LEF1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description lymphoid enhancer-binding factor 1|This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 51176)
External Link http://www.ncbi.nlm.nih.gov/gene/51176
Similar Terms
Downloads & Tools

Genes

81 interacting proteins for LEF1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AES amino-terminal enhancer of split
ALX4 ALX homeobox 4
ALYREF Aly/REF export factor
CDX1 caudal type homeobox 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CTBP1 C-terminal binding protein 1
CTBP2 C-terminal binding protein 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DACT1 dishevelled-binding antagonist of beta-catenin 1
DAZAP2 DAZ associated protein 2
DPYSL2 dihydropyrimidinase-like 2
E2F1 E2F transcription factor 1
EGR1 early growth response 1
EP300 E1A binding protein p300
FHIT fragile histidine triad
GSK3B glycogen synthase kinase 3 beta
H2AFB1 H2A histone family, member B1
H2AFX H2A histone family, member X
H2AFZ H2A histone family, member Z
H2BFS H2B histone family, member S (pseudogene)
H3F3A H3 histone, family 3A
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC8 histone deacetylase 8
HINT1 histidine triad nucleotide binding protein 1
HIST1H2AB histone cluster 1, H2ab
HIST1H2AC histone cluster 1, H2ac
HIST1H2AD histone cluster 1, H2ad
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BA histone cluster 1, H2ba
HIST1H2BB histone cluster 1, H2bb
HIST1H2BD histone cluster 1, H2bd
HIST1H2BF histone cluster 1, H2bf
HIST1H2BH histone cluster 1, H2bh
HIST1H2BJ histone cluster 1, H2bj
HIST1H2BK histone cluster 1, H2bk
HIST1H2BL histone cluster 1, H2bl
HIST1H2BM histone cluster 1, H2bm
HIST1H2BN histone cluster 1, H2bn
HIST1H2BO histone cluster 1, H2bo
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HIST2H2AA4 histone cluster 2, H2aa4
HIST2H2AC histone cluster 2, H2ac
HIST2H2BE histone cluster 2, H2be
HIST2H3A histone cluster 2, H3a
HIST3H2BB histone cluster 3, H2bb
HIST3H3 histone cluster 3, H3
IGF1R insulin-like growth factor 1 receptor
KPNA1 karyopherin alpha 1 (importin alpha 5)
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MITF microphthalmia-associated transcription factor
MYB v-myb avian myeloblastosis viral oncogene homolog
NARF nuclear prelamin A recognition factor
NLK nemo-like kinase
NOTCH1 notch 1
NRARP NOTCH-regulated ankyrin repeat protein
PIAS4 protein inhibitor of activated STAT, 4
PITX2 paired-like homeodomain 2
RNF14 ring finger protein 14
RUNX2 runt-related transcription factor 2
RUVBL1 RuvB-like AAA ATPase 1
SETD8 SET domain containing (lysine methyltransferase) 8
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
STAT5A signal transducer and activator of transcription 5A
SUMO2 small ubiquitin-like modifier 2
TCF4 transcription factor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE2 transducin-like enhancer of split 2
TLE3 transducin-like enhancer of split 3
TLE4 transducin-like enhancer of split 4
TLE6 transducin-like enhancer of split 6
UBC ubiquitin C
UBTF upstream binding transcription factor, RNA polymerase I
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
ZBTB3 zinc finger and BTB domain containing 3