LJI308_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.155896
VIM vimentin 0.129694
MT2A metallothionein 2A 0.120841
AHNAK AHNAK nucleoprotein 0.105463
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.102876
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0819884
NDRG1 N-myc downstream regulated 1 0.0760644
TMSB10 thymosin beta 10 0.0715768
LDHA lactate dehydrogenase A 0.0661016
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0630408
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0626995
SQSTM1 sequestosome 1 0.0613179
AKAP12 A kinase (PRKA) anchor protein 12 0.0536207
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0495972
PTMA prothymosin, alpha 0.0478321
TRIO trio Rho guanine nucleotide exchange factor 0.0473049
RHOBTB3 Rho-related BTB domain containing 3 0.0443524
RPS3 ribosomal protein S3 0.0414581
NAV2 neuron navigator 2 0.0411484
FTL ferritin, light polypeptide 0.0401134
HDAC9 histone deacetylase 9 0.0397475
STC1 stanniocalcin 1 0.039291
FNDC3B fibronectin type III domain containing 3B 0.0379723
RPL37A ribosomal protein L37a 0.0374989
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0370899
NAP1L1 nucleosome assembly protein 1-like 1 0.0350291
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0349394
RPS8 ribosomal protein S8 0.0342512
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0340608
TPT1 tumor protein, translationally-controlled 1 0.0330255
EEF2 eukaryotic translation elongation factor 2 0.0324711
MYH9 myosin, heavy chain 9, non-muscle 0.0316908
B2M beta-2-microglobulin 0.031569
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0314705
LMNA lamin A/C 0.0314685
CALR calreticulin 0.0312173
CSTB cystatin B (stefin B) 0.0305754
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0304012
SPTBN1 spectrin, beta, non-erythrocytic 1 0.030286
ENO1 enolase 1, (alpha) 0.0298074
SOX9 SRY (sex determining region Y)-box 9 0.0293693
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0290085
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0289328
RPL12 ribosomal protein L12 0.0287511
RPLP2 ribosomal protein, large, P2 0.028728
PCBP2 poly(rC) binding protein 2 0.0286701
RPS6 ribosomal protein S6 0.0281619
UBC ubiquitin C 0.0280919
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0276841
S100A6 S100 calcium binding protein A6 0.0274643
S100A10 S100 calcium binding protein A10 0.027019
FLNA filamin A, alpha 0.0269157
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0268613
RACK1 receptor for activated C kinase 1 0.0266878
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.026361
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0260409
RPL23 ribosomal protein L23 0.0259224
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0258917
RPS12 ribosomal protein S12 0.0257478
RPL26 ribosomal protein L26 0.0254673
TPM4 tropomyosin 4 0.0252625
ACTG1 actin gamma 1 0.0249498
PRRC2C proline-rich coiled-coil 2C 0.0244971
FLNB filamin B, beta 0.0241056
IFITM3 interferon induced transmembrane protein 3 0.0239317
EIF1 eukaryotic translation initiation factor 1 0.0239256
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0237379
MBNL2 muscleblind-like splicing regulator 2 0.0236737
FAM107B family with sequence similarity 107, member B 0.0236451
RND3 Rho family GTPase 3 0.0235336
RPL36 ribosomal protein L36 0.0233729
FOSL1 FOS-like antigen 1 0.023355
SFTPA2 surfactant protein A2 0.0233516
RPL28 ribosomal protein L28 0.022855
RPL35A ribosomal protein L35a 0.0223465
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0220741
RPS27A ribosomal protein S27a 0.0218163
PKM pyruvate kinase, muscle 0.0218152
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0214054
APP amyloid beta (A4) precursor protein 0.0213295
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0212805
RPL31 ribosomal protein L31 0.0212383
OGA O-GlcNAcase 0.0212138
RPLP1 ribosomal protein, large, P1 0.0211949
TPM3 tropomyosin 3 0.0209722
RPS19 ribosomal protein S19 0.020892
DSCAM Down syndrome cell adhesion molecule 0.0208867
NIBAN2 niban apoptosis regulator 2 0.0207937
ZFP36L1 ZFP36 ring finger protein-like 1 0.0207387
SEPTIN9 septin 9 0.0202025
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0201842
BHLHE40 basic helix-loop-helix family, member e40 0.0201133
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0200735
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0196857
HLA-E major histocompatibility complex, class I, E 0.019651
GOLGA4 golgin A4 0.0193044
RPS13 ribosomal protein S13 0.0192808
EIF4A1 eukaryotic translation initiation factor 4A1 0.0192094
ATP13A3 ATPase type 13A3 0.0189981
RPL19 ribosomal protein L19 0.0189757

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.237199
FN1 fibronectin 1 -0.136984
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.136622
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.107181
ABI3BP ABI family, member 3 (NESH) binding protein -0.0902087
COL5A1 collagen, type V, alpha 1 -0.0779564
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0752248
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0744488
COL8A1 collagen, type VIII, alpha 1 -0.0721859
LOX lysyl oxidase -0.0688421
MAP1B microtubule-associated protein 1B -0.0581208
SAMD9 sterile alpha motif domain containing 9 -0.0580626
PODXL podocalyxin-like -0.0570335
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0493215
SUCNR1 succinate receptor 1 -0.0484716
PRSS23 protease, serine, 23 -0.0455277
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0429969
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0427695
NAV1 neuron navigator 1 -0.0423443
CDH13 cadherin 13 -0.0398654
DCLK2 doublecortin-like kinase 2 -0.039577
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0389446
RIGI RNA sensor RIG-I -0.0342401
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0337854
THBS2 thrombospondin 2 -0.0312857
SORBS2 sorbin and SH3 domain containing 2 -0.0300851
COL5A2 collagen, type V, alpha 2 -0.0275438
OASL 2'-5'-oligoadenylate synthetase-like -0.0270349
FLT1 fms-related tyrosine kinase 1 -0.0265503
PLXNA2 plexin A2 -0.0261355
PLAT plasminogen activator, tissue -0.0257801
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0255705
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0250822
IL7R interleukin 7 receptor -0.0245258
SLC38A1 solute carrier family 38, member 1 -0.0238437
MEIS2 Meis homeobox 2 -0.0228106
VEGFC vascular endothelial growth factor C -0.0221828
CYTH3 cytohesin 3 -0.022104
MX2 MX dynamin-like GTPase 2 -0.0219773
PDE4D phosphodiesterase 4D, cAMP-specific -0.0219077
JAZF1 JAZF zinc finger 1 -0.0215803
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0209649
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.020939
WARS1 tryptophanyl-tRNA synthetase 1 -0.0209148
PCDH7 protocadherin 7 -0.0208205
FNDC3A fibronectin type III domain containing 3A -0.0204645
SRPK2 SRSF protein kinase 2 -0.0203615
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -0.0198809
TNS3 tensin 3 -0.0197286
COL1A2 collagen, type I, alpha 2 -0.0192442
CUX1 cut-like homeobox 1 -0.0192131
COL1A1 collagen, type I, alpha 1 -0.0190525
SLC39A11 solute carrier family 39, member 11 -0.0183437
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0182565
LRRC17 leucine rich repeat containing 17 -0.0182111
ZNF217 zinc finger protein 217 -0.0178248
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0173328
MED13L mediator complex subunit 13-like -0.0169472
DGKG diacylglycerol kinase, gamma 90kDa -0.0168329
KRT81 keratin 81, type II -0.0166604
FGF13 fibroblast growth factor 13 -0.0163556
FMN2 formin 2 -0.0162486
GLIS3 GLIS family zinc finger 3 -0.0161831
ZBTB20 zinc finger and BTB domain containing 20 -0.0160359
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -0.0151986
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0151137
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0149722
LY6E lymphocyte antigen 6 complex, locus E -0.0144789
SPAG9 sperm associated antigen 9 -0.0144291
COL4A2 collagen, type IV, alpha 2 -0.0143749
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0142976
SH3KBP1 SH3-domain kinase binding protein 1 -0.013946
RAI14 retinoic acid induced 14 -0.0139222
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0137289
TENT5A terminal nucleotidyltransferase 5A -0.0135668
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.013196
CEP112 centrosomal protein 112kDa -0.0130684
IGFBP6 insulin-like growth factor binding protein 6 -0.012904
TRABD2B TraB domain containing 2B -0.0128752
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0127239
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0126458
LAMB1 laminin, beta 1 -0.0125413
AOPEP aminopeptidase O (putative) -0.0125099
NPR2 natriuretic peptide receptor 2 -0.0123368
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0123347
MRPS6 mitochondrial ribosomal protein S6 -0.0123132
RAD51B RAD51 paralog B -0.0120901
CKAP4 cytoskeleton-associated protein 4 -0.0120291
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0118664
TUBB tubulin, beta class I -0.0118414
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0118241
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0116434
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0116295
PARD3 par-3 family cell polarity regulator -0.0115874
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0115576
PDIA3 protein disulfide isomerase family A, member 3 -0.0113888
PLCB4 phospholipase C, beta 4 -0.0113866
TPM1 tropomyosin 1 (alpha) -0.0113637
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.011149
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.011146