LJI308_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the LJI308_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.104498
RPL23 ribosomal protein L23 0.0938597
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0787254
ZSWIM6 zinc finger, SWIM-type containing 6 0.0735749
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0703344
TLE4 transducin-like enhancer of split 4 0.0701179
RPS3 ribosomal protein S3 0.0666983
RPL37A ribosomal protein L37a 0.0665583
AHNAK AHNAK nucleoprotein 0.0663683
VCL vinculin 0.0609049
EIF1 eukaryotic translation initiation factor 1 0.0599864
ACTG1 actin gamma 1 0.0577947
NPAS2 neuronal PAS domain protein 2 0.0574244
RPS6 ribosomal protein S6 0.0555679
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.055295
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0552079
RPL4 ribosomal protein L4 0.0535083
TPT1 tumor protein, translationally-controlled 1 0.0528205
DST dystonin 0.0527772
LPIN1 lipin 1 0.05165
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0481526
B2M beta-2-microglobulin 0.0471651
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0470812
RPL26 ribosomal protein L26 0.0464936
PDE4D phosphodiesterase 4D, cAMP-specific 0.0453496
MACF1 microtubule-actin crosslinking factor 1 0.0448451
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0430181
RPS12 ribosomal protein S12 0.0425005
VMP1 vacuole membrane protein 1 0.0422248
PKM pyruvate kinase, muscle 0.0411556
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0387896
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0387842
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0386266
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0382457
AKAP12 A kinase (PRKA) anchor protein 12 0.0380453
AKAP13 A kinase (PRKA) anchor protein 13 0.0369918
PCBP2 poly(rC) binding protein 2 0.0367542
FTL ferritin, light polypeptide 0.0366739
RPL35A ribosomal protein L35a 0.035916
RNF213 ring finger protein 213 0.0358907
TPM4 tropomyosin 4 0.0354567
EXT1 exostosin glycosyltransferase 1 0.0350873
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0337896
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0337115
BBX bobby sox homolog (Drosophila) 0.0335839
RPS27A ribosomal protein S27a 0.0328015
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.031918
NAP1L1 nucleosome assembly protein 1-like 1 0.0312548
CTNND1 catenin (cadherin-associated protein), delta 1 0.0308988
SRRM2 serine/arginine repetitive matrix 2 0.0304949
RPL35 ribosomal protein L35 0.0302417
RACK1 receptor for activated C kinase 1 0.0301379
EEF2 eukaryotic translation elongation factor 2 0.0301071
RPS8 ribosomal protein S8 0.0298763
TMSB10 thymosin beta 10 0.0297463
RPS27 ribosomal protein S27 0.029703
PTPRK protein tyrosine phosphatase, receptor type, K 0.0296725
CENPF centromere protein F, 350/400kDa 0.0291994
RPL7 ribosomal protein L7 0.0291284
MYO1E myosin IE 0.0291066
DSCAM Down syndrome cell adhesion molecule 0.0290248
H3-3B H3.3 histone B 0.0290212
RPLP1 ribosomal protein, large, P1 0.0289903
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0286463
LMNA lamin A/C 0.0282178
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0280812
RPL13A ribosomal protein L13a 0.0278359
ENO1 enolase 1, (alpha) 0.0273197
PGK1 phosphoglycerate kinase 1 0.0268853
S100A10 S100 calcium binding protein A10 0.0267069
RPL31 ribosomal protein L31 0.026236
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0257895
FAM107B family with sequence similarity 107, member B 0.0251077
SEPTIN7 septin 7 0.0249727
LDHA lactate dehydrogenase A 0.0248085
RPS29 ribosomal protein S29 0.0244654
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0241727
RPS19 ribosomal protein S19 0.0241076
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0239182
KDM3A lysine (K)-specific demethylase 3A 0.0238686
LPP LIM domain containing preferred translocation partner in lipoma 0.0237687
PCM1 pericentriolar material 1 0.0235777
TRIB2 tribbles pseudokinase 2 0.0235136
RPS17 ribosomal protein S17 0.023444
RPL38 ribosomal protein L38 0.0233613
RPL37 ribosomal protein L37 0.023325
MYH9 myosin, heavy chain 9, non-muscle 0.0232775
RCOR1 REST corepressor 1 0.0232074
RPS16 ribosomal protein S16 0.0230499
APP amyloid beta (A4) precursor protein 0.0228581
MED13 mediator complex subunit 13 0.0227568
TPR translocated promoter region, nuclear basket protein 0.022722
KDM4C lysine (K)-specific demethylase 4C 0.0227189
KPNB1 karyopherin (importin) beta 1 0.022561
ITCH itchy E3 ubiquitin protein ligase 0.0225374
ANXA2 annexin A2 0.0224809
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0224554
RPL27 ribosomal protein L27 0.0221473
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0218187
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0217682

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.252638
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0409791
PTPRD protein tyrosine phosphatase, receptor type, D -0.035364
LSAMP limbic system-associated membrane protein -0.0318208
PLAT plasminogen activator, tissue -0.0315703
MEIS2 Meis homeobox 2 -0.0282328
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0279312
RPTOR regulatory associated protein of MTOR, complex 1 -0.0278733
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0271448
ANGPT1 angiopoietin 1 -0.0269079
CADM2 cell adhesion molecule 2 -0.026545
NALF1 NALCN channel auxiliary factor 1 -0.025158
DNAH14 dynein, axonemal, heavy chain 14 -0.0223472
PLCB4 phospholipase C, beta 4 -0.0219557
CEMIP cell migration inducing protein, hyaluronan binding -0.0219046
NRP1 neuropilin 1 -0.0217008
ZBTB20 zinc finger and BTB domain containing 20 -0.0212877
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0205242
NREP neuronal regeneration related protein -0.0204361
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0202628
SETD5 SET domain containing 5 -0.0200997
IGFBP5 insulin-like growth factor binding protein 5 -0.0200055
TNRC6B trinucleotide repeat containing 6B -0.0197481
ATRNL1 attractin-like 1 -0.0196569
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0196178
TET2 tet methylcytosine dioxygenase 2 -0.0196037
IGFBP3 insulin-like growth factor binding protein 3 -0.0194881
DACH2 dachshund family transcription factor 2 -0.0194516
VCAN versican -0.0191418
GPC5 glypican 5 -0.0187137
COL4A5 collagen, type IV, alpha 5 -0.0186874
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0185873
AFF3 AF4/FMR2 family, member 3 -0.0181288
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0179388
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0178071
BICD1 bicaudal D homolog 1 (Drosophila) -0.0177178
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0173643
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0171728
RGS5 regulator of G-protein signaling 5 -0.0168735
MAPK10 mitogen-activated protein kinase 10 -0.0167534
TASOR2 transcription activation suppressor family member 2 -0.0167319
KIF26B kinesin family member 26B -0.0166508
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 -0.0166271
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.016557
RNF145 ring finger protein 145 -0.0163495
ANKRD17 ankyrin repeat domain 17 -0.0163199
RSF1 remodeling and spacing factor 1 -0.0162169
NCAM2 neural cell adhesion molecule 2 -0.0154107
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0153929
VEGFA vascular endothelial growth factor A -0.0151884
KLHL5 kelch-like family member 5 -0.0151513
IGFBP4 insulin-like growth factor binding protein 4 -0.0151484
PTEN phosphatase and tensin homolog -0.0150848
BCLAF1 BCL2-associated transcription factor 1 -0.0149009
GREM2 gremlin 2, DAN family BMP antagonist -0.0146672
PROC protein C (inactivator of coagulation factors Va and VIIIa) -0.014642
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -0.0146233
STC1 stanniocalcin 1 -0.014611
ACLY ATP citrate lyase -0.0145617
NCOR2 nuclear receptor corepressor 2 -0.014477
MLEC malectin -0.0144405
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D -0.0144105
DGKH diacylglycerol kinase, eta -0.0143527
MTUS1 microtubule associated tumor suppressor 1 -0.0143295
RAP1B RAP1B, member of RAS oncogene family -0.0142815
PDIA3 protein disulfide isomerase family A, member 3 -0.0142733
TAPBP TAP binding protein (tapasin) -0.0138707
CNTN4 contactin 4 -0.0138314
RPRD2 regulation of nuclear pre-mRNA domain containing 2 -0.013778
FBXL20 F-box and leucine-rich repeat protein 20 -0.013679
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -0.013658
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0136325
PRRC2B proline-rich coiled-coil 2B -0.0135148
C1ORF21 chromosome 1 open reading frame 21 -0.0134872
HAND2 heart and neural crest derivatives expressed 2 -0.0134829
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0134757
CDH13 cadherin 13 -0.0132306
TBC1D16 TBC1 domain family, member 16 -0.0131779
RCOR3 REST corepressor 3 -0.0130792
RGS4 regulator of G-protein signaling 4 -0.0130457
SOCS5 suppressor of cytokine signaling 5 -0.0130001
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0129286
PIAS1 protein inhibitor of activated STAT, 1 -0.0129191
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -0.0128642
PRRX1 paired related homeobox 1 -0.0128387
ZNF451 zinc finger protein 451 -0.0127906
MIMS1 mitochondrial inner membrane scaffold 1 -0.0127768
INSIG2 insulin induced gene 2 -0.0127554
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0126206
ZFC3H1 zinc finger, C3H1-type containing -0.0125968
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.0125494
CORIN corin, serine peptidase -0.0125399
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0124867
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0124475
CUX2 cut-like homeobox 2 -0.0124427
CCND1 cyclin D1 -0.0124289
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0124196
HBS1L HBS1-like translational GTPase -0.0123898
LOC102724023 ES1 protein homolog, mitochondrial -0.0123058
FRMD6 FERM domain containing 6 -0.012212