LJI308_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

196 genes differentially expressed following the LJI308_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.200354
VIM vimentin 0.200314
AKAP12 A kinase (PRKA) anchor protein 12 0.180611
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.165051
FTL ferritin, light polypeptide 0.114013
RPS16 ribosomal protein S16 0.11091
ENO1 enolase 1, (alpha) 0.107188
RPS6 ribosomal protein S6 0.103969
TPT1 tumor protein, translationally-controlled 1 0.102057
RPL12 ribosomal protein L12 0.0980045
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0974886
RPS19 ribosomal protein S19 0.0964648
RPL4 ribosomal protein L4 0.0937291
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0933222
B2M beta-2-microglobulin 0.0862757
TMSB10 thymosin beta 10 0.0854951
PKM pyruvate kinase, muscle 0.0753503
RPL35A ribosomal protein L35a 0.0751266
RPS8 ribosomal protein S8 0.0737588
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0661835
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0647651
RPS12 ribosomal protein S12 0.063165
FN1 fibronectin 1 0.05946
PGK1 phosphoglycerate kinase 1 0.0587285
EIF1 eukaryotic translation initiation factor 1 0.0586179
ANXA2 annexin A2 0.0575184
ACTG1 actin gamma 1 0.0568039
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0552313
RPLP2 ribosomal protein, large, P2 0.0547568
RPS3 ribosomal protein S3 0.052651
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0517773
LDHA lactate dehydrogenase A 0.0515048
MT2A metallothionein 2A 0.0503542
RPLP1 ribosomal protein, large, P1 0.0494116
AHNAK AHNAK nucleoprotein 0.0487723
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0477495
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0466745
LPP LIM domain containing preferred translocation partner in lipoma 0.0429999
GOLGA4 golgin A4 0.0399742
DDIT4 DNA-damage-inducible transcript 4 0.0390525
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0384881
KPNB1 karyopherin (importin) beta 1 0.0382256
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0368238
JMJD1C jumonji domain containing 1C 0.0363912
UBE2H ubiquitin-conjugating enzyme E2H 0.0349152
FNDC3A fibronectin type III domain containing 3A 0.0344029
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0336645
SRRM2 serine/arginine repetitive matrix 2 0.032744
RPS14 ribosomal protein S14 0.0323698
ITCH itchy E3 ubiquitin protein ligase 0.0313456
LMO7 LIM domain 7 0.0297135
DSCAM Down syndrome cell adhesion molecule 0.0296804
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0292277
TRIO trio Rho guanine nucleotide exchange factor 0.0282238
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.027918
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0264186
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0226535
SBF2 SET binding factor 2 0.0223981
RPL36 ribosomal protein L36 0.0218879
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0213245
ITPRID2 ITPR interacting domain containing 2 0.0212104
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0206576
PCBP2 poly(rC) binding protein 2 0.0200332
TPM4 tropomyosin 4 0.0194609
DOCK4 dedicator of cytokinesis 4 0.0194491
DST dystonin 0.0191561
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0188664
RPL37A ribosomal protein L37a 0.017474
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0167113
IQGAP1 IQ motif containing GTPase activating protein 1 0.0165943
LOC112694756 uncharaterized LOC112694756 0.0164827
MYL12B myosin, light chain 12B, regulatory 0.0151858
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0150188
MYO1E myosin IE 0.0147152
AEBP2 AE binding protein 2 0.0143635
SPAG9 sperm associated antigen 9 0.0137843
CCNI cyclin I 0.0125677
ZFAND3 zinc finger, AN1-type domain 3 0.0119866
SEPTIN9 septin 9 0.00940117
ZNF292 zinc finger protein 292 0.00907953
EPCAM epithelial cell adhesion molecule 0.00904812
ALCAM activated leukocyte cell adhesion molecule 0.00686562
KDM4C lysine (K)-specific demethylase 4C 0.00681883
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.00665016
PICALM phosphatidylinositol binding clathrin assembly protein 0.00648182
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.00534897
CALU calumenin 0.00522243
HSPA8 heat shock 70kDa protein 8 0.00505089
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.00476807
MYOF myoferlin 0.00382734
EEF2 eukaryotic translation elongation factor 2 0.00344374
EXT1 exostosin glycosyltransferase 1 0.00321744
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.00278884
KLF5 Kruppel-like factor 5 (intestinal) 0.0024846
HDAC9 histone deacetylase 9 3.52181E-4
VCL vinculin 3.23009E-4

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.235432
NKD1 naked cuticle homolog 1 (Drosophila) -0.146205
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.142316
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.117402
RABGAP1L RAB GTPase activating protein 1-like -0.0997061
MAML2 mastermind-like 2 (Drosophila) -0.0923711
NAV2 neuron navigator 2 -0.0900165
SYT1 synaptotagmin I -0.089132
CMIP c-Maf inducing protein -0.0818227
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0760632
ZBTB20 zinc finger and BTB domain containing 20 -0.0755028
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0747963
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.074668
TENM3 teneurin transmembrane protein 3 -0.0734353
GMDS GDP-mannose 4,6-dehydratase -0.072518
AKAP9 A kinase (PRKA) anchor protein 9 -0.0702105
TBC1D22A TBC1 domain family, member 22A -0.0667066
PTPRM protein tyrosine phosphatase, receptor type, M -0.0663579
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0647846
CARD16 caspase recruitment domain family, member 16 -0.0639851
EGR1 early growth response 1 -0.063833
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0624153
MBD5 methyl-CpG binding domain protein 5 -0.06085
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0576791
SLC38A2 solute carrier family 38, member 2 -0.0566156
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0564034
EFNA5 ephrin-A5 -0.0551623
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0521128
HELZ helicase with zinc finger -0.0512953
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0506565
INTS6 integrator complex subunit 6 -0.0499945
KMT2C lysine (K)-specific methyltransferase 2C -0.0484747
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0445411
NCOR1 nuclear receptor corepressor 1 -0.0400788
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0394924
DLG1 discs, large homolog 1 (Drosophila) -0.0378874
THSD4 thrombospondin, type I, domain containing 4 -0.037792
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0375981
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0359908
IGFBP3 insulin-like growth factor binding protein 3 -0.0350346
FNIP1 folliculin interacting protein 1 -0.0344339
RBM25 RNA binding motif protein 25 -0.0336022
PSD3 pleckstrin and Sec7 domain containing 3 -0.0334811
PARD3 par-3 family cell polarity regulator -0.0334255
SMYD3 SET and MYND domain containing 3 -0.0329712
VMP1 vacuole membrane protein 1 -0.0329474
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0328638
RTN4 reticulon 4 -0.0327388
PTK2 protein tyrosine kinase 2 -0.0326162
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0324893
PRKCA protein kinase C, alpha -0.0312296
ATXN2 ataxin 2 -0.0311243
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0294177
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0285616
EML4 echinoderm microtubule associated protein like 4 -0.02788
FHIT fragile histidine triad -0.0272846
KTN1 kinectin 1 (kinesin receptor) -0.0268405
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0268042
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0265539
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0260995
FTH1 ferritin, heavy polypeptide 1 -0.0253662
TRIP12 thyroid hormone receptor interactor 12 -0.0248724
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0248558
NF1 neurofibromin 1 -0.0246115
HDLBP high density lipoprotein binding protein -0.0244307
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0243152
DGKH diacylglycerol kinase, eta -0.0237804
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0225261
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0222324
ZNF638 zinc finger protein 638 -0.0221784
PTBP2 polypyrimidine tract binding protein 2 -0.0214101
PDE10A phosphodiesterase 10A -0.0192975
TJP1 tight junction protein 1 -0.0186655
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0181106
AKAP13 A kinase (PRKA) anchor protein 13 -0.0175479
FLNB filamin B, beta -0.0172516
PDGFC platelet derived growth factor C -0.0162639
NAP1L1 nucleosome assembly protein 1-like 1 -0.0158888
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0151966
RPS20 ribosomal protein S20 -0.0147912
ASPH aspartate beta-hydroxylase -0.0144586
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0142174
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0130651
DOCK5 dedicator of cytokinesis 5 -0.0126986
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0115074
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.010662
ARB2A ARB2 cotranscriptional regulator A -0.010591
GIGYF2 GRB10 interacting GYF protein 2 -0.00792321
MORF4L2 mortality factor 4 like 2 -0.00764974
YTHDF2 YTH N(6)-methyladenosine RNA binding protein 2 -0.00756278
FNDC3B fibronectin type III domain containing 3B -0.00601403
ELL2 elongation factor, RNA polymerase II, 2 -0.00582975
PDE4D phosphodiesterase 4D, cAMP-specific -0.00540648
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.00445024
TRAF3 TNF receptor-associated factor 3 -0.00434061
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.00429713
LAMB3 laminin, beta 3 -0.00375813
MBNL1 muscleblind-like splicing regulator 1 -0.00343665
TBC1D5 TBC1 domain family, member 5 -0.00339971
KDM2A lysine (K)-specific demethylase 2A -0.00332668