| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | leptin receptor|The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).[provided by RefSeq, Nov 2010] (NCBI Entrez Gene Database, 3953) |
| External Link | https://ncbi.nlm.nih.gov/gene/3953 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the LEPR gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SSBP2 | single-stranded DNA binding protein 2 | 0.0464458 |
| NFATC3 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 | 0.0219395 |
| MGP | matrix Gla protein | 0.0171165 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | 0.0138842 |
| METTL7A | methyltransferase like 7A | 0.0135666 |
| KRT19 | keratin 19, type I | 0.0126393 |
| ESR1 | estrogen receptor 1 | 0.0120772 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.0118708 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.0117622 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.0116451 |
| SEPP1 | selenoprotein P, plasma, 1 | 0.0116372 |
| RPA3 | replication protein A3, 14kDa | 0.0109381 |
| RAB25 | RAB25, member RAS oncogene family | 0.0105263 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.010514 |
| INSIG1 | insulin induced gene 1 | 0.0105006 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0104923 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0102823 |
| PRDX2 | peroxiredoxin 2 | 0.0101931 |
| CD302 | CD302 molecule | 0.0101059 |
| OLFM1 | olfactomedin 1 | 0.010104 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.0100093 |
| FBP1 | fructose-1,6-bisphosphatase 1 | 0.00997921 |
| SDC2 | syndecan 2 | 0.00994186 |
| C7 | complement component 7 | 0.0098513 |
| AGR2 | anterior gradient 2 | 0.00981873 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.00981326 |
| HOXC6 | homeobox C6 | 0.00978164 |
| IQGAP2 | IQ motif containing GTPase activating protein 2 | 0.00972213 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.00963083 |
| DPYD | dihydropyrimidine dehydrogenase | 0.00959793 |
| ZBTB18 | zinc finger and BTB domain containing 18 | 0.00959325 |
| IDH2 | isocitrate dehydrogenase 2 (NADP+), mitochondrial | 0.00956418 |
| PPA2 | pyrophosphatase (inorganic) 2 | 0.00944185 |
| KANK2 | KN motif and ankyrin repeat domains 2 | 0.00943249 |
| METRN | meteorin, glial cell differentiation regulator | 0.00940961 |
| FBXO5 | F-box protein 5 | 0.00934119 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | 0.00926989 |
| PLPP3 | phospholipid phosphatase 3 | 0.00922191 |
| GPSM2 | G-protein signaling modulator 2 | 0.00921512 |
| CLU | clusterin | 0.00920245 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | 0.00919474 |
| LYZ | lysozyme | 0.00914465 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.00913997 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.00912403 |
| DCLK1 | doublecortin-like kinase 1 | 0.00909978 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | 0.00909839 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.00906048 |
| PCP4 | Purkinje cell protein 4 | 0.00905688 |
| YEATS4 | YEATS domain containing 4 | 0.00898882 |
| C3ORF14 | chromosome 3 open reading frame 14 | 0.00898819 |
| WDR61 | WD repeat domain 61 | 0.00895496 |
| ARMT1 | acidic residue methyltransferase 1 | 0.00893487 |
| PTK2 | protein tyrosine kinase 2 | 0.00882855 |
| STK26 | serine/threonine protein kinase 26 | 0.00881326 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00878964 |
| SPC25 | SPC25, NDC80 kinetochore complex component | 0.0087853 |
| THYN1 | thymocyte nuclear protein 1 | 0.00876149 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.00872076 |
| TMEM106C | transmembrane protein 106C | 0.00870327 |
| CCNA2 | cyclin A2 | 0.00870173 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.00860754 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.00860048 |
| CDCA4 | cell division cycle associated 4 | 0.00855783 |
| ASF1B | anti-silencing function 1B histone chaperone | 0.00850635 |
| NDP | Norrie disease (pseudoglioma) | 0.00848428 |
| MYO5C | myosin VC | 0.00837363 |
| TMEM106B | transmembrane protein 106B | 0.00837325 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.00834338 |
| FGFR3 | fibroblast growth factor receptor 3 | 0.00833819 |
| CRLF1 | cytokine receptor-like factor 1 | 0.00831634 |
| NRGN | neurogranin (protein kinase C substrate, RC3) | 0.00824734 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | 0.00820147 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | 0.00820034 |
| RAB20 | RAB20, member RAS oncogene family | 0.00816683 |
| NUDT1 | nudix (nucleoside diphosphate linked moiety X)-type motif 1 | 0.00814793 |
| MYH11 | myosin, heavy chain 11, smooth muscle | 0.00812823 |
| DHRS11 | dehydrogenase/reductase (SDR family) member 11 | 0.00812741 |
| MAGED1 | melanoma antigen family D1 | 0.00812471 |
| WWOX | WW domain containing oxidoreductase | 0.00812429 |
| ELOVL6 | ELOVL fatty acid elongase 6 | 0.00810732 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.00807497 |
| CHRDL1 | chordin-like 1 | 0.00806488 |
| MICU2 | mitochondrial calcium uptake 2 | 0.00804252 |
| ZNF443 | zinc finger protein 443 | 0.00798471 |
| CRIP2 | cysteine-rich protein 2 | 0.00798453 |
| HMGB2 | high mobility group box 2 | 0.0079746 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | 0.00795941 |
| NDNF | neuron-derived neurotrophic factor | 0.00793746 |
| SAP30 | Sin3A-associated protein, 30kDa | 0.00789778 |
| FAM3C | family with sequence similarity 3, member C | 0.00788894 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.00786928 |
| SFTPB | surfactant protein B | 0.00786557 |
| BARD1 | BRCA1 associated RING domain 1 | 0.00785001 |
| NEK2 | NIMA-related kinase 2 | 0.00782982 |
| CST3 | cystatin C | 0.00781994 |
| TRMT5 | tRNA methyltransferase 5 | 0.00779098 |
| SPART | spartin | 0.00769233 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | 0.00766271 |
| RAB11A | RAB11A, member RAS oncogene family | 0.00764825 |
| ARL3 | ADP-ribosylation factor-like 3 | 0.00764171 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | 0.00764167 |
| TSPAN13 | tetraspanin 13 | 0.00760004 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00759288 |
| GCA | grancalcin, EF-hand calcium binding protein | 0.00758481 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 0.00758217 |
| LIPT1 | lipoyltransferase 1 | 0.00758012 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.00755091 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.00754936 |
| CTSW | cathepsin W | 0.00752951 |
| CCNF | cyclin F | 0.00752004 |
| ATF1 | activating transcription factor 1 | 0.0074743 |
| MOCS2 | molybdenum cofactor synthesis 2 | 0.00744073 |
| OIP5 | Opa interacting protein 5 | 0.00742687 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.0074081 |
| RAPSN | receptor-associated protein of the synapse | 0.00740626 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.00740626 |
| SFTPC | surfactant protein C | 0.00737461 |
| RPS5 | ribosomal protein S5 | 0.00737451 |
| HMGN5 | high mobility group nucleosome binding domain 5 | 0.00737371 |
| MBIP | MAP3K12 binding inhibitory protein 1 | 0.00735343 |
| KIF15 | kinesin family member 15 | 0.00734748 |
| ADK | adenosine kinase | 0.007338 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.00733774 |
| KHK | ketohexokinase (fructokinase) | 0.00733689 |
| RNASEH2A | ribonuclease H2, subunit A | 0.0073363 |
| ACOX2 | acyl-CoA oxidase 2, branched chain | 0.00733469 |
| CBX3 | chromobox homolog 3 | 0.00733166 |
| MAOA | monoamine oxidase A | 0.00729051 |
| CRIP1 | cysteine-rich protein 1 (intestinal) | 0.00726905 |
| DBF4 | DBF4 zinc finger | 0.00725351 |
| XPNPEP2 | X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound | 0.00722492 |
| NELL2 | NEL-like 2 (chicken) | 0.00721844 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.00714719 |
| CD209 | CD209 molecule | 0.007145 |
| RBBP7 | retinoblastoma binding protein 7 | 0.00714002 |
| NPTN | neuroplastin | 0.00713966 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.00713046 |
| BGN | biglycan | 0.00712554 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.00710458 |
| BEX1 | brain expressed, X-linked 1 | 0.00710253 |
| SLC9A3R1 | solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1 | 0.00707913 |
| HAPLN1 | hyaluronan and proteoglycan link protein 1 | 0.00707487 |
| MDFIC | MyoD family inhibitor domain containing | 0.00705639 |
| GATM | glycine amidinotransferase (L-arginine:glycine amidinotransferase) | 0.00704615 |
| ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 | 0.00701836 |
| FAM172A | family with sequence similarity 172, member A | 0.00699401 |
| CUTC | cutC copper transporter | 0.00699311 |
| APOA1 | apolipoprotein A-I | 0.00697486 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.0069617 |
| CD96 | CD96 molecule | 0.00695202 |
| RAD51AP1 | RAD51 associated protein 1 | 0.00694594 |
| MSMO1 | methylsterol monooxygenase 1 | 0.00694559 |
| ID4 | inhibitor of DNA binding 4, dominant negative helix-loop-helix protein | 0.00694324 |
| RMI1 | RecQ mediated genome instability 1 | 0.0069254 |
| NDC80 | NDC80 kinetochore complex component | 0.0069213 |
| SFTPA2 | surfactant protein A2 | 0.00689424 |
| CDS1 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 | 0.00687756 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.00686852 |
| HELLS | helicase, lymphoid-specific | 0.00685196 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00684412 |
| PLN | phospholamban | 0.00684273 |
| MPHOSPH9 | M-phase phosphoprotein 9 | 0.00683495 |
| TMEM100 | transmembrane protein 100 | 0.00681782 |
| PLEKHF2 | pleckstrin homology domain containing, family F (with FYVE domain) member 2 | 0.00680021 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | 0.00679474 |
| RNF167 | ring finger protein 167 | 0.00679122 |
| LBR | lamin B receptor | 0.00678437 |
| CTSK | cathepsin K | 0.00678194 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00677979 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 0.00676847 |
| ERLIN1 | ER lipid raft associated 1 | 0.00674223 |
| PEX2 | peroxisomal biogenesis factor 2 | 0.00673041 |
| C12ORF29 | chromosome 12 open reading frame 29 | 0.00672568 |
| SOBP | sine oculis binding protein homolog (Drosophila) | 0.00672101 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.00671868 |
| LEPR | leptin receptor | 0.00671751 |
| SRP9 | signal recognition particle 9kDa | 0.00670609 |
| HS3ST1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 1 | 0.006695 |
| IL17RB | interleukin 17 receptor B | 0.00668728 |
| XIC | X chromosome inactivation center | 0.00667503 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.00667398 |
| TEX30 | testis expressed 30 | 0.00667368 |
| CYFIP2 | cytoplasmic FMR1 interacting protein 2 | 0.00667353 |
| AZF1 | azoospermia factor 1 | 0.00667264 |
| CLEC10A | C-type lectin domain family 10, member A | 0.00665989 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.00661743 |
| NAT1 | N-acetyltransferase 1 (arylamine N-acetyltransferase) | 0.00661641 |
| RFC5 | replication factor C (activator 1) 5, 36.5kDa | 0.00661404 |
| ENO1 | enolase 1, (alpha) | 0.00660878 |
| FABP6 | fatty acid binding protein 6, ileal | 0.00660556 |
| KIF20A | kinesin family member 20A | 0.00660179 |
| RAMP1 | receptor (G protein-coupled) activity modifying protein 1 | 0.00659646 |
| AKAP11 | A kinase (PRKA) anchor protein 11 | 0.00658526 |
| RACGAP1 | Rac GTPase activating protein 1 | 0.00657123 |
| USP1 | ubiquitin specific peptidase 1 | 0.00657041 |
| APOC3 | apolipoprotein C-III | 0.00656228 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | 0.00655331 |
| VRK1 | vaccinia related kinase 1 | 0.00655085 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | 0.00655043 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | 0.00654542 |
| KIF11 | kinesin family member 11 | 0.00653839 |
| CHEK2 | checkpoint kinase 2 | 0.0065292 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.00652798 |
| SYT1 | synaptotagmin I | 0.00652364 |
| DMBT1 | deleted in malignant brain tumors 1 | 0.00651681 |
| PCOLCE2 | procollagen C-endopeptidase enhancer 2 | 0.00647916 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | 0.00647026 |
| SIRT3 | sirtuin 3 | 0.00645849 |
| SUZ12 | SUZ12 polycomb repressive complex 2 subunit | 0.00643559 |
| LY75 | lymphocyte antigen 75 | 0.00643556 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | 0.00642989 |
| NSL1 | NSL1, MIS12 kinetochore complex component | 0.00642244 |
| CCL13 | chemokine (C-C motif) ligand 13 | 0.00641991 |
| TMPO | thymopoietin | 0.00641707 |
| IL2RG | interleukin 2 receptor, gamma | 0.00641196 |
| RBBP8 | retinoblastoma binding protein 8 | 0.00640955 |
| PRKD3 | protein kinase D3 | 0.00640406 |
| CDC7 | cell division cycle 7 | 0.00640089 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.00639534 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00635778 |
| B3GNT1 | 0.00634985 | |
| WDR76 | WD repeat domain 76 | 0.00634939 |
| CDC42EP3 | CDC42 effector protein (Rho GTPase binding) 3 | 0.00634596 |
| ALDOC | aldolase C, fructose-bisphosphate | 0.00634345 |
| TMEM38B | transmembrane protein 38B | 0.00633718 |
| COL21A1 | collagen, type XXI, alpha 1 | 0.00632787 |
| AMFR | autocrine motility factor receptor, E3 ubiquitin protein ligase | 0.00631867 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.00630572 |
| ANGEL2 | angel homolog 2 (Drosophila) | 0.00629969 |
| RNASEH2B | ribonuclease H2, subunit B | 0.00629088 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.00628873 |
| SRSF3 | serine/arginine-rich splicing factor 3 | 0.00628568 |
| PNKP | polynucleotide kinase 3'-phosphatase | 0.00628231 |
| ACTL6A | actin-like 6A | 0.00626941 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00626367 |
| COMMD8 | COMM domain containing 8 | 0.00625691 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.00624968 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.00624867 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00623177 |
| CCDC47 | coiled-coil domain containing 47 | 0.00621946 |
| SEPTIN7 | septin 7 | 0.00621822 |
| PDGFC | platelet derived growth factor C | 0.0062142 |
| GRB14 | growth factor receptor-bound protein 14 | 0.0062117 |
| FANCL | Fanconi anemia, complementation group L | 0.00620804 |
| LSM2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.00618813 |
| NAP1L3 | nucleosome assembly protein 1-like 3 | 0.00618325 |
| ADRA2A | adrenoceptor alpha 2A | 0.00617999 |
| FRZB | frizzled-related protein | 0.0061784 |
| NR2F2 | nuclear receptor subfamily 2, group F, member 2 | 0.00616018 |
| REG3A | regenerating islet-derived 3 alpha | 0.00615767 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0220591 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0212146 |
| S100A8 | S100 calcium binding protein A8 | -0.0210555 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.0197912 |
| PERP | PERP, TP53 apoptosis effector | -0.0182459 |
| KLK10 | kallikrein-related peptidase 10 | -0.0182428 |
| MAP7 | microtubule-associated protein 7 | -0.0178094 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | -0.0170053 |
| C3 | complement component 3 | -0.0167748 |
| ASS1 | argininosuccinate synthase 1 | -0.0165741 |
| KRT14 | keratin 14, type I | -0.0160165 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0159354 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.0157316 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.0157018 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | -0.0151375 |
| S100A9 | S100 calcium binding protein A9 | -0.0150312 |
| TRIM29 | tripartite motif containing 29 | -0.014741 |
| ATF3 | activating transcription factor 3 | -0.0146414 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.0145129 |
| CA2 | carbonic anhydrase II | -0.0144825 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0142134 |
| AREG | amphiregulin | -0.0141957 |
| MVP | major vault protein | -0.0141528 |
| HMOX1 | heme oxygenase 1 | -0.0139544 |
| SIK1 | salt-inducible kinase 1 | -0.0139022 |
| NNMT | nicotinamide N-methyltransferase | -0.0137571 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0133123 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.0132636 |
| IER5 | immediate early response 5 | -0.0130529 |
| GJA1 | gap junction protein, alpha 1, 43kDa | -0.0129441 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0127679 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0127675 |
| NXN | nucleoredoxin | -0.0127531 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0126623 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | -0.0126139 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0126126 |
| IRS2 | insulin receptor substrate 2 | -0.0123843 |
| KLK11 | kallikrein-related peptidase 11 | -0.0123325 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | -0.0123258 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0121775 |
| HIST1H2BD | histone cluster 1, H2bd | -0.0120296 |
| HSPA2 | heat shock 70kDa protein 2 | -0.0119527 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.011864 |
| ADM | adrenomedullin | -0.0117328 |
| KLK6 | kallikrein-related peptidase 6 | -0.0116744 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | -0.0115059 |
| LCN2 | lipocalin 2 | -0.0113749 |
| JMJD6 | jumonji domain containing 6 | -0.0113685 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0113417 |
| RND3 | Rho family GTPase 3 | -0.0112529 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0111805 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.0111308 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0110964 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.011068 |
| TSPO | translocator protein (18kDa) | -0.0110382 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0109594 |
| RGCC | regulator of cell cycle | -0.0109385 |
| IL1RN | interleukin 1 receptor antagonist | -0.010858 |
| PXDN | peroxidasin | -0.0108236 |
| FN1 | fibronectin 1 | -0.0106915 |
| OPTN | optineurin | -0.0106665 |
| APOD | apolipoprotein D | -0.0106321 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.0106251 |
| S100A7 | S100 calcium binding protein A7 | -0.0105665 |
| ALOX5AP | arachidonate 5-lipoxygenase-activating protein | -0.0105574 |
| TRIP6 | thyroid hormone receptor interactor 6 | -0.0105439 |
| NID2 | nidogen 2 (osteonidogen) | -0.0105159 |
| OXTR | oxytocin receptor | -0.0104604 |
| PLPP2 | phospholipid phosphatase 2 | -0.0104278 |
| KRT17 | keratin 17, type I | -0.0103952 |
| GNAS | GNAS complex locus | -0.0102867 |
| ANXA3 | annexin A3 | -0.0102187 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.0101826 |
| THBS2 | thrombospondin 2 | -0.0100721 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0100425 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.0100231 |
| COL5A1 | collagen, type V, alpha 1 | -0.00999396 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.00999028 |
| ZC3H12A | zinc finger CCCH-type containing 12A | -0.00998983 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | -0.00996828 |
| KLF4 | Kruppel-like factor 4 (gut) | -0.00993395 |
| KLF6 | Kruppel-like factor 6 | -0.00991592 |
| MYOF | myoferlin | -0.00989972 |
| HTRA1 | HtrA serine peptidase 1 | -0.0098525 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00980713 |
| EPHA2 | EPH receptor A2 | -0.00975843 |
| PLK2 | polo-like kinase 2 | -0.00974157 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.00974034 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | -0.00970382 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.00966041 |
| CLTB | clathrin, light chain B | -0.00955933 |
| ANXA1 | annexin A1 | -0.00955239 |
| CXCL11 | chemokine (C-X-C motif) ligand 11 | -0.009528 |
| SYNGR3 | synaptogyrin 3 | -0.00950337 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | -0.00945976 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00942594 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | -0.00933741 |
| TRIM16 | tripartite motif containing 16 | -0.00928872 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.00928084 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | -0.00924702 |
| KRT23 | keratin 23, type I | -0.00924513 |
| KLK7 | kallikrein-related peptidase 7 | -0.00918689 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00917874 |
| LRRC15 | leucine rich repeat containing 15 | -0.00917487 |
| JUNB | jun B proto-oncogene | -0.00913297 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.00912551 |
| RGS1 | regulator of G-protein signaling 1 | -0.00910738 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00895258 |
| SNAI2 | snail family zinc finger 2 | -0.00893307 |
| IL32 | interleukin 32 | -0.00891429 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | -0.00887864 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0088773 |
| GPX2 | glutathione peroxidase 2 | -0.00879534 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | -0.00878929 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.00878651 |
| SOX11 | SRY (sex determining region Y)-box 11 | -0.00878086 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | -0.00877909 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.00876427 |
| PUM3 | pumilio RNA binding family member 3 | -0.00875978 |
| KLHL24 | kelch-like family member 24 | -0.00875471 |
| KLK5 | kallikrein-related peptidase 5 | -0.0087235 |
| SLC38A2 | solute carrier family 38, member 2 | -0.00871362 |
| ZFP36 | ZFP36 ring finger protein | -0.00865856 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.00861577 |
| PRSS23 | protease, serine, 23 | -0.00860392 |
| AK1 | adenylate kinase 1 | -0.00852597 |
| CAPN3 | calpain 3, (p94) | -0.00851201 |
| MMP1 | matrix metallopeptidase 1 | -0.00847433 |
| MYO1B | myosin IB | -0.00842221 |
| GAL | galanin/GMAP prepropeptide | -0.00839797 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | -0.00838713 |
| MITF | microphthalmia-associated transcription factor | -0.00829669 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | -0.00827431 |
| HIST1H2BK | histone cluster 1, H2bk | -0.00827293 |
| DEFB1 | defensin, beta 1 | -0.00826751 |
| IFRD1 | interferon-related developmental regulator 1 | -0.00825863 |
| TDO2 | tryptophan 2,3-dioxygenase | -0.00825331 |
| CST1 | cystatin SN | -0.00825229 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0082217 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | -0.00821899 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.00820781 |
| DNAJC6 | DnaJ (Hsp40) homolog, subfamily C, member 6 | -0.00819747 |
| OLFML2A | olfactomedin-like 2A | -0.00819004 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.00816643 |
| NPAS2 | neuronal PAS domain protein 2 | -0.00813033 |
| PPIF | peptidylprolyl isomerase F | -0.00809687 |
| VSNL1 | visinin-like 1 | -0.00808931 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.00806724 |
| MCM2 | minichromosome maintenance complex component 2 | -0.00803413 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00802633 |
| MX1 | MX dynamin-like GTPase 1 | -0.00799162 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00795627 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00794708 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | -0.00793023 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.00790596 |
| NRCAM | neuronal cell adhesion molecule | -0.00789951 |
| MAGEA3 | melanoma antigen family A3 | -0.00784969 |
| MIR22HG | MIR22 host gene | -0.00777458 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | -0.00777238 |
| IFNGR1 | interferon gamma receptor 1 | -0.00777231 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | -0.0077627 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.00775488 |
| FOSL2 | FOS-like antigen 2 | -0.00773362 |
| RUNX1 | runt-related transcription factor 1 | -0.0077122 |
| ZNF91 | zinc finger protein 91 | -0.00771164 |
| SPATA20 | spermatogenesis associated 20 | -0.00769085 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | -0.00767216 |
| LRRC8D | leucine rich repeat containing 8 family, member D | -0.0076709 |
| VCL | vinculin | -0.0076644 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.00765893 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | -0.00762747 |
| CTSD | cathepsin D | -0.00759174 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00759045 |
| EGR1 | early growth response 1 | -0.00757027 |
| CFB | complement factor B | -0.00753429 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | -0.00751074 |
| DSP | desmoplakin | -0.0075071 |
| STC2 | stanniocalcin 2 | -0.00749038 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.00748688 |
| COL10A1 | collagen, type X, alpha 1 | -0.00746977 |
| POPDC3 | popeye domain containing 3 | -0.00745561 |
| GAB2 | GRB2-associated binding protein 2 | -0.00745153 |
| CEL | carboxyl ester lipase | -0.00743459 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.00742254 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | -0.00740921 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.00740741 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.00738255 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -0.00738126 |
| CD37 | CD37 molecule | -0.00737878 |
| INHBB | inhibin, beta B | -0.00737863 |
| COL15A1 | collagen, type XV, alpha 1 | -0.00737247 |
| LOXL2 | lysyl oxidase-like 2 | -0.00737207 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00736897 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 | -0.00734904 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.00734466 |
| RELA | v-rel avian reticuloendotheliosis viral oncogene homolog A | -0.00734217 |
| CRYAB | crystallin, alpha B | -0.00733152 |
| VGLL4 | vestigial-like family member 4 | -0.00733023 |
| PSAT1 | phosphoserine aminotransferase 1 | -0.0073294 |
| TUFT1 | tuftelin 1 | -0.00732015 |
| TRIM22 | tripartite motif containing 22 | -0.00730274 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0072859 |
| TNFSF4 | tumor necrosis factor (ligand) superfamily, member 4 | -0.00727548 |
| RRAGC | Ras-related GTP binding C | -0.00726663 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.00726242 |
| HIST1H2AC | histone cluster 1, H2ac | -0.00725682 |
| FHL2 | four and a half LIM domains 2 | -0.00725616 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00725607 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.00724315 |
| TWIST1 | twist family bHLH transcription factor 1 | -0.00721966 |
| RGS16 | regulator of G-protein signaling 16 | -0.00721897 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | -0.00720401 |
| DCN | decorin | -0.00720174 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -0.00717641 |
| PRAME | preferentially expressed antigen in melanoma | -0.00715458 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00713583 |
| ANTXR1 | anthrax toxin receptor 1 | -0.00713561 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.00708847 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.00708148 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | -0.00707777 |
| RRAGA | Ras-related GTP binding A | -0.0070702 |
| CTSL | cathepsin L | -0.00706719 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | -0.00698991 |
| LBH | limb bud and heart development | -0.00698694 |
| GDF15 | growth differentiation factor 15 | -0.00697435 |
| MAP7D1 | MAP7 domain containing 1 | -0.00696655 |
| REXO2 | RNA exonuclease 2 | -0.00695898 |
| DUSP10 | dual specificity phosphatase 10 | -0.00691871 |
| RABEP2 | rabaptin, RAB GTPase binding effector protein 2 | -0.00689404 |
| FCGBP | Fc fragment of IgG binding protein | -0.00689077 |
| MORC4 | MORC family CW-type zinc finger 4 | -0.00688869 |
| COL11A1 | collagen, type XI, alpha 1 | -0.00688394 |
| PFKP | phosphofructokinase, platelet | -0.00677463 |
| HPGDS | hematopoietic prostaglandin D synthase | -0.00677075 |
| PRRG1 | proline rich Gla (G-carboxyglutamic acid) 1 | -0.00676371 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | -0.00673977 |
| ADRB2 | adrenoceptor beta 2, surface | -0.00673288 |
| IRF1 | interferon regulatory factor 1 | -0.00672123 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.0067155 |
| LGALS4 | lectin, galactoside-binding, soluble, 4 | -0.0067001 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.00669182 |
| RTN2 | reticulon 2 | -0.00668425 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.00667767 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.00667281 |
| EPYC | epiphycan | -0.00666615 |
| RIN2 | Ras and Rab interactor 2 | -0.00666329 |
| GPX1 | glutathione peroxidase 1 | -0.00666282 |
| PLK3 | polo-like kinase 3 | -0.00665444 |
| CCND3 | cyclin D3 | -0.00662778 |
