LHX1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description LIM homeobox 1|This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor important for the development of the renal and urogenital systems. This gene is a candidate for Mayer-Rokitansky-Kuster-Hauser syndrome, a disorder characterized by anomalies in the female genital tract. [provided by RefSeq, Dec 2010] (NCBI Entrez Gene Database, 3975)
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Genes

328 genes differentially expressed following the LHX1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.84531
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.84531
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.84531
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 2.84531
SIGLEC9 sialic acid binding Ig-like lectin 9 2.84531
NEU4 sialidase 4 2.84531
SSTR4 somatostatin receptor 4 2.84531
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.84531
LYZL6 lysozyme-like 6 2.84531
SP7 Sp7 transcription factor 2.84531
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.84531
GJB1 gap junction protein, beta 1, 32kDa 2.84531
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.84531
SH2D7 SH2 domain containing 7 2.84531
NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2.84531
CHADL chondroadherin-like 2.84531
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.84531
LIPN lipase, family member N 2.84531
CD19 CD19 molecule 2.84531
PRICKLE4 prickle homolog 4 (Drosophila) 2.84531
AKR1C2 aldo-keto reductase family 1, member C2 2.84531
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.84531
PDYN prodynorphin 2.84531
PKP1 plakophilin 1 2.84531
TRAT1 T cell receptor associated transmembrane adaptor 1 2.84531
PTGFR prostaglandin F receptor (FP) 2.84531
EPHB3 EPH receptor B3 2.84531
STAP1 signal transducing adaptor family member 1 2.84531
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.84531
CCDC87 coiled-coil domain containing 87 2.84531
TWIST1 twist family bHLH transcription factor 1 2.84531
HOXB1 homeobox B1 2.84531
WFDC13 WAP four-disulfide core domain 13 2.84531
NFE2 nuclear factor, erythroid 2 2.84531
MNX1 motor neuron and pancreas homeobox 1 2.84531
NEUROD4 neuronal differentiation 4 2.84531
SPAG8 sperm associated antigen 8 2.84531
TMEM132C transmembrane protein 132C 2.84531
NMUR2 neuromedin U receptor 2 2.84531
LY6G6F lymphocyte antigen 6 complex, locus G6F 2.84531
C1ORF141 chromosome 1 open reading frame 141 2.84531
TDRD7 tudor domain containing 7 2.84531
NLRP10 NLR family, pyrin domain containing 10 2.84531
OCSTAMP osteoclast stimulatory transmembrane protein 2.84531
KRT78 keratin 78, type II 2.84531
TAS2R19 taste receptor, type 2, member 19 2.84531
BMP5 bone morphogenetic protein 5 2.84531
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 2.84531
THEMIS thymocyte selection associated 2.84531
MAGEC3 melanoma antigen family C3 2.84531
AGTR1 angiotensin II receptor, type 1 2.84531
GNG14 G protein subunit gamma 14 2.84531
MT3 metallothionein 3 2.84531
ZNF726 zinc finger protein 726 2.84531
YIPF7 Yip1 domain family, member 7 2.84531
TAS2R60 taste receptor, type 2, member 60 2.84531
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 2.84531
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.84531
ZG16 zymogen granule protein 16 2.84531
DNAAF1 dynein, axonemal, assembly factor 1 2.84531
CASZ1 castor zinc finger 1 2.84531
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.84531
NIBAN3 niban apoptosis regulator 3 2.84531
H1-8 H1.8 linker histone 2.84531
TEX13D TEX13 family member D 2.84531
CPNE8-AS1 CPNE8 antisense RNA 1 2.84531
TMDD1 transmembrane and death domain 1 2.84531
CIMIP3 ciliary microtubule inner protein 3 2.84531
PRRT1B proline rich transmembrane protein 1B 2.84531
CIMAP1D CIMAP1 family member D 2.84531
LOC124902436 talanin 2.84531
GNG5B G protein subunit gamma 5B 2.84531
LY6L lymphocyte antigen 6 family member L 2.84531
GSG1L2 GSG1 like 2 2.84531
TUBB8B tubulin beta 8B 2.84531
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.84531
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 2.84531
SLAMF7 SLAM family member 7 2.84531
HAPLN2 hyaluronan and proteoglycan link protein 2 2.84531
CXCL16 chemokine (C-X-C motif) ligand 16 2.84531
MSX1 msh homeobox 1 2.84531
PSAPL1 prosaposin-like 1 (gene/pseudogene) 2.84531
PTPRH protein tyrosine phosphatase, receptor type, H 2.84531
KLHL33 kelch-like family member 33 2.84531
PCDHA7 protocadherin alpha 7 2.84531
ACOT4 acyl-CoA thioesterase 4 2.84531
ZNF174 zinc finger protein 174 2.84531
LECT2 leukocyte cell-derived chemotaxin 2 2.84531
TACR2 tachykinin receptor 2 2.84531
RGS21 regulator of G-protein signaling 21 2.84531
MIOX myo-inositol oxygenase 2.84531
TSPAN1 tetraspanin 1 2.84531
SPATA22 spermatogenesis associated 22 2.84531
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.84531
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.84531
NDP Norrie disease (pseudoglioma) 2.84531
TINAG tubulointerstitial nephritis antigen 2.84531
PRG3 proteoglycan 3 2.84531
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.84531
OOSP2 oocyte secreted protein 2 2.84531
MEP1B meprin A, beta 2.84531
MAB21L3 mab-21-like 3 (C. elegans) 2.84531
ZBP1 Z-DNA binding protein 1 2.84531
LCNL1 lipocalin-like 1 2.84531
LY96 lymphocyte antigen 96 2.84531
TTLL12 tubulin tyrosine ligase-like family member 12 2.84531
CT55 cancer/testis antigen 55 2.84531
NOG noggin 2.84531
ODF1 outer dense fiber of sperm tails 1 2.84531
CFAP61 cilia and flagella associated protein 61 2.84531
FCRLB Fc receptor-like B 2.84531
APOD apolipoprotein D 2.84531
ALAS2 5'-aminolevulinate synthase 2 2.84531
PLA2G12B phospholipase A2, group XIIB 2.84531
IL13RA2 interleukin 13 receptor, alpha 2 2.84531
GSTA1 glutathione S-transferase alpha 1 2.84531
PLA2G4D phospholipase A2, group IVD (cytosolic) 2.84531
PRSS38 protease, serine, 38 2.84531
RAD51AP2 RAD51 associated protein 2 2.84531
EFCC1 EF-hand and coiled-coil domain containing 1 2.84531
HK3 hexokinase 3 (white cell) 2.84531
CD53 CD53 molecule 2.84531
TRIM50 tripartite motif containing 50 2.84531
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.84531
EVPLL envoplakin-like 2.84531
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 2.84531
NPFFR1 neuropeptide FF receptor 1 2.84531
FBXO40 F-box protein 40 2.84531
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.84531
ZNF596 zinc finger protein 596 2.84531
ZNF843 zinc finger protein 843 2.84531
HGH1 HGH1 homolog (S. cerevisiae) 2.84531
KLK2 kallikrein-related peptidase 2 2.84531
CDHR5 cadherin-related family member 5 2.84531
CRYBB2 crystallin, beta B2 2.84531
LRRC15 leucine rich repeat containing 15 2.84531
MOB3C MOB kinase activator 3C 2.84531
COL11A2 collagen, type XI, alpha 2 2.84531
ZNF471 zinc finger protein 471 2.84531
SLFN12L schlafen family member 12-like 2.84531
FOXP3 forkhead box P3 2.84531
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.84531
CETP cholesteryl ester transfer protein, plasma 2.84531
CLCA4 chloride channel accessory 4 2.84531
CLCA2 chloride channel accessory 2 2.84531
PLA2G5 phospholipase A2, group V 2.84531
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.84531
NPAS4 neuronal PAS domain protein 4 2.84531
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.84531
RNF148 ring finger protein 148 2.84531
AOC1 amine oxidase, copper containing 1 2.84531
ANGPTL3 angiopoietin-like 3 2.84531
ANGPTL5 angiopoietin-like 5 2.84531
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 2.84531
TEX36 testis expressed 36 2.84531
ART1 ADP-ribosyltransferase 1 2.84531
CFI complement factor I 2.84531
SYT2 synaptotagmin II 2.84531
CHRM1 cholinergic receptor, muscarinic 1 2.84531
MGP matrix Gla protein 2.84531
NTSR1 neurotensin receptor 1 (high affinity) 2.84531
CD28 CD28 molecule 2.84531
DMBT1 deleted in malignant brain tumors 1 2.84531
CD27 CD27 molecule 2.84531
KIF4B kinesin family member 4B 2.84531
HIGD2B HIG1 hypoxia inducible domain family, member 2B 2.84531
FCN1 ficolin (collagen/fibrinogen domain containing) 1 2.84531
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.84531
LYPD5 LY6/PLAUR domain containing 5 2.84531
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.84531
EPO erythropoietin 2.84531
TYR tyrosinase 2.84531
TSPAN19 tetraspanin 19 2.84531
C5AR2 complement component 5a receptor 2 2.84531
ADCY4 adenylate cyclase 4 2.84531
TBC1D28 TBC1 domain family, member 28 2.84531
CDH18 cadherin 18, type 2 2.83264
MEDAG mesenteric estrogen-dependent adipogenesis 2.78565
SAXO5 stabilizer of axonemal microtubules 5 2.73506
INHBA inhibin, beta A 2.73506
TMEM106C transmembrane protein 106C 2.69752
RNFT2 ring finger protein, transmembrane 2 2.63741
CTH cystathionine gamma-lyase 2.58514
ZNF547 zinc finger protein 547 2.54611
FAIM Fas apoptotic inhibitory molecule 2.543
INCENP inner centromere protein antigens 135/155kDa 2.543
NBDY negative regulator of P-body association 2.53809
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin 2.52332
CHID1 chitinase domain containing 1 2.44542
DRG2 developmentally regulated GTP binding protein 2 2.41719
LRRC8C leucine rich repeat containing 8 family, member C 2.4066
PARP16 poly (ADP-ribose) polymerase family, member 16 2.39967
NRSN1 neurensin 1 2.39079
LGMN legumain 2.33919
TMEM191C transmembrane protein 191C 2.30918
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.30918
MTERF4 mitochondrial transcription termination factor 4 2.30632
MINAR2 membrane integral NOTCH2 associated receptor 2 2.28436
VIT vitrin 2.28436
PDCL2 phosducin-like 2 2.28436
DUSP26 dual specificity phosphatase 26 (putative) 2.28436
TTLL2 tubulin tyrosine ligase-like family member 2 2.26129
FAM177B family with sequence similarity 177, member B 2.26129
TCEAL9 transcription elongation factor A like 9 2.2451
CREB3L2 cAMP responsive element binding protein 3-like 2 2.24283
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 2.23083
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 2.21812
ZC3H3 zinc finger CCCH-type containing 3 2.21323
PI4K2B phosphatidylinositol 4-kinase type 2 beta 2.21323
MRPL41 mitochondrial ribosomal protein L41 2.18021
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 2.1775
MAMDC2 MAM domain containing 2 2.1775
RPL7L1 ribosomal protein L7-like 1 2.17255
ZBED11 zinc finger BED-type containing 11 2.15907
ANAPC15 anaphase promoting complex subunit 15 2.15018
UBE4A ubiquitination factor E4A 2.13133
TSLIG3B tRNA splicing ligase complex subunit 3B 2.13042
CDA cytidine deaminase 2.13012
CAMKMT calmodulin-lysine N-methyltransferase 2.12724
NCKAP1 NCK-associated protein 1 2.10802
KAT2A K(lysine) acetyltransferase 2A 2.09335
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) 2.09335
LRRC40 leucine rich repeat containing 40 2.09265
GADD45B growth arrest and DNA-damage-inducible, beta 2.09104
MIA2 melanoma inhibitory activity 2 2.08677
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 2.0832
MLF2 myeloid leukemia factor 2 2.07579
ZNF140 zinc finger protein 140 2.07189
NTM neurotrimin 2.07189
RAB4B RAB4B, member RAS oncogene family 2.05471
SFR1 SWI5-dependent recombination repair 1 2.04966
SLC30A8 solute carrier family 30 (zinc transporter), member 8 2.04831
DLL1 delta-like 1 (Drosophila) 2.03681
POPDC3 popeye domain containing 3 2.02053
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 2.01147
BMAL1 basic helix-loop-helix ARNT like 1 2.01147
ADAMTS18 ADAM metallopeptidase with thrombospondin type 1 motif, 18 2.00172

decreased expression

Symbol Name Standardized Value
TMC2 transmembrane channel-like 2 -2.84531
UPB1 ureidopropionase, beta -2.84531
STBD1 starch binding domain 1 -2.84531
DES desmin -2.84531
SHBG sex hormone-binding globulin -2.84531
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.84531
F7 coagulation factor VII (serum prothrombin conversion accelerator) -2.84531
STX11 syntaxin 11 -2.84531
PROC protein C (inactivator of coagulation factors Va and VIIIa) -2.84531
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.84531
HOMEZ homeobox and leucine zipper encoding -2.84531
DLX4 distal-less homeobox 4 -2.84531
TRIM36 tripartite motif containing 36 -2.84531
TMEM88 transmembrane protein 88 -2.84531
SP6 Sp6 transcription factor -2.84531
LRRC63 leucine rich repeat containing 63 -2.84531
CHD7 chromodomain helicase DNA binding protein 7 -2.84531
CLCF1 cardiotrophin-like cytokine factor 1 -2.84531
PNPLA8 patatin-like phospholipase domain containing 8 -2.84531
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -2.84531
CCDC74B coiled-coil domain containing 74B -2.84531
ERVFRD-1 endogenous retrovirus group FRD, member 1 -2.84531
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.84531
SAMD5 sterile alpha motif domain containing 5 -2.84531
TEX29 testis expressed 29 -2.84531
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 -2.84531
SAMD11 sterile alpha motif domain containing 11 -2.84531
LOC122526780 uncharacterized LOC122526780 -2.84531
SLC46A1 solute carrier family 46 (folate transporter), member 1 -2.84531
EIF4E1B eukaryotic translation initiation factor 4E family member 1B -2.84531
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 -2.84531
HSPB6 heat shock protein, alpha-crystallin-related, B6 -2.84531
ASXL1 additional sex combs like transcriptional regulator 1 -2.79103
PRCP prolylcarboxypeptidase (angiotensinase C) -2.71186
EIF3K eukaryotic translation initiation factor 3, subunit K -2.69359
MTOR mechanistic target of rapamycin (serine/threonine kinase) -2.68779
TOX4 TOX high mobility group box family member 4 -2.6833
H2BC4 H2B clustered histone 4 -2.67924
SLC25A30 solute carrier family 25, member 30 -2.67192
SUSD6 sushi domain containing 6 -2.58514
FAM219A family with sequence similarity 219, member A -2.53443
AEN apoptosis enhancing nuclease -2.50044
SAMD4A sterile alpha motif domain containing 4A -2.40999
CLU clusterin -2.40755
PIGW phosphatidylinositol glycan anchor biosynthesis, class W -2.40141
SVIL supervillin -2.39967
ATP5F1D ATP synthase F1 subunit delta -2.36457
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.34818
CLIC6 chloride intracellular channel 6 -2.33597
LSM11 LSM11, U7 small nuclear RNA associated -2.30918
XIRP2 xin actin binding repeat containing 2 -2.30918
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) -2.28436
SLX4IP SLX4 interacting protein -2.26411
KLF9 Kruppel-like factor 9 -2.2451
MVB12A multivesicular body subunit 12A -2.23963
FAM110A family with sequence similarity 110, member A -2.23777
RAMP1 receptor (G protein-coupled) activity modifying protein 1 -2.23585
CDK9 cyclin-dependent kinase 9 -2.23519
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.22973
CNBP CCHC-type zinc finger, nucleic acid binding protein -2.22521
SFT2D3 SFT2 domain containing 3 -2.21323
RPS26 ribosomal protein S26 -2.201
ZNF281 zinc finger protein 281 -2.19202
SHISAL1 shisa like 1 -2.18021
RRAGC Ras-related GTP binding C -2.16343
FANCI Fanconi anemia, complementation group I -2.14907
F2R coagulation factor II (thrombin) receptor -2.14622
PSORS1C2 psoriasis susceptibility 1 candidate 2 -2.13042
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 -2.13042
RAB40A RAB40A, member RAS oncogene family -2.13042
ECEL1 endothelin converting enzyme-like 1 -2.13042
IL4I1 interleukin 4 induced 1 -2.13042
TESK1 testis-specific kinase 1 -2.12021
FAM133A family with sequence similarity 133, member A -2.11443
ZNF76 zinc finger protein 76 -2.09244
ZNF362 zinc finger protein 362 -2.09244
NPR1 natriuretic peptide receptor 1 -2.08644
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -2.0832
KNOP1 lysine-rich nucleolar protein 1 -2.0832
H1-0 H1.0 linker histone -2.07579
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.07579
ZNF296 zinc finger protein 296 -2.07097
ENG endoglin -2.05354
FYB2 FYN binding protein 2 -2.02104
KBTBD12 kelch repeat and BTB (POZ) domain containing 12 -2.02104
ICAM1 intercellular adhesion molecule 1 -2.02104
PRODH proline dehydrogenase (oxidase) 1 -2.02104
TRA2A transformer 2 alpha homolog (Drosophila) -2.02104
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.02104
KMT5B lysine methyltransferase 5B -2.02053
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -2.01768