LEF1_UP.V1 Gene Set

Dataset MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations
Category transcriptomics
Type gene perturbation
Description gene perturbation identified as [gene symbol]_[perturbation or condition] (Molecular Signatures Database)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/LEF1_UP.V1_UP
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Genes

385 genes differentially expressed following the LEF1_UP.V1 gene perturbation from the MSigDB Signatures of Differentially Expressed Genes for Cancer Gene Perturbations dataset.

increased expression

Symbol Name
ADAM19 ADAM metallopeptidase domain 19
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8
ADGRE2 adhesion G protein-coupled receptor E2
ADGRG2 adhesion G protein-coupled receptor G2
ADIRF adipogenesis regulatory factor
AKAP12 A kinase (PRKA) anchor protein 12
ALLC allantoicase
ANO1 anoctamin 1, calcium activated chloride channel
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARC activity-regulated cytoskeleton-associated protein
ARG2 arginase 2
ARHGAP4 Rho GTPase activating protein 4
ARID3B AT rich interactive domain 3B (BRIGHT-like)
AUTS2 autism susceptibility candidate 2
AXL AXL receptor tyrosine kinase
BMP7 bone morphogenetic protein 7
C14ORF132 chromosome 14 open reading frame 132
CARD9 caspase recruitment domain family, member 9
CBS cystathionine-beta-synthase
CCND2 cyclin D2
CCR7 chemokine (C-C motif) receptor 7
CD302 CD302 molecule
CDA cytidine deaminase
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21
CHGB chromogranin B
CHST10 carbohydrate sulfotransferase 10
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL6A1 collagen, type VI, alpha 1
COL9A3 collagen, type IX, alpha 3
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CST7 cystatin F (leukocystatin)
CTH cystathionine gamma-lyase
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYBRD1 cytochrome b reductase 1
DBN1 drebrin 1
DCLK1 doublecortin-like kinase 1
DENND1C DENN/MADD domain containing 1C
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK4 dickkopf WNT signaling pathway inhibitor 4
DLL3 delta-like 3 (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
EDAR ectodysplasin A receptor
EGR2 early growth response 2
EGR3 early growth response 3
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ELOVL5 ELOVL fatty acid elongase 5
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
EN2 engrailed homeobox 2
EPB41L4A erythrocyte membrane protein band 4.1 like 4A
ERVMER34-1 endogenous retrovirus group MER34, member 1
FADS1 fatty acid desaturase 1
FBXO17 F-box protein 17
FGF13 fibroblast growth factor 13
FGF3 fibroblast growth factor 3
FGF9 fibroblast growth factor 9
FHL1 four and a half LIM domains 1
FJX1 four jointed box 1 (Drosophila)
FLNC filamin C, gamma
FN1 fibronectin 1
FNBP1 formin binding protein 1
FNDC4 fibronectin type III domain containing 4
FOSL1 FOS-like antigen 1
FOXF2 forkhead box F2
FOXG1 forkhead box G1
G0S2 G0/G1 switch 2
GATA3 GATA binding protein 3
GJB1 gap junction protein, beta 1, 32kDa
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HAS2 hyaluronan synthase 2
HBA2 hemoglobin, alpha 2
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HOXB2 homeobox B2
HSPA1A heat shock 70kDa protein 1A
IGFBP6 insulin-like growth factor binding protein 6
IGFBP7 insulin-like growth factor binding protein 7
IL11 interleukin 11
INHBE inhibin, beta E
ISYNA1 inositol-3-phosphate synthase 1
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KCTD12 potassium channel tetramerization domain containing 12
KRT13 keratin 13, type I
KRT23 keratin 23, type I
KRT5 keratin 5, type II
KRT76 keratin 76, type II
KRT81 keratin 81, type II
L1CAM L1 cell adhesion molecule
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS1 lectin, galactoside-binding, soluble, 1
LINC00341 long intergenic non-protein coding RNA 341
LMO2 LIM domain only 2 (rhombotin-like 1)
LOXL1 lysyl oxidase-like 1
LPL lipoprotein lipase
LTBP2 latent transforming growth factor beta binding protein 2
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MAP1B microtubule-associated protein 1B
MAP7D3 MAP7 domain containing 3
MFAP2 microfibrillar-associated protein 2
MIA melanoma inhibitory activity
MLN motilin
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MSN moesin
MYL9 myosin, light chain 9, regulatory
NELL2 NEL-like 2 (chicken)
NES nestin
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
NRIP3 nuclear receptor interacting protein 3
NTSR1 neurotensin receptor 1 (high affinity)
OBSL1 obscurin-like 1
PARVB parvin, beta
PAX6 paired box 6
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PCSK5 proprotein convertase subtilisin/kexin type 5
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM4 PDZ and LIM domain 4
PDZD2 PDZ domain containing 2
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHLDA3 pleckstrin homology-like domain, family A, member 3
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLTP phospholipid transfer protein
PMEPA1 prostate transmembrane protein, androgen induced 1
PRF1 perforin 1 (pore forming protein)
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCDBP protein kinase C, delta binding protein
PRPH peripherin
PRPS1 phosphoribosyl pyrophosphate synthetase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAI2 retinoic acid induced 2
RAMP2 receptor (G protein-coupled) activity modifying protein 2
RBP1 retinol binding protein 1, cellular
RGCC regulator of cell cycle
ROR2 receptor tyrosine kinase-like orphan receptor 2
RPP25 ribonuclease P/MRP 25kDa subunit
RRAGD Ras-related GTP binding D
RUNX3 runt-related transcription factor 3
RYR1 ryanodine receptor 1 (skeletal)
S100A2 S100 calcium binding protein A2
S100A3 S100 calcium binding protein A3
S100A4 S100 calcium binding protein A4
SCML1 sex comb on midleg-like 1 (Drosophila)
SCN5A sodium channel, voltage gated, type V alpha subunit
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2D2A SH2 domain containing 2A
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9
SLC26A4 solute carrier family 26 (anion exchanger), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35G2 solute carrier family 35, member G2
SLC43A3 solute carrier family 43, member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLIT1 slit homolog 1 (Drosophila)
SPRR2B small proline-rich protein 2B
STC2 stanniocalcin 2
STRA6 stimulated by retinoic acid 6
TCEA2 transcription elongation factor A (SII), 2
TCHH trichohyalin
TGM2 transglutaminase 2
TH tyrosine hydroxylase
TM4SF5 transmembrane 4 L six family member 5
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM47 transmembrane protein 47
TMOD1 tropomodulin 1
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TREML2 triggering receptor expressed on myeloid cells-like 2
TRIM48 tripartite motif containing 48
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TUBB2B tubulin, beta 2B class IIb
TULP2 tubby like protein 2
VIM vimentin
WASF3 WAS protein family, member 3
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
WWC2 WW and C2 domain containing 2
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa
ZFPM2 zinc finger protein, FOG family member 2
ZNF134 zinc finger protein 134
ZNF22 zinc finger protein 22
ZNF236 zinc finger protein 236
ZNF350 zinc finger protein 350

decreased expression

Symbol Name
ACSF2 acyl-CoA synthetase family member 2
ACSL5 acyl-CoA synthetase long-chain family member 5
AGR2 anterior gradient 2
AIM1 absent in melanoma 1
AKR1C3 aldo-keto reductase family 1, member C3
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKFY1 ankyrin repeat and FYVE domain containing 1
AP1M2 adaptor-related protein complex 1, mu 2 subunit
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
BDKRB2 bradykinin receptor B2
BTN3A3 butyrophilin, subfamily 3, member A3
C1ORF115 chromosome 1 open reading frame 115
C4BPB complement component 4 binding protein, beta
C5ORF45 chromosome 5 open reading frame 45
CAT catalase
CCL20 chemokine (C-C motif) ligand 20
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDK3 cyclin-dependent kinase 3
CDX2 caudal type homeobox 2
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLEC2D C-type lectin domain family 2, member D
CNN3 calponin 3, acidic
COCH cochlin
CPE carboxypeptidase E
CPOX coproporphyrinogen oxidase
CTGF connective tissue growth factor
CTSH cathepsin H
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DAPK1 death-associated protein kinase 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DISC1 disrupted in schizophrenia 1
DIXDC1 DIX domain containing 1
DMXL2 Dmx-like 2
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1
EFHD1 EF-hand domain family, member D1
EFNB2 ephrin-B2
EHF ets homologous factor
EHMT2 euchromatic histone-lysine N-methyltransferase 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ELL3 elongation factor RNA polymerase II-like 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
ERAP2 endoplasmic reticulum aminopeptidase 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM134B family with sequence similarity 134, member B
FAM172A family with sequence similarity 172, member A
FAM83E family with sequence similarity 83, member E
FBXL15 F-box and leucine-rich repeat protein 15
FGFBP1 fibroblast growth factor binding protein 1
FOXA1 forkhead box A1
FPGT fucose-1-phosphate guanylyltransferase
GALC galactosylceramidase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAREM GRB2 associated, regulator of MAPK1
GATA6 GATA binding protein 6
GDE1 glycerophosphodiester phosphodiesterase 1
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GRB14 growth factor receptor-bound protein 14
GSPT2 G1 to S phase transition 2
GSTM3 glutathione S-transferase mu 3 (brain)
HAUS4 HAUS augmin-like complex, subunit 4
HCFC1R1 host cell factor C1 regulator 1 (XPO1 dependent)
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HNF1B HNF1 homeobox B
HOXB13 homeobox B13
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL17RB interleukin 17 receptor B
IL18 interleukin 18
IL20RA interleukin 20 receptor, alpha
IL33 interleukin 33
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1
KDM5D lysine (K)-specific demethylase 5D
KIAA0319L KIAA0319-like
KIAA0485 uncharacterized LOC57235
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLRC3 killer cell lectin-like receptor subfamily C, member 3
KLRF1 killer cell lectin-like receptor subfamily F, member 1
KRT20 keratin 20, type I
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
MANBA mannosidase, beta A, lysosomal
MANEA mannosidase, endo-alpha
MANSC1 MANSC domain containing 1
MARC1 mitochondrial amidoxime reducing component 1
MARCH2 membrane-associated ring finger (C3HC4) 2, E3 ubiquitin protein ligase
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MFGE8 milk fat globule-EGF factor 8 protein
MGC12488
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MOCOS molybdenum cofactor sulfurase
MST1L macrophage stimulating 1-like
MVP major vault protein
MXD3 MAX dimerization protein 3
MYRIP myosin VIIA and Rab interacting protein
NLRP2 NLR family, pyrin domain containing 2
NME3 NME/NM23 nucleoside diphosphate kinase 3
NSUN6 NOP2/Sun domain family, member 6
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OPN3 opsin 3
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCP4 Purkinje cell protein 4
PDGFC platelet derived growth factor C
PDGFRL platelet-derived growth factor receptor-like
PDZK1IP1 PDZK1 interacting protein 1
PF4 platelet factor 4
PIAS3 protein inhibitor of activated STAT, 3
PITX2 paired-like homeodomain 2
PLAC8 placenta-specific 8
PLLP plasmolipin
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLSCR4 phospholipid scramblase 4
PROS1 protein S (alpha)
PRR15L proline rich 15-like
PRSS1 protease, serine, 1 (trypsin 1)
PRSS8 protease, serine, 8
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAB25 RAB25, member RAS oncogene family
RAB26 RAB26, member RAS oncogene family
RAB27B RAB27B, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RBM47 RNA binding motif protein 47
RBP4 retinol binding protein 4, plasma
RHOBTB2 Rho-related BTB domain containing 2
RNF144A ring finger protein 144A
RRAGB Ras-related GTP binding B
S100A14 S100 calcium binding protein A14
SAMD9 sterile alpha motif domain containing 9
SCG5 secretogranin V
SEC31B SEC31 homolog B (S. cerevisiae)
SELENBP1 selenium binding protein 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SEPP1 selenoprotein P, plasma, 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3GL2 SH3-domain GRB2-like 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A18 solute carrier family 22, member 18
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLC44A4 solute carrier family 44, member 4
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SMAD4 SMAD family member 4
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAT4 signal transducer and activator of transcription 4
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TCEAL1 transcription elongation factor A (SII)-like 1
TEX14 testis expressed 14
TFF1 trefoil factor 1
TLR3 toll-like receptor 3
TM4SF1 transmembrane 4 L six family member 1
TMED3 transmembrane emp24 protein transport domain containing 3
TMEM135 transmembrane protein 135
TMEM144 transmembrane protein 144
TMEM14A transmembrane protein 14A
TMEM53 transmembrane protein 53
TMPRSS3 transmembrane protease, serine 3
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TNNC1 troponin C type 1 (slow)
TNS3 tensin 3
TPM1 tropomyosin 1 (alpha)
TRAF3IP2 TRAF3 interacting protein 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPAN1 tetraspanin 1
TSPAN8 tetraspanin 8
USP18 ubiquitin specific peptidase 18
VILL villin-like
XK X-linked Kx blood group
ZNF711 zinc finger protein 711