LJI308_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.201301
MT2A metallothionein 2A 0.184342
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.166845
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.109214
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0842621
FTL ferritin, light polypeptide 0.0811747
LDHA lactate dehydrogenase A 0.0809796
RPS8 ribosomal protein S8 0.0763806
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0715227
RPS12 ribosomal protein S12 0.0708436
AHNAK AHNAK nucleoprotein 0.0675681
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0631431
RPS3 ribosomal protein S3 0.0598566
PTMA prothymosin, alpha 0.0580089
RPL12 ribosomal protein L12 0.0561983
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0546782
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0539558
RPL26 ribosomal protein L26 0.0503905
TPT1 tumor protein, translationally-controlled 1 0.0470935
RACK1 receptor for activated C kinase 1 0.0451994
ENO1 enolase 1, (alpha) 0.0451499
MT1E metallothionein 1E 0.0437479
CANX calnexin 0.0427211
SPAG9 sperm associated antigen 9 0.03997
RPL37A ribosomal protein L37a 0.0394356
PGK1 phosphoglycerate kinase 1 0.0393091
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0392566
RPL5 ribosomal protein L5 0.0385917
EEF2 eukaryotic translation elongation factor 2 0.0377278
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.037541
SQSTM1 sequestosome 1 0.0374719
DST dystonin 0.0374282
TMSB10 thymosin beta 10 0.0366036
LOC112694756 uncharaterized LOC112694756 0.0358745
EREG epiregulin 0.0357735
RPL4 ribosomal protein L4 0.0345323
RPL31 ribosomal protein L31 0.032795
RPS27A ribosomal protein S27a 0.0325738
UBC ubiquitin C 0.0322801
KTN1 kinectin 1 (kinesin receptor) 0.0311938
ACTG1 actin gamma 1 0.0301267
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0299013
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0296386
IFITM1 interferon induced transmembrane protein 1 0.0295387
RPL36 ribosomal protein L36 0.0289612
RPL23 ribosomal protein L23 0.0284382
RPL18 ribosomal protein L18 0.0280075
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0276589
RPL27 ribosomal protein L27 0.0273783
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0273031
PCBP2 poly(rC) binding protein 2 0.0269924
CALR calreticulin 0.0267163
RPS19 ribosomal protein S19 0.0264194
ERRFI1 ERBB receptor feedback inhibitor 1 0.0263812
RPS4X ribosomal protein S4, X-linked 0.0261237
CAPRIN2 caprin family member 2 0.0258807
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0256835
RPL7A ribosomal protein L7a 0.0252052
NAP1L1 nucleosome assembly protein 1-like 1 0.0246832
EIF1 eukaryotic translation initiation factor 1 0.0246457
NIBAN2 niban apoptosis regulator 2 0.0246215
SDC4 syndecan 4 0.0240335
EEF1G eukaryotic translation elongation factor 1 gamma 0.0240209
EIF4A1 eukaryotic translation initiation factor 4A1 0.0238744
RPL19 ribosomal protein L19 0.0237618
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0235702
ENO2 enolase 2 (gamma, neuronal) 0.0235181
RPLP0 ribosomal protein, large, P0 0.0231502
YBX1 Y box binding protein 1 0.0228674
RPLP2 ribosomal protein, large, P2 0.022777
RPS6 ribosomal protein S6 0.0227002
EZR ezrin 0.0225409
RPS13 ribosomal protein S13 0.0224582
HDAC9 histone deacetylase 9 0.0223206
RPL11 ribosomal protein L11 0.0221447
SRRM2 serine/arginine repetitive matrix 2 0.0219371
GARS1 glycyl-tRNA synthetase 1 0.0218295
MORF4L2 mortality factor 4 like 2 0.0217911
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0215522
MT1X metallothionein 1X 0.0214028
ANGPTL4 angiopoietin-like 4 0.0211138
RPL37 ribosomal protein L37 0.021089
HDLBP high density lipoprotein binding protein 0.0209728
CXCL8 chemokine (C-X-C motif) ligand 8 0.0209281
AKAP9 A kinase (PRKA) anchor protein 9 0.0207462
RPS27 ribosomal protein S27 0.0206973
PLK2 polo-like kinase 2 0.0206751
TTC3 tetratricopeptide repeat domain 3 0.0205857
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0202138
RPL13A ribosomal protein L13a 0.0198781
APLP2 amyloid beta (A4) precursor-like protein 2 0.0198267
RPL35A ribosomal protein L35a 0.0196732
KDM3A lysine (K)-specific demethylase 3A 0.0196696
SET SET nuclear proto-oncogene 0.0194482
EIF4A2 eukaryotic translation initiation factor 4A2 0.0194084
DDIT4 DNA-damage-inducible transcript 4 0.0192345
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0190439
SFTPA2 surfactant protein A2 0.0186567
JUN jun proto-oncogene 0.0186099
RPLP1 ribosomal protein, large, P1 0.0185689

decreased expression

Symbol Name Standardized Value
TP63 tumor protein p63 -0.0819083
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0771163
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0709553
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0709046
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0489009
CD44 CD44 molecule (Indian blood group) -0.0481784
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0472586
CADM2 cell adhesion molecule 2 -0.0418623
TSC22D1 TSC22 domain family, member 1 -0.0399417
PSD3 pleckstrin and Sec7 domain containing 3 -0.038225
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0363767
CFAP299 cilia and flagella associated protein 299 -0.0343483
DPYD dihydropyrimidine dehydrogenase -0.0337772
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0334079
EHBP1 EH domain binding protein 1 -0.0326404
WARS1 tryptophanyl-tRNA synthetase 1 -0.0300557
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0292552
RIGI RNA sensor RIG-I -0.0273134
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0264287
COL5A2 collagen, type V, alpha 2 -0.0244177
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0235149
RAD51B RAD51 paralog B -0.0229072
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0221469
DPH6 diphthamine biosynthesis 6 -0.0211605
TTC28 tetratricopeptide repeat domain 28 -0.0210377
TNS3 tensin 3 -0.0209221
EFNA5 ephrin-A5 -0.0199429
DLG1 discs, large homolog 1 (Drosophila) -0.0198011
PDE10A phosphodiesterase 10A -0.0195565
RAB27B RAB27B, member RAS oncogene family -0.0178607
RNF213 ring finger protein 213 -0.0176896
SDK1 sidekick cell adhesion molecule 1 -0.0173874
VMP1 vacuole membrane protein 1 -0.0170141
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0160268
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0160187
THSD4 thrombospondin, type I, domain containing 4 -0.0159887
PTK2 protein tyrosine kinase 2 -0.0157848
FAF1 Fas (TNFRSF6) associated factor 1 -0.0157527
DNER delta/notch-like EGF repeat containing -0.0155841
DNAH14 dynein, axonemal, heavy chain 14 -0.015562
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0154203
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0149102
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0144275
EXOC4 exocyst complex component 4 -0.0142109
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.013184
ZMYND8 zinc finger, MYND-type containing 8 -0.0128708
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0128338
SAMHD1 SAM domain and HD domain 1 -0.0127902
PARD3 par-3 family cell polarity regulator -0.0124927
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.012443
PIAS2 protein inhibitor of activated STAT, 2 -0.0124208
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0122001
AMBRA1 autophagy/beclin-1 regulator 1 -0.0117529
ACACA acetyl-CoA carboxylase alpha -0.0116443
DIAPH3 diaphanous-related formin 3 -0.0114991
ETV6 ets variant 6 -0.0114664
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0113764
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.011367
TGM2 transglutaminase 2 -0.0113297
TPRG1 tumor protein p63 regulated 1 -0.011117
ZMIZ2 zinc finger, MIZ-type containing 2 -0.0107842
SMIM44 small integral membrane protein 44 -0.0107837
PLSCR1 phospholipid scramblase 1 -0.0106654
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0105144
EPHA4 EPH receptor A4 -0.0104473
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0103477
XAF1 XIAP associated factor 1 -0.0101139
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0101117
OSMR oncostatin M receptor -0.010095
LMNTD1 lamin tail domain containing 1 -0.0100245
TAS2R14 taste receptor, type 2, member 14 -0.00998358
FBXO11 F-box protein 11 -0.00969956
KCNK5 potassium channel, two pore domain subfamily K, member 5 -0.00964997
PMP22 peripheral myelin protein 22 -0.00957674
SRPK2 SRSF protein kinase 2 -0.00957006
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.00943374
RGS5 regulator of G-protein signaling 5 -0.00929643
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.00925643
RANBP17 RAN binding protein 17 -0.00923025
LRP1B low density lipoprotein receptor-related protein 1B -0.00909608
SPIDR scaffolding protein involved in DNA repair -0.00900662
FERMT1 fermitin family member 1 -0.00896529
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -0.00895839
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.00895297
NEBL nebulette -0.00884144
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -0.00884137
ANTXR2 anthrax toxin receptor 2 -0.00875595
MACROD1 MACRO domain containing 1 -0.00874379
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.00874368
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.00873429
CCDC91 coiled-coil domain containing 91 -0.00870678
SLC38A6 solute carrier family 38, member 6 -0.00864178
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0086051
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -0.00851101
CSMD3 CUB and Sushi multiple domains 3 -0.00849062
LY6E lymphocyte antigen 6 complex, locus E -0.0084557
SKIL SKI-like proto-oncogene -0.00843099
OASL 2'-5'-oligoadenylate synthetase-like -0.00837565
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0083726
MNAT1 MNAT CDK-activating kinase assembly factor 1 -0.00824128