -0.005535
ASRGL1 asparaginase like 1 -0.00553449
OPHN1 oligophrenin 1 -0.00551772
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 -0.00551004
CENPBD1P1 CENPB DNA-binding domains containing 1 pseudogene 1 -0.00550245
NAE1 NEDD8 activating enzyme E1 subunit 1 -0.00549122
USP9Y ubiquitin specific peptidase 9, Y-linked -0.00548956
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00548507
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -0.0054841
UBE2S ubiquitin-conjugating enzyme E2S -0.00545842
PRMT1 protein arginine methyltransferase 1 -0.00544892
KLK2 kallikrein-related peptidase 2 -0.00544702
ABHD2 abhydrolase domain containing 2 -0.0054419
NPIPB3 nuclear pore complex interacting protein family, member B3 -0.00542043
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.00542024
CCR2 chemokine (C-C motif) receptor 2 -0.00539507
PCP4 Purkinje cell protein 4 -0.00538813
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.00538579
RAD21 RAD21 homolog (S. pombe) -0.0053822
LIG1 ligase I, DNA, ATP-dependent -0.00537682
PRELID3B PRELI domain containing 3B -0.00536257
PSRC1 proline/serine-rich coiled-coil 1 -0.00534486
DKK2 dickkopf WNT signaling pathway inhibitor 2 -0.00532609
SPINK4 serine peptidase inhibitor, Kazal type 4 -0.00531275
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide -0.00530752
CA9 carbonic anhydrase IX -0.00530732
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0052964
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -0.00527763
EMX2 empty spiracles homeobox 2 -0.00527613
HMGB2 high mobility group box 2 -0.00527223
IL33 interleukin 33 -0.00526504
PAN2 PAN2 poly(A) specific ribonuclease subunit -0.0052408
CXCL9 chemokine (C-X-C motif) ligand 9 -0.00523334
MATN2 matrilin 2 -0.00523037
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A -0.00522401
PAGE4 P antigen family, member 4 (prostate associated) -0.00519378
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) -0.00518799
FABP5 fatty acid binding protein 5 (psoriasis-associated) -0.00518777
TPM2 tropomyosin 2 (beta) -0.00518398
MYH11 myosin, heavy chain 11, smooth muscle -0.00515642
MEOX2 mesenchyme homeobox 2 -0.00515507
NELFCD negative elongation factor complex member C/D -0.00514405
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 -0.00513423
GNG10 guanine nucleotide binding protein (G protein), gamma 10 -0.00512127
SORD sorbitol dehydrogenase -0.0051198
MMP7 matrix metallopeptidase 7 -0.00511769
GZMK granzyme K (granzyme 3; tryptase II) -0.00511358
HNRNPL heterogeneous nuclear ribonucleoprotein L -0.00511066
LSR lipolysis stimulated lipoprotein receptor -0.00509632
NPEPL1 aminopeptidase-like 1 -0.0050877
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -0.0050858
FADS1 fatty acid desaturase 1 -0.00508356
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -0.00507739
STEAP1 six transmembrane epithelial antigen of the prostate 1 -0.00507618
MSMB microseminoprotein, beta- -0.00507444
NPR3 natriuretic peptide receptor 3 -0.00505943
CKM creatine kinase, muscle -0.0050506
NELL2 NEL-like 2 (chicken) -0.00504469
HMGN4 high mobility group nucleosomal binding domain 4 -0.00503188
FABP7 fatty acid binding protein 7, brain -0.00502023
CD3D CD3d molecule, delta (CD3-TCR complex) -0.00499691
PIMREG PICALM interacting mitotic regulator -0.00498056
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -0.0049804
LOC730101 uncharacterized LOC730101 -0.00497877
ADRA2A adrenoceptor alpha 2A -0.00496499
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide -0.00494268
SPA17 sperm autoantigenic protein 17 -0.00491252
LOX lysyl oxidase -0.00490911
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.00490414
TPM3 tropomyosin 3 -0.00490413
MOXD1 monooxygenase, DBH-like 1 -0.0049031
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -0.0048863
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -0.00488175
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) -0.0048721
REG1A regenerating islet-derived 1 alpha -0.00486075
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.00485414
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -0.00485151
AXL AXL receptor tyrosine kinase -0.00484261
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.00484173
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.00482713
GSTA4 glutathione S-transferase alpha 4 -0.00482339
MACROD1 MACRO domain containing 1 -0.00481769
UBA3 ubiquitin-like modifier activating enzyme 3 -0.0048122
EIF5A eukaryotic translation initiation factor 5A -0.00481106
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase -0.00479323
CD8A CD8a molecule -0.00477347
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) -0.00474571
PRMT2 protein arginine methyltransferase 2 -0.00473992
WBP5 WW domain binding protein 5 -0.004739
TSPAN13 tetraspanin 13 -0.00473561
ACP3 acid phosphatase 3 -0.00473251
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.00472917
NMU neuromedin U -0.00472033
ISL1 ISL LIM homeobox 1 -0.00469536
IL1RAP interleukin 1 receptor accessory protein -0.00468355
GPX1 glutathione peroxidase 1 -0.00468137
EPS8 epidermal growth factor receptor pathway substrate 8 -0.00467651
BMP4 bone morphogenetic protein 4 -0.00463634
EPHA3 EPH receptor A3 -0.00463487
PHYH phytanoyl-CoA 2-hydroxylase -0.00463129
GMPR guanosine monophosphate reductase -0.00463049
RNASEH2A ribonuclease H2, subunit A -0.00462859
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.00461329
HPGDS hematopoietic prostaglandin D synthase -0.00460156
PRDX3 peroxiredoxin 3 -0.00459277
SOX11 SRY (sex determining region Y)-box 11 -0.00457992
PDLIM5 PDZ and LIM domain 5 -0.00457812
RHOBTB1 Rho-related BTB domain containing 1 -0.0045756
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -0.00457346
COL1A2 collagen, type I, alpha 2 -0.00456969
RANBP1 RAN binding protein 1 -0.0045656
MB myoglobin -0.00455102
AMPD1 adenosine monophosphate deaminase 1 -0.00454597
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -0.00454541
LRP4 low density lipoprotein receptor-related protein 4 -0.00454488
CD69 CD69 molecule -0.00453852
CDKN3 cyclin-dependent kinase inhibitor 3 -0.00453081
HOXB13 homeobox B13 -0.00453014
MIS18A MIS18 kinetochore protein A -0.00452577
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.00452159
NQO2 NAD(P)H dehydrogenase, quinone 2 -0.00451528
RBL2 retinoblastoma-like 2 -0.00449083
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00448679
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -0.00445432
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.00445215
PTOV1 prostate tumor overexpressed 1 -0.00444725
OIP5 Opa interacting protein 5 -0.0044411
MYOT myotilin -0.00443737
MYH2 myosin, heavy chain 2, skeletal muscle, adult -0.0044305
SYNM synemin, intermediate filament protein -0.00442378
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 -0.00442153
MANSC1 MANSC domain containing 1 -0.00441268
PIGT phosphatidylinositol glycan anchor biosynthesis, class T -0.00441266
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2 -0.00440609
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 -0.0043975
PRDX2 peroxiredoxin 2 -0.00439177
COG4 component of oligomeric golgi complex 4 -0.00438962
RGS1 regulator of G-protein signaling 1 -0.0043866
LOXL1 lysyl oxidase-like 1 -0.00437771
MYL1 myosin, light chain 1, alkali; skeletal, fast -0.00437612
RNF125 ring finger protein 125, E3 ubiquitin protein ligase -0.00436779
CCL19 chemokine (C-C motif) ligand 19 -0.00436493
GLCE glucuronic acid epimerase -0.00435767
DTYMK deoxythymidylate kinase (thymidylate kinase) -0.00435637
TKTL1 transketolase-like 1 -0.00434845
MYL2 myosin, light chain 2, regulatory, cardiac, slow -0.00434096
GTSE1 G-2 and S-phase expressed 1 -0.00434083
MRPL16 mitochondrial ribosomal protein L16 -0.00433645
PRKCB protein kinase C, beta -0.00433505
DAPK1 death-associated protein kinase 1 -0.00432553
CSK c-src tyrosine kinase -0.00432362
NYNRIN NYN domain and retroviral integrase containing -0.00432272
ICMT isoprenylcysteine carboxyl methyltransferase -0.00431676
TIMELESS timeless circadian clock -0.00431492
TMEM47 transmembrane protein 47 -0.0043039
THYN1 thymocyte nuclear protein 1 -0.00430008