| Dataset | MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database) |
| External Link | http://www.broadinstitute.org/gsea/msigdb/cards/LEF1_UP.V1_UP |
| Similar Terms | |
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385 genes differentially expressed following the LEF1_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.
| Symbol | Name |
|---|---|
| ADAM19 | ADAM metallopeptidase domain 19 |
| ADAMTS8 | ADAM metallopeptidase with thrombospondin type 1 motif, 8 |
| ADGRE2 | adhesion G protein-coupled receptor E2 |
| ADGRG2 | adhesion G protein-coupled receptor G2 |
| ADIRF | adipogenesis regulatory factor |
| AKAP12 | A kinase (PRKA) anchor protein 12 |
| ALLC | allantoicase |
| ANO1 | anoctamin 1, calcium activated chloride channel |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G |
| ARC | activity-regulated cytoskeleton-associated protein |
| ARG2 | arginase 2 |
| ARHGAP4 | Rho GTPase activating protein 4 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) |
| AUTS2 | autism susceptibility candidate 2 |
| AXL | AXL receptor tyrosine kinase |
| BMP7 | bone morphogenetic protein 7 |
| C14ORF132 | chromosome 14 open reading frame 132 |
| CARD9 | caspase recruitment domain family, member 9 |
| CBS | cystathionine-beta-synthase |
| CCND2 | cyclin D2 |
| CCR7 | chemokine (C-C motif) receptor 7 |
| CD302 | CD302 molecule |
| CDA | cytidine deaminase |
| CDKN2A | cyclin-dependent kinase inhibitor 2A |
| CEACAM21 | carcinoembryonic antigen-related cell adhesion molecule 21 |
| CHGB | chromogranin B |
| CHST10 | carbohydrate sulfotransferase 10 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 |
| CHST2 | carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 |
| COL6A1 | collagen, type VI, alpha 1 |
| COL9A3 | collagen, type IX, alpha 3 |
| CRABP2 | cellular retinoic acid binding protein 2 |
| CRIP1 | cysteine-rich protein 1 (intestinal) |
| CST7 | cystatin F (leukocystatin) |
| CTH | cystathionine gamma-lyase |
| CXCR2 | chemokine (C-X-C motif) receptor 2 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 |
| CYBRD1 | cytochrome b reductase 1 |
| DBN1 | drebrin 1 |
| DCLK1 | doublecortin-like kinase 1 |
| DENND1C | DENN/MADD domain containing 1C |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 |
| DKK4 | dickkopf WNT signaling pathway inhibitor 4 |
| DLL3 | delta-like 3 (Drosophila) |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 |
| EDAR | ectodysplasin A receptor |
| EGR2 | early growth response 2 |
| EGR3 | early growth response 3 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) |
| ELOVL5 | ELOVL fatty acid elongase 5 |
| EMP1 | epithelial membrane protein 1 |
| EMP3 | epithelial membrane protein 3 |
| EN2 | engrailed homeobox 2 |
| EPB41L4A | erythrocyte membrane protein band 4.1 like 4A |
| ERVMER34-1 | endogenous retrovirus group MER34, member 1 |
| FADS1 | fatty acid desaturase 1 |
| FBXO17 | F-box protein 17 |
| FGF13 | fibroblast growth factor 13 |
| FGF3 | fibroblast growth factor 3 |
| FGF9 | fibroblast growth factor 9 |
| FHL1 | four and a half LIM domains 1 |
| FJX1 | four jointed box 1 (Drosophila) |
| FLNC | filamin C, gamma |
| FN1 | fibronectin 1 |
| FNBP1 | formin binding protein 1 |
| FNDC4 | fibronectin type III domain containing 4 |
| FOSL1 | FOS-like antigen 1 |
| FOXF2 | forkhead box F2 |
| FOXG1 | forkhead box G1 |
| G0S2 | G0/G1 switch 2 |
| GATA3 | GATA binding protein 3 |
| GJB1 | gap junction protein, beta 1, 32kDa |
| GNAL | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 |
| GNG4 | guanine nucleotide binding protein (G protein), gamma 4 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) |
| HAS2 | hyaluronan synthase 2 |
| HBA2 | hemoglobin, alpha 2 |
| HEY2 | hes-related family bHLH transcription factor with YRPW motif 2 |
| HOXB2 | homeobox B2 |
| HSPA1A | heat shock 70kDa protein 1A |
| IGFBP6 | insulin-like growth factor binding protein 6 |
| IGFBP7 | insulin-like growth factor binding protein 7 |
| IL11 | interleukin 11 |
| INHBE | inhibin, beta E |
| ISYNA1 | inositol-3-phosphate synthase 1 |
| KCNG1 | potassium channel, voltage gated modifier subfamily G, member 1 |
| KCNJ12 | potassium channel, inwardly rectifying subfamily J, member 12 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 |
| KCTD12 | potassium channel tetramerization domain containing 12 |
| KRT13 | keratin 13, type I |
| KRT23 | keratin 23, type I |
| KRT5 | keratin 5, type II |
| KRT76 | keratin 76, type II |
| KRT81 | keratin 81, type II |
| L1CAM | L1 cell adhesion molecule |
| LCK | LCK proto-oncogene, Src family tyrosine kinase |
| LGALS1 | lectin, galactoside-binding, soluble, 1 |
| LINC00341 | long intergenic non-protein coding RNA 341 |
| LMO2 | LIM domain only 2 (rhombotin-like 1) |
| LOXL1 | lysyl oxidase-like 1 |
| LPL | lipoprotein lipase |
| LTBP2 | latent transforming growth factor beta binding protein 2 |
| MAOA | monoamine oxidase A |
| MAOB | monoamine oxidase B |
| MAP1B | microtubule-associated protein 1B |
| MAP7D3 | MAP7 domain containing 3 |
| MFAP2 | microfibrillar-associated protein 2 |
| MIA | melanoma inhibitory activity |
| MLN | motilin |
| MPP6 | membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6) |
| MSN | moesin |
| MYL9 | myosin, light chain 9, regulatory |
| NELL2 | NEL-like 2 (chicken) |
| NES | nestin |
| NMNAT2 | nicotinamide nucleotide adenylyltransferase 2 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) |
| NRIP1 | nuclear receptor interacting protein 1 |
| NRIP3 | nuclear receptor interacting protein 3 |
| NTSR1 | neurotensin receptor 1 (high affinity) |
| OBSL1 | obscurin-like 1 |
| PARVB | parvin, beta |
| PAX6 | paired box 6 |
| PCSK1N | proprotein convertase subtilisin/kexin type 1 inhibitor |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 |
| PDGFA | platelet-derived growth factor alpha polypeptide |
| PDLIM4 | PDZ and LIM domain 4 |
| PDZD2 | PDZ domain containing 2 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 |
| PLEKHF1 | pleckstrin homology domain containing, family F (with FYVE domain) member 1 |
| PLEKHO1 | pleckstrin homology domain containing, family O member 1 |
| PLTP | phospholipid transfer protein |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 |
| PRF1 | perforin 1 (pore forming protein) |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit |
| PRKCDBP | protein kinase C, delta binding protein |
| PRPH | peripherin |
| PRPS1 | phosphoribosyl pyrophosphate synthetase 1 |
| PTGDS | prostaglandin D2 synthase 21kDa (brain) |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 |
| RAI2 | retinoic acid induced 2 |
| RAMP2 | receptor (G protein-coupled) activity modifying protein 2 |
| RBP1 | retinol binding protein 1, cellular |
| RGCC | regulator of cell cycle |
| ROR2 | receptor tyrosine kinase-like orphan receptor 2 |
| RPP25 | ribonuclease P/MRP 25kDa subunit |
| RRAGD | Ras-related GTP binding D |
| RUNX3 | runt-related transcription factor 3 |
| RYR1 | ryanodine receptor 1 (skeletal) |
| S100A2 | S100 calcium binding protein A2 |
| S100A3 | S100 calcium binding protein A3 |
| S100A4 | S100 calcium binding protein A4 |
| SCML1 | sex comb on midleg-like 1 (Drosophila) |
| SCN5A | sodium channel, voltage gated, type V alpha subunit |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
| SH2D2A | SH2 domain containing 2A |
| SLC17A9 | solute carrier family 17 (vesicular nucleotide transporter), member 9 |
| SLC26A4 | solute carrier family 26 (anion exchanger), member 4 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 |
| SLC35G2 | solute carrier family 35, member G2 |
| SLC43A3 | solute carrier family 43, member 3 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 |
| SLIT1 | slit homolog 1 (Drosophila) |
| SPRR2B | small proline-rich protein 2B |
| STC2 | stanniocalcin 2 |
| STRA6 | stimulated by retinoic acid 6 |
| TCEA2 | transcription elongation factor A (SII), 2 |
| TCHH | trichohyalin |
| TGM2 | transglutaminase 2 |
| TH | tyrosine hydroxylase |
| TM4SF5 | transmembrane 4 L six family member 5 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) |
| TMEM47 | transmembrane protein 47 |
| TMOD1 | tropomodulin 1 |
| TNFRSF1B | tumor necrosis factor receptor superfamily, member 1B |
| TREML2 | triggering receptor expressed on myeloid cells-like 2 |
| TRIM48 | tripartite motif containing 48 |
| TRPV2 | transient receptor potential cation channel, subfamily V, member 2 |
| TRPV6 | transient receptor potential cation channel, subfamily V, member 6 |
| TUBB2B | tubulin, beta 2B class IIb |
| TULP2 | tubby like protein 2 |
| VIM | vimentin |
| WASF3 | WAS protein family, member 3 |
| WNT5A | wingless-type MMTV integration site family, member 5A |
| WT1 | Wilms tumor 1 |
| WWC2 | WW and C2 domain containing 2 |
| ZAP70 | zeta-chain (TCR) associated protein kinase 70kDa |
| ZFPM2 | zinc finger protein, FOG family member 2 |
| ZNF134 | zinc finger protein 134 |
| ZNF22 | zinc finger protein 22 |
| ZNF236 | zinc finger protein 236 |
| ZNF350 | zinc finger protein 350 |
| Symbol | Name |
|---|---|
| ACSF2 | acyl-CoA synthetase family member 2 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 |
| AGR2 | anterior gradient 2 |
| AIM1 | absent in melanoma 1 |
| AKR1C3 | aldo-keto reductase family 1, member C3 |
| ALCAM | activated leukocyte cell adhesion molecule |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) |
| ANKFY1 | ankyrin repeat and FYVE domain containing 1 |
| AP1M2 | adaptor-related protein complex 1, mu 2 subunit |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide |
| ATP2A1 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 |
| BDH2 | 3-hydroxybutyrate dehydrogenase, type 2 |
| BDKRB2 | bradykinin receptor B2 |
| BTN3A3 | butyrophilin, subfamily 3, member A3 |
| C1ORF115 | chromosome 1 open reading frame 115 |
| C4BPB | complement component 4 binding protein, beta |
| C5ORF45 | chromosome 5 open reading frame 45 |
| CAT | catalase |
| CCL20 | chemokine (C-C motif) ligand 20 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) |
| CDK3 | cyclin-dependent kinase 3 |
| CDX2 | caudal type homeobox 2 |
| CFTR | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) |
| CLEC2D | C-type lectin domain family 2, member D |
| CNN3 | calponin 3, acidic |
| COCH | cochlin |
| CPE | carboxypeptidase E |
| CPOX | coproporphyrinogen oxidase |
| CTGF | connective tissue growth factor |
| CTSH | cathepsin H |
| CXCL2 | chemokine (C-X-C motif) ligand 2 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 |
| CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 |
| CYP2J2 | cytochrome P450, family 2, subfamily J, polypeptide 2 |
| DAPK1 | death-associated protein kinase 1 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 |
| DECR1 | 2,4-dienoyl CoA reductase 1, mitochondrial |
| DISC1 | disrupted in schizophrenia 1 |
| DIXDC1 | DIX domain containing 1 |
| DMXL2 | Dmx-like 2 |
| DPP4 | dipeptidyl-peptidase 4 |
| DPYSL3 | dihydropyrimidinase-like 3 |
| DYNC2LI1 | dynein, cytoplasmic 2, light intermediate chain 1 |
| EFHD1 | EF-hand domain family, member D1 |
| EFNB2 | ephrin-B2 |
| EHF | ets homologous factor |
| EHMT2 | euchromatic histone-lysine N-methyltransferase 2 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) |
| ELL3 | elongation factor RNA polymerase II-like 3 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) |
| ENTPD3 | ectonucleoside triphosphate diphosphohydrolase 3 |
| ERAP2 | endoplasmic reticulum aminopeptidase 2 |
| ERN2 | endoplasmic reticulum to nucleus signaling 2 |
| FAM134B | family with sequence similarity 134, member B |
| FAM172A | family with sequence similarity 172, member A |
| FAM83E | family with sequence similarity 83, member E |
| FBXL15 | F-box and leucine-rich repeat protein 15 |
| FGFBP1 | fibroblast growth factor binding protein 1 |
| FOXA1 | forkhead box A1 |
| FPGT | fucose-1-phosphate guanylyltransferase |
| GALC | galactosylceramidase |
| GALNT12 | polypeptide N-acetylgalactosaminyltransferase 12 |
| GAREM | GRB2 associated, regulator of MAPK1 |
| GATA6 | GATA binding protein 6 |
| GDE1 | glycerophosphodiester phosphodiesterase 1 |
| GDPD3 | glycerophosphodiester phosphodiesterase domain containing 3 |
| GRB14 | growth factor receptor-bound protein 14 |
| GSPT2 | G1 to S phase transition 2 |
| GSTM3 | glutathione S-transferase mu 3 (brain) |
| HAUS4 | HAUS augmin-like complex, subunit 4 |
| HCFC1R1 | host cell factor C1 regulator 1 (XPO1 dependent) |
| HDHD1 | haloacid dehalogenase-like hydrolase domain containing 1 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 |
| HNF1B | HNF1 homeobox B |
| HOXB13 | homeobox B13 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein |
| IL17RB | interleukin 17 receptor B |
| IL18 | interleukin 18 |
| IL20RA | interleukin 20 receptor, alpha |
| IL33 | interleukin 33 |
| KCNQ1 | potassium channel, voltage gated KQT-like subfamily Q, member 1 |
| KCNV1 | potassium channel, voltage gated modifier subfamily V, member 1 |
| KDM5D | lysine (K)-specific demethylase 5D |
| KIAA0319L | KIAA0319-like |
| KIAA0485 | uncharacterized LOC57235 |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| KLRC3 | killer cell lectin-like receptor subfamily C, member 3 |
| KLRF1 | killer cell lectin-like receptor subfamily F, member 1 |
| KRT20 | keratin 20, type I |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 |
| LIMCH1 | LIM and calponin homology domains 1 |
| MANBA | mannosidase, beta A, lysosomal |
| MANEA | mannosidase, endo-alpha |
| MANSC1 | MANSC domain containing 1 |
| MARC1 | mitochondrial amidoxime reducing component 1 |
| MARCH2 | membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase |
| MDFIC | MyoD family inhibitor domain containing |
| MEF2C | myocyte enhancer factor 2C |
| MFGE8 | milk fat globule-EGF factor 8 protein |
| MGC12488 | |
| MLLT3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 |
| MOCOS | molybdenum cofactor sulfurase |
| MST1L | macrophage stimulating 1-like |
| MVP | major vault protein |
| MXD3 | MAX dimerization protein 3 |
| MYRIP | myosin VIIA and Rab interacting protein |
| NLRP2 | NLR family, pyrin domain containing 2 |
| NME3 | NME/NM23 nucleoside diphosphate kinase 3 |
| NSUN6 | NOP2/Sun domain family, member 6 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 |
| OPN3 | opsin 3 |
| OSGEPL1 | O-sialoglycoprotein endopeptidase-like 1 |
| PAK1 | p21 protein (Cdc42/Rac)-activated kinase 1 |
| PAPSS2 | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 |
| PCP4 | Purkinje cell protein 4 |
| PDGFC | platelet derived growth factor C |
| PDGFRL | platelet-derived growth factor receptor-like |
| PDZK1IP1 | PDZK1 interacting protein 1 |
| PF4 | platelet factor 4 |
| PIAS3 | protein inhibitor of activated STAT, 3 |
| PITX2 | paired-like homeodomain 2 |
| PLAC8 | placenta-specific 8 |
| PLLP | plasmolipin |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 |
| PLSCR4 | phospholipid scramblase 4 |
| PROS1 | protein S (alpha) |
| PRR15L | proline rich 15-like |
| PRSS1 | protease, serine, 1 (trypsin 1) |
| PRSS8 | protease, serine, 8 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) |
| RAB25 | RAB25, member RAS oncogene family |
| RAB26 | RAB26, member RAS oncogene family |
| RAB27B | RAB27B, member RAS oncogene family |
| RABL6 | RAB, member RAS oncogene family-like 6 |
| RAC2 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
| RBM47 | RNA binding motif protein 47 |
| RBP4 | retinol binding protein 4, plasma |
| RHOBTB2 | Rho-related BTB domain containing 2 |
| RNF144A | ring finger protein 144A |
| RRAGB | Ras-related GTP binding B |
| S100A14 | S100 calcium binding protein A14 |
| SAMD9 | sterile alpha motif domain containing 9 |
| SCG5 | secretogranin V |
| SEC31B | SEC31 homolog B (S. cerevisiae) |
| SELENBP1 | selenium binding protein 1 |
| SEMA3F | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F |
| SEPP1 | selenoprotein P, plasma, 1 |
| SH3BGRL | SH3 domain binding glutamate-rich protein like |
| SH3GL2 | SH3-domain GRB2-like 2 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| SLC22A18 | solute carrier family 22, member 18 |
| SLC24A1 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 |
| SLC44A4 | solute carrier family 44, member 4 |
| SLC6A20 | solute carrier family 6 (proline IMINO transporter), member 20 |
| SMAD4 | SMAD family member 4 |
| SMPDL3A | sphingomyelin phosphodiesterase, acid-like 3A |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing |
| STAT4 | signal transducer and activator of transcription 4 |
| SULT1C2 | sulfotransferase family, cytosolic, 1C, member 2 |
| TCEAL1 | transcription elongation factor A (SII)-like 1 |
| TEX14 | testis expressed 14 |
| TFF1 | trefoil factor 1 |
| TLR3 | toll-like receptor 3 |
| TM4SF1 | transmembrane 4 L six family member 1 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 |
| TMEM135 | transmembrane protein 135 |
| TMEM144 | transmembrane protein 144 |
| TMEM14A | transmembrane protein 14A |
| TMEM53 | transmembrane protein 53 |
| TMPRSS3 | transmembrane protease, serine 3 |
| TNFSF15 | tumor necrosis factor (ligand) superfamily, member 15 |
| TNNC1 | troponin C type 1 (slow) |
| TNS3 | tensin 3 |
| TPM1 | tropomyosin 1 (alpha) |
| TRAF3IP2 | TRAF3 interacting protein 2 |
| TRPM4 | transient receptor potential cation channel, subfamily M, member 4 |
| TSPAN1 | tetraspanin 1 |
| TSPAN8 | tetraspanin 8 |
| USP18 | ubiquitin specific peptidase 18 |
| VILL | villin-like |
| XK | X-linked Kx blood group |
| ZNF711 | zinc finger protein 711 |
