LJI308_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.339079
TMSB10 thymosin beta 10 0.152532
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.133794
FTL ferritin, light polypeptide 0.1134
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.109888
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.109414
RPS12 ribosomal protein S12 0.103166
RPS8 ribosomal protein S8 0.0894332
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0862697
RPS3 ribosomal protein S3 0.0861815
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0837859
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.078502
RPL23 ribosomal protein L23 0.0754674
AREG amphiregulin 0.0735421
NAP1L1 nucleosome assembly protein 1-like 1 0.0688424
RPL37A ribosomal protein L37a 0.0663558
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0658256
RPS27A ribosomal protein S27a 0.0632276
TPT1 tumor protein, translationally-controlled 1 0.0623299
RPL26 ribosomal protein L26 0.0606861
EIF1 eukaryotic translation initiation factor 1 0.0601879
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0596135
RPS6 ribosomal protein S6 0.0593292
RACK1 receptor for activated C kinase 1 0.0588798
RPL12 ribosomal protein L12 0.0573927
RPL35A ribosomal protein L35a 0.0564941
RPL19 ribosomal protein L19 0.0558746
PTMA prothymosin, alpha 0.055731
RPS19 ribosomal protein S19 0.055629
CNRIP1 cannabinoid receptor interacting protein 1 0.0530967
RPLP2 ribosomal protein, large, P2 0.0525109
RPLP1 ribosomal protein, large, P1 0.0511611
AHNAK AHNAK nucleoprotein 0.0479235
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0458783
RPL11 ribosomal protein L11 0.0455458
TPI1 triosephosphate isomerase 1 0.0454888
RPL9 ribosomal protein L9 0.0453478
RPS13 ribosomal protein S13 0.0446542
RPL37 ribosomal protein L37 0.0441848
RPL5 ribosomal protein L5 0.0438563
RPLP0 ribosomal protein, large, P0 0.0438438
ACTG1 actin gamma 1 0.0437109
CALR calreticulin 0.0432337
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0416952
MYL12B myosin, light chain 12B, regulatory 0.0412377
LDHA lactate dehydrogenase A 0.0410737
RPL27 ribosomal protein L27 0.0410015
PCBP2 poly(rC) binding protein 2 0.0403363
YBX1 Y box binding protein 1 0.0400096
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0397472
RPL31 ribosomal protein L31 0.0390632
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0384208
RPL4 ribosomal protein L4 0.0382925
RPL36 ribosomal protein L36 0.0377042
NACA nascent polypeptide-associated complex alpha subunit 0.0367754
RPS27 ribosomal protein S27 0.036663
RPL7 ribosomal protein L7 0.0364719
ENO1 enolase 1, (alpha) 0.035595
RPS16 ribosomal protein S16 0.0336823
RPL13A ribosomal protein L13a 0.033637
EIF4A2 eukaryotic translation initiation factor 4A2 0.0335766
EEF2 eukaryotic translation elongation factor 2 0.0318696
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0318172
RPL34 ribosomal protein L34 0.0309471
RPS4X ribosomal protein S4, X-linked 0.0307764
RPS29 ribosomal protein S29 0.0306217
RPS23 ribosomal protein S23 0.0283031
KDM3A lysine (K)-specific demethylase 3A 0.0278218
KTN1 kinectin 1 (kinesin receptor) 0.0277353
SQSTM1 sequestosome 1 0.0275269
RPS17 ribosomal protein S17 0.0270946
RPS20 ribosomal protein S20 0.0267308
YBX3 Y box binding protein 3 0.0265136
EEF1G eukaryotic translation elongation factor 1 gamma 0.0262898
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.02627
RPS14 ribosomal protein S14 0.0261163
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0254996
RPL36A ribosomal protein L36a 0.0253301
SET SET nuclear proto-oncogene 0.025041
RPS24 ribosomal protein S24 0.0248847
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0247106
PDE4D phosphodiesterase 4D, cAMP-specific 0.0245317
CANX calnexin 0.024364
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0242583
RPL38 ribosomal protein L38 0.023743
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.023261
RPS2 ribosomal protein S2 0.0231941
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0230556
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0228581
ATP5F1E ATP synthase F1 subunit epsilon 0.0228029
TPR translocated promoter region, nuclear basket protein 0.0227888
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0227729
RPS5 ribosomal protein S5 0.0227046
WWOX WW domain containing oxidoreductase 0.0226931
RPL7A ribosomal protein L7a 0.0221948
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0221227
LOC112694756 uncharaterized LOC112694756 0.0219744
S100A6 S100 calcium binding protein A6 0.0219464
RPL15 ribosomal protein L15 0.0218569
PRDX1 peroxiredoxin 1 0.0218285

decreased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 -0.115436
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.104516
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0818815
RASAL2 RAS protein activator like 2 -0.068631
PCDH7 protocadherin 7 -0.063768
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0605425
EHBP1 EH domain binding protein 1 -0.0560972
DPYD dihydropyrimidine dehydrogenase -0.0560175
NHSL1 NHS-like 1 -0.0523483
DST dystonin -0.0520193
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0468083
MMP12 matrix metallopeptidase 12 -0.0467321
ZNF804A zinc finger protein 804A -0.0457326
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0427311
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0417302
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0402212
CARD16 caspase recruitment domain family, member 16 -0.036184
SYT1 synaptotagmin I -0.0330577
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0322059
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0313174
NF1 neurofibromin 1 -0.0303557
DLC1 DLC1 Rho GTPase activating protein -0.0299705
BIRC6 baculoviral IAP repeat containing 6 -0.0299254
ANKRD28 ankyrin repeat domain 28 -0.0296714
CCN2 cellular communication network factor 2 -0.0293697
NAV3 neuron navigator 3 -0.0291792
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0290815
CMIP c-Maf inducing protein -0.0284419
DTNA dystrobrevin, alpha -0.0283757
CELF2 CUGBP, Elav-like family member 2 -0.0268075
MKI67 marker of proliferation Ki-67 -0.0268061
SBF2 SET binding factor 2 -0.0254129
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0250136
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.0245312
MARCHF4 membrane associated ring-CH-type finger 4 -0.0241519
CLDN1 claudin 1 -0.0239298
EGFR epidermal growth factor receptor -0.0220854
EGR1 early growth response 1 -0.0218922
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0216107
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0207852
SLC38A2 solute carrier family 38, member 2 -0.0206237
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0203313
P3H2 prolyl 3-hydroxylase 2 -0.0202593
TMEM123 transmembrane protein 123 -0.0202527
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.020158
ADGRG6 adhesion G protein-coupled receptor G6 -0.0200573
CSMD3 CUB and Sushi multiple domains 3 -0.0199549
ANKRD12 ankyrin repeat domain 12 -0.0191704
CUX1 cut-like homeobox 1 -0.0189613
PRR16 proline rich 16 -0.0189267
TSPAN5 tetraspanin 5 -0.0188533
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0186911
ANKRD17 ankyrin repeat domain 17 -0.0182889
EXOC4 exocyst complex component 4 -0.0182474
MACF1 microtubule-actin crosslinking factor 1 -0.0182046
FCHSD2 FCH and double SH3 domains 2 -0.0181363
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0181206
NABP1 nucleic acid binding protein 1 -0.0174419
JMJD1C jumonji domain containing 1C -0.0171273
USP34 ubiquitin specific peptidase 34 -0.0170168
ERBIN erbb2 interacting protein -0.0169208
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0168897
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0166219
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0166041
TRIO trio Rho guanine nucleotide exchange factor -0.0165091
TAS2R14 taste receptor, type 2, member 14 -0.0164944
NEBL nebulette -0.0163798
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1 -0.0162812
MSRB3 methionine sulfoxide reductase B3 -0.0161118
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0159664
SRBD1 S1 RNA binding domain 1 -0.0159028
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0158577
ECT2 epithelial cell transforming 2 -0.0158545
THSD4 thrombospondin, type I, domain containing 4 -0.0158307
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.0157153
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0156283
MED12L mediator complex subunit 12-like -0.0150753
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0150722
MTCL1 microtubule crosslinking factor 1 -0.0149785
RABGAP1L RAB GTPase activating protein 1-like -0.0149106
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0148708
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0147302
DIAPH2 diaphanous-related formin 2 -0.0146629
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0146561
ELP4 elongator acetyltransferase complex subunit 4 -0.014639
ZNF407 zinc finger protein 407 -0.0145696
KSR2 kinase suppressor of ras 2 -0.0145003
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0144846
SRPK2 SRSF protein kinase 2 -0.0142148
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.013814
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0137636
KIF18B kinesin family member 18B -0.0137199
FSTL5 follistatin-like 5 -0.0135201
FER fer (fps/fes related) tyrosine kinase -0.0132734
SPIDR scaffolding protein involved in DNA repair -0.0132257
L3MBTL4 l(3)mbt-like 4 (Drosophila) -0.0131461
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0131312
EML4 echinoderm microtubule associated protein like 4 -0.0131055
TM4SF1 transmembrane 4 L six family member 1 -0.0130238
TGM2 transglutaminase 2 -0.0129662