LJI308_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PCBP2 poly(rC) binding protein 2 0.0893751
FN1 fibronectin 1 0.0834359
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0638667
IFI6 interferon, alpha-inducible protein 6 0.0401445
LDHA lactate dehydrogenase A 0.0397893
SOD2 superoxide dismutase 2, mitochondrial 0.0382951
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0368788
ENO1 enolase 1, (alpha) 0.0344526
RPS12 ribosomal protein S12 0.03425
AHNAK AHNAK nucleoprotein 0.0322791
B2M beta-2-microglobulin 0.031683
LOX lysyl oxidase 0.0315771
IFI44L interferon-induced protein 44-like 0.0291013
ZSWIM6 zinc finger, SWIM-type containing 6 0.0282718
APLP2 amyloid beta (A4) precursor-like protein 2 0.027341
INTS6 integrator complex subunit 6 0.0269408
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0259494
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0255802
CA12 carbonic anhydrase XII 0.0254449
IFITM1 interferon induced transmembrane protein 1 0.024825
RPL4 ribosomal protein L4 0.0246539
SQSTM1 sequestosome 1 0.0246199
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0237713
NAP1L1 nucleosome assembly protein 1-like 1 0.0235292
PARP14 poly (ADP-ribose) polymerase family, member 14 0.023528
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0226761
IGFBP3 insulin-like growth factor binding protein 3 0.0224862
FAM20C family with sequence similarity 20, member C 0.02243
RNF213 ring finger protein 213 0.021964
HDAC9 histone deacetylase 9 0.0217814
DST dystonin 0.0216954
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0213158
RPL37A ribosomal protein L37a 0.0212365
HLA-E major histocompatibility complex, class I, E 0.0199884
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0197705
RPS8 ribosomal protein S8 0.0196696
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0195731
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0195132
AADAC arylacetamide deacetylase 0.0194489
SFTPA2 surfactant protein A2 0.0188004
RPS17 ribosomal protein S17 0.0184837
RPL31 ribosomal protein L31 0.0183497
RPS27 ribosomal protein S27 0.0182021
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0176143
ANGPTL4 angiopoietin-like 4 0.0174743
RPL3 ribosomal protein L3 0.0171653
PLIN2 perilipin 2 0.0170975
CUX1 cut-like homeobox 1 0.0167756
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0166541
KTN1 kinectin 1 (kinesin receptor) 0.0164468
C1R complement component 1, r subcomponent 0.0164087
PTPRB protein tyrosine phosphatase, receptor type, B 0.0159877
FBN1 fibrillin 1 0.0159307
TGFB1 transforming growth factor, beta 1 0.0156368
EXT1 exostosin glycosyltransferase 1 0.0154775
RPS3 ribosomal protein S3 0.0153033
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0152624
JUN jun proto-oncogene 0.0151854
DDIT3 DNA-damage-inducible transcript 3 0.0151217
SOX9 SRY (sex determining region Y)-box 9 0.0150535
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0148106
FNIP1 folliculin interacting protein 1 0.0146914
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0146545
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0145645
PKM pyruvate kinase, muscle 0.014448
MX1 MX dynamin-like GTPase 1 0.0143991
ISG15 ISG15 ubiquitin-like modifier 0.0142763
SP100 SP100 nuclear antigen 0.0141523
SOS1 son of sevenless homolog 1 (Drosophila) 0.0139558
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0138499
RND3 Rho family GTPase 3 0.0137733
APP amyloid beta (A4) precursor protein 0.01372
RPL27 ribosomal protein L27 0.0136636
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0134652
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0134638
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0133636
NCOR2 nuclear receptor corepressor 2 0.0131504
GYS1 glycogen synthase 1 (muscle) 0.013036
SLIT2 slit homolog 2 (Drosophila) 0.0129843
NTN4 netrin 4 0.0129284
RASAL2 RAS protein activator like 2 0.012773
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0127694
UBC ubiquitin C 0.0127559
NAV2 neuron navigator 2 0.0126075
MX2 MX dynamin-like GTPase 2 0.0125867
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0124956
HLA-B major histocompatibility complex, class I, B 0.0124725
ASPH aspartate beta-hydroxylase 0.0123462
SRRM2 serine/arginine repetitive matrix 2 0.012086
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0120205
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0119111
RPL26 ribosomal protein L26 0.0118536
LRMDA leucine rich melanocyte differentiation associated 0.0113428
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0111484
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0110986
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0110728
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0110599
VEGFA vascular endothelial growth factor A 0.0110123
MYH9 myosin, heavy chain 9, non-muscle 0.0109578
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0109295

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.136292
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0726084
MT2A metallothionein 2A -0.0650996
TMSB10 thymosin beta 10 -0.0610212
EFNA5 ephrin-A5 -0.0605735
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0594256
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0573031
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0550132
STC1 stanniocalcin 1 -0.0517368
CD44 CD44 molecule (Indian blood group) -0.0482113
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0477081
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0441985
ELL2 elongation factor, RNA polymerase II, 2 -0.0431242
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0422619
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0405525
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0403335
NRP1 neuropilin 1 -0.0385918
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0379038
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0378026
GOLGA4 golgin A4 -0.037055
PDE4D phosphodiesterase 4D, cAMP-specific -0.0368225
ANTXR2 anthrax toxin receptor 2 -0.0361822
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.035168
RBM39 RNA binding motif protein 39 -0.0350985
BASP1 brain abundant, membrane attached signal protein 1 -0.0342062
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.033344
SDK1 sidekick cell adhesion molecule 1 -0.0333415
OSMR oncostatin M receptor -0.0324461
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0314256
SPRED2 sprouty-related, EVH1 domain containing 2 -0.028565
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0283626
NPC1 Niemann-Pick disease, type C1 -0.0282111
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0275186
ARHGAP5 Rho GTPase activating protein 5 -0.0252955
HMGA2 high mobility group AT-hook 2 -0.0248191
FBXL13 F-box and leucine-rich repeat protein 13 -0.0245797
AKAP13 A kinase (PRKA) anchor protein 13 -0.0244729
CDCP1 CUB domain containing protein 1 -0.0237862
DOCK5 dedicator of cytokinesis 5 -0.0237284
KDM2A lysine (K)-specific demethylase 2A -0.02334
TFPI2 tissue factor pathway inhibitor 2 -0.0229124
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0228692
ZMYND8 zinc finger, MYND-type containing 8 -0.0228128
RAB27B RAB27B, member RAS oncogene family -0.0227953
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0224652
TM4SF1 transmembrane 4 L six family member 1 -0.0217682
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0217439
RAP1B RAP1B, member of RAS oncogene family -0.0217355
KLF6 Kruppel-like factor 6 -0.0213319
CDH13 cadherin 13 -0.0212007
ZNF292 zinc finger protein 292 -0.021092
HAS2 hyaluronan synthase 2 -0.0210519
LMAN1 lectin, mannose-binding, 1 -0.0199827
OGA O-GlcNAcase -0.0187058
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0182788
PARD3 par-3 family cell polarity regulator -0.0181762
EIF1 eukaryotic translation initiation factor 1 -0.0178278
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.017723
GRB10 growth factor receptor-bound protein 10 -0.0177022
GLCCI1 glucocorticoid induced 1 -0.0175411
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0172625
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0167513
IER3 immediate early response 3 -0.0164606
YBX3 Y box binding protein 3 -0.0163064
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0162155
EREG epiregulin -0.0161534
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0161234
RIOK3 RIO kinase 3 -0.0160731
USP3 ubiquitin specific peptidase 3 -0.0159982
MSRB3 methionine sulfoxide reductase B3 -0.0157246
COG5 component of oligomeric golgi complex 5 -0.0156145
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0155871
FAM107B family with sequence similarity 107, member B -0.0154062
EMP1 epithelial membrane protein 1 -0.0153872
PCNX1 pecanex 1 -0.0153531
USP34 ubiquitin specific peptidase 34 -0.0151514
SRP54 signal recognition particle 54kDa -0.0151377
PTBP3 polypyrimidine tract binding protein 3 -0.0149602
TOP1 topoisomerase (DNA) I -0.0149267
LUZP1 leucine zipper protein 1 -0.0147245
SLC38A1 solute carrier family 38, member 1 -0.0147097
GCC2 GRIP and coiled-coil domain containing 2 -0.0146858
MTSS1 metastasis suppressor 1 -0.0146785
NUMB numb homolog (Drosophila) -0.0146135
CDK17 cyclin-dependent kinase 17 -0.0145807
BMAL2 basic helix-loop-helix ARNT like 2 -0.0145769
GPAT3 glycerol-3-phosphate acyltransferase 3 -0.0145664
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.014559
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0144804
RNF149 ring finger protein 149 -0.0142641
RPS21 ribosomal protein S21 -0.0140878
PRRC2C proline-rich coiled-coil 2C -0.0140857
KMT2E lysine (K)-specific methyltransferase 2E -0.0140754
KMT2C lysine (K)-specific methyltransferase 2C -0.0139905
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0138764
ANKRD28 ankyrin repeat domain 28 -0.0138761
DAAM1 dishevelled associated activator of morphogenesis 1 -0.013876
BIRC6 baculoviral IAP repeat containing 6 -0.0138102
AKAP12 A kinase (PRKA) anchor protein 12 -0.0134177
RUNX1 runt-related transcription factor 1 -0.013283