| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LJI308 perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the LJI308_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.169361 |
| VIM | vimentin | 0.130268 |
| FN1 | fibronectin 1 | 0.129635 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.128608 |
| LDHA | lactate dehydrogenase A | 0.128116 |
| ENO1 | enolase 1, (alpha) | 0.117684 |
| FNDC3B | fibronectin type III domain containing 3B | 0.10578 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.10323 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.098674 |
| AHNAK | AHNAK nucleoprotein | 0.0899064 |
| MT2A | metallothionein 2A | 0.0832964 |
| CADM1 | cell adhesion molecule 1 | 0.0808525 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0774659 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0720627 |
| RPS8 | ribosomal protein S8 | 0.0660597 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0642383 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0621425 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0573257 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0557937 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0553287 |
| CALR | calreticulin | 0.054664 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0542633 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0537104 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0506721 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | 0.050146 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0497006 |
| CALU | calumenin | 0.0482232 |
| COL5A1 | collagen, type V, alpha 1 | 0.0478924 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0443542 |
| RPL7 | ribosomal protein L7 | 0.0441362 |
| ACTG1 | actin gamma 1 | 0.0423403 |
| SQSTM1 | sequestosome 1 | 0.0421157 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0406579 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0405569 |
| GOLGB1 | golgin B1 | 0.0404158 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0404106 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0401126 |
| RPL23 | ribosomal protein L23 | 0.0398284 |
| B2M | beta-2-microglobulin | 0.0395872 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0395454 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0390489 |
| APP | amyloid beta (A4) precursor protein | 0.0386491 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0364749 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0357357 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0353995 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0353089 |
| EGFR | epidermal growth factor receptor | 0.0344046 |
| RACK1 | receptor for activated C kinase 1 | 0.034161 |
| RPL12 | ribosomal protein L12 | 0.0338982 |
| RPL11 | ribosomal protein L11 | 0.0332201 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0330449 |
| HLA-E | major histocompatibility complex, class I, E | 0.0327089 |
| YBX1 | Y box binding protein 1 | 0.0326216 |
| PGK1 | phosphoglycerate kinase 1 | 0.0323449 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0320419 |
| FTL | ferritin, light polypeptide | 0.0318617 |
| RPL5 | ribosomal protein L5 | 0.031805 |
| SP100 | SP100 nuclear antigen | 0.0314428 |
| COL3A1 | collagen, type III, alpha 1 | 0.0314383 |
| RUNX1 | runt-related transcription factor 1 | 0.0313095 |
| HDLBP | high density lipoprotein binding protein | 0.0313005 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0308664 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0306727 |
| RPL18 | ribosomal protein L18 | 0.0297535 |
| S100A9 | S100 calcium binding protein A9 | 0.0295949 |
| RPL4 | ribosomal protein L4 | 0.0295622 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0294805 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0294419 |
| ATXN1 | ataxin 1 | 0.0288782 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0286509 |
| TMSB10 | thymosin beta 10 | 0.0286173 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0281802 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0280785 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0279511 |
| FLNA | filamin A, alpha | 0.0276662 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0275747 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.0275162 |
| UBC | ubiquitin C | 0.0274513 |
| FAT1 | FAT atypical cadherin 1 | 0.0273375 |
| RPS19 | ribosomal protein S19 | 0.0269605 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0266444 |
| SMAD3 | SMAD family member 3 | 0.0264193 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0263346 |
| DST | dystonin | 0.0261722 |
| FAM162A | family with sequence similarity 162, member A | 0.0260734 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0260071 |
| PCBP2 | poly(rC) binding protein 2 | 0.0259418 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.025577 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.025403 |
| TPI1 | triosephosphate isomerase 1 | 0.0252416 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0252092 |
| COL1A1 | collagen, type I, alpha 1 | 0.0251927 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0250144 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0247073 |
| RPS27A | ribosomal protein S27a | 0.024581 |
| MTDH | metadherin | 0.0242849 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.024214 |
| JAG1 | jagged 1 | 0.0241398 |
| RPLP1 | ribosomal protein, large, P1 | 0.0239918 |
| RPL3 | ribosomal protein L3 | 0.0238368 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.306423 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.135598 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0909757 |
| STC1 | stanniocalcin 1 | -0.0714346 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0676021 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0554908 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0499499 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0472544 |
| HMGA2 | high mobility group AT-hook 2 | -0.0402985 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0397297 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.039416 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0352589 |
| EGR1 | early growth response 1 | -0.0342051 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.033217 |
| CLMP | CXADR-like membrane protein | -0.0329612 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0321259 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0285994 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0267793 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0264215 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0253319 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0243289 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0242578 |
| COL1A2 | collagen, type I, alpha 2 | -0.0226958 |
| OXR1 | oxidation resistance 1 | -0.0213411 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0200439 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0191786 |
| ANTXR2 | anthrax toxin receptor 2 | -0.019118 |
| BNC2 | basonuclin 2 | -0.018832 |
| VEPH1 | ventricular zone expressed PH domain-containing 1 | -0.018739 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0185567 |
| ATP13A3 | ATPase type 13A3 | -0.0180063 |
| SQLE | squalene epoxidase | -0.0176806 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0175147 |
| NRP1 | neuropilin 1 | -0.0170586 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | -0.0163615 |
| VMP1 | vacuole membrane protein 1 | -0.0160792 |
| CDH13 | cadherin 13 | -0.0155543 |
| TMEM41B | transmembrane protein 41B | -0.0154832 |
| COG5 | component of oligomeric golgi complex 5 | -0.0151592 |
| INHBA | inhibin, beta A | -0.0150633 |
| TPM4 | tropomyosin 4 | -0.0147494 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.014597 |
| RAI14 | retinoic acid induced 14 | -0.0145813 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.0142594 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0142185 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0142052 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0141967 |
| WASF2 | WAS protein family, member 2 | -0.0140564 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0138685 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0137598 |
| GLIS3 | GLIS family zinc finger 3 | -0.0135876 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0134968 |
| RND3 | Rho family GTPase 3 | -0.0134584 |
| PFN1 | profilin 1 | -0.0134194 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0134186 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0126234 |
| POSTN | periostin, osteoblast specific factor | -0.0126096 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0124929 |
| HMGA1 | high mobility group AT-hook 1 | -0.0123448 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0123158 |
| FOSL1 | FOS-like antigen 1 | -0.0122674 |
| NUCB2 | nucleobindin 2 | -0.012055 |
| OSMR | oncostatin M receptor | -0.0116665 |
| ATM | ATM serine/threonine kinase | -0.0113543 |
| SRPK1 | SRSF protein kinase 1 | -0.0113294 |
| FRMD4A | FERM domain containing 4A | -0.0112295 |
| MTSS1 | metastasis suppressor 1 | -0.0109792 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0109009 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | -0.0108863 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0108064 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0107825 |
| TAPBP | TAP binding protein (tapasin) | -0.0106946 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0106083 |
| KLF6 | Kruppel-like factor 6 | -0.0104475 |
| TUBB6 | tubulin, beta 6 class V | -0.0103704 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0100571 |
| IL1B | interleukin 1, beta | -0.0100268 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.00990835 |
| APOLD1 | apolipoprotein L domain containing 1 | -0.00987983 |
| PDLIM5 | PDZ and LIM domain 5 | -0.00978323 |
| INSIG1 | insulin induced gene 1 | -0.00975227 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.00965676 |
| CCND1 | cyclin D1 | -0.0095423 |
| IL6 | interleukin 6 | -0.00951403 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.00945274 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.00935553 |
| DOCK5 | dedicator of cytokinesis 5 | -0.00931029 |
| DNER | delta/notch-like EGF repeat containing | -0.00927713 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00920219 |
| ITGA11 | integrin, alpha 11 | -0.00907856 |
| RGS17 | regulator of G-protein signaling 17 | -0.00904632 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.00898767 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.00897025 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.00890906 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.00890686 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.00887823 |
| RNF13 | ring finger protein 13 | -0.00887263 |
| FAF2 | Fas associated factor family member 2 | -0.00886996 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.00882343 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | -0.00881567 |
