| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | LJI308 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the LJI308_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.161245 |
| ENO1 | enolase 1, (alpha) | 0.100388 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0723433 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0522886 |
| RNF213 | ring finger protein 213 | 0.050829 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.047399 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0456683 |
| TF | transferrin | 0.0453349 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0452609 |
| DSPP | dentin sialophosphoprotein | 0.0443601 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0405701 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0388499 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.038589 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0370158 |
| CP | ceruloplasmin (ferroxidase) | 0.0361315 |
| ASPH | aspartate beta-hydroxylase | 0.0350328 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0345245 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0341627 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.033621 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0323739 |
| SDC4 | syndecan 4 | 0.0323499 |
| KRT8 | keratin 8, type II | 0.0319188 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0306694 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0304696 |
| FRMD5 | FERM domain containing 5 | 0.0296001 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0287484 |
| FERMT1 | fermitin family member 1 | 0.0280259 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0273082 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0270392 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0269966 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0267371 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.0265535 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.025595 |
| B2M | beta-2-microglobulin | 0.0248994 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.024869 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0247665 |
| HLA-E | major histocompatibility complex, class I, E | 0.0243906 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0242743 |
| SQSTM1 | sequestosome 1 | 0.0241678 |
| KYNU | kynureninase | 0.0241377 |
| UBC | ubiquitin C | 0.0240218 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0234057 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0231271 |
| TCIM | transcriptional and immune response regulator | 0.0223633 |
| LAMA4 | laminin, alpha 4 | 0.0221077 |
| TPM4 | tropomyosin 4 | 0.0219243 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0218627 |
| CTSB | cathepsin B | 0.0218134 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.021732 |
| PGK1 | phosphoglycerate kinase 1 | 0.0212929 |
| AFDN | afadin, adherens junction formation factor | 0.0212424 |
| PEG3 | paternally expressed 3 | 0.0209603 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0209277 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.020849 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0204449 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0200514 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0198688 |
| FN1 | fibronectin 1 | 0.0197747 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0197278 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.019675 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.019537 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0193802 |
| SP100 | SP100 nuclear antigen | 0.0193489 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0193373 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0192647 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0188248 |
| MSI2 | musashi RNA-binding protein 2 | 0.0188188 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0188047 |
| GK | glycerol kinase | 0.0187729 |
| RPL4 | ribosomal protein L4 | 0.018772 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0187639 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0187439 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0186651 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.018548 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0184665 |
| RASA2 | RAS p21 protein activator 2 | 0.0184332 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0183926 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0183034 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | 0.0182098 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.0181365 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0180297 |
| KRT23 | keratin 23, type I | 0.0178896 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0177521 |
| S100A6 | S100 calcium binding protein A6 | 0.0174762 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0173852 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0173486 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0172814 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0170619 |
| WDR45B | WD repeat domain 45B | 0.0169485 |
| TMEM181 | transmembrane protein 181 | 0.0168648 |
| RNF149 | ring finger protein 149 | 0.0167757 |
| SLK | STE20-like kinase | 0.0167063 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.016647 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0165451 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0164324 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0164152 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | 0.0162717 |
| APP | amyloid beta (A4) precursor protein | 0.0161286 |
| KRT19 | keratin 19, type I | 0.0160809 |
| GDF15 | growth differentiation factor 15 | 0.0160049 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.319089 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.209689 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.171625 |
| APOA2 | apolipoprotein A-II | -0.076678 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0705734 |
| RPS6 | ribosomal protein S6 | -0.0647204 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0605604 |
| C3 | complement component 3 | -0.0592825 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0592068 |
| FTL | ferritin, light polypeptide | -0.0537122 |
| HMGA1 | high mobility group AT-hook 1 | -0.0504265 |
| RPL11 | ribosomal protein L11 | -0.0497192 |
| EGR1 | early growth response 1 | -0.0462487 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0408474 |
| RPL37A | ribosomal protein L37a | -0.0407441 |
| DENND4A | DENN/MADD domain containing 4A | -0.0404043 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0403735 |
| RPLP1 | ribosomal protein, large, P1 | -0.0401761 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0388352 |
| PLIN2 | perilipin 2 | -0.0385001 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0381065 |
| RPL19 | ribosomal protein L19 | -0.0373784 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0373321 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0365872 |
| RPL32 | ribosomal protein L32 | -0.0364424 |
| RPS13 | ribosomal protein S13 | -0.0364242 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0353348 |
| RPS19 | ribosomal protein S19 | -0.0335702 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0325966 |
| PHF3 | PHD finger protein 3 | -0.0324335 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.031738 |
| LCOR | ligand dependent nuclear receptor corepressor | -0.0316069 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.031101 |
| PFN1 | profilin 1 | -0.0309297 |
| APOB | apolipoprotein B | -0.0303549 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0301171 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0291908 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0286327 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0281167 |
| MT2A | metallothionein 2A | -0.0278695 |
| RPS23 | ribosomal protein S23 | -0.0274031 |
| RPL9 | ribosomal protein L9 | -0.0268792 |
| RPS10 | ribosomal protein S10 | -0.0268191 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0265559 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0265262 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.026481 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0261181 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.025795 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0255922 |
| PARD3 | par-3 family cell polarity regulator | -0.0253547 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0253451 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0251192 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.0248736 |
| RPS16 | ribosomal protein S16 | -0.0246696 |
| STK17A | serine/threonine kinase 17a | -0.0240291 |
| RPS12 | ribosomal protein S12 | -0.0239631 |
| RTN4 | reticulon 4 | -0.0237605 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0236512 |
| VEGFA | vascular endothelial growth factor A | -0.0230159 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0229112 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0227823 |
| RPS8 | ribosomal protein S8 | -0.0225924 |
| RPL34 | ribosomal protein L34 | -0.0225805 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0224671 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0223927 |
| BCL2L1 | BCL2-like 1 | -0.0221316 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0220944 |
| RPL26 | ribosomal protein L26 | -0.0220304 |
| LYZ | lysozyme | -0.0215026 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0211843 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.0211112 |
| EHBP1 | EH domain binding protein 1 | -0.0210693 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0209206 |
| DSTN | destrin (actin depolymerizing factor) | -0.0208586 |
| RPL8 | ribosomal protein L8 | -0.0208144 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0206384 |
| TRAM1 | translocation associated membrane protein 1 | -0.020341 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0202502 |
| CNKSR3 | CNKSR family member 3 | -0.0201289 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0198364 |
| RPS21 | ribosomal protein S21 | -0.0196667 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | -0.0193102 |
| A2M | alpha-2-macroglobulin | -0.0192927 |
| PTCHD4 | patched domain containing 4 | -0.0188513 |
| SRSF11 | serine/arginine-rich splicing factor 11 | -0.0188231 |
| RNASEH2A | ribonuclease H2, subunit A | -0.0187563 |
| FOXP1 | forkhead box P1 | -0.0187532 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0187249 |
| RPS24 | ribosomal protein S24 | -0.0185701 |
| APOH | apolipoprotein H (beta-2-glycoprotein I) | -0.0185268 |
| GPHN | gephyrin | -0.0185031 |
| MED13L | mediator complex subunit 13-like | -0.0185016 |
| RPL35A | ribosomal protein L35a | -0.0184919 |
| BPIFB2 | BPI fold containing family B, member 2 | -0.0183465 |
| ZNF451 | zinc finger protein 451 | -0.0183092 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0182216 |
| ITGB5 | integrin, beta 5 | -0.0182198 |
| UTRN | utrophin | -0.0182197 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0182031 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | -0.018096 |
