LHX8 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description LIM homeobox 8|The protein encoded by this gene is a member of the LIM homeobox family of proteins, which are involved in patterning and differentiation of various tissue types. These proteins contain two tandemly repeated cysteine-rich double-zinc finger motifs known as LIM domains, in addition to a DNA-binding homeodomain. This family member is a transcription factor that plays a role in tooth morphogenesis. It is also involved in oogenesis and in neuronal differentiation. This gene is a candidate gene for cleft palate, and it is also associated with odontoma formation. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 431707)
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Genes

293 genes differentially expressed following the LHX8 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
GPR101 G protein-coupled receptor 101 2.45208
HBA2 hemoglobin, alpha 2 2.45208
TAS2R5 taste receptor, type 2, member 5 2.45208
SIX2 SIX homeobox 2 2.45208
HRH1 histamine receptor H1 2.45208
FOLR1 folate receptor 1 (adult) 2.45208
YES1 YES proto-oncogene 1, Src family tyrosine kinase 2.45208
OR8A1 olfactory receptor, family 8, subfamily A, member 1 2.45208
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.45208
KLF17 Kruppel-like factor 17 2.45208
CPED1 cadherin-like and PC-esterase domain containing 1 2.45208
C4ORF17 chromosome 4 open reading frame 17 2.45208
GGT5 gamma-glutamyltransferase 5 2.45208
PRB4 proline-rich protein BstNI subfamily 4 2.45208
OASL 2'-5'-oligoadenylate synthetase-like 2.45208
CAPN14 calpain 14 2.45208
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 2.45208
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.45208
LOC390937 Ets2 repressor factor-like 2.45208
AKR1C2 aldo-keto reductase family 1, member C2 2.45208
MGAM2 maltase-glucoamylase 2 (putative) 2.45208
PSENEN presenilin enhancer gamma secretase subunit 2.45208
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.45208
MROH2B maestro heat-like repeat family member 2B 2.45208
GLRA3 glycine receptor, alpha 3 2.45208
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.45208
ANKK1 ankyrin repeat and kinase domain containing 1 2.45208
OC90 otoconin 90 2.45208
GNRHR gonadotropin-releasing hormone receptor 2.45208
CIITA class II, major histocompatibility complex, transactivator 2.45208
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.45208
GFRA3 GDNF family receptor alpha 3 2.45208
TNNI1 troponin I type 1 (skeletal, slow) 2.45208
PNMA5 paraneoplastic Ma antigen family member 5 2.45208
AMTN amelotin 2.45208
SH2D6 SH2 domain containing 6 2.45208
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.45208
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 2.45208
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.45208
CHRD chordin 2.45208
C10ORF67 chromosome 10 open reading frame 67 2.45208
NSG2 neuronal vesicle trafficking associated 2 2.45208
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.45208
ALPG alkaline phosphatase, germ cell 2.45208
H1-6 H1.6 linker histone, cluster member 2.45208
MISP3 MISP family member 3 2.45208
NSD2 nuclear receptor binding SET domain protein 2 2.45208
PTH1R parathyroid hormone 1 receptor 2.45208
CLDN16 claudin 16 2.45208
CRACDL CRACD like 2.45208
CALHM5 calcium homeostasis modulator family member 5 2.45208
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.45208
SPMAP2L sperm microtubule associated protein 2 like 2.45208
SPMIP3 sperm microtubule inner protein 3 2.45208
PNMA8C PNMA family member 8C 2.45208
SMIM31 small integral membrane protein 31 2.45208
SOFU1 sperm-oocyte fusion factor 1 2.45208
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.45208
JAML junction adhesion molecule like 2.45208
FRG2C FSHD region gene 2 family, member C 2.45208
SPRR2E small proline-rich protein 2E 2.45208
OPN5 opsin 5 2.45208
IL1R1 interleukin 1 receptor, type I 2.45208
NPFF neuropeptide FF-amide peptide precursor 2.45208
C6ORF118 chromosome 6 open reading frame 118 2.45208
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.45208
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.45208
ADGRG1 adhesion G protein-coupled receptor G1 2.45208
TLR1 toll-like receptor 1 2.45208
HAL histidine ammonia-lyase 2.45208
ASIC4 acid sensing (proton gated) ion channel family member 4 2.45208
FMO3 flavin containing monooxygenase 3 2.45208
PDF peptide deformylase (mitochondrial) 2.45208
RDH8 retinol dehydrogenase 8 (all-trans) 2.45208
LY6H lymphocyte antigen 6 complex, locus H 2.45208
GCSAM germinal center-associated, signaling and motility 2.45208
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.45208
ANAPC15 anaphase promoting complex subunit 15 2.45208
PRG4 proteoglycan 4 2.45208
CATSPERT catsper channel auxiliary subunit tau 2.45208
CLEC18A C-type lectin domain family 18, member A 2.45208
ANKRD61 ankyrin repeat domain 61 2.45208
GLOD5 glyoxalase domain containing 5 2.45208
SCT secretin 2.45208
OLFML1 olfactomedin-like 1 2.45208
NIPAL4 NIPA-like domain containing 4 2.45208
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.45208
CDH19 cadherin 19, type 2 2.45208
WNT7B wingless-type MMTV integration site family, member 7B 2.45208
CXCR6 chemokine (C-X-C motif) receptor 6 2.45208
ADORA3 adenosine A3 receptor 2.45208
KRT17 keratin 17, type I 2.45208
CPO carboxypeptidase O 2.45208
NPPA natriuretic peptide A 2.45208
LRRC43 leucine rich repeat containing 43 2.45208
MYF6 myogenic factor 6 (herculin) 2.45208
CT55 cancer/testis antigen 55 2.45208
LCNL1 lipocalin-like 1 2.45208
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.45208
COX7B2 cytochrome c oxidase subunit VIIb2 2.45208
VWA3A von Willebrand factor A domain containing 3A 2.45208
PRTN3 proteinase 3 2.45208
OR5B2 olfactory receptor, family 5, subfamily B, member 2 2.45208
FLRT3 fibronectin leucine rich transmembrane protein 3 2.45208
TRIM7 tripartite motif containing 7 2.45208
C1ORF105 chromosome 1 open reading frame 105 2.45208
CASQ2 calsequestrin 2 (cardiac muscle) 2.45208
LAMB4 laminin, beta 4 2.45208
FAM151A family with sequence similarity 151, member A 2.45208
TPPP2 tubulin polymerization-promoting protein family member 2 2.45208
BEAN1 brain expressed, associated with NEDD4, 1 2.45208
IL1A interleukin 1, alpha 2.45208
KISS1 KiSS-1 metastasis-suppressor 2.45208
P2RX3 purinergic receptor P2X, ligand gated ion channel, 3 2.45208
PLA1A phospholipase A1 member A 2.45208
LRRC15 leucine rich repeat containing 15 2.45208
PHACTR3 phosphatase and actin regulator 3 2.45208
SAMD5 sterile alpha motif domain containing 5 2.45208
CALR3 calreticulin 3 2.45208
PRSS57 protease, serine, 57 2.45208
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.45208
GRAP2 GRB2-related adaptor protein 2 2.45208
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.45208
GALR2 galanin receptor 2 2.45208
BIN2 bridging integrator 2 2.45208
ISLR2 immunoglobulin superfamily containing leucine-rich repeat 2 2.45208
PPP1R3A protein phosphatase 1, regulatory subunit 3A 2.45208
ICAM2 intercellular adhesion molecule 2 2.45208
RAB7B RAB7B, member RAS oncogene family 2.45208
IL18R1 interleukin 18 receptor 1 2.45208
TMEM88 transmembrane protein 88 2.45208
MROH2A maestro heat-like repeat family member 2A 2.45208
CHAD chondroadherin 2.45208
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.45208
RNASE9 ribonuclease, RNase A family, 9 (non-active) 2.45208
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.45208
WDFY4 WDFY family member 4 2.45208
ANKRD33 ankyrin repeat domain 33 2.45208
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.45208
SLC7A4 solute carrier family 7, member 4 2.45208
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.45208
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.45208
IL2RA interleukin 2 receptor, alpha 2.45208
R3HDML R3H domain containing-like 2.45208
STEAP4 STEAP family member 4 2.45208
CMYA5 cardiomyopathy associated 5 2.41187
DPH7 diphthamide biosynthesis 7 2.35627
ZSCAN2 zinc finger and SCAN domain containing 2 2.30771
DORIP1 dopamine receptor interacting protein 1 2.30683
NNAT neuronatin 2.3044
HSF5 heat shock transcription factor family member 5 2.29842
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 2.28849
CLEC4A C-type lectin domain family 4, member A 2.28715
H3C11 H3 clustered histone 11 2.26885
SELENOM selenoprotein M 2.26885
CDC14B cell division cycle 14B 2.26885
JADE2 jade family PHD finger 2 2.26885
FAM149A family with sequence similarity 149, member A 2.26243
SPDYA speedy/RINGO cell cycle regulator family member A 2.24361
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 2.24237
NOSTRIN nitric oxide synthase trafficking 2.24221
CNIH2 cornichon family AMPA receptor auxiliary protein 2 2.19737
MPPE1 metallophosphoesterase 1 2.19507
VTA1 vesicle (multivesicular body) trafficking 1 2.19088
CPNE5 copine V 2.18167
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 2.13354
NUBP1 nucleotide binding protein 1 2.11568
UTP11 UTP11 small subunit processome component 2.10888
FANCM Fanconi anemia, complementation group M 2.10888
CDK5RAP1 CDK5 regulatory subunit associated protein 1 2.09853
SRCAP Snf2-related CREBBP activator protein 2.08102
EXO5 exonuclease 5 2.06248
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.05929
GPRC5B G protein-coupled receptor, class C, group 5, member B 2.0521
SETBP1 SET binding protein 1 2.04631
FDXACB1 ferredoxin-fold anticodon binding domain containing 1 2.04587
ATXN7L2 ataxin 7-like 2 2.0319
ZNF844 zinc finger protein 844 2.0319
FNDC10 fibronectin type III domain containing 10 2.02621
TTC9 tetratricopeptide repeat domain 9 2.02149
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 2.01829
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 2.01769
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 2.011
MSH6 mutS homolog 6 2.01073
JPH1 junctophilin 1 2.00813
ASMTL acetylserotonin O-methyltransferase-like 2.00737
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 2.00079

decreased expression

Symbol Name Standardized Value
NWD1 NACHT and WD repeat domain containing 1 -2.45208
TMEFF2 transmembrane protein with EGF-like and two follistatin-like domains 2 -2.45208
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.45208
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.45208
GON4L gon-4-like (C. elegans) -2.45208
VASH2 vasohibin 2 -2.45208
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.45208
SPAG16 sperm associated antigen 16 -2.45208
ACE angiotensin I converting enzyme -2.45208
PGAM2 phosphoglycerate mutase 2 (muscle) -2.45208
PDCD11 programmed cell death 11 -2.45208
CHGB chromogranin B -2.45208
CRYGS crystallin, gamma S -2.45208
RNF114 ring finger protein 114 -2.45208
ZNF146 zinc finger protein 146 -2.45208
POM121L2 POM121 transmembrane nucleoporin-like 2 -2.45208
HEYL hes-related family bHLH transcription factor with YRPW motif-like -2.45208
TSPAN17 tetraspanin 17 -2.45208
SMIM19 small integral membrane protein 19 -2.45208
PLPP7 phospholipid phosphatase 7 (inactive) -2.45208
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa -2.45208
ZNF273 zinc finger protein 273 -2.45208
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 -2.35627
C20ORF203 chromosome 20 open reading frame 203 -2.35627
COQ4 coenzyme Q4 -2.35627
PTPRA protein tyrosine phosphatase, receptor type, A -2.32897
ZNF747 zinc finger protein 747 -2.32661
PEX39 peroxisomal biogenesis factor 39 -2.32661
CASP10 caspase 10, apoptosis-related cysteine peptidase -2.3044
PDE1A phosphodiesterase 1A, calmodulin-dependent -2.3044
CD24 CD24 molecule -2.29017
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 -2.28918
MARCKS myristoylated alanine-rich protein kinase C substrate -2.28715
MDFIC MyoD family inhibitor domain containing -2.27616
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.26885
CENPL centromere protein L -2.26885
PRDM6 PR domain containing 6 -2.26885
RNF39 ring finger protein 39 -2.26885
ATP5MGL ATP synthase membrane subunit g like -2.26885
ERFE erythroferrone -2.26885
FAM107A family with sequence similarity 107, member A -2.26885
RAB37 RAB37, member RAS oncogene family -2.26885
PKD2L1 polycystic kidney disease 2-like 1 -2.26885
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 -2.26885
MAP7D3 MAP7 domain containing 3 -2.26885
SPARCL1 SPARC-like 1 (hevin) -2.26885
TPTE transmembrane phosphatase with tensin homology -2.26885
GOLGA6L7 golgin A6 family like 7 -2.26885
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.26885
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -2.26885
BGN biglycan -2.26885
CAPN11 calpain 11 -2.26885
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) -2.26885
NICN1 nicolin 1 -2.26885
MPZL2 myelin protein zero-like 2 -2.26885
CAV2 caveolin 2 -2.26885
NLRC3 NLR family, CARD domain containing 3 -2.26885
GPR12 G protein-coupled receptor 12 -2.26885
BTNL2 butyrophilin-like 2 -2.26885
NREP neuronal regeneration related protein -2.26885
FAM209A family with sequence similarity 209, member A -2.26885
ISL1 ISL LIM homeobox 1 -2.26885
ZFR2 zinc finger RNA binding protein 2 -2.26885
CD70 CD70 molecule -2.26885
MORN5 MORN repeat containing 5 -2.26885
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -2.26885
RIN1 Ras and Rab interactor 1 -2.26885
PRSS50 protease, serine, 50 -2.26885
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -2.26885
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -2.26885
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -2.26885
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 -2.26885
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) -2.26885
ADM5 adrenomedullin 5 (putative) -2.26885
ZNF223 zinc finger protein 223 -2.26243
CDK7 cyclin-dependent kinase 7 -2.20192
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.20041
DAZAP2 DAZ associated protein 2 -2.19507
KIAA1191 KIAA1191 -2.16757
NPIPB5 nuclear pore complex interacting protein family, member B5 -2.16361
CPEB4 cytoplasmic polyadenylation element binding protein 4 -2.14794
SPTY2D1 SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) -2.11015
MAP3K15 mitogen-activated protein kinase kinase kinase 15 -2.10888
FEZF1 FEZ family zinc finger 1 -2.10888
NR2C1 nuclear receptor subfamily 2, group C, member 1 -2.10888
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.09474
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein -2.09472
PCDH17 protocadherin 17 -2.09472
NEO1 neogenin 1 -2.08746
YEATS2 YEATS domain containing 2 -2.06103
KHDC1 KH homology domain containing 1 -2.06103
SPATC1L spermatogenesis and centriole associated 1-like -2.0521
FOSL2 FOS-like antigen 2 -2.04995
PTRH2 peptidyl-tRNA hydrolase 2 -2.04995
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.04869
KANTR KDM5C adjacent non-coding transcript -2.04631
CMTM1 CKLF-like MARVEL transmembrane domain containing 1 -2.0319
MAML3 mastermind-like 3 (Drosophila) -2.0319
ZCCHC7 zinc finger, CCHC domain containing 7 -2.0319
MYSM1 Myb-like, SWIRM and MPN domains 1 -2.0319
DXO decapping exoribonuclease -2.0319
ARF3 ADP-ribosylation factor 3 -2.0319
DGLUCY D-glutamate cyclase -2.03008
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.01769
SNX6 sorting nexin 6 -2.00813
TRIM68 tripartite motif containing 68 -2.00737