LJI308_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.185873
B2M beta-2-microglobulin 0.180153
TPT1 tumor protein, translationally-controlled 1 0.153823
GCLC glutamate-cysteine ligase, catalytic subunit 0.136159
LCN2 lipocalin 2 0.125109
HLA-B major histocompatibility complex, class I, B 0.115626
FTL ferritin, light polypeptide 0.107638
EPSTI1 epithelial stromal interaction 1 (breast) 0.105696
EXT1 exostosin glycosyltransferase 1 0.102102
IFI6 interferon, alpha-inducible protein 6 0.100947
ANXA2 annexin A2 0.0939361
INTS6 integrator complex subunit 6 0.092025
MT2A metallothionein 2A 0.0917807
RNF213 ring finger protein 213 0.0885291
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0881065
SQSTM1 sequestosome 1 0.0840073
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0838332
AREG amphiregulin 0.0807752
SMAD3 SMAD family member 3 0.0745336
ZSWIM6 zinc finger, SWIM-type containing 6 0.0744319
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0721942
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0684584
SP100 SP100 nuclear antigen 0.0680033
TMC5 transmembrane channel-like 5 0.0635613
C6ORF132 chromosome 6 open reading frame 132 0.0625314
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0615295
TJP1 tight junction protein 1 0.0610551
RAB7A RAB7A, member RAS oncogene family 0.0608101
BAIAP2L1 BAI1-associated protein 2-like 1 0.0604089
MAP7 microtubule-associated protein 7 0.0602582
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0601173
HLA-E major histocompatibility complex, class I, E 0.0597546
RPL7L1 ribosomal protein L7-like 1 0.0595559
KLF5 Kruppel-like factor 5 (intestinal) 0.0580148
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0573985
FNDC3B fibronectin type III domain containing 3B 0.0569466
PERP PERP, TP53 apoptosis effector 0.0567043
MYO1E myosin IE 0.055852
S100P S100 calcium binding protein P 0.0555074
ACTG1 actin gamma 1 0.0544982
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.054377
AKAP13 A kinase (PRKA) anchor protein 13 0.0539882
RIGI RNA sensor RIG-I 0.0536671
EFNB2 ephrin-B2 0.0527068
SLC38A1 solute carrier family 38, member 1 0.0520164
XAF1 XIAP associated factor 1 0.0514671
PGK1 phosphoglycerate kinase 1 0.0512229
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.050435
VCL vinculin 0.0501652
ERBIN erbb2 interacting protein 0.0488979
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0486971
PTMA prothymosin, alpha 0.0483782
MUC20 mucin 20, cell surface associated 0.0472543
SDC4 syndecan 4 0.0470017
KRT19 keratin 19, type I 0.0469186
HLA-A major histocompatibility complex, class I, A 0.0461881
FTH1 ferritin, heavy polypeptide 1 0.0456111
MACC1 metastasis associated in colon cancer 1 0.0439154
ANKRD10 ankyrin repeat domain 10 0.0439151
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0432861
LDHA lactate dehydrogenase A 0.0432107
MCTP1 multiple C2 domains, transmembrane 1 0.0426589
CSTB cystatin B (stefin B) 0.0425572
RPL35A ribosomal protein L35a 0.0424486
APOL1 apolipoprotein L, 1 0.0421744
TMSB10 thymosin beta 10 0.0416449
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0414691
LIMA1 LIM domain and actin binding 1 0.0406123
ASPH aspartate beta-hydroxylase 0.0405593
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0400565
DST dystonin 0.0399357
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0398013
HKDC1 hexokinase domain containing 1 0.0392968
HLA-C major histocompatibility complex, class I, C 0.0380645
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0379242
STS steroid sulfatase (microsomal), isozyme S 0.0377621
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0377549
MX2 MX dynamin-like GTPase 2 0.0375595
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0369749
IFITM3 interferon induced transmembrane protein 3 0.0365522
PLSCR1 phospholipid scramblase 1 0.036479
LAMA4 laminin, alpha 4 0.0362047
EIF1 eukaryotic translation initiation factor 1 0.0361692
BCL2L1 BCL2-like 1 0.0343674
RPL37A ribosomal protein L37a 0.0332465
LPP LIM domain containing preferred translocation partner in lipoma 0.0330126
KYNU kynureninase 0.0329819
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0329637
H3-3B H3.3 histone B 0.0327227
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0325882
WSB1 WD repeat and SOCS box containing 1 0.0320736
TM4SF19 transmembrane 4 L six family member 19 0.0320544
RPS12 ribosomal protein S12 0.0319906
GMDS GDP-mannose 4,6-dehydratase 0.0319746
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0316608
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0314629
NCEH1 neutral cholesterol ester hydrolase 1 0.0314027
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0312431
RPS24 ribosomal protein S24 0.031173
CATSPERB catsper channel auxiliary subunit beta 0.0308919

decreased expression

Symbol Name Standardized Value
UBC ubiquitin C -0.0750376
RNF43 ring finger protein 43 -0.0518141
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0460571
TXNIP thioredoxin interacting protein -0.0450471
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0404783
PDIA3 protein disulfide isomerase family A, member 3 -0.040267
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0373274
NRIP1 nuclear receptor interacting protein 1 -0.0356531
COG6 component of oligomeric golgi complex 6 -0.0349555
BTBD9 BTB (POZ) domain containing 9 -0.0339198
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0328584
PTEN phosphatase and tensin homolog -0.0326422
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0318072
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0312883
PTBP3 polypyrimidine tract binding protein 3 -0.0307613
BCLAF1 BCL2-associated transcription factor 1 -0.0295649
NCKAP5 NCK-associated protein 5 -0.0291365
PDIA4 protein disulfide isomerase family A, member 4 -0.0285227
DIAPH3 diaphanous-related formin 3 -0.0258508
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0258342
UBAC2 UBA domain containing 2 -0.0258233
EHF ets homologous factor -0.0247012
HBS1L HBS1-like translational GTPase -0.0229919
CD46 CD46 molecule, complement regulatory protein -0.0225849
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0216673
PRELID2 PRELI domain containing 2 -0.0214938
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked -0.0209357
ETNK1 ethanolamine kinase 1 -0.0205529
MCTP2 multiple C2 domains, transmembrane 2 -0.0200395
ZNRF3 zinc and ring finger 3 -0.020028
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0197674
ESRP1 epithelial splicing regulatory protein 1 -0.0190489
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0190178
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0189012
RBM33 RNA binding motif protein 33 -0.0188768
METTL15 methyltransferase like 15 -0.0188387
ARRDC3 arrestin domain containing 3 -0.0188116
TFG TRK-fused gene -0.0188092
WDR26 WD repeat domain 26 -0.0184551
MEIS2 Meis homeobox 2 -0.0183574
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.018176
ZNF638 zinc finger protein 638 -0.01816
HELZ helicase with zinc finger -0.0175445
STRN3 striatin, calmodulin binding protein 3 -0.0174083
ZC3H11A zinc finger CCCH-type containing 11A -0.0171744
TNRC6A trinucleotide repeat containing 6A -0.017016
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0166772
SPG11 spastic paraplegia 11 (autosomal recessive) -0.0166008
TMEM39A transmembrane protein 39A -0.0162784
ZFC3H1 zinc finger, C3H1-type containing -0.0162401
GLCE glucuronic acid epimerase -0.0159447
USP3 ubiquitin specific peptidase 3 -0.01581
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0156052
CRLS1 cardiolipin synthase 1 -0.0155729
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0155168
MBNL2 muscleblind-like splicing regulator 2 -0.0154579
CCNL1 cyclin L1 -0.015398
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0152979
TMEM161B transmembrane protein 161B -0.0152741
SPPL3 signal peptide peptidase like 3 -0.0152651
EIF2A eukaryotic translation initiation factor 2A, 65kDa -0.0152141
SORBS1 sorbin and SH3 domain containing 1 -0.0152001
ZNF207 zinc finger protein 207 -0.0151881
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0151844
SREBF2 sterol regulatory element binding transcription factor 2 -0.0146658
PRPF8 pre-mRNA processing factor 8 -0.0146437
IFNGR1 interferon gamma receptor 1 -0.0145797
GRK3 G protein-coupled receptor kinase 3 -0.0144722
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0144395
CDK5RAP2 CDK5 regulatory subunit associated protein 2 -0.0143618
PRRC1 proline-rich coiled-coil 1 -0.0143053
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0141559
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0140292
OARD1 O-acyl-ADP-ribose deacylase 1 -0.0140045
BLTP1 bridge-like lipid transfer protein family member 1 -0.013963
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -0.0138652
RREB1 ras responsive element binding protein 1 -0.0138242
TTC3 tetratricopeptide repeat domain 3 -0.0137732
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0137603
BIRC6 baculoviral IAP repeat containing 6 -0.0136865
GALK2 galactokinase 2 -0.0135894
CALU calumenin -0.0135122
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0134881
TOB1 transducer of ERBB2, 1 -0.0134469
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0133672
SRRM1 serine/arginine repetitive matrix 1 -0.0133538
TMEM62 transmembrane protein 62 -0.0132555
ZNF652 zinc finger protein 652 -0.0132371
IL20RA interleukin 20 receptor, alpha -0.0131933
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0130032
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0128967
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -0.0128273
PDE8A phosphodiesterase 8A -0.0127401
SMC4 structural maintenance of chromosomes 4 -0.0126829
ATAD2 ATPase family, AAA domain containing 2 -0.0126723
NAMPT nicotinamide phosphoribosyltransferase -0.012658
TNIK TRAF2 and NCK interacting kinase -0.0126447
CCNK cyclin K -0.0126139
COG3 component of oligomeric golgi complex 3 -0.0125745
SUCO SUN domain containing ossification factor -0.0125176