LJI308_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.10359
B2M beta-2-microglobulin 0.0961011
MT2A metallothionein 2A 0.0861893
PTMA prothymosin, alpha 0.0856044
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0700334
RPS6 ribosomal protein S6 0.0667321
RPS12 ribosomal protein S12 0.0648756
FTL ferritin, light polypeptide 0.0646311
ENO1 enolase 1, (alpha) 0.0642798
RPL37A ribosomal protein L37a 0.0583676
TPT1 tumor protein, translationally-controlled 1 0.0566744
RPS13 ribosomal protein S13 0.0545881
RPS8 ribosomal protein S8 0.0533439
HLA-B major histocompatibility complex, class I, B 0.0486749
NDRG1 N-myc downstream regulated 1 0.0452725
SFTPA2 surfactant protein A2 0.0448174
AKAP9 A kinase (PRKA) anchor protein 9 0.0442332
EIF1 eukaryotic translation initiation factor 1 0.0437818
RPS21 ribosomal protein S21 0.0428095
RPLP1 ribosomal protein, large, P1 0.0424506
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0422567
CANX calnexin 0.0421146
FTH1 ferritin, heavy polypeptide 1 0.0418777
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0412707
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.040525
RPLP2 ribosomal protein, large, P2 0.040473
RPL11 ribosomal protein L11 0.040256
RPS3 ribosomal protein S3 0.0402079
IFITM3 interferon induced transmembrane protein 3 0.0398837
RPS27A ribosomal protein S27a 0.0395914
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.038583
RPS19 ribosomal protein S19 0.0383134
SQSTM1 sequestosome 1 0.0380756
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0378092
RPL23 ribosomal protein L23 0.0376162
WSB1 WD repeat and SOCS box containing 1 0.0364247
LDHA lactate dehydrogenase A 0.0358306
RPL19 ribosomal protein L19 0.0354734
IFI6 interferon, alpha-inducible protein 6 0.0352658
RPL12 ribosomal protein L12 0.0349197
CALR calreticulin 0.0345316
RPS27 ribosomal protein S27 0.0342773
IFITM1 interferon induced transmembrane protein 1 0.0341723
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0336208
KMT2E lysine (K)-specific methyltransferase 2E 0.0333856
HM13 histocompatibility (minor) 13 0.0327654
EEF2 eukaryotic translation elongation factor 2 0.03248
ISG15 ISG15 ubiquitin-like modifier 0.0324343
RPL13A ribosomal protein L13a 0.0321711
MORF4L2 mortality factor 4 like 2 0.0320537
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0317202
P4HB prolyl 4-hydroxylase, beta polypeptide 0.031589
ADM adrenomedullin 0.0314511
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.031141
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0308258
UBC ubiquitin C 0.0305311
FNDC3B fibronectin type III domain containing 3B 0.0303289
DSCAM Down syndrome cell adhesion molecule 0.0301448
CTSA cathepsin A 0.0299794
RPL31 ribosomal protein L31 0.0298427
PGK1 phosphoglycerate kinase 1 0.0298007
RPL26 ribosomal protein L26 0.0297806
HLA-A major histocompatibility complex, class I, A 0.029387
APLP2 amyloid beta (A4) precursor-like protein 2 0.0291116
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0290912
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0290408
RPL37 ribosomal protein L37 0.0286586
YBX1 Y box binding protein 1 0.0285324
RPL27 ribosomal protein L27 0.0285293
RPL28 ribosomal protein L28 0.0283294
GOLGA4 golgin A4 0.0282246
RPS25 ribosomal protein S25 0.028142
DDIT4 DNA-damage-inducible transcript 4 0.0280426
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0280276
RPL10A ribosomal protein L10a 0.0278721
ACBD3 acyl-CoA binding domain containing 3 0.0278696
VEGFA vascular endothelial growth factor A 0.0275595
RPL7 ribosomal protein L7 0.0274839
PDIA3 protein disulfide isomerase family A, member 3 0.0274587
MTDH metadherin 0.0274233
WNK1 WNK lysine deficient protein kinase 1 0.0273673
GARS1 glycyl-tRNA synthetase 1 0.0272125
PCBP2 poly(rC) binding protein 2 0.0269264
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0264836
SEC31A SEC31 homolog A (S. cerevisiae) 0.0263588
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0246127
COPB1 coatomer protein complex, subunit beta 1 0.0245592
NCOR2 nuclear receptor corepressor 2 0.0245219
TGM2 transglutaminase 2 0.0241946
S100A9 S100 calcium binding protein A9 0.0238849
RPL35 ribosomal protein L35 0.0237079
BHLHE40 basic helix-loop-helix family, member e40 0.0235784
TMSB10 thymosin beta 10 0.0235282
PKM pyruvate kinase, muscle 0.0232918
HYOU1 hypoxia up-regulated 1 0.0230886
DENND4C DENN/MADD domain containing 4C 0.0228695
RPS23 ribosomal protein S23 0.0227137
IFI27 interferon, alpha-inducible protein 27 0.0226423
RPL30 ribosomal protein L30 0.0225052
RPS16 ribosomal protein S16 0.0223496

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.231259
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.198895
DPYD dihydropyrimidine dehydrogenase -0.0862673
MTSS1 metastasis suppressor 1 -0.0796233
PDE4D phosphodiesterase 4D, cAMP-specific -0.0777949
LMO7 LIM domain 7 -0.0678203
FLNB filamin B, beta -0.0628545
RAI14 retinoic acid induced 14 -0.060347
SULF1 sulfatase 1 -0.0594025
TRIO trio Rho guanine nucleotide exchange factor -0.0558018
PALLD palladin, cytoskeletal associated protein -0.0548986
AOPEP aminopeptidase O (putative) -0.0530815
FOXO1 forkhead box O1 -0.0518893
SLC35F3 solute carrier family 35, member F3 -0.0515286
ABI3BP ABI family, member 3 (NESH) binding protein -0.0511331
PDLIM5 PDZ and LIM domain 5 -0.0508181
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0501183
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0474668
HSPG2 heparan sulfate proteoglycan 2 -0.0463865
ZEB1 zinc finger E-box binding homeobox 1 -0.0439763
SMYD3 SET and MYND domain containing 3 -0.0432436
BCAR3 breast cancer anti-estrogen resistance 3 -0.0417425
MECOM MDS1 and EVI1 complex locus -0.0411966
MBNL1 muscleblind-like splicing regulator 1 -0.0405169
RABGAP1L RAB GTPase activating protein 1-like -0.0399642
FOXP1 forkhead box P1 -0.0383835
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0376707
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0376491
DOK5 docking protein 5 -0.0374409
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0367236
PSD3 pleckstrin and Sec7 domain containing 3 -0.0360633
ITGA6 integrin, alpha 6 -0.0360311
CD44 CD44 molecule (Indian blood group) -0.0339693
HDAC9 histone deacetylase 9 -0.032803
JMJD1C jumonji domain containing 1C -0.0325589
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.032384
EXOC4 exocyst complex component 4 -0.0323026
UTRN utrophin -0.0314459
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0305079
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.0292832
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0291845
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0291223
MACF1 microtubule-actin crosslinking factor 1 -0.0290429
DOCK4 dedicator of cytokinesis 4 -0.02904
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0288398
SULF2 sulfatase 2 -0.0287679
DOCK9 dedicator of cytokinesis 9 -0.0287146
RNF217 ring finger protein 217 -0.0286582
MEIS2 Meis homeobox 2 -0.0282551
RASAL2 RAS protein activator like 2 -0.0271733
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0270287
C4BPB complement component 4 binding protein, beta -0.0267859
PTK2 protein tyrosine kinase 2 -0.0267291
NRG1 neuregulin 1 -0.0263828
SAMD9 sterile alpha motif domain containing 9 -0.0263214
AMOTL1 angiomotin like 1 -0.0260504
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0255833
SOX5 SRY (sex determining region Y)-box 5 -0.0254943
ARHGAP29 Rho GTPase activating protein 29 -0.0253368
MAML2 mastermind-like 2 (Drosophila) -0.0246134
PODXL podocalyxin-like -0.0245505
HMGA2 high mobility group AT-hook 2 -0.0244025
COL4A5 collagen, type IV, alpha 5 -0.0240348
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0232803
DGKH diacylglycerol kinase, eta -0.0226266
MYOF myoferlin -0.0224526
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0223131
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0221728
CALB1 calbindin 1, 28kDa -0.0220848
ARHGAP18 Rho GTPase activating protein 18 -0.0220205
KLF5 Kruppel-like factor 5 (intestinal) -0.0219217
ANO1 anoctamin 1, calcium activated chloride channel -0.0218478
TSC22D1 TSC22 domain family, member 1 -0.0217096
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0216667
TBC1D22A TBC1 domain family, member 22A -0.021628
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.021457
CNTNAP3 contactin associated protein-like 3 -0.0212091
OSBPL6 oxysterol binding protein-like 6 -0.020854
CDK6 cyclin-dependent kinase 6 -0.0208276
CAV1 caveolin 1, caveolae protein, 22kDa -0.0204816
PCDH9 protocadherin 9 -0.0203074
EGFR epidermal growth factor receptor -0.020299
MTAP methylthioadenosine phosphorylase -0.0202738
OSMR oncostatin M receptor -0.0198229
TENM4 teneurin transmembrane protein 4 -0.0198169
THSD4 thrombospondin, type I, domain containing 4 -0.0196398
NEK7 NIMA-related kinase 7 -0.019472
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0193482
KCTD12 potassium channel tetramerization domain containing 12 -0.0192692
AKAP13 A kinase (PRKA) anchor protein 13 -0.0188939
KIAA1671 KIAA1671 -0.0188831
BMAL2 basic helix-loop-helix ARNT like 2 -0.0187303
PTPRB protein tyrosine phosphatase, receptor type, B -0.0184424
RAD51B RAD51 paralog B -0.0183377
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0179235
AHNAK AHNAK nucleoprotein -0.0175567
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0170213
PYGL phosphorylase, glycogen, liver -0.016954
ATG7 autophagy related 7 -0.0168466
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0167034