LJI308_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.173961
TXNRD1 thioredoxin reductase 1 0.160028
LMO7 LIM domain 7 0.153519
KRT17 keratin 17, type I 0.129753
TPT1 tumor protein, translationally-controlled 1 0.108381
DSCAM Down syndrome cell adhesion molecule 0.0928684
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0895742
PKM pyruvate kinase, muscle 0.0871049
LDHA lactate dehydrogenase A 0.0819095
RPS3 ribosomal protein S3 0.0815247
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0802961
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0778473
LAMB3 laminin, beta 3 0.0778404
RPS8 ribosomal protein S8 0.076917
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0768263
RPS12 ribosomal protein S12 0.0746759
RPS16 ribosomal protein S16 0.0715075
VIM vimentin 0.0704606
ACTG1 actin gamma 1 0.0699255
RPL37A ribosomal protein L37a 0.0676958
RPS19 ribosomal protein S19 0.0628742
SAMD4A sterile alpha motif domain containing 4A 0.0612945
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0611298
RPL23 ribosomal protein L23 0.0609019
TM4SF1 transmembrane 4 L six family member 1 0.0603752
AFF1 AF4/FMR2 family, member 1 0.0585713
POTEF POTE ankyrin domain family, member F 0.0578023
SQSTM1 sequestosome 1 0.0550407
ENO1 enolase 1, (alpha) 0.0544133
B2M beta-2-microglobulin 0.0520789
FN1 fibronectin 1 0.0512206
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0511863
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.050686
PTMA prothymosin, alpha 0.0501732
CANX calnexin 0.0500354
RPS5 ribosomal protein S5 0.0498781
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0494887
AKAP9 A kinase (PRKA) anchor protein 9 0.0488583
RPL4 ribosomal protein L4 0.0477871
NF1 neurofibromin 1 0.0477844
RPL19 ribosomal protein L19 0.0476579
HLA-B major histocompatibility complex, class I, B 0.0467731
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0462225
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.045537
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0448084
RPS6 ribosomal protein S6 0.0441866
NEBL nebulette 0.0435801
ANXA2 annexin A2 0.0430524
RPL11 ribosomal protein L11 0.0429239
ZSWIM6 zinc finger, SWIM-type containing 6 0.0421668
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0411199
BPTF bromodomain PHD finger transcription factor 0.0400592
KYNU kynureninase 0.0398175
FNDC3A fibronectin type III domain containing 3A 0.0398133
PNRC1 proline-rich nuclear receptor coactivator 1 0.0397964
EIF4A1 eukaryotic translation initiation factor 4A1 0.039377
RPL12 ribosomal protein L12 0.0381428
RPLP1 ribosomal protein, large, P1 0.0376895
MTUS1 microtubule associated tumor suppressor 1 0.0373842
RUNX1 runt-related transcription factor 1 0.0371152
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0369988
RPS13 ribosomal protein S13 0.036898
EEF2 eukaryotic translation elongation factor 2 0.0361949
CSDE1 cold shock domain containing E1, RNA-binding 0.0359002
CALR calreticulin 0.0353326
APLP2 amyloid beta (A4) precursor-like protein 2 0.0347029
RPL36 ribosomal protein L36 0.0346863
LAMC2 laminin, gamma 2 0.0342432
SMAD3 SMAD family member 3 0.0335212
RPL35A ribosomal protein L35a 0.0332481
RSF1 remodeling and spacing factor 1 0.0331616
HSPA8 heat shock 70kDa protein 8 0.0324331
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.032047
PTK2 protein tyrosine kinase 2 0.0320401
NAV2 neuron navigator 2 0.0318757
EIF1 eukaryotic translation initiation factor 1 0.0317578
SPAG9 sperm associated antigen 9 0.0309779
SP100 SP100 nuclear antigen 0.0301705
DSG2 desmoglein 2 0.0300027
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0299151
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0298087
RPL34 ribosomal protein L34 0.0296883
AEBP2 AE binding protein 2 0.0295654
ATP11A ATPase, class VI, type 11A 0.029514
FRK fyn-related Src family tyrosine kinase 0.0291774
KATNBL1 katanin p80 subunit B-like 1 0.0290457
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0288605
EGFR epidermal growth factor receptor 0.0284595
GOLGA4 golgin A4 0.0284248
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0281718
SMAD4 SMAD family member 4 0.0281097
ANKRD11 ankyrin repeat domain 11 0.0279866
RPL38 ribosomal protein L38 0.0279847
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.027945
HDAC9 histone deacetylase 9 0.0279217
S100A10 S100 calcium binding protein A10 0.0279115
RPS17 ribosomal protein S17 0.027288
CHD9 chromodomain helicase DNA binding protein 9 0.0271262
MBNL1 muscleblind-like splicing regulator 1 0.0270523
RPS27 ribosomal protein S27 0.0269562

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.104141
GRB10 growth factor receptor-bound protein 10 -0.0913263
MUC16 mucin 16, cell surface associated -0.0828241
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0701633
PTPRM protein tyrosine phosphatase, receptor type, M -0.0649817
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.060872
NEK7 NIMA-related kinase 7 -0.0579537
GPC6 glypican 6 -0.0564375
ASPH aspartate beta-hydroxylase -0.0550712
RAB8B RAB8B, member RAS oncogene family -0.0526196
RAI14 retinoic acid induced 14 -0.0476866
KDM6A lysine (K)-specific demethylase 6A -0.0465057
PTEN phosphatase and tensin homolog -0.0462815
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0456586
STRN3 striatin, calmodulin binding protein 3 -0.0449786
CSNK1A1 casein kinase 1, alpha 1 -0.0448743
THBS1 thrombospondin 1 -0.0444838
TSHZ2 teashirt zinc finger homeobox 2 -0.044418
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0442889
SRPK2 SRSF protein kinase 2 -0.0437415
ANTXR2 anthrax toxin receptor 2 -0.0430979
PDE4B phosphodiesterase 4B, cAMP-specific -0.0428068
ESYT2 extended synaptotagmin-like protein 2 -0.0426885
ABHD17C abhydrolase domain containing 17C -0.04265
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0412029
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.040894
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0403297
FOXO1 forkhead box O1 -0.0402161
IGF1R insulin-like growth factor 1 receptor -0.0399744
MACF1 microtubule-actin crosslinking factor 1 -0.0397489
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0393452
LGALS3 lectin, galactoside-binding, soluble, 3 -0.039262
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0390789
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.039054
DST dystonin -0.0378623
RIGI RNA sensor RIG-I -0.0377804
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0374434
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0374217
USP6NL USP6 N-terminal like -0.037333
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0372944
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0372154
QKI QKI, KH domain containing, RNA binding -0.036978
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0369216
YAP1 Yes-associated protein 1 -0.0365025
ZMYND8 zinc finger, MYND-type containing 8 -0.0364465
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0352877
ATXN1 ataxin 1 -0.0348161
SEPTIN2 septin 2 -0.0348083
SMC5 structural maintenance of chromosomes 5 -0.0347921
HMGA2 high mobility group AT-hook 2 -0.0346687
RAP1B RAP1B, member of RAS oncogene family -0.0346086
SLMAP sarcolemma associated protein -0.0341565
TNIK TRAF2 and NCK interacting kinase -0.0340216
NPTN neuroplastin -0.0339586
PRKCSH protein kinase C substrate 80K-H -0.0337911
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0337502
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0334045
EZR ezrin -0.0331412
TRIM33 tripartite motif containing 33 -0.0330432
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0325419
RNF145 ring finger protein 145 -0.0321423
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0320444
BIRC6 baculoviral IAP repeat containing 6 -0.0318307
UGCG UDP-glucose ceramide glucosyltransferase -0.0317086
CDK14 cyclin-dependent kinase 14 -0.0315914
LRMDA leucine rich melanocyte differentiation associated -0.0313615
ARHGAP12 Rho GTPase activating protein 12 -0.0311323
RORA RAR-related orphan receptor A -0.0311214
ABLIM1 actin binding LIM protein 1 -0.0309704
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0309681
MXD1 MAX dimerization protein 1 -0.0303424
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0301902
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0301728
STC1 stanniocalcin 1 -0.0301352
EGR1 early growth response 1 -0.0300919
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0299969
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0297461
RBM47 RNA binding motif protein 47 -0.0296201
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0295863
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0293075
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0292516
TMEM135 transmembrane protein 135 -0.0287424
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0285979
ZNF207 zinc finger protein 207 -0.0283848
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0283845
KDM1A lysine (K)-specific demethylase 1A -0.0283014
TSC22D2 TSC22 domain family, member 2 -0.0282746
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0281995
FOXP1 forkhead box P1 -0.0281486
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0280161
AFDN afadin, adherens junction formation factor -0.027954
PPARD peroxisome proliferator-activated receptor delta -0.0279506
CDH13 cadherin 13 -0.0278524
CLIP1 CAP-GLY domain containing linker protein 1 -0.02779
RC3H1 ring finger and CCCH-type domains 1 -0.0275093
NKD1 naked cuticle homolog 1 (Drosophila) -0.0273082
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0271491
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0270518
ITPRID2 ITPR interacting domain containing 2 -0.0269005
KDM5B lysine (K)-specific demethylase 5B -0.0268959