LJI308_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in KATO III cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the LJI308_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.270126
B2M beta-2-microglobulin 0.134108
FTL ferritin, light polypeptide 0.133547
DSPP dentin sialophosphoprotein 0.108143
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0996096
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0948037
TPT1 tumor protein, translationally-controlled 1 0.0927947
RPS6 ribosomal protein S6 0.0874714
EIF1 eukaryotic translation initiation factor 1 0.0812997
RPL23 ribosomal protein L23 0.0796605
TMC5 transmembrane channel-like 5 0.0787245
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0780172
RPS3 ribosomal protein S3 0.0756113
NUPR1 nuclear protein, transcriptional regulator, 1 0.0754583
RPL35A ribosomal protein L35a 0.0676331
RPS19 ribosomal protein S19 0.0671634
RPS8 ribosomal protein S8 0.0666541
RPL26 ribosomal protein L26 0.0653535
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0636958
AKAP9 A kinase (PRKA) anchor protein 9 0.0598451
HLA-E major histocompatibility complex, class I, E 0.0595389
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0594485
RPS12 ribosomal protein S12 0.0582658
RPLP1 ribosomal protein, large, P1 0.0575348
PTMA prothymosin, alpha 0.0569155
AHNAK AHNAK nucleoprotein 0.0566418
MBNL2 muscleblind-like splicing regulator 2 0.0537286
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.052979
NDRG1 N-myc downstream regulated 1 0.0529381
HLA-A major histocompatibility complex, class I, A 0.0525654
RPL12 ribosomal protein L12 0.0512576
RPS25 ribosomal protein S25 0.050712
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0504733
RPL19 ribosomal protein L19 0.0501321
IFI27 interferon, alpha-inducible protein 27 0.0493653
MACC1 metastasis associated in colon cancer 1 0.0488362
EXT1 exostosin glycosyltransferase 1 0.0484796
PGK1 phosphoglycerate kinase 1 0.0483402
ATF5 activating transcription factor 5 0.0473235
IFI6 interferon, alpha-inducible protein 6 0.0457564
ZNF292 zinc finger protein 292 0.0453777
KLF5 Kruppel-like factor 5 (intestinal) 0.0443574
RPS16 ribosomal protein S16 0.0437813
RNF213 ring finger protein 213 0.0436544
PNRC1 proline-rich nuclear receptor coactivator 1 0.0418196
LOC102724023 ES1 protein homolog, mitochondrial 0.0417539
RPL18 ribosomal protein L18 0.0408917
EPCAM epithelial cell adhesion molecule 0.0407398
LCN2 lipocalin 2 0.0405577
RPS27 ribosomal protein S27 0.0401185
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0399725
PCBP2 poly(rC) binding protein 2 0.039892
RPS27A ribosomal protein S27a 0.0389594
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0387237
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0383722
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0363989
RPL7 ribosomal protein L7 0.035833
RPL37A ribosomal protein L37a 0.0357
ENO1 enolase 1, (alpha) 0.0355034
SFTPA2 surfactant protein A2 0.0354976
RPL13A ribosomal protein L13a 0.0349855
CANX calnexin 0.0346605
IFITM1 interferon induced transmembrane protein 1 0.0343603
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.034039
RPL11 ribosomal protein L11 0.0337333
GOLGA4 golgin A4 0.0336028
CLDN4 claudin 4 0.0335704
LDHA lactate dehydrogenase A 0.0332207
KDM3A lysine (K)-specific demethylase 3A 0.0329829
RPLP0 ribosomal protein, large, P0 0.0326104
RPS17 ribosomal protein S17 0.0321011
RPS21 ribosomal protein S21 0.0320014
RPL28 ribosomal protein L28 0.0318576
MYH9 myosin, heavy chain 9, non-muscle 0.0316719
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.031548
RPS11 ribosomal protein S11 0.0315163
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.031424
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0313629
DSCAM Down syndrome cell adhesion molecule 0.0312374
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.03104
DSTN destrin (actin depolymerizing factor) 0.0310108
TXNIP thioredoxin interacting protein 0.0309563
RPL4 ribosomal protein L4 0.0309229
RPL34 ribosomal protein L34 0.0307172
RPL9 ribosomal protein L9 0.0306248
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0303254
WDR45B WD repeat domain 45B 0.0300982
S100A9 S100 calcium binding protein A9 0.0299218
SPTBN1 spectrin, beta, non-erythrocytic 1 0.029635
RPLP2 ribosomal protein, large, P2 0.0294286
RPL5 ribosomal protein L5 0.0292198
RPL36A ribosomal protein L36a 0.0291088
CALR calreticulin 0.0290855
RPL27 ribosomal protein L27 0.0290037
RPL32 ribosomal protein L32 0.0288373
GOLGB1 golgin B1 0.0287542
UBC ubiquitin C 0.028417
RPL7A ribosomal protein L7a 0.028063
RPL30 ribosomal protein L30 0.0280532
RPS4X ribosomal protein S4, X-linked 0.0278891

decreased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase -0.194059
NPSR1 neuropeptide S receptor 1 -0.165049
MAML2 mastermind-like 2 (Drosophila) -0.123427
CEMIP cell migration inducing protein, hyaluronan binding -0.10936
FLNB filamin B, beta -0.0633377
EHBP1 EH domain binding protein 1 -0.0610132
TNIK TRAF2 and NCK interacting kinase -0.0576419
FAT1 FAT atypical cadherin 1 -0.0502052
ITGA6 integrin, alpha 6 -0.0449249
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0433179
BCL2L1 BCL2-like 1 -0.0405905
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0329922
UBASH3B ubiquitin associated and SH3 domain containing B -0.032772
CDK6 cyclin-dependent kinase 6 -0.0323769
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0283046
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0280563
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.027746
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0273527
ANXA2 annexin A2 -0.0270751
PRKCA protein kinase C, alpha -0.0270717
TRPS1 trichorhinophalangeal syndrome I -0.0261616
YAP1 Yes-associated protein 1 -0.0258347
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0250548
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0243943
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0242047
ASPH aspartate beta-hydroxylase -0.023674
CAPN8 calpain 8 -0.0236553
DENND1A DENN/MADD domain containing 1A -0.0235429
POTEF POTE ankyrin domain family, member F -0.0235215
TCF12 transcription factor 12 -0.0233386
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0232225
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0229599
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0227793
OSBPL10 oxysterol binding protein-like 10 -0.0213463
ANO1 anoctamin 1, calcium activated chloride channel -0.0206522
CCND1 cyclin D1 -0.0202117
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0201961
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0200085
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0199977
ACACA acetyl-CoA carboxylase alpha -0.019558
FRMD5 FERM domain containing 5 -0.0195528
SHB Src homology 2 domain containing adaptor protein B -0.0194991
TFRC transferrin receptor -0.0191591
INTS6 integrator complex subunit 6 -0.0191014
IL1RAP interleukin 1 receptor accessory protein -0.0190177
WARS1 tryptophanyl-tRNA synthetase 1 -0.0188039
SH3RF1 SH3 domain containing ring finger 1 -0.0185831
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.01836
DLC1 DLC1 Rho GTPase activating protein -0.0182617
WWC1 WW and C2 domain containing 1 -0.0180609
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0179236
PDLIM5 PDZ and LIM domain 5 -0.0177118
SULF2 sulfatase 2 -0.017592
TNS4 tensin 4 -0.017588
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0174953
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0174482
CD46 CD46 molecule, complement regulatory protein -0.0174426
PTPRG protein tyrosine phosphatase, receptor type, G -0.017377
ECT2 epithelial cell transforming 2 -0.0172837
MED13 mediator complex subunit 13 -0.0171459
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0170249
EGR1 early growth response 1 -0.0168103
CUX1 cut-like homeobox 1 -0.0167666
RCOR1 REST corepressor 1 -0.0166378
TPM4 tropomyosin 4 -0.0160028
DIAPH2 diaphanous-related formin 2 -0.0159883
FMNL2 formin-like 2 -0.0159038
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0157477
DOCK5 dedicator of cytokinesis 5 -0.0156473
PKP4 plakophilin 4 -0.0156296
XYLT1 xylosyltransferase I -0.0156172
NHSL1 NHS-like 1 -0.0155877
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0153058
LAMA4 laminin, alpha 4 -0.0152733
FAF1 Fas (TNFRSF6) associated factor 1 -0.0151806
ARHGAP6 Rho GTPase activating protein 6 -0.015174
RRM2 ribonucleotide reductase M2 -0.0150803
SH3D19 SH3 domain containing 19 -0.0146772
KRT18 keratin 18, type I -0.0146623
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0146495
SKAP1 src kinase associated phosphoprotein 1 -0.0145375
SLC25A51 solute carrier family 25, member 51 -0.0145203
TGFA transforming growth factor, alpha -0.0144501
OSBPL3 oxysterol binding protein-like 3 -0.0144174
EMP1 epithelial membrane protein 1 -0.014364
DLG1 discs, large homolog 1 (Drosophila) -0.0143023
PHF14 PHD finger protein 14 -0.0142317
KRT86 keratin 86, type II -0.0141828
ONECUT3 one cut homeobox 3 -0.0141424
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0136487
FOSL1 FOS-like antigen 1 -0.0134452
KLK10 kallikrein-related peptidase 10 -0.0134028
ITGB4 integrin, beta 4 -0.0133603
ADAM32 ADAM metallopeptidase domain 32 -0.0133458
FASN fatty acid synthase -0.0132334
TMPRSS4 transmembrane protease, serine 4 -0.0132214
MPRIP myosin phosphatase Rho interacting protein -0.0132053
INSIG1 insulin induced gene 1 -0.0132022
TMCC1 transmembrane and coiled-coil domain family 1 -0.0131057
TAS2R14 taste receptor, type 2, member 14 -0.0131035