LJI308_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.149203
MCL1 myeloid cell leukemia 1 0.0997528
IFI6 interferon, alpha-inducible protein 6 0.0978542
RPS3 ribosomal protein S3 0.0954157
VIM vimentin 0.0797225
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0730466
RPS12 ribosomal protein S12 0.0723088
HLA-B major histocompatibility complex, class I, B 0.0710193
RPL37A ribosomal protein L37a 0.0623831
KTN1 kinectin 1 (kinesin receptor) 0.0603575
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.05871
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0510053
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0498815
RPL37 ribosomal protein L37 0.0490591
COPA coatomer protein complex, subunit alpha 0.0487067
SET SET nuclear proto-oncogene 0.0454012
VCL vinculin 0.0453962
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0444523
INTS6 integrator complex subunit 6 0.0435144
CALR calreticulin 0.0430858
XPOT exportin, tRNA 0.0410009
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0402463
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0373587
RPL4 ribosomal protein L4 0.0367629
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0362195
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0351489
AEBP2 AE binding protein 2 0.0349047
PRELID2 PRELI domain containing 2 0.034839
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0345373
SEC31A SEC31 homolog A (S. cerevisiae) 0.0342236
RPS17 ribosomal protein S17 0.0342046
RPS8 ribosomal protein S8 0.0338912
TPT1 tumor protein, translationally-controlled 1 0.0330482
RPS27 ribosomal protein S27 0.0328677
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0320356
PCBP2 poly(rC) binding protein 2 0.0319913
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0316055
RPL27 ribosomal protein L27 0.031458
CAMTA1 calmodulin binding transcription activator 1 0.0311382
RBM39 RNA binding motif protein 39 0.0309153
CANX calnexin 0.0307948
USP34 ubiquitin specific peptidase 34 0.0305163
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0292721
UBC ubiquitin C 0.0292346
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0291455
AHNAK AHNAK nucleoprotein 0.0288747
ANKRD11 ankyrin repeat domain 11 0.0285138
LOC102724023 ES1 protein homolog, mitochondrial 0.0282048
RAD51B RAD51 paralog B 0.028021
RPL31 ribosomal protein L31 0.0279405
HLA-A major histocompatibility complex, class I, A 0.0278792
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0274789
FBXO11 F-box protein 11 0.0272723
MORF4L2 mortality factor 4 like 2 0.0272294
NAP1L1 nucleosome assembly protein 1-like 1 0.0261825
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0259292
NFE2L1 nuclear factor, erythroid 2-like 1 0.0258464
ADAR adenosine deaminase, RNA-specific 0.0254639
MARS1 methionyl-tRNA synthetase 1 0.0253772
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0252971
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.025227
IARS1 isoleucyl-tRNA synthetase 1 0.0251785
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0251499
TPM3 tropomyosin 3 0.0251292
ENO1 enolase 1, (alpha) 0.0250969
UBE2H ubiquitin-conjugating enzyme E2H 0.0247341
HYOU1 hypoxia up-regulated 1 0.0244787
PYGL phosphorylase, glycogen, liver 0.0243345
RPL11 ribosomal protein L11 0.0241893
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0241569
SFTPA2 surfactant protein A2 0.0238472
ZNF207 zinc finger protein 207 0.0237908
HDGF hepatoma-derived growth factor 0.0237484
EIF1 eukaryotic translation initiation factor 1 0.023672
FTL ferritin, light polypeptide 0.0236077
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0233513
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0232965
MYH9 myosin, heavy chain 9, non-muscle 0.0232214
WSB1 WD repeat and SOCS box containing 1 0.022684
DDIT3 DNA-damage-inducible transcript 3 0.0226568
HLA-E major histocompatibility complex, class I, E 0.0226472
FDPS farnesyl diphosphate synthase 0.0224258
HDAC8 histone deacetylase 8 0.0223752
RPS19 ribosomal protein S19 0.0223385
AKAP9 A kinase (PRKA) anchor protein 9 0.0222451
RNF213 ring finger protein 213 0.0221193
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0219313
SSR1 signal sequence receptor, alpha 0.0219284
SQSTM1 sequestosome 1 0.0214747
WWOX WW domain containing oxidoreductase 0.0213339
APLP2 amyloid beta (A4) precursor-like protein 2 0.0213238
BRD2 bromodomain containing 2 0.021249
DSPP dentin sialophosphoprotein 0.0212134
RPL26 ribosomal protein L26 0.0210009
RPS13 ribosomal protein S13 0.0209654
GOLGB1 golgin B1 0.0208946
CARS1 cysteinyl-tRNA synthetase 1 0.0208785
PGM3 phosphoglucomutase 3 0.0205599
RPL3 ribosomal protein L3 0.0205478
RACK1 receptor for activated C kinase 1 0.0203579

decreased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 -0.170426
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119578
TXNRD1 thioredoxin reductase 1 -0.0903352
TRIO trio Rho guanine nucleotide exchange factor -0.0416307
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0409968
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0407365
PHIP pleckstrin homology domain interacting protein -0.0396469
PFN1 profilin 1 -0.0381771
YBX3 Y box binding protein 3 -0.0375721
MYL12B myosin, light chain 12B, regulatory -0.0368953
TM4SF1 transmembrane 4 L six family member 1 -0.0357001
MARCHF4 membrane associated ring-CH-type finger 4 -0.0356503
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0355385
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0354393
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0336269
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0319679
RPS21 ribosomal protein S21 -0.0313956
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0305868
SMC4 structural maintenance of chromosomes 4 -0.0298031
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0297076
ANO6 anoctamin 6 -0.0296916
GPHN gephyrin -0.0291193
RRM2 ribonucleotide reductase M2 -0.0283587
MATR3 matrin 3 -0.0276414
RPS15 ribosomal protein S15 -0.0274701
RPL8 ribosomal protein L8 -0.0264797
NIPBL Nipped-B homolog (Drosophila) -0.0263222
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0261323
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.025456
PDE4D phosphodiesterase 4D, cAMP-specific -0.0246369
RUSC2 RUN and SH3 domain containing 2 -0.0246121
CBX3 chromobox homolog 3 -0.0245322
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0243883
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0242027
PCNX1 pecanex 1 -0.0240268
SCAF11 SR-related CTD-associated factor 11 -0.0239688
MKI67 marker of proliferation Ki-67 -0.0238168
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0236153
CENPF centromere protein F, 350/400kDa -0.0231526
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0230728
ANKRD12 ankyrin repeat domain 12 -0.0229745
BMAL2 basic helix-loop-helix ARNT like 2 -0.0228061
EGR1 early growth response 1 -0.0227396
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0224998
DIAPH3 diaphanous-related formin 3 -0.0224623
HSPH1 heat shock 105kDa/110kDa protein 1 -0.022197
ATP5F1B ATP synthase F1 subunit beta -0.0219447
RPLP1 ribosomal protein, large, P1 -0.0219125
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0218273
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0213537
BRWD3 bromodomain and WD repeat domain containing 3 -0.0210414
GLO1 glyoxalase I -0.0210106
RASAL2 RAS protein activator like 2 -0.0207478
PRRC2C proline-rich coiled-coil 2C -0.0202592
RPL32 ribosomal protein L32 -0.0200913
SEPTIN7 septin 7 -0.0190622
RTN4 reticulon 4 -0.0189686
BASP1 brain abundant, membrane attached signal protein 1 -0.0188765
FUS FUS RNA binding protein -0.0188237
EML4 echinoderm microtubule associated protein like 4 -0.018751
ATP11A ATPase, class VI, type 11A -0.0183635
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0182122
ANKRD28 ankyrin repeat domain 28 -0.018176
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0181536
IGF1R insulin-like growth factor 1 receptor -0.0179221
IGF2 insulin-like growth factor 2 -0.0178787
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0177748
MTPN myotrophin -0.017651
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0176373
MT1X metallothionein 1X -0.0175776
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0174953
ACTN1 actinin, alpha 1 -0.0173885
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0173676
ABI2 abl-interactor 2 -0.0172461
AKAP12 A kinase (PRKA) anchor protein 12 -0.0171645
KLF6 Kruppel-like factor 6 -0.0170717
SRRM1 serine/arginine repetitive matrix 1 -0.0170551
SBF2 SET binding factor 2 -0.0169654
PALS2 protein associated with LIN7 2, MAGUK p55 family member -0.0168097
SINHCAF SIN3-HDAC complex associated factor -0.0167172
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0166827
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0166826
MIS18BP1 MIS18 binding protein 1 -0.0166584
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0166151
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) -0.0166136
KMT2A lysine (K)-specific methyltransferase 2A -0.0164486
GRAMD1B GRAM domain containing 1B -0.016046
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0159932
STC1 stanniocalcin 1 -0.0158261
XPO1 exportin 1 -0.0158144
RICTOR RPTOR independent companion of MTOR, complex 2 -0.015807
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0157637
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0157153
WBP11 WW domain binding protein 11 -0.015622
SGO2 shugoshin 2 -0.0155876
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) -0.0154807
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 -0.0153627
CHD1 chromodomain helicase DNA binding protein 1 -0.0153277
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0153133
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0152962