LJI308_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.120442
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0956259
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.094411
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0941158
TM4SF1 transmembrane 4 L six family member 1 0.0929217
PTMA prothymosin, alpha 0.0926021
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0918658
TPT1 tumor protein, translationally-controlled 1 0.0799323
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.075618
CANX calnexin 0.0693669
GDA guanine deaminase 0.0693126
ENO1 enolase 1, (alpha) 0.0692257
TXNRD1 thioredoxin reductase 1 0.0688112
FTL ferritin, light polypeptide 0.064606
RPLP1 ribosomal protein, large, P1 0.0628908
RPS12 ribosomal protein S12 0.0619397
COL8A1 collagen, type VIII, alpha 1 0.0617852
RPL4 ribosomal protein L4 0.0592354
LDHA lactate dehydrogenase A 0.0591804
RPS8 ribosomal protein S8 0.0591533
RPL23 ribosomal protein L23 0.0580871
PGK1 phosphoglycerate kinase 1 0.0574028
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0570204
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0535061
BZW1 basic leucine zipper and W2 domains 1 0.052689
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0521007
GRAMD1B GRAM domain containing 1B 0.0519447
MT2A metallothionein 2A 0.0516602
EZR ezrin 0.04994
RPL31 ribosomal protein L31 0.0496746
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0496318
RPL26 ribosomal protein L26 0.0487658
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0486578
AHNAK AHNAK nucleoprotein 0.0481546
EIF1 eukaryotic translation initiation factor 1 0.0475506
RPL12 ribosomal protein L12 0.0473703
B2M beta-2-microglobulin 0.0445739
ASPH aspartate beta-hydroxylase 0.044524
RPL37A ribosomal protein L37a 0.0439075
TFPI2 tissue factor pathway inhibitor 2 0.0430993
TBXT T-box transcription factor T 0.0429325
RPS3 ribosomal protein S3 0.0428309
PM20D1 peptidase M20 domain containing 1 0.0422402
NAMPT nicotinamide phosphoribosyltransferase 0.0419327
RPS19 ribosomal protein S19 0.0405231
HLA-B major histocompatibility complex, class I, B 0.0404054
ITPRID2 ITPR interacting domain containing 2 0.0399578
RPS27 ribosomal protein S27 0.0394679
PCBP2 poly(rC) binding protein 2 0.038759
WARS1 tryptophanyl-tRNA synthetase 1 0.0375848
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0374416
MCL1 myeloid cell leukemia 1 0.0365957
RPL13A ribosomal protein L13a 0.0359228
RPS27A ribosomal protein S27a 0.0357514
UBC ubiquitin C 0.0356302
ZEB2 zinc finger E-box binding homeobox 2 0.0352874
CALR calreticulin 0.034125
RPL27 ribosomal protein L27 0.0341063
SQSTM1 sequestosome 1 0.0340806
SPAG9 sperm associated antigen 9 0.0338231
SMYD3 SET and MYND domain containing 3 0.0335162
RPS24 ribosomal protein S24 0.0329769
NAP1L1 nucleosome assembly protein 1-like 1 0.0329342
CENPF centromere protein F, 350/400kDa 0.0322874
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0321875
KYNU kynureninase 0.0320387
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0319347
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0317205
RPS16 ribosomal protein S16 0.031303
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0309728
ACTG1 actin gamma 1 0.030709
IFIH1 interferon induced with helicase C domain 1 0.0299632
TGFBR1 transforming growth factor, beta receptor 1 0.0299062
RPL36A ribosomal protein L36a 0.0298885
APP amyloid beta (A4) precursor protein 0.0289033
RPS14 ribosomal protein S14 0.02877
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0287499
RPL3 ribosomal protein L3 0.0285067
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0285015
MKI67 marker of proliferation Ki-67 0.0282966
SFTPA2 surfactant protein A2 0.0281146
KRT19 keratin 19, type I 0.0277639
FNDC3A fibronectin type III domain containing 3A 0.0277359
RPL9 ribosomal protein L9 0.0276848
PDLIM5 PDZ and LIM domain 5 0.0275996
RBM39 RNA binding motif protein 39 0.0275185
IQGAP1 IQ motif containing GTPase activating protein 1 0.0270062
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0269207
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0266094
RPLP0 ribosomal protein, large, P0 0.0256481
BMERB1 bMERB domain containing 1 0.0256307
NCOA7 nuclear receptor coactivator 7 0.0255818
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0255778
OASL 2'-5'-oligoadenylate synthetase-like 0.025343
IGF1R insulin-like growth factor 1 receptor 0.0253389
SOX4 SRY (sex determining region Y)-box 4 0.0252085
KDM3A lysine (K)-specific demethylase 3A 0.0251786
RPL35A ribosomal protein L35a 0.0251301
CXCL8 chemokine (C-X-C motif) ligand 8 0.0248803
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0248325

decreased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 -0.0766586
EFNA5 ephrin-A5 -0.0731015
IGFBP3 insulin-like growth factor binding protein 3 -0.0633625
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0579572
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0556461
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.049214
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0464678
COL5A2 collagen, type V, alpha 2 -0.0408407
PRKN parkin RBR E3 ubiquitin protein ligase -0.0402814
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0342552
AUTS2 autism susceptibility candidate 2 -0.0331023
FN1 fibronectin 1 -0.0305382
LSAMP limbic system-associated membrane protein -0.0284666
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0282461
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0273424
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0270344
MARCHF1 membrane associated ring-CH-type finger 1 -0.0262899
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0257199
NRCAM neuronal cell adhesion molecule -0.0251111
LIMCH1 LIM and calponin homology domains 1 -0.0245154
PTEN phosphatase and tensin homolog -0.0238727
MBD5 methyl-CpG binding domain protein 5 -0.0232528
KMT2E lysine (K)-specific methyltransferase 2E -0.0226457
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0224669
DENND1A DENN/MADD domain containing 1A -0.0223943
EGR1 early growth response 1 -0.0223002
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0221435
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0220965
DNER delta/notch-like EGF repeat containing -0.02183
RNF145 ring finger protein 145 -0.0215705
MAML3 mastermind-like 3 (Drosophila) -0.0208812
TMEM144 transmembrane protein 144 -0.0208219
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0207927
NHSL1 NHS-like 1 -0.0198009
LAMA5 laminin, alpha 5 -0.0193047
COL4A5 collagen, type IV, alpha 5 -0.0192897
RAD51B RAD51 paralog B -0.0191628
PDIA3 protein disulfide isomerase family A, member 3 -0.019077
NBEAL1 neurobeachin-like 1 -0.0181732
EPHA4 EPH receptor A4 -0.0180911
CHD1 chromodomain helicase DNA binding protein 1 -0.0180826
HELZ helicase with zinc finger -0.0178586
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0175888
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.017557
HDAC4 histone deacetylase 4 -0.0175333
PLCB4 phospholipase C, beta 4 -0.0175026
NCOR2 nuclear receptor corepressor 2 -0.0174735
MYO9A myosin IXA -0.0166115
SDCCAG8 serologically defined colon cancer antigen 8 -0.0166102
IL1RAP interleukin 1 receptor accessory protein -0.0161933
CADM2 cell adhesion molecule 2 -0.0160421
GLIS3 GLIS family zinc finger 3 -0.0159958
PTPRD protein tyrosine phosphatase, receptor type, D -0.0159279
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0158096
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0157215
NPAS2 neuronal PAS domain protein 2 -0.0154041
NCKAP5 NCK-associated protein 5 -0.0153382
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0151483
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0149799
SOX6 SRY (sex determining region Y)-box 6 -0.0149339
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0144536
PFN1 profilin 1 -0.0142187
WWTR1 WW domain containing transcription regulator 1 -0.0142126
DOCK7 dedicator of cytokinesis 7 -0.0140751
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit -0.0140681
EYA4 EYA transcriptional coactivator and phosphatase 4 -0.0139485
MYOF myoferlin -0.0138242
LAMB1 laminin, beta 1 -0.0137067
USP34 ubiquitin specific peptidase 34 -0.0135751
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0132573
CA12 carbonic anhydrase XII -0.0132312
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0132063
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 -0.0130392
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0129426
VCL vinculin -0.0128891
ITPK1 inositol-tetrakisphosphate 1-kinase -0.0128573
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.01257
FLRT2 fibronectin leucine rich transmembrane protein 2 -0.0125588
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.012555
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) -0.0123987
CEP170 centrosomal protein 170kDa -0.0122505
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0121707
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0121618
TNRC6C trinucleotide repeat containing 6C -0.0120167
KDM4C lysine (K)-specific demethylase 4C -0.0118881
DPY19L1 dpy-19-like 1 (C. elegans) -0.0117792
TMEM178B transmembrane protein 178B -0.0117726
DTNA dystrobrevin, alpha -0.011637
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0116064
MCTP1 multiple C2 domains, transmembrane 1 -0.0115875
MSN moesin -0.0115709
LAMB4 laminin, beta 4 -0.0115558
CTSC cathepsin C -0.0115523
PCDH9 protocadherin 9 -0.01143
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0114234
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0113683
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0113258
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0113037
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0112571
CHD1L chromodomain helicase DNA binding protein 1-like -0.0112313