LIVF001-006 Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
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Genes

120 genes differentially expressed following the LIVF001-006 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
PFKL phosphofructokinase, liver 9.11347
MEF2C myocyte enhancer factor 2C 6.46677
BAD BCL2-associated agonist of cell death 5.57538
GFOD1 glucose-fructose oxidoreductase domain containing 1 4.91193
U2AF1 U2 small nuclear RNA auxiliary factor 1 4.86982
NUSAP1 nucleolar and spindle associated protein 1 4.66437
CBR3 carbonyl reductase 3 4.41265
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 4.31626
CD93 CD93 molecule 4.30002
CREB1 cAMP responsive element binding protein 1 4.24679
HAT1 histone acetyltransferase 1 4.19886
CD320 CD320 molecule 4.19211
KANSL1L KAT8 regulatory NSL complex subunit 1-like 4.16612
CALHM2 calcium homeostasis modulator 2 4.00552
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.96646
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 3.82156
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.81707
SNHG3 small nucleolar RNA host gene 3 3.77971
CAMK1 calcium/calmodulin-dependent protein kinase I 3.64989
E2F8 E2F transcription factor 8 3.64394
IL4 interleukin 4 3.63511
UBFD1 ubiquitin family domain containing 1 3.62392
CAST calpastatin 3.58593
ZNF112 zinc finger protein 112 3.58529
DMC1 DNA meiotic recombinase 1 3.52761
MMRN1 multimerin 1 3.52205
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 3.5203
TYMS thymidylate synthetase 3.50189
GRIK1 glutamate receptor, ionotropic, kainate 1 3.48586
IFT57 intraflagellar transport 57 3.47875
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 3.46988
FEZF2 FEZ family zinc finger 2 3.45004
DOCK3 dedicator of cytokinesis 3 3.44513
GPER1 G protein-coupled estrogen receptor 1 3.4288
B2M beta-2-microglobulin 3.4272
GPR22 G protein-coupled receptor 22 3.37688
EPHA7 EPH receptor A7 3.35951
HYAL4 hyaluronoglucosaminidase 4 3.3561
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 3.35028
WIPI2 WD repeat domain, phosphoinositide interacting 2 3.34989
ZNF271P zinc finger protein 271, pseudogene 3.31641
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) 3.29989
TBR1 T-box, brain, 1 3.28888
AJAP1 adherens junctions associated protein 1 3.28829
ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 3.26488
EHBP1L1 EH domain binding protein 1-like 1 3.25623
KRT13 keratin 13, type I 3.23555
EIF4A1 eukaryotic translation initiation factor 4A1 3.23388
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 3.22702
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 3.20462
FBXO40 F-box protein 40 3.20055
SREK1IP1 SREK1-interacting protein 1 3.17907
KCNK15 potassium channel, two pore domain subfamily K, member 15 3.17801
NDUFAF7 NADH dehydrogenase (ubiquinone) complex I, assembly factor 7 3.15258
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 3.13918
PITPNB phosphatidylinositol transfer protein, beta 3.13729
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 3.1363
LHX6 LIM homeobox 6 3.13357
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3 3.12315
MMRN2 multimerin 2 3.10789
CD34 CD34 molecule 3.09744
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 3.08041
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.0699
FOSB FBJ murine osteosarcoma viral oncogene homolog B 3.04531
SH2B2 SH2B adaptor protein 2 3.03255
ADCYAP1R1 adenylate cyclase activating polypeptide 1 (pituitary) receptor type I 3.00769

decreased expression

Symbol Name Standardized Value
PLEKHJ1 pleckstrin homology domain containing, family J member 1 -6.08085
KTN1 kinectin 1 (kinesin receptor) -4.7718
CDC20 cell division cycle 20 -4.56598
PPP1R13B protein phosphatase 1, regulatory subunit 13B -4.39848
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.36282
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -4.23853
APOE apolipoprotein E -4.2
VAV3 vav 3 guanine nucleotide exchange factor -4.01831
MT2A metallothionein 2A -4.01453
GAGE1 G antigen 1 -3.99909
CHGB chromogranin B -3.92211
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 -3.86615
CCR7 chemokine (C-C motif) receptor 7 -3.82121
GK3 glycerol kinase 3 -3.77148
ANK1 ankyrin 1, erythrocytic -3.72658
TFCP2L1 transcription factor CP2-like 1 -3.68034
NTS neurotensin -3.66593
ITK IL2-inducible T-cell kinase -3.64952
ADGRE5 adhesion G protein-coupled receptor E5 -3.64445
FAM163A family with sequence similarity 163, member A -3.62608
TLR4 toll-like receptor 4 -3.58355
ASCL3 achaete-scute family bHLH transcription factor 3 -3.55402
PRKCQ protein kinase C, theta -3.52222
PTRH2 peptidyl-tRNA hydrolase 2 -3.52198
SELPLG selectin P ligand -3.52139
OPTN optineurin -3.5128
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 -3.50831
CLCN2 chloride channel, voltage-sensitive 2 -3.45514
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.44064
MPP1 membrane protein, palmitoylated 1, 55kDa -3.38432
IL15RA interleukin 15 receptor, alpha -3.36391
BEAN1 brain expressed, associated with NEDD4, 1 -3.35967
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) -3.34823
DRD2 dopamine receptor D2 -3.3362
MT1X metallothionein 1X -3.32569
ATP7B ATPase, Cu++ transporting, beta polypeptide -3.31524
USH1C Usher syndrome 1C (autosomal recessive, severe) -3.3067
RHOBTB1 Rho-related BTB domain containing 1 -3.28462
TRPV1 transient receptor potential cation channel, subfamily V, member 1 -3.26485
VIPR1 vasoactive intestinal peptide receptor 1 -3.26009
UMOD uromodulin -3.22609
FGF1 fibroblast growth factor 1 (acidic) -3.20846
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 -3.16985
FPR2 formyl peptide receptor 2 -3.15738
RAB31 RAB31, member RAS oncogene family -3.12448
BCL2L14 BCL2-like 14 (apoptosis facilitator) -3.1034
SIX3 SIX homeobox 3 -3.09149
OARD1 O-acyl-ADP-ribose deacylase 1 -3.08684
GIMAP5 GTPase, IMAP family member 5 -3.07564
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 -3.06904
CD8B CD8b molecule -3.03968
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 -3.01968
LINC00574 long intergenic non-protein coding RNA 574 -3.01828
PROX1 prospero homeobox 1 -3.00655