LIVF001-025 Gene Set

Dataset LINCS L1000 CMAP Chemical Perturbation Consensus Signatures
Category transcriptomics
Type small molecule perturbation
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Genes

612 genes differentially expressed following the LIVF001-025 small molecule perturbation from the LINCS L1000 CMAP Chemical Perturbation Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 9.15977
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 7.33674
UBE2L6 ubiquitin-conjugating enzyme E2L 6 6.56303
TCEA2 transcription elongation factor A (SII), 2 5.59571
DHX16 DEAH (Asp-Glu-Ala-His) box polypeptide 16 5.45655
NME7 NME/NM23 family member 7 5.31916
CELF3 CUGBP, Elav-like family member 3 5.05917
FANCE Fanconi anemia, complementation group E 5.05042
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial 4.98021
PRSS23 protease, serine, 23 4.88278
CRHR1 corticotropin releasing hormone receptor 1 4.81316
HPSE heparanase 4.79427
IPO13 importin 13 4.76798
SPATA7 spermatogenesis associated 7 4.7494
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 4.73803
ADA adenosine deaminase 4.73477
CDK5RAP3 CDK5 regulatory subunit associated protein 3 4.73471
PRCP prolylcarboxypeptidase (angiotensinase C) 4.73392
ZDHHC8BP ZDHHC8B, pseudogene 4.66261
SPTBN4 spectrin, beta, non-erythrocytic 4 4.64347
ANO10 anoctamin 10 4.62349
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta 4.59231
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 4.56483
FHOD3 formin homology 2 domain containing 3 4.55493
ZDHHC13 zinc finger, DHHC-type containing 13 4.50702
DSE dermatan sulfate epimerase 4.5054
MAGEH1 melanoma antigen family H1 4.45498
DCTN3 dynactin 3 (p22) 4.44774
PCDHA9 protocadherin alpha 9 4.39568
ADAM9 ADAM metallopeptidase domain 9 4.37108
SDK2 sidekick cell adhesion molecule 2 4.35704
RPS5 ribosomal protein S5 4.33815
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 4.3188
SYCP1 synaptonemal complex protein 1 4.29816
PLCH2 phospholipase C, eta 2 4.29647
RAB28 RAB28, member RAS oncogene family 4.28213
CCND3 cyclin D3 4.27172
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 4.25087
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.24622
TMEM45A transmembrane protein 45A 4.24489
CREG1 cellular repressor of E1A-stimulated genes 1 4.24279
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 4.1917
IFNAR1 interferon (alpha, beta and omega) receptor 1 4.17888
ADAP2 ArfGAP with dual PH domains 2 4.15665
CASP10 caspase 10, apoptosis-related cysteine peptidase 4.14151
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 4.10672
GM2A GM2 ganglioside activator 4.0906
TIGAR TP53 induced glycolysis regulatory phosphatase 4.08269
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 4.05248
MPZL1 myelin protein zero-like 1 4.04085
PTGDR2 prostaglandin D2 receptor 2 4.03819
TPMT thiopurine S-methyltransferase 4.0363
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal) 4.03267
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 4.02736
HLA-F major histocompatibility complex, class I, F 4.02629
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 4.01772
DRD2 dopamine receptor D2 4.01304
ZNF205 zinc finger protein 205 4.01004
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 4.00247
MBOAT2 membrane bound O-acyltransferase domain containing 2 3.96118
CEP290 centrosomal protein 290kDa 3.93343
ARMCX4 armadillo repeat containing, X-linked 4 3.92617
CADPS Ca++-dependent secretion activator 3.92047
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 3.90582
MNAT1 MNAT CDK-activating kinase assembly factor 1 3.90404
ACTL8 actin-like 8 3.88893
KCTD14 potassium channel tetramerization domain containing 14 3.88747
MAPKBP1 mitogen-activated protein kinase binding protein 1 3.87776
AMPD2 adenosine monophosphate deaminase 2 3.8427
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 3.83253
PAPSS1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 3.83221
IFI6 interferon, alpha-inducible protein 6 3.82938
RFK riboflavin kinase 3.82125
MAP2 microtubule-associated protein 2 3.81497
CDHR1 cadherin-related family member 1 3.81302
GDAP2 ganglioside induced differentiation associated protein 2 3.80829
GAS6 growth arrest-specific 6 3.80007
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 3.79923
PDE1B phosphodiesterase 1B, calmodulin-dependent 3.7969
ACYP1 acylphosphatase 1, erythrocyte (common) type 3.79474
ZC2HC1A zinc finger, C2HC-type containing 1A 3.77714
TRIM62 tripartite motif containing 62 3.77222
SHB Src homology 2 domain containing adaptor protein B 3.77141
CD9 CD9 molecule 3.76913
PFKM phosphofructokinase, muscle 3.75708
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.75541
PLEKHS1 pleckstrin homology domain containing, family S member 1 3.74724
PARD6B par-6 family cell polarity regulator beta 3.74716
TPD52 tumor protein D52 3.72117
NXPH4 neurexophilin 4 3.70406
CMTR1 cap methyltransferase 1 3.70352
RAB11FIP1 RAB11 family interacting protein 1 (class I) 3.69489
MAN2B1 mannosidase, alpha, class 2B, member 1 3.68056
BBS9 Bardet-Biedl syndrome 9 3.67919
ROM1 retinal outer segment membrane protein 1 3.67791
HLA-C major histocompatibility complex, class I, C 3.67668
MYT1 myelin transcription factor 1 3.65951
ALDOC aldolase C, fructose-bisphosphate 3.65801
RING1 ring finger protein 1 3.65734
PPT1 palmitoyl-protein thioesterase 1 3.65375
ATP10D ATPase, class V, type 10D 3.64521
IFT27 intraflagellar transport 27 3.63662
UCN urocortin 3.62696
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 3.62569
CCKAR cholecystokinin A receptor 3.62489
GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 3.61688
BACE2 beta-site APP-cleaving enzyme 2 3.61215
PEX3 peroxisomal biogenesis factor 3 3.61191
OSTM1 osteopetrosis associated transmembrane protein 1 3.61119
GPATCH2L G patch domain containing 2-like 3.6089
ZFC3H1 zinc finger, C3H1-type containing 3.60503
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 3.60393
CRLF3 cytokine receptor-like factor 3 3.60392
STK38 serine/threonine kinase 38 3.60377
LINC02249 long intergenic non-protein coding RNA 2249 3.60192
ADCYAP1 adenylate cyclase activating polypeptide 1 (pituitary) 3.59773
SRCAP Snf2-related CREBBP activator protein 3.59478
NRXN1 neurexin 1 3.59433
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 3.59303
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 3.5897
ADRA2B adrenoceptor alpha 2B 3.58553
TTC9 tetratricopeptide repeat domain 9 3.5775
ZBTB22 zinc finger and BTB domain containing 22 3.57626
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 3.57347
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 3.57199
DIPK1A divergent protein kinase domain 1A 3.56095
MEF2D myocyte enhancer factor 2D 3.55514
ASCL3 achaete-scute family bHLH transcription factor 3 3.54896
FGD6 FYVE, RhoGEF and PH domain containing 6 3.5481
NSF N-ethylmaleimide-sensitive factor 3.54585
RUSC2 RUN and SH3 domain containing 2 3.54299
EPHB6 EPH receptor B6 3.53722
WDR47 WD repeat domain 47 3.53703
HTRA1 HtrA serine peptidase 1 3.52961
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 3.52531
EZR ezrin 3.52096
RBBP5 retinoblastoma binding protein 5 3.51315
PHF1 PHD finger protein 1 3.50756
LGALS9 lectin, galactoside-binding, soluble, 9 3.49876
DPEP1 dipeptidase 1 (renal) 3.4918
DNAJC24 DnaJ (Hsp40) homolog, subfamily C, member 24 3.47776
SYP synaptophysin 3.47446
KLHDC8A kelch domain containing 8A 3.47254
VGF VGF nerve growth factor inducible 3.46786
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 3.46608
CALU calumenin 3.45404
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 3.44702
TMEM35A transmembrane protein 35A 3.44406
TDRKH tudor and KH domain containing 3.44247
EMC2 ER membrane protein complex subunit 2 3.43385
PKP2 plakophilin 2 3.42746
GDAP1 ganglioside induced differentiation associated protein 1 3.41183
CCNH cyclin H 3.41118
TIMP1 TIMP metallopeptidase inhibitor 1 3.40025
PURG purine-rich element binding protein G 3.39949
FBXO11 F-box protein 11 3.39941
RADX RPA1 related single stranded DNA binding protein, X-linked 3.39815
CADM3 cell adhesion molecule 3 3.39553
CXXC4 CXXC finger protein 4 3.39279
MEAK7 MTOR associated protein, eak-7 homolog 3.38967
PLS1 plastin 1 3.38065
MAPK9 mitogen-activated protein kinase 9 3.37095
CALCOCO2 calcium binding and coiled-coil domain 2 3.36914
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 3.36712
RGS13 regulator of G-protein signaling 13 3.36493
BBX bobby sox homolog (Drosophila) 3.36206
STK3 serine/threonine kinase 3 3.36014
RPL8 ribosomal protein L8 3.35431
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae) 3.35345
PRKCI protein kinase C, iota 3.34682
PELO pelota homolog (Drosophila) 3.34646
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 3.34552
CNPY4 canopy FGF signaling regulator 4 3.33742
CTNND1 catenin (cadherin-associated protein), delta 1 3.33708
GAL3ST4 galactose-3-O-sulfotransferase 4 3.33617
SDHAP1 succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1 3.33196
HLA-B major histocompatibility complex, class I, B 3.32918
RIGI RNA sensor RIG-I 3.32454
DMXL2 Dmx-like 2 3.32284
GRN granulin 3.32274
TMSB10 thymosin beta 10 3.32271
MICA MHC class I polypeptide-related sequence A 3.32031
HUNK hormonally up-regulated Neu-associated kinase 3.31872
SERGEF secretion regulating guanine nucleotide exchange factor 3.31603
ATG4A autophagy related 4A, cysteine peptidase 3.31603
HLA-G major histocompatibility complex, class I, G 3.31498
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 3.30911
RAB6B RAB6B, member RAS oncogene family 3.29386
DNAI1 dynein, axonemal, intermediate chain 1 3.29244
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 3.27721
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 3.27298
TCF21 transcription factor 21 3.26405
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 3.25996
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 3.25669
KLK1 kallikrein 1 3.25505
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.25306
ADGRL1 adhesion G protein-coupled receptor L1 3.24573
OSBPL3 oxysterol binding protein-like 3 3.24291
TRAPPC14 trafficking protein particle complex subunit 14 3.24076
IL11RA interleukin 11 receptor, alpha 3.2336
CBR1 carbonyl reductase 1 3.23154
IGFBP3 insulin-like growth factor binding protein 3 3.23147
MEIS2 Meis homeobox 2 3.23118
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha 3.22811
PCBP3 poly(rC) binding protein 3 3.21808
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 3.21685
KCTD17 potassium channel tetramerization domain containing 17 3.21278
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD) 3.20956
BLVRA biliverdin reductase A 3.2076
ATOSB atos homolog B 3.20519
C10ORF88 chromosome 10 open reading frame 88 3.20413
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa 3.20253
PTN pleiotrophin 3.18749
FYN FYN proto-oncogene, Src family tyrosine kinase 3.18533
ACO2 aconitase 2, mitochondrial 3.18499
SPATS2 spermatogenesis associated, serine-rich 2 3.18246
CLSTN3 calsyntenin 3 3.18222
PCSK5 proprotein convertase subtilisin/kexin type 5 3.17819
GPR162 G protein-coupled receptor 162 3.17724
SMIM8 small integral membrane protein 8 3.17383
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 3.17361
NPTN neuroplastin 3.17074
ZNF576 zinc finger protein 576 3.16964
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 3.16751
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 3.16607
ADGRG1 adhesion G protein-coupled receptor G1 3.16393
PREPL prolyl endopeptidase-like 3.15949
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 3.14969
PCDHGB5 protocadherin gamma subfamily B, 5 3.14879
PICK1 protein interacting with PRKCA 1 3.14771
CHMP5 charged multivesicular body protein 5 3.14629
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 3.13847
PGK1 phosphoglycerate kinase 1 3.13452
NECAP1 NECAP endocytosis associated 1 3.13312
SIX5 SIX homeobox 5 3.13016
IQSEC2 IQ motif and Sec7 domain 2 3.12469
IL10RB interleukin 10 receptor, beta 3.12431
MARCHF6 membrane associated ring-CH-type finger 6 3.11837
BZW2 basic leucine zipper and W2 domains 2 3.11826
RALYL RALY RNA binding protein-like 3.11668
CSNK1G1 casein kinase 1, gamma 1 3.1139
SRPK1 SRSF protein kinase 1 3.11182
SEPTIN10 septin 10 3.11096
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 3.11018
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 3.10867
CD22 CD22 molecule 3.10607
ZSCAN9 zinc finger and SCAN domain containing 9 3.10323
FKBP15 FK506 binding protein 15, 133kDa 3.10195
HSPA4L heat shock 70kDa protein 4-like 3.10002
SCAMP5 secretory carrier membrane protein 5 3.0983
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 3.09773
FOXO4 forkhead box O4 3.0952
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 3.08674
IFT74 intraflagellar transport 74 3.08568
ACOT11 acyl-CoA thioesterase 11 3.08414
TXNRD1 thioredoxin reductase 1 3.08279
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.08009
RGS2 regulator of G-protein signaling 2 3.07747
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 3.07747
GSTM4 glutathione S-transferase mu 4 3.07506
PTPRO protein tyrosine phosphatase, receptor type, O 3.07492
CPA4 carboxypeptidase A4 3.07251
SCN2B sodium channel, voltage gated, type II beta subunit 3.07196
LRP12 low density lipoprotein receptor-related protein 12 3.07166
PIBF1 progesterone immunomodulatory binding factor 1 3.07141
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 3.06999
PPM1E protein phosphatase, Mg2+/Mn2+ dependent, 1E 3.06981
CRELD1 cysteine-rich with EGF-like domains 1 3.06719
SSTR3 somatostatin receptor 3 3.06547
FER fer (fps/fes related) tyrosine kinase 3.06316
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 3.06211
TRPC1 transient receptor potential cation channel, subfamily C, member 1 3.06086
MOSPD1 motile sperm domain containing 1 3.05647
NDRG3 NDRG family member 3 3.05639
MPPED1 metallophosphoesterase domain containing 1 3.05567
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 3.0541
STX2 syntaxin 2 3.0485
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 3.04729
BTG2 BTG family, member 2 3.04489
CA8 carbonic anhydrase VIII 3.03794
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 3.03359
KLK8 kallikrein-related peptidase 8 3.02826
KCTD12 potassium channel tetramerization domain containing 12 3.02202
PGAP1 post-GPI attachment to proteins 1 3.02074
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.01825
PROCR protein C receptor, endothelial 3.01541
ADIPOR1 adiponectin receptor 1 3.01418
GIPC1 GIPC PDZ domain containing family, member 1 3.00985
RIC8B RIC8 guanine nucleotide exchange factor B 3.00946
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) 3.00915
NCOA3 nuclear receptor coactivator 3 3.00801
SCPEP1 serine carboxypeptidase 1 3.00718

decreased expression

Symbol Name Standardized Value
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -7.60006
C5 complement component 5 -6.92419
ERBB3 erb-b2 receptor tyrosine kinase 3 -6.79571
TMEM97 transmembrane protein 97 -6.71943
ENOSF1 enolase superfamily member 1 -6.64022
GLUD1 glutamate dehydrogenase 1 -6.60259
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha -6.46546
FGG fibrinogen gamma chain -6.37433
DUSP3 dual specificity phosphatase 3 -6.35466
ARSL arylsulfatase L -6.35024
CPN1 carboxypeptidase N, polypeptide 1 -6.26409
AKR1D1 aldo-keto reductase family 1, member D1 -6.09792
FGA fibrinogen alpha chain -6.02827
ST7 suppression of tumorigenicity 7 -5.96743
TYMS thymidylate synthetase -5.84145
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -5.83013
UBE2C ubiquitin-conjugating enzyme E2C -5.60276
F2 coagulation factor II (thrombin) -5.57501
A1CF APOBEC1 complementation factor -5.57404
ADI1 acireductone dioxygenase 1 -5.51615
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -5.51012
C4ORF19 chromosome 4 open reading frame 19 -5.48061
SERPINA4 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4 -5.46554
PBLD phenazine biosynthesis-like protein domain containing -5.46181
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -5.43193
SLC30A10 solute carrier family 30, member 10 -5.27987
APOH apolipoprotein H (beta-2-glycoprotein I) -5.25806
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -5.24608
F7 coagulation factor VII (serum prothrombin conversion accelerator) -5.1906
PATZ1 POZ (BTB) and AT hook containing zinc finger 1 -5.13031
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 -5.10899
HGD homogentisate 1,2-dioxygenase -5.02728
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G -4.99269
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 -4.97292
PMF1 polyamine-modulated factor 1 -4.95351
APOA2 apolipoprotein A-II -4.92438
APOC3 apolipoprotein C-III -4.91823
GLB1 galactosidase, beta 1 -4.91467
NNT nicotinamide nucleotide transhydrogenase -4.91278
FBXW4 F-box and WD repeat domain containing 4 -4.89982
ERBB2 erb-b2 receptor tyrosine kinase 2 -4.88395
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -4.87246
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -4.82659
PPIF peptidylprolyl isomerase F -4.81422
VTN vitronectin -4.80363
FGB fibrinogen beta chain -4.78386
AMBP alpha-1-microglobulin/bikunin precursor -4.76541
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -4.7497
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 -4.74706
PDGFA platelet-derived growth factor alpha polypeptide -4.7357
DECR2 2,4-dienoyl CoA reductase 2, peroxisomal -4.66575
COL18A1 collagen, type XVIII, alpha 1 -4.6641
CHAD chondroadherin -4.64029
BRD3 bromodomain containing 3 -4.63435
TM4SF4 transmembrane 4 L six family member 4 -4.61539
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -4.55821
PDZK1 PDZ domain containing 1 -4.55071
ELOVL2 ELOVL fatty acid elongase 2 -4.54576
EGFR epidermal growth factor receptor -4.54031
FGFR4 fibroblast growth factor receptor 4 -4.53105
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -4.5072
MTTP microsomal triglyceride transfer protein -4.4929
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -4.48968
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase -4.48777
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -4.48734
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 -4.4779
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -4.47295
FOXM1 forkhead box M1 -4.4688
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -4.44367
PAH phenylalanine hydroxylase -4.43766
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 -4.43466
APOM apolipoprotein M -4.42283
AHSG alpha-2-HS-glycoprotein -4.42244
ETNPPL ethanolamine-phosphate phospho-lyase -4.40183
DHTKD1 dehydrogenase E1 and transketolase domain containing 1 -4.37146
CPB2 carboxypeptidase B2 (plasma) -4.34513
FADS1 fatty acid desaturase 1 -4.34499
SNX5 sorting nexin 5 -4.32075
PCBP2 poly(rC) binding protein 2 -4.31771
TFR2 transferrin receptor 2 -4.29213
GNAS GNAS complex locus -4.29158
SOAT2 sterol O-acyltransferase 2 -4.27236
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -4.26091
HPD 4-hydroxyphenylpyruvate dioxygenase -4.22986
KLKB1 kallikrein B, plasma (Fletcher factor) 1 -4.22495
CSN3 casein kappa -4.2196
F5 coagulation factor V (proaccelerin, labile factor) -4.17766
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -4.17639
PROZ protein Z, vitamin K-dependent plasma glycoprotein -4.16662
FGFR3 fibroblast growth factor receptor 3 -4.12951
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 -4.10467
POLE polymerase (DNA directed), epsilon, catalytic subunit -4.10207
RAPSN receptor-associated protein of the synapse -4.08618
CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43 -4.08594
C2ORF72 chromosome 2 open reading frame 72 -4.0714
GDF5 growth differentiation factor 5 -4.04623
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme -4.04459
TACC3 transforming, acidic coiled-coil containing protein 3 -4.03872
LIPC lipase, hepatic -4.02498
MCM5 minichromosome maintenance complex component 5 -4.02472
MLH1 mutL homolog 1 -4.02452
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -4.01406
F11 coagulation factor XI -3.99986
CCR7 chemokine (C-C motif) receptor 7 -3.99423
MTARC1 mitochondrial amidoxime reducing component 1 -3.99257
RABL6 RAB, member RAS oncogene family-like 6 -3.99199
ZWINT ZW10 interacting kinetochore protein -3.98789
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -3.98332
C8A complement component 8, alpha polypeptide -3.96616
C1RL complement component 1, r subcomponent-like -3.95939
GLUD2 glutamate dehydrogenase 2 -3.95531
NIPSNAP1 nipsnap homolog 1 (C. elegans) -3.94374
IGHMBP2 immunoglobulin mu binding protein 2 -3.94197
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -3.92789
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma -3.92672
C11ORF24 chromosome 11 open reading frame 24 -3.91097
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -3.90279
ZFHX3 zinc finger homeobox 3 -3.90138
FTCD formimidoyltransferase cyclodeaminase -3.89443
LRP5 low density lipoprotein receptor-related protein 5 -3.89356
ASGR1 asialoglycoprotein receptor 1 -3.89208
CX3CL1 chemokine (C-X3-C motif) ligand 1 -3.89122
SHLD2 shieldin complex subunit 2 -3.88979
UPB1 ureidopropionase, beta -3.88611
ZBTB16 zinc finger and BTB domain containing 16 -3.88161
PROC protein C (inactivator of coagulation factors Va and VIIIa) -3.88017
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -3.87379
AUTS2 autism susceptibility candidate 2 -3.87137
NSD2 nuclear receptor binding SET domain protein 2 -3.8651
ASGR2 asialoglycoprotein receptor 2 -3.85444
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -3.84722
NME4 NME/NM23 nucleoside diphosphate kinase 4 -3.8472
PYGL phosphorylase, glycogen, liver -3.84142
GCGR glucagon receptor -3.81434
HPN hepsin -3.80764
ZBED1 zinc finger, BED-type containing 1 -3.80642
LIG1 ligase I, DNA, ATP-dependent -3.799
SLC2A4RG SLC2A4 regulator -3.79122
PROS1 protein S (alpha) -3.78884
TP73-AS1 TP73 antisense RNA 1 -3.78052
HMGN2 high mobility group nucleosomal binding domain 2 -3.77321
TTR transthyretin -3.75399
PEBP1 phosphatidylethanolamine binding protein 1 -3.75078
TAT tyrosine aminotransferase -3.7463
BRPF1 bromodomain and PHD finger containing, 1 -3.74358
ADGRA3 adhesion G protein-coupled receptor A3 -3.73289
GCHFR GTP cyclohydrolase I feedback regulator -3.72612
BRD1 bromodomain containing 1 -3.72092
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa -3.71733
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -3.71396
APOA1 apolipoprotein A-I -3.71099
DHCR24 24-dehydrocholesterol reductase -3.70561
TBC1D5 TBC1 domain family, member 5 -3.693
CPN2 carboxypeptidase N, polypeptide 2 -3.69007
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -3.68751
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -3.68606
WSB2 WD repeat and SOCS box containing 2 -3.68281
MTARC2 mitochondrial amidoxime reducing component 2 -3.66382
F9 coagulation factor IX -3.65492
KIF20A kinesin family member 20A -3.64059
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase -3.63576
APOB apolipoprotein B -3.63224
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 -3.62869
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -3.61492
DYNLL1 dynein, light chain, LC8-type 1 -3.59817
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28 -3.59674
LPAR3 lysophosphatidic acid receptor 3 -3.58639
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -3.58576
DENND5A DENN/MADD domain containing 5A -3.57691
CEBPD CCAAT/enhancer binding protein (C/EBP), delta -3.57002
AFM afamin -3.56789
RYR1 ryanodine receptor 1 (skeletal) -3.56262
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) -3.5565
AGXT alanine-glyoxylate aminotransferase -3.55414
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -3.54237
HMGA2 high mobility group AT-hook 2 -3.53724
JADE1 jade family PHD finger 1 -3.52608
PGAM1 phosphoglycerate mutase 1 (brain) -3.50839
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.50174
MAPK6 mitogen-activated protein kinase 6 -3.50093
TGFBR3 transforming growth factor, beta receptor III -3.48798
SYCP2 synaptonemal complex protein 2 -3.48569
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -3.48481
ZNF512B zinc finger protein 512B -3.48427
GTSE1 G-2 and S-phase expressed 1 -3.48402
MEPCE methylphosphate capping enzyme -3.47403
TTC31 tetratricopeptide repeat domain 31 -3.47377
KCTD15 potassium channel tetramerization domain containing 15 -3.47173
SIAH2 siah E3 ubiquitin protein ligase 2 -3.46755
JPT2 Jupiter microtubule associated homolog 2 -3.4655
UBA2 ubiquitin-like modifier activating enzyme 2 -3.4604
SUMO3 small ubiquitin-like modifier 3 -3.45611
SRSF7 serine/arginine-rich splicing factor 7 -3.45013
HMGB1 high mobility group box 1 -3.4495
ONECUT2 one cut homeobox 2 -3.44936
NUP210 nucleoporin 210kDa -3.44581
MRPS16 mitochondrial ribosomal protein S16 -3.44519
CFLAR CASP8 and FADD-like apoptosis regulator -3.43976
SGF29 SAGA complex associated factor 29 -3.43841
ZNF282 zinc finger protein 282 -3.43473
HPX hemopexin -3.42834
CA5A carbonic anhydrase VA, mitochondrial -3.42538
TIMELESS timeless circadian clock -3.42058
CHPT1 choline phosphotransferase 1 -3.4048
BRCA1 breast cancer 1, early onset -3.40376
THOC5 THO complex 5 -3.39972
SMG5 SMG5 nonsense mediated mRNA decay factor -3.39247
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) -3.39146
CCNT2 cyclin T2 -3.39142
ZNF134 zinc finger protein 134 -3.39079
EP400 E1A binding protein p400 -3.38772
SORBS3 sorbin and SH3 domain containing 3 -3.38531
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 -3.3843
GAMT guanidinoacetate N-methyltransferase -3.38268
STOM stomatin -3.37972
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -3.37646
ACTMAP actin maturation protease -3.37573
AKAP7 A kinase (PRKA) anchor protein 7 -3.37266
TOE1 target of EGR1, member 1 (nuclear) -3.36768
MASP2 mannan-binding lectin serine peptidase 2 -3.36456
DTX4 deltex 4, E3 ubiquitin ligase -3.3609
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -3.35449
PRC1 protein regulator of cytokinesis 1 -3.35246
STAG1 stromal antigen 1 -3.34787
CSN1S1 casein alpha s1 -3.34
CC2D2B coiled-coil and C2 domain containing 2B -3.33755
FA2H fatty acid 2-hydroxylase -3.33227
LPA lipoprotein, Lp(a) -3.32696
APOC2 apolipoprotein C-II -3.32688
HTT huntingtin -3.32673
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.32301
GYS2 glycogen synthase 2 (liver) -3.32002
HDAC6 histone deacetylase 6 -3.31855
PFN1 profilin 1 -3.30376
TP53 tumor protein p53 -3.30175
ATP5MC2 ATP synthase membrane subunit c locus 2 -3.29881
ACAT2 acetyl-CoA acetyltransferase 2 -3.29208
RNF10 ring finger protein 10 -3.2883
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 -3.28641
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 -3.28519
ZC3H13 zinc finger CCCH-type containing 13 -3.27979
FOXA2 forkhead box A2 -3.27599
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -3.2752
FMO5 flavin containing monooxygenase 5 -3.27313
TMPRSS6 transmembrane protease, serine 6 -3.26581
EXOSC8 exosome component 8 -3.26483
BAAT bile acid CoA:amino acid N-acyltransferase -3.26483
HHEX hematopoietically expressed homeobox -3.26414
SPP2 secreted phosphoprotein 2, 24kDa -3.2626
BLTP3B bridge-like lipid transfer protein family member 3B -3.26212
CDK3 cyclin-dependent kinase 3 -3.26108
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4 -3.25465
GON4L gon-4-like (C. elegans) -3.25149
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 -3.25113
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -3.24173
TATDN2 TatD DNase domain containing 2 -3.23898
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 -3.23812
DERA deoxyribose-phosphate aldolase (putative) -3.23676
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 -3.23554
TBL1X transducin (beta)-like 1X-linked -3.22945
FXYD1 FXYD domain containing ion transport regulator 1 -3.21984
PLG plasminogen -3.21967
UBP1 upstream binding protein 1 (LBP-1a) -3.2139
WTAP Wilms tumor 1 associated protein -3.20914
ELF1 E74-like factor 1 (ets domain transcription factor) -3.20623
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 -3.2
SLC44A1 solute carrier family 44 (choline transporter), member 1 -3.19832
TARBP2 TAR (HIV-1) RNA binding protein 2 -3.19416
NID1 nidogen 1 -3.1904
PPP1R8 protein phosphatase 1, regulatory subunit 8 -3.19037
MECP2 methyl CpG binding protein 2 -3.18994
GAL3ST1 galactose-3-O-sulfotransferase 1 -3.18945
ICAM3 intercellular adhesion molecule 3 -3.18236
CDT1 chromatin licensing and DNA replication factor 1 -3.17833
QPRT quinolinate phosphoribosyltransferase -3.17731
COBLL1 cordon-bleu WH2 repeat protein-like 1 -3.1769
DEDD death effector domain containing -3.17676
BMPR1A bone morphogenetic protein receptor, type IA -3.17598
SPHK2 sphingosine kinase 2 -3.17365
SLC43A1 solute carrier family 43 (amino acid system L transporter), member 1 -3.17302
RBMX RNA binding motif protein, X-linked -3.17229
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 -3.17098
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -3.16925
FANCC Fanconi anemia, complementation group C -3.16531
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -3.16199
CBS cystathionine-beta-synthase -3.16091
HARS2 histidyl-tRNA synthetase 2, mitochondrial -3.15854
CBX5 chromobox homolog 5 -3.14398
ECH1 enoyl CoA hydratase 1, peroxisomal -3.13915
IL12RB2 interleukin 12 receptor, beta 2 -3.13843
FANCI Fanconi anemia, complementation group I -3.13434
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 -3.13087
MAT1A methionine adenosyltransferase I, alpha -3.1298
H2AX H2A.X variant histone -3.12903
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -3.11599
MST1 macrophage stimulating 1 -3.11239
TNF tumor necrosis factor -3.11153
FBXO7 F-box protein 7 -3.10947
GYG2 glycogenin 2 -3.09115
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3 -3.09059
SET SET nuclear proto-oncogene -3.08892
MPST mercaptopyruvate sulfurtransferase -3.08774
NBN nibrin -3.08322
HGFAC HGF activator -3.06881
POLR2D polymerase (RNA) II (DNA directed) polypeptide D -3.06843
NF2 neurofibromin 2 (merlin) -3.06072
CTPS1 CTP synthase 1 -3.0606
ARPP19 cAMP-regulated phosphoprotein, 19kDa -3.05917
SETD5 SET domain containing 5 -3.05912
GNMT glycine N-methyltransferase -3.0543
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H -3.05004
MLXIPL MLX interacting protein-like -3.04624
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) -3.04595
FGL1 fibrinogen-like 1 -3.04035
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 -3.02793
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -3.02649
KNG1 kininogen 1 -3.01881
ZFP36L1 ZFP36 ring finger protein-like 1 -3.01713
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -3.01032
SLCO4C1 solute carrier organic anion transporter family, member 4C1 -3.0029