| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | leptin|This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3952) |
| External Link | https://ncbi.nlm.nih.gov/gene/3952 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the LEP gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PRDX2 | peroxiredoxin 2 | 0.0183276 |
| AKR7A2 | aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) | 0.0165304 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0160948 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 0.0141256 |
| RPA3 | replication protein A3, 14kDa | 0.0136331 |
| AKR7A3 | aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) | 0.0132692 |
| CDCA4 | cell division cycle associated 4 | 0.0128148 |
| RPS5 | ribosomal protein S5 | 0.0122551 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | 0.0122438 |
| LYZ | lysozyme | 0.0121836 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.0120735 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.0119872 |
| OLFM4 | olfactomedin 4 | 0.0119791 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.0117975 |
| SERPINF1 | serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 | 0.0116638 |
| VCAM1 | vascular cell adhesion molecule 1 | 0.011459 |
| LTF | lactotransferrin | 0.0114435 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.0113898 |
| BIRC5 | baculoviral IAP repeat containing 5 | 0.011285 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.0112251 |
| TMEM38B | transmembrane protein 38B | 0.0112013 |
| CCNA2 | cyclin A2 | 0.0109484 |
| CHEK2 | checkpoint kinase 2 | 0.0109155 |
| MOXD1 | monooxygenase, DBH-like 1 | 0.0109146 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.0108615 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0107781 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.0105427 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.0105202 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.0104705 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0104058 |
| THAP12 | THAP domain containing 12 | 0.0103908 |
| DCK | deoxycytidine kinase | 0.0103879 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.0103771 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.0101828 |
| CLCA1 | chloride channel accessory 1 | 0.0101718 |
| LRRC17 | leucine rich repeat containing 17 | 0.0101153 |
| TMEM14B | transmembrane protein 14B | 0.0100611 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.0100555 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0100199 |
| METTL7A | methyltransferase like 7A | 0.00998491 |
| PAFAH1B3 | platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) | 0.00994902 |
| NDUFB6 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa | 0.00988264 |
| ALDOA | aldolase A, fructose-bisphosphate | 0.00985103 |
| SUB1 | SUB1 homolog (S. cerevisiae) | 0.00984629 |
| WDR61 | WD repeat domain 61 | 0.00978346 |
| CDC20 | cell division cycle 20 | 0.00973745 |
| PPA2 | pyrophosphatase (inorganic) 2 | 0.00971604 |
| ATF1 | activating transcription factor 1 | 0.00953635 |
| DACH1 | dachshund family transcription factor 1 | 0.00950005 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.009481 |
| CRYL1 | crystallin, lambda 1 | 0.00945063 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.00943551 |
| HOPX | HOP homeobox | 0.00930826 |
| INSIG1 | insulin induced gene 1 | 0.00929693 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.00928788 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00927198 |
| RAPSN | receptor-associated protein of the synapse | 0.00918145 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.00914415 |
| PTTG1 | pituitary tumor-transforming 1 | 0.00912525 |
| CDK1 | cyclin-dependent kinase 1 | 0.00911837 |
| ASF1A | anti-silencing function 1A histone chaperone | 0.00907596 |
| ECI2 | enoyl-CoA delta isomerase 2 | 0.00906358 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.00903655 |
| PLN | phospholamban | 0.00902965 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.00900871 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00899046 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00895335 |
| TRMT5 | tRNA methyltransferase 5 | 0.00892354 |
| HMGB2 | high mobility group box 2 | 0.00891172 |
| FAM162A | family with sequence similarity 162, member A | 0.00889706 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.00889243 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.00888033 |
| THYN1 | thymocyte nuclear protein 1 | 0.00884095 |
| TSPAN6 | tetraspanin 6 | 0.00881177 |
| RNASEH2A | ribonuclease H2, subunit A | 0.00880562 |
| RMI1 | RecQ mediated genome instability 1 | 0.00879438 |
| PSMD10 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 | 0.0087274 |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | 0.0086809 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00867282 |
| LOXL1 | lysyl oxidase-like 1 | 0.00861701 |
| LSM2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00860424 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00858882 |
| MAT2B | methionine adenosyltransferase II, beta | 0.00854503 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.00849825 |
| SPINK4 | serine peptidase inhibitor, Kazal type 4 | 0.00849104 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.00845955 |
| CALD1 | caldesmon 1 | 0.00842049 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.00840151 |
| PRMT1 | protein arginine methyltransferase 1 | 0.00836654 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00830522 |
| RUVBL1 | RuvB-like AAA ATPase 1 | 0.00829947 |
| HMGB3 | high mobility group box 3 | 0.0082973 |
| FXYD6 | FXYD domain containing ion transport regulator 6 | 0.00822935 |
| F2R | coagulation factor II (thrombin) receptor | 0.00822847 |
| SELENOF | selenoprotein F | 0.00818074 |
| RCN2 | reticulocalbin 2, EF-hand calcium binding domain | 0.00815004 |
| MOCS2 | molybdenum cofactor synthesis 2 | 0.00814631 |
| COPS4 | COP9 signalosome subunit 4 | 0.00811433 |
| CDH3 | cadherin 3, type 1, P-cadherin (placental) | 0.00809382 |
| AP2S1 | adaptor-related protein complex 2, sigma 1 subunit | 0.00807169 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | 0.00806402 |
| FBXO5 | F-box protein 5 | 0.00803335 |
| ARID4A | AT rich interactive domain 4A (RBP1-like) | 0.00800692 |
| TP53 | tumor protein p53 | 0.00796345 |
| FRZB | frizzled-related protein | 0.00792684 |
| CRLF1 | cytokine receptor-like factor 1 | 0.00789608 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | 0.00788263 |
| CD2 | CD2 molecule | 0.00788013 |
| COMMD10 | COMM domain containing 10 | 0.00786781 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.00786046 |
| GEMIN2 | gem (nuclear organelle) associated protein 2 | 0.00783999 |
| AK4 | adenylate kinase 4 | 0.00783038 |
| CDC42EP4 | CDC42 effector protein (Rho GTPase binding) 4 | 0.00781378 |
| B3GNT1 | 0.00780798 | |
| GAMT | guanidinoacetate N-methyltransferase | 0.00780653 |
| COMMD8 | COMM domain containing 8 | 0.00779049 |
| FPGS | folylpolyglutamate synthase | 0.00778124 |
| SLC25A11 | solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 | 0.00777097 |
| VRK1 | vaccinia related kinase 1 | 0.00776424 |
| NMU | neuromedin U | 0.00775986 |
| DUT | deoxyuridine triphosphatase | 0.00775824 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | 0.00775046 |
| CHKB | choline kinase beta | 0.00774813 |
| DNASE1L3 | deoxyribonuclease I-like 3 | 0.00768697 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | 0.00768267 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | 0.00768214 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00767557 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.00766854 |
| PIMREG | PICALM interacting mitotic regulator | 0.00766829 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00763832 |
| CCNF | cyclin F | 0.00763433 |
| PRDX4 | peroxiredoxin 4 | 0.00762416 |
| SSX2IP | synovial sarcoma, X breakpoint 2 interacting protein | 0.00760493 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | 0.0075955 |
| KLHDC3 | kelch domain containing 3 | 0.00759318 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.0075904 |
| SRP9 | signal recognition particle 9kDa | 0.00757887 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | 0.00757565 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.00757335 |
| NSL1 | NSL1, MIS12 kinetochore complex component | 0.00756918 |
| ACTL6A | actin-like 6A | 0.00756851 |
| GLO1 | glyoxalase I | 0.00756226 |
| PPP2R5C | protein phosphatase 2, regulatory subunit B', gamma | 0.00754277 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00752257 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.00752028 |
| TMX1 | thioredoxin-related transmembrane protein 1 | 0.00747941 |
| GSTA4 | glutathione S-transferase alpha 4 | 0.00747302 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.00746956 |
| PRRX1 | paired related homeobox 1 | 0.00745673 |
| PDLIM3 | PDZ and LIM domain 3 | 0.00745069 |
| POLR2L | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa | 0.00743106 |
| CA9 | carbonic anhydrase IX | 0.00742802 |
| FOXG1 | forkhead box G1 | 0.00742027 |
| PAICS | phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase | 0.00741697 |
| HPRT1 | hypoxanthine phosphoribosyltransferase 1 | 0.00740118 |
| LIG1 | ligase I, DNA, ATP-dependent | 0.00739276 |
| ASH2L | ash2 (absent, small, or homeotic)-like (Drosophila) | 0.00737579 |
| PRKD3 | protein kinase D3 | 0.00735689 |
| KDM5D | lysine (K)-specific demethylase 5D | 0.00733114 |
| STMN1 | stathmin 1 | 0.00731333 |
| AURKB | aurora kinase B | 0.00730216 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 0.00729685 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.0072829 |
| DPM3 | dolichyl-phosphate mannosyltransferase polypeptide 3 | 0.00728265 |
| DYNLT1 | dynein, light chain, Tctex-type 1 | 0.00723044 |
| KIF15 | kinesin family member 15 | 0.00722718 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00716688 |
| OIP5 | Opa interacting protein 5 | 0.00716318 |
| PLPP3 | phospholipid phosphatase 3 | 0.00715489 |
| TFDP1 | transcription factor Dp-1 | 0.00714868 |
| TMEM106C | transmembrane protein 106C | 0.00714354 |
| H1-0 | H1.0 linker histone | 0.00713787 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.00712461 |
| FCGBP | Fc fragment of IgG binding protein | 0.00712215 |
| TPGS2 | tubulin polyglutamylase complex subunit 2 | 0.00711181 |
| MDFIC | MyoD family inhibitor domain containing | 0.00710732 |
| CNN3 | calponin 3, acidic | 0.00709353 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | 0.00706402 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.00706006 |
| CILP | cartilage intermediate layer protein, nucleotide pyrophosphohydrolase | 0.00705633 |
| PLSCR4 | phospholipid scramblase 4 | 0.00704453 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00704368 |
| ARMT1 | acidic residue methyltransferase 1 | 0.00703508 |
| NEK2 | NIMA-related kinase 2 | 0.00702641 |
| FAM3C | family with sequence similarity 3, member C | 0.00701146 |
| UBE2N | ubiquitin-conjugating enzyme E2N | 0.00700454 |
| TMED7 | transmembrane emp24 protein transport domain containing 7 | 0.00699097 |
| GLRX5 | glutaredoxin 5 | 0.00698562 |
| PSRC1 | proline/serine-rich coiled-coil 1 | 0.00698102 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.00695907 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 0.00695838 |
| TMEM165 | transmembrane protein 165 | 0.00694992 |
| GSTO1 | glutathione S-transferase omega 1 | 0.00694238 |
| RSBN1 | round spermatid basic protein 1 | 0.00694222 |
| NIPSNAP2 | nipsnap homolog 2 | 0.00693054 |
| KDELR2 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 | 0.00692956 |
| GSTT1 | glutathione S-transferase theta 1 | 0.00691779 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0069145 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | 0.00691224 |
| NUDT21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | 0.00689665 |
| HPF1 | histone PARylation factor 1 | 0.00688965 |
| YEATS4 | YEATS domain containing 4 | 0.00687786 |
| OGFOD3 | 2-oxoglutarate and iron-dependent oxygenase domain containing 3 | 0.00687493 |
| EVL | Enah/Vasp-like | 0.00686491 |
| FST | follistatin | 0.00683806 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.0068273 |
| PRDX3 | peroxiredoxin 3 | 0.00681023 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.00680688 |
| ACADM | acyl-CoA dehydrogenase, C-4 to C-12 straight chain | 0.00680259 |
| TMEM14A | transmembrane protein 14A | 0.00680135 |
| ELP5 | elongator acetyltransferase complex subunit 5 | 0.00679682 |
| DEPDC1 | DEP domain containing 1 | 0.00679612 |
| UQCRC1 | ubiquinol-cytochrome c reductase core protein I | 0.00678766 |
| PCP4 | Purkinje cell protein 4 | 0.00677381 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.00675523 |
| PSMB3 | proteasome (prosome, macropain) subunit, beta type, 3 | 0.00672617 |
| ADH5 | alcohol dehydrogenase 5 (class III), chi polypeptide | 0.00672528 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00669913 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 0.00669802 |
| UNG | uracil-DNA glycosylase | 0.0066961 |
| DEK | DEK proto-oncogene | 0.0066633 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | 0.00666133 |
| EAPP | E2F-associated phosphoprotein | 0.00665949 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | 0.00664703 |
| LRRC40 | leucine rich repeat containing 40 | 0.00663525 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | 0.00663485 |
| MARCKSL1 | MARCKS-like 1 | 0.00662488 |
| IGF1 | insulin-like growth factor 1 (somatomedin C) | 0.00661601 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | 0.00661567 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.00660544 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.00660485 |
| TRAPPC2L | trafficking protein particle complex 2-like | 0.00659263 |
| MIS12 | MIS12 kinetochore complex component | 0.00658887 |
| MGP | matrix Gla protein | 0.00656639 |
| CD300A | CD300a molecule | 0.00656602 |
| CNOT8 | CCR4-NOT transcription complex, subunit 8 | 0.00655561 |
| SNRPG | small nuclear ribonucleoprotein polypeptide G | 0.00654807 |
| COQ2 | coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | 0.00654348 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.00651664 |
| NREP | neuronal regeneration related protein | 0.00651081 |
| SELENBP1 | selenium binding protein 1 | 0.00650505 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0065049 |
| MT3 | metallothionein 3 | 0.00650354 |
| SPC25 | SPC25, NDC80 kinetochore complex component | 0.00646502 |
| FXYD1 | FXYD domain containing ion transport regulator 1 | 0.006465 |
| FABP7 | fatty acid binding protein 7, brain | 0.00646351 |
| HMBS | hydroxymethylbilane synthase | 0.00645992 |
| C20ORF27 | chromosome 20 open reading frame 27 | 0.0064496 |
| SLC2A4RG | SLC2A4 regulator | 0.00644394 |
| CDCA3 | cell division cycle associated 3 | 0.00644278 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA1A | heat shock 70kDa protein 1A | -0.0230487 |
| XIC | X chromosome inactivation center | -0.0194683 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0183646 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.016995 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0161426 |
| MAGEA3 | melanoma antigen family A3 | -0.015308 |
| HMOX1 | heme oxygenase 1 | -0.0145918 |
| ANXA1 | annexin A1 | -0.0142154 |
| ZMAT3 | zinc finger, matrin-type 3 | -0.0138082 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0133931 |
| MVP | major vault protein | -0.0128123 |
| MX1 | MX dynamin-like GTPase 1 | -0.0127881 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0126973 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.0124206 |
| RBM34 | RNA binding motif protein 34 | -0.01236 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | -0.0123242 |
| MYOF | myoferlin | -0.0120744 |
| APOD | apolipoprotein D | -0.0120356 |
| HSPB8 | heat shock 22kDa protein 8 | -0.0119511 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.0119301 |
| ATF3 | activating transcription factor 3 | -0.0118332 |
| CRYAB | crystallin, alpha B | -0.0118323 |
| SIK1 | salt-inducible kinase 1 | -0.0118011 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | -0.0116 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.0115843 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.011563 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.0115626 |
| S100P | S100 calcium binding protein P | -0.0113663 |
| IRS2 | insulin receptor substrate 2 | -0.0113441 |
| MGLL | monoglyceride lipase | -0.0112876 |
| KRT7 | keratin 7, type II | -0.0111233 |
| SYNGR3 | synaptogyrin 3 | -0.011101 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | -0.0110644 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0110098 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.0108586 |
| S100A11 | S100 calcium binding protein A11 | -0.010774 |
| HIST1H2BD | histone cluster 1, H2bd | -0.0107486 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | -0.0106965 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.0106708 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0106176 |
| MAGEA12 | melanoma antigen family A12 | -0.0105224 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.01041 |
| TUFT1 | tuftelin 1 | -0.0103808 |
| DEFB1 | defensin, beta 1 | -0.0102915 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0102739 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.0101688 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0101676 |
| PRAME | preferentially expressed antigen in melanoma | -0.0101384 |
| IER5 | immediate early response 5 | -0.0101096 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.0100679 |
| KLK10 | kallikrein-related peptidase 10 | -0.0100649 |
| TGFA | transforming growth factor, alpha | -0.0100022 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.00999682 |
| IRF7 | interferon regulatory factor 7 | -0.00996581 |
| ZBED2 | zinc finger, BED-type containing 2 | -0.00995408 |
| BCL3 | B-cell CLL/lymphoma 3 | -0.00993169 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.00986921 |
| KLK11 | kallikrein-related peptidase 11 | -0.00984325 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | -0.00982527 |
| DOCK9 | dedicator of cytokinesis 9 | -0.00981828 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.00980512 |
| RND3 | Rho family GTPase 3 | -0.00974931 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | -0.00970193 |
| NEFH | neurofilament, heavy polypeptide | -0.00962643 |
| GDF15 | growth differentiation factor 15 | -0.00960523 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.00956393 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.00956198 |
| ASS1 | argininosuccinate synthase 1 | -0.00953856 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00952332 |
| CUX1 | cut-like homeobox 1 | -0.00951189 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00950847 |
| PCDH9 | protocadherin 9 | -0.0095002 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.00948778 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00945387 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00940297 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.00934627 |
| EIF6 | eukaryotic translation initiation factor 6 | -0.00933785 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.0092715 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00924558 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00917284 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00914248 |
| FHL2 | four and a half LIM domains 2 | -0.00911653 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.00911609 |
| PRSS23 | protease, serine, 23 | -0.00903844 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.00898389 |
| LIMK2 | LIM domain kinase 2 | -0.00896439 |
| CST1 | cystatin SN | -0.00894815 |
| GUSBP3 | glucuronidase, beta pseudogene 3 | -0.00892256 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | -0.00890417 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0088862 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00885425 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.00884028 |
| MT1X | metallothionein 1X | -0.00883821 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00881107 |
| TRIB3 | tribbles pseudokinase 3 | -0.00880846 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00880244 |
| NRCAM | neuronal cell adhesion molecule | -0.00879426 |
| TRIP6 | thyroid hormone receptor interactor 6 | -0.00876757 |
| VLDLR | very low density lipoprotein receptor | -0.00874783 |
| OXTR | oxytocin receptor | -0.00870133 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.00869766 |
| KYNU | kynureninase | -0.00868174 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 | -0.0086794 |
| PLXNB2 | plexin B2 | -0.00866209 |
| NPIPB3 | nuclear pore complex interacting protein family, member B3 | -0.00864571 |
| NNMT | nicotinamide N-methyltransferase | -0.00864441 |
| GAB2 | GRB2-associated binding protein 2 | -0.00860602 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.00859133 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0085813 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.00857845 |
| KRT14 | keratin 14, type I | -0.00856574 |
| LAMC2 | laminin, gamma 2 | -0.00848805 |
| MMP7 | matrix metallopeptidase 7 | -0.00842442 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | -0.0084197 |
| ATF4 | activating transcription factor 4 | -0.00838781 |
| MUC16 | mucin 16, cell surface associated | -0.00838206 |
| NOTCH2NL | notch 2 N-terminal like | -0.00835515 |
| MAGEA1 | melanoma antigen family A1 | -0.00835388 |
| LBH | limb bud and heart development | -0.00833964 |
| LAMP1 | lysosomal-associated membrane protein 1 | -0.00832008 |
| IGF1R | insulin-like growth factor 1 receptor | -0.00831264 |
| FN1 | fibronectin 1 | -0.00830995 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -0.00828335 |
| KRT23 | keratin 23, type I | -0.00825324 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | -0.00823792 |
| ZFP36 | ZFP36 ring finger protein | -0.00822857 |
| PHIP | pleckstrin homology domain interacting protein | -0.00822325 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0082165 |
| ELMO1 | engulfment and cell motility 1 | -0.00816468 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.00816428 |
| IL1B | interleukin 1, beta | -0.00816037 |
| SERINC5 | serine incorporator 5 | -0.00814971 |
| CAV2 | caveolin 2 | -0.00813771 |
| PLCB4 | phospholipase C, beta 4 | -0.00813268 |
| COBL | cordon-bleu WH2 repeat protein | -0.00811429 |
| SPR | sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase) | -0.00810255 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00809779 |
| OGA | O-GlcNAcase | -0.00806838 |
| KLHL24 | kelch-like family member 24 | -0.00806807 |
| ABHD4 | abhydrolase domain containing 4 | -0.00802798 |
| DEPTOR | DEP domain containing MTOR-interacting protein | -0.0080136 |
| ZNF394 | zinc finger protein 394 | -0.00801272 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | -0.00797602 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | -0.00797385 |
| NOP56 | NOP56 ribonucleoprotein | -0.00796826 |
| YBX3 | Y box binding protein 3 | -0.0079673 |
| ANKRD11 | ankyrin repeat domain 11 | -0.00791241 |
| STK38 | serine/threonine kinase 38 | -0.00787542 |
| LCN2 | lipocalin 2 | -0.00786983 |
| NKX2-2 | NK2 homeobox 2 | -0.00786865 |
| RHBDF1 | rhomboid 5 homolog 1 (Drosophila) | -0.00785598 |
| FOLR1 | folate receptor 1 (adult) | -0.00784223 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.00783987 |
| IGF2R | insulin-like growth factor 2 receptor | -0.00782589 |
| OSBPL2 | oxysterol binding protein-like 2 | -0.00782561 |
| AKAP8 | A kinase (PRKA) anchor protein 8 | -0.00781663 |
| INAVA | innate immunity activator | -0.00781383 |
| MFAP3L | microfibrillar-associated protein 3-like | -0.00780503 |
| PTHLH | parathyroid hormone-like hormone | -0.00779775 |
| MAPK8IP3 | mitogen-activated protein kinase 8 interacting protein 3 | -0.00779378 |
| PRSS21 | protease, serine, 21 (testisin) | -0.00778741 |
| RTCA | RNA 3'-terminal phosphate cyclase | -0.00778524 |
| CCND3 | cyclin D3 | -0.00778104 |
| OPN3 | opsin 3 | -0.00774306 |
| NPIPA1 | nuclear pore complex interacting protein family, member A1 | -0.0077341 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.00773383 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.00772932 |
| SSX1 | synovial sarcoma, X breakpoint 1 | -0.00770006 |
| PERP | PERP, TP53 apoptosis effector | -0.00769095 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.00768708 |
| SLC38A1 | solute carrier family 38, member 1 | -0.00768586 |
| ALDH5A1 | aldehyde dehydrogenase 5 family, member A1 | -0.00768469 |
| TRIM22 | tripartite motif containing 22 | -0.00768046 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.00767655 |
| EGR1 | early growth response 1 | -0.00766429 |
| AMOTL2 | angiomotin like 2 | -0.00765616 |
| KLK6 | kallikrein-related peptidase 6 | -0.0076494 |
| VAMP1 | vesicle-associated membrane protein 1 (synaptobrevin 1) | -0.00763777 |
| BTG2 | BTG family, member 2 | -0.00762918 |
| SP100 | SP100 nuclear antigen | -0.00762853 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.00760608 |
| OFD1 | oral-facial-digital syndrome 1 | -0.00759424 |
| RRAGC | Ras-related GTP binding C | -0.00758687 |
| JUP | junction plakoglobin | -0.00758331 |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | -0.00756589 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.00754026 |
| ITGAV | integrin, alpha V | -0.00750839 |
| SLC31A2 | solute carrier family 31 (copper transporter), member 2 | -0.00749836 |
| GALNT7 | polypeptide N-acetylgalactosaminyltransferase 7 | -0.00747816 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | -0.00744572 |
| EPS8L2 | EPS8-like 2 | -0.00743982 |
| OPTN | optineurin | -0.00743492 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00742901 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00742678 |
| COL7A1 | collagen, type VII, alpha 1 | -0.00741564 |
| CD9 | CD9 molecule | -0.00741133 |
| SLC7A7 | solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 | -0.00740154 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.00739774 |
| USP9X | ubiquitin specific peptidase 9, X-linked | -0.00738168 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | -0.00737034 |
| AFF1 | AF4/FMR2 family, member 1 | -0.00736886 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.00736555 |
| IL6 | interleukin 6 | -0.00736118 |
| FOXO1 | forkhead box O1 | -0.00734369 |
| COL11A1 | collagen, type XI, alpha 1 | -0.00731488 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.00731463 |
| MKNK2 | MAP kinase interacting serine/threonine kinase 2 | -0.00728527 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | -0.00726705 |
| MCM2 | minichromosome maintenance complex component 2 | -0.00725047 |
| KRT18 | keratin 18, type I | -0.00724961 |
| SPAG9 | sperm associated antigen 9 | -0.00724395 |
| MYRF | myelin regulatory factor | -0.00724348 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.00723468 |
| TFAP2C | transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) | -0.00722487 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00721326 |
| HIST1H2BK | histone cluster 1, H2bk | -0.00719724 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.00717571 |
| CFB | complement factor B | -0.00716531 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | -0.00716247 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.00715159 |
| LOC105375355 | uroplakin-3b | -0.00711861 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.00709343 |
| INA | internexin neuronal intermediate filament protein, alpha | -0.00709276 |
| BMP7 | bone morphogenetic protein 7 | -0.00708436 |
| AUTS2 | autism susceptibility candidate 2 | -0.00707152 |
| TMEM87A | transmembrane protein 87A | -0.00706903 |
| PIEZO1 | piezo-type mechanosensitive ion channel component 1 | -0.00706512 |
| TPBG | trophoblast glycoprotein | -0.00706087 |
| CADM1 | cell adhesion molecule 1 | -0.00705298 |
| IFI44L | interferon-induced protein 44-like | -0.00704857 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.00702902 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.00702594 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.00702107 |
| NPAS2 | neuronal PAS domain protein 2 | -0.00701669 |
| PARP12 | poly (ADP-ribose) polymerase family, member 12 | -0.00701539 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0070119 |
| WWC1 | WW and C2 domain containing 1 | -0.0070107 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0070065 |
| CFD | complement factor D (adipsin) | -0.00700138 |
| LARP6 | La ribonucleoprotein domain family, member 6 | -0.007001 |
| SMAD3 | SMAD family member 3 | -0.00699256 |
| DTX4 | deltex 4, E3 ubiquitin ligase | -0.00699116 |
| RRAD | Ras-related associated with diabetes | -0.00697404 |
| SIRPA | signal-regulatory protein alpha | -0.00696797 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.00694756 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.00694294 |
| SCGB1D2 | secretoglobin, family 1D, member 2 | -0.00694261 |
| LEF1 | lymphoid enhancer-binding factor 1 | -0.00694055 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.00692575 |
