LJI308_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.190176
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.172123
ASPH aspartate beta-hydroxylase 0.106833
EGFR epidermal growth factor receptor 0.106792
ENO1 enolase 1, (alpha) 0.0947882
PTMA prothymosin, alpha 0.0753669
LDHA lactate dehydrogenase A 0.0745056
FTL ferritin, light polypeptide 0.0711726
MT2A metallothionein 2A 0.0687457
MCL1 myeloid cell leukemia 1 0.06837
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0681794
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0677522
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0666757
PKM pyruvate kinase, muscle 0.0662965
GRAMD1B GRAM domain containing 1B 0.0599107
RPL37A ribosomal protein L37a 0.0581704
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0519404
S100A10 S100 calcium binding protein A10 0.0516316
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0514595
DSCAM Down syndrome cell adhesion molecule 0.0507765
INTS6 integrator complex subunit 6 0.0501752
SPAG9 sperm associated antigen 9 0.0479885
S100P S100 calcium binding protein P 0.0469608
SEC61G Sec61 gamma subunit 0.0464712
PGK1 phosphoglycerate kinase 1 0.0464365
IGFBP5 insulin-like growth factor binding protein 5 0.0461858
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0457507
IFI6 interferon, alpha-inducible protein 6 0.045256
HOMER1 homer scaffolding protein 1 0.0448721
ANXA2 annexin A2 0.0442736
CALR calreticulin 0.0438608
RPS3 ribosomal protein S3 0.0432536
ZSWIM6 zinc finger, SWIM-type containing 6 0.0431851
THSD4 thrombospondin, type I, domain containing 4 0.0425883
RPS12 ribosomal protein S12 0.0424548
MORF4L2 mortality factor 4 like 2 0.041824
TMSB10 thymosin beta 10 0.0412207
NSUN6 NOP2/Sun domain family, member 6 0.0405718
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.040424
LOC112694756 uncharaterized LOC112694756 0.0403136
EXT1 exostosin glycosyltransferase 1 0.0401259
LMO7 LIM domain 7 0.04007
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0389555
ACTG1 actin gamma 1 0.0381919
CANX calnexin 0.0381031
HYOU1 hypoxia up-regulated 1 0.0379008
RPS8 ribosomal protein S8 0.0377222
GOLGB1 golgin B1 0.0375575
APLP2 amyloid beta (A4) precursor-like protein 2 0.036869
PDLIM5 PDZ and LIM domain 5 0.0354339
CXCL8 chemokine (C-X-C motif) ligand 8 0.0353203
AHNAK AHNAK nucleoprotein 0.0351894
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0351036
TPT1 tumor protein, translationally-controlled 1 0.0350864
RPL4 ribosomal protein L4 0.034688
RPS25 ribosomal protein S25 0.0344826
UBC ubiquitin C 0.0342239
LAMC2 laminin, gamma 2 0.0336988
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0327245
ERRFI1 ERBB receptor feedback inhibitor 1 0.0325419
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0317069
TXNRD1 thioredoxin reductase 1 0.0313479
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0310642
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0309709
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0305261
BZW1 basic leucine zipper and W2 domains 1 0.0304507
EZR ezrin 0.0304087
MYOF myoferlin 0.0302079
MYO1E myosin IE 0.0296849
TPI1 triosephosphate isomerase 1 0.0296644
EIF1 eukaryotic translation initiation factor 1 0.029655
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0295786
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.029412
HDLBP high density lipoprotein binding protein 0.0290088
SEC31A SEC31 homolog A (S. cerevisiae) 0.0288414
RPS6 ribosomal protein S6 0.0286722
CSNK1A1 casein kinase 1, alpha 1 0.0284816
PDE4D phosphodiesterase 4D, cAMP-specific 0.0282706
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0281904
RPL31 ribosomal protein L31 0.0277875
SIK3 SIK family kinase 3 0.0277598
MYH9 myosin, heavy chain 9, non-muscle 0.0277573
SLTM SAFB-like, transcription modulator 0.0275084
MAP7 microtubule-associated protein 7 0.027478
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0274322
TES testin LIM domain protein 0.0274115
PATJ PATJ crumbs cell polarity complex component 0.027211
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0271484
RPLP1 ribosomal protein, large, P1 0.027129
ELL2 elongation factor, RNA polymerase II, 2 0.0270112
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.026768
RPS24 ribosomal protein S24 0.0266739
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0262973
TJP1 tight junction protein 1 0.0262901
RPS17 ribosomal protein S17 0.0261342
FBXO11 F-box protein 11 0.0260696
RPS27A ribosomal protein S27a 0.0258739
PCBP2 poly(rC) binding protein 2 0.025828
NABP1 nucleic acid binding protein 1 0.02561
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0252935

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0807362
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.022843
BIRC3 baculoviral IAP repeat containing 3 -0.0223459
CAV1 caveolin 1, caveolae protein, 22kDa -0.0203363
NAMPT nicotinamide phosphoribosyltransferase -0.0190432
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0179979
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0165773
TMEM165 transmembrane protein 165 -0.0157415
ITSN2 intersectin 2 -0.015178
TNRC6A trinucleotide repeat containing 6A -0.0149289
FAM13A family with sequence similarity 13, member A -0.0149219
MT1X metallothionein 1X -0.014335
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0139485
FTH1 ferritin, heavy polypeptide 1 -0.0133103
FOSL1 FOS-like antigen 1 -0.0121095
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0113824
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0109167
SLMAP sarcolemma associated protein -0.0107664
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0101925
RNF145 ring finger protein 145 -0.0101755
TNS3 tensin 3 -0.00981165
EFNA5 ephrin-A5 -0.00978905
PIAS1 protein inhibitor of activated STAT, 1 -0.00953612
UVRAG UV radiation resistance associated -0.00946645
ARRDC3 arrestin domain containing 3 -0.00936543
CP ceruloplasmin (ferroxidase) -0.00906053
SOD2 superoxide dismutase 2, mitochondrial -0.00902399
USP3 ubiquitin specific peptidase 3 -0.00899032
PMP22 peripheral myelin protein 22 -0.00855221
NDE1 nudE neurodevelopment protein 1 -0.00849709
ZMYND8 zinc finger, MYND-type containing 8 -0.00848373
PTEN phosphatase and tensin homolog -0.00819487
CYFIP1 cytoplasmic FMR1 interacting protein 1 -0.00814332
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.00807822
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.00800634
MCTP1 multiple C2 domains, transmembrane 1 -0.00789321
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0077887
CDCP1 CUB domain containing protein 1 -0.00775088
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.00771896
IFNAR2 interferon (alpha, beta and omega) receptor 2 -0.00764205
LRRC8C leucine rich repeat containing 8 family, member C -0.00738373
ATG7 autophagy related 7 -0.00728128
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.00700655
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.00692535
RCOR3 REST corepressor 3 -0.00682186
SPPL3 signal peptide peptidase like 3 -0.00671487
UBA6 ubiquitin-like modifier activating enzyme 6 -0.00671256
NUP54 nucleoporin 54kDa -0.006635
ABLIM1 actin binding LIM protein 1 -0.0066096
ATP13A3 ATPase type 13A3 -0.0065911
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -0.00655696
ZC3H6 zinc finger CCCH-type containing 6 -0.00653508
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.00646071
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.00633815
PARD3 par-3 family cell polarity regulator -0.00633718
ADGRA3 adhesion G protein-coupled receptor A3 -0.00630726
RBM26 RNA binding motif protein 26 -0.00629188
IRS2 insulin receptor substrate 2 -0.00628127
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.00618627
SMAD3 SMAD family member 3 -0.00616879
SCAF11 SR-related CTD-associated factor 11 -0.00614264
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.00606583
IGF2 insulin-like growth factor 2 -0.00601655
KNOP1 lysine-rich nucleolar protein 1 -0.00598999
MARK2 MAP/microtubule affinity-regulating kinase 2 -0.00596814
ANKRD28 ankyrin repeat domain 28 -0.00590434
MKI67 marker of proliferation Ki-67 -0.00588237
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.00583025
IFNAR1 interferon (alpha, beta and omega) receptor 1 -0.00581002
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.00578483
CPNE8 copine VIII -0.00577465
CAB39 calcium binding protein 39 -0.00577246
CABLES1 Cdk5 and Abl enzyme substrate 1 -0.00576948
KCMF1 potassium channel modulatory factor 1 -0.00576167
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.00574166
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 -0.00571685
VGLL4 vestigial-like family member 4 -0.00562004
VPS26C VPS26 endosomal protein sorting factor C -0.00560972
FBXO42 F-box protein 42 -0.00552845
IGF2R insulin-like growth factor 2 receptor -0.00544795
RNASE3 ribonuclease, RNase A family, 3 -0.00542041
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.00539113
ADAM28 ADAM metallopeptidase domain 28 -0.00537535
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 -0.00533817
SEC24B SEC24 family member B -0.00530018
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -0.00528312
TBK1 TANK-binding kinase 1 -0.00518698
MLF1 myeloid leukemia factor 1 -0.00517746
OSBPL9 oxysterol binding protein-like 9 -0.00517125
ALCAM activated leukocyte cell adhesion molecule -0.00515505
SPIRE1 spire-type actin nucleation factor 1 -0.00515383
TCERG1 transcription elongation regulator 1 -0.00515365
TRAF3 TNF receptor-associated factor 3 -0.00513933
BACE2 beta-site APP-cleaving enzyme 2 -0.00509932
MTMR12 myotubularin related protein 12 -0.00507387
NCOA6 nuclear receptor coactivator 6 -0.00505881
ARHGAP21 Rho GTPase activating protein 21 -0.00505693
EPS15 epidermal growth factor receptor pathway substrate 15 -0.00503959
ZFP36 ZFP36 ring finger protein -0.00503324
CNOT9 CCR4-NOT transcription complex subunit 9 -0.00501814