LJI308_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.288485
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.231742
PTMA prothymosin, alpha 0.171021
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.140371
PABPC1 poly(A) binding protein, cytoplasmic 1 0.119531
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.103488
MT2A metallothionein 2A 0.101877
LAMB3 laminin, beta 3 0.099094
EIF1 eukaryotic translation initiation factor 1 0.0951595
AHNAK AHNAK nucleoprotein 0.0915521
ACTG1 actin gamma 1 0.0886559
RPS3 ribosomal protein S3 0.0863752
TPT1 tumor protein, translationally-controlled 1 0.0844141
RPL37A ribosomal protein L37a 0.0821007
RPS8 ribosomal protein S8 0.080612
RPL35A ribosomal protein L35a 0.0774023
SQSTM1 sequestosome 1 0.0750022
RPS12 ribosomal protein S12 0.0747778
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0721198
HLA-B major histocompatibility complex, class I, B 0.0702253
IFI27 interferon, alpha-inducible protein 27 0.0699955
RPS6 ribosomal protein S6 0.0688289
IFI6 interferon, alpha-inducible protein 6 0.0682953
CANX calnexin 0.0681733
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0666628
RPL23 ribosomal protein L23 0.0658809
CALR calreticulin 0.0633048
ISG15 ISG15 ubiquitin-like modifier 0.0622716
LAMC2 laminin, gamma 2 0.0622503
APLP2 amyloid beta (A4) precursor-like protein 2 0.061869
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0612728
G0S2 G0/G1 switch 2 0.0573726
LDHA lactate dehydrogenase A 0.0569917
ZSWIM6 zinc finger, SWIM-type containing 6 0.0568656
HLA-A major histocompatibility complex, class I, A 0.0568234
RPLP1 ribosomal protein, large, P1 0.0565468
RPLP2 ribosomal protein, large, P2 0.0565153
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0561858
UPP1 uridine phosphorylase 1 0.0549614
MAP1B microtubule-associated protein 1B 0.0543599
RPS13 ribosomal protein S13 0.0537765
RACK1 receptor for activated C kinase 1 0.0536738
SDC4 syndecan 4 0.053431
NAP1L1 nucleosome assembly protein 1-like 1 0.0527514
NDRG1 N-myc downstream regulated 1 0.0522972
ENO1 enolase 1, (alpha) 0.052124
RPL37 ribosomal protein L37 0.0516359
RPL9 ribosomal protein L9 0.051463
RPS29 ribosomal protein S29 0.0513748
RPS17 ribosomal protein S17 0.051194
RPS27A ribosomal protein S27a 0.0501117
RPL4 ribosomal protein L4 0.0499024
RBM25 RNA binding motif protein 25 0.0485104
VIM vimentin 0.0477703
PRRC2C proline-rich coiled-coil 2C 0.0474956
RPL31 ribosomal protein L31 0.0474338
RPS19 ribosomal protein S19 0.0466829
TMSB10 thymosin beta 10 0.0465838
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0458542
RPS25 ribosomal protein S25 0.0457885
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.045554
HMGB2 high mobility group box 2 0.0453378
RPS27 ribosomal protein S27 0.0448223
RPL12 ribosomal protein L12 0.0446655
PLEC plectin 0.0440327
H3-3B H3.3 histone B 0.0438881
UBC ubiquitin C 0.0428334
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.042714
TUFT1 tuftelin 1 0.0419707
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0418357
RPL5 ribosomal protein L5 0.0415438
B2M beta-2-microglobulin 0.0409301
RPL15 ribosomal protein L15 0.040611
KTN1 kinectin 1 (kinesin receptor) 0.0401866
CD63 CD63 molecule 0.0399696
RPL27 ribosomal protein L27 0.039498
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0387476
RPS14 ribosomal protein S14 0.0387372
RPL26 ribosomal protein L26 0.0386702
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0385037
SLC38A1 solute carrier family 38, member 1 0.0381805
RPS16 ribosomal protein S16 0.0381012
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0377422
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0377229
IFITM3 interferon induced transmembrane protein 3 0.0377009
CSTB cystatin B (stefin B) 0.0373366
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0370573
RPL13A ribosomal protein L13a 0.0368737
RPL11 ribosomal protein L11 0.0367692
BHLHE40 basic helix-loop-helix family, member e40 0.0366143
DSPP dentin sialophosphoprotein 0.0363682
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0362126
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0362031
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0360872
PCBP2 poly(rC) binding protein 2 0.0360397
RPL8 ribosomal protein L8 0.0357519
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.035019
EEF2 eukaryotic translation elongation factor 2 0.034366
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0337865
RPS23 ribosomal protein S23 0.0334189

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0843056
LPP LIM domain containing preferred translocation partner in lipoma -0.056617
EFNA5 ephrin-A5 -0.053176
TRIO trio Rho guanine nucleotide exchange factor -0.0497217
LIMCH1 LIM and calponin homology domains 1 -0.039544
ARRDC3 arrestin domain containing 3 -0.0360449
MAML2 mastermind-like 2 (Drosophila) -0.0295041
RUNX1 runt-related transcription factor 1 -0.0284541
SACK1A scaffolding CK1 anchoring protein A -0.0283394
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.027829
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.027772
LMO7 LIM domain 7 -0.0253977
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0253833
SAMD4A sterile alpha motif domain containing 4A -0.0242046
CD2AP CD2-associated protein -0.0232836
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0229888
ASPH aspartate beta-hydroxylase -0.0227142
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0226428
TSC22D2 TSC22 domain family, member 2 -0.0222054
ANTXR2 anthrax toxin receptor 2 -0.0217521
OSMR oncostatin M receptor -0.0217
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0207649
FAM3C family with sequence similarity 3, member C -0.0206288
ITCH itchy E3 ubiquitin protein ligase -0.0202504
CCND1 cyclin D1 -0.0189111
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.018637
TMSB4X thymosin beta 4, X-linked -0.0177279
ARHGAP29 Rho GTPase activating protein 29 -0.0175756
MRPS6 mitochondrial ribosomal protein S6 -0.0175332
F3 coagulation factor III (thromboplastin, tissue factor) -0.017479
ATXN1 ataxin 1 -0.0174012
STRN3 striatin, calmodulin binding protein 3 -0.0173636
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0172013
GSK3B glycogen synthase kinase 3 beta -0.0168264
ATP11A ATPase, class VI, type 11A -0.0163618
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0162907
FRMD5 FERM domain containing 5 -0.0162039
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0160168
MCTP2 multiple C2 domains, transmembrane 2 -0.0159358
CDCP1 CUB domain containing protein 1 -0.0155713
TMEM165 transmembrane protein 165 -0.0148223
SVIL supervillin -0.014774
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0142704
CREB3L2 cAMP responsive element binding protein 3-like 2 -0.0142201
ITGA1 integrin, alpha 1 -0.0136716
CAB39 calcium binding protein 39 -0.0135967
FER fer (fps/fes related) tyrosine kinase -0.0132738
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0125378
NRIP1 nuclear receptor interacting protein 1 -0.0124441
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0123674
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0122688
LOXL2 lysyl oxidase-like 2 -0.0122211
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0121946
NAV2 neuron navigator 2 -0.0120853
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0120844
NF1 neurofibromin 1 -0.0120835
ETV6 ets variant 6 -0.01196
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0119344
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0117678
ARHGAP10 Rho GTPase activating protein 10 -0.0117603
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0116642
SBF2 SET binding factor 2 -0.0113536
ARF1 ADP-ribosylation factor 1 -0.0113438
ADGRF1 adhesion G protein-coupled receptor F1 -0.0113344
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0112911
EXOC6B exocyst complex component 6B -0.011164
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0111418
SFTPA1 surfactant protein A1 -0.0111316
ADNP activity-dependent neuroprotector homeobox -0.011127
S100A4 S100 calcium binding protein A4 -0.010984
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0109532
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0109343
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0108322
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0106685
RASAL2 RAS protein activator like 2 -0.0105094
TSPAN5 tetraspanin 5 -0.0103278
ANO6 anoctamin 6 -0.0102735
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0101084
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0100513
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0100497
LMAN1 lectin, mannose-binding, 1 -0.010012
ADAM19 ADAM metallopeptidase domain 19 -0.00998807
TRAM1 translocation associated membrane protein 1 -0.00987393
ADGRG6 adhesion G protein-coupled receptor G6 -0.00976709
KLF7 Kruppel-like factor 7 (ubiquitous) -0.00965977
PATJ PATJ crumbs cell polarity complex component -0.00961351
PRKCA protein kinase C, alpha -0.00955466
MTUS1 microtubule associated tumor suppressor 1 -0.00950619
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) -0.00947023
ZBTB20 zinc finger and BTB domain containing 20 -0.00941701
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0094032
AK1 adenylate kinase 1 -0.00932071
CD47 CD47 molecule -0.00923363
MYOF myoferlin -0.00923014
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.00912856
EGFR epidermal growth factor receptor -0.00909502
PRRC1 proline-rich coiled-coil 1 -0.00890762
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.00887894
VCL vinculin -0.0088772
NBAS neuroblastoma amplified sequence -0.00886747