LJI308_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.146224
FTL ferritin, light polypeptide 0.115416
RPS12 ribosomal protein S12 0.114424
SOD2 superoxide dismutase 2, mitochondrial 0.104507
HLA-B major histocompatibility complex, class I, B 0.104114
ADM adrenomedullin 0.0968386
UGCG UDP-glucose ceramide glucosyltransferase 0.0929405
RPL37A ribosomal protein L37a 0.0809684
IER3 immediate early response 3 0.0807866
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0791407
B2M beta-2-microglobulin 0.0759742
MT2A metallothionein 2A 0.0709983
CADM1 cell adhesion molecule 1 0.0703677
RPS3 ribosomal protein S3 0.0674536
HDAC9 histone deacetylase 9 0.0660019
LDHA lactate dehydrogenase A 0.0625292
RPS8 ribosomal protein S8 0.0615737
RPS6 ribosomal protein S6 0.0605362
TPT1 tumor protein, translationally-controlled 1 0.060124
NAP1L1 nucleosome assembly protein 1-like 1 0.0521869
FBXO32 F-box protein 32 0.0511597
SQSTM1 sequestosome 1 0.0482456
HLA-E major histocompatibility complex, class I, E 0.0455332
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0454275
RPLP2 ribosomal protein, large, P2 0.0432623
WTAP Wilms tumor 1 associated protein 0.0427222
SFTPA2 surfactant protein A2 0.0426142
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0421069
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.041074
RND3 Rho family GTPase 3 0.0408682
CTSD cathepsin D 0.0400632
RPL7A ribosomal protein L7a 0.0388319
TRIO trio Rho guanine nucleotide exchange factor 0.0386351
RPL26 ribosomal protein L26 0.0375551
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0371659
RACK1 receptor for activated C kinase 1 0.0371448
RPL5 ribosomal protein L5 0.0369196
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0357797
EIF1 eukaryotic translation initiation factor 1 0.0356924
RPL31 ribosomal protein L31 0.0346327
HLA-A major histocompatibility complex, class I, A 0.0344439
IFITM3 interferon induced transmembrane protein 3 0.0341061
RPS13 ribosomal protein S13 0.0335243
RPL36A ribosomal protein L36a 0.0329073
RPL9 ribosomal protein L9 0.0324137
RPS25 ribosomal protein S25 0.0323614
KYNU kynureninase 0.032199
SOX9 SRY (sex determining region Y)-box 9 0.0321761
RPL35A ribosomal protein L35a 0.0315923
IFI6 interferon, alpha-inducible protein 6 0.0314709
SPAG9 sperm associated antigen 9 0.0312881
CALR calreticulin 0.0309737
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0306597
ZSWIM6 zinc finger, SWIM-type containing 6 0.0305761
ENO2 enolase 2 (gamma, neuronal) 0.0304627
RPL12 ribosomal protein L12 0.0301818
ZMIZ1 zinc finger, MIZ-type containing 1 0.030042
PCBP2 poly(rC) binding protein 2 0.0298436
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0292181
RPL37 ribosomal protein L37 0.0292155
HILPDA hypoxia inducible lipid droplet-associated 0.0290424
KTN1 kinectin 1 (kinesin receptor) 0.0282738
INTS6 integrator complex subunit 6 0.028235
TIMP2 TIMP metallopeptidase inhibitor 2 0.0278075
UBE2H ubiquitin-conjugating enzyme E2H 0.0274547
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0272355
CTSA cathepsin A 0.0266483
BRD2 bromodomain containing 2 0.0266214
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0260298
RPL4 ribosomal protein L4 0.0256898
DSCAM Down syndrome cell adhesion molecule 0.0255618
NACA nascent polypeptide-associated complex alpha subunit 0.0255577
PTMA prothymosin, alpha 0.0255216
GADD45B growth arrest and DNA-damage-inducible, beta 0.0254912
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.025458
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 0.025407
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0253917
RPS17 ribosomal protein S17 0.0248935
ERBIN erbb2 interacting protein 0.0246714
RPL7 ribosomal protein L7 0.0246653
MORF4L2 mortality factor 4 like 2 0.0240476
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0238327
RPL36 ribosomal protein L36 0.0238172
RPS10 ribosomal protein S10 0.0238146
RPL13A ribosomal protein L13a 0.023741
RPL11 ribosomal protein L11 0.0237101
MYOF myoferlin 0.0229271
OGA O-GlcNAcase 0.0228504
WSB1 WD repeat and SOCS box containing 1 0.0223934
RPS19 ribosomal protein S19 0.0219268
RPL27 ribosomal protein L27 0.0218664
RPL19 ribosomal protein L19 0.0215166
RB1CC1 RB1-inducible coiled-coil 1 0.0214708
IFITM1 interferon induced transmembrane protein 1 0.0213338
TMSB10 thymosin beta 10 0.0212977
RAB7A RAB7A, member RAS oncogene family 0.0207276
RPL23 ribosomal protein L23 0.0206627
ZHX2 zinc fingers and homeoboxes 2 0.0206338
DDIT4 DNA-damage-inducible transcript 4 0.0205547
DDIT3 DNA-damage-inducible transcript 3 0.0204029

decreased expression

Symbol Name Standardized Value
GLIS3 GLIS family zinc finger 3 -0.085211
FN1 fibronectin 1 -0.0786265
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.070818
AKAP12 A kinase (PRKA) anchor protein 12 -0.0654529
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0643079
VCAN versican -0.0629627
CD44 CD44 molecule (Indian blood group) -0.0527433
COL6A3 collagen, type VI, alpha 3 -0.0525599
HMGA2 high mobility group AT-hook 2 -0.0433999
IGFBP3 insulin-like growth factor binding protein 3 -0.041606
FRMD4A FERM domain containing 4A -0.0369506
NAMPT nicotinamide phosphoribosyltransferase -0.0349929
BICC1 BicC family RNA binding protein 1 -0.0338421
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0300052
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0290779
THBS1 thrombospondin 1 -0.0288975
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0281755
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.02725
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0270325
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0263059
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0262062
CDH13 cadherin 13 -0.0256061
RAI14 retinoic acid induced 14 -0.023492
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0228201
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0227247
EFNA5 ephrin-A5 -0.0227116
ZMYND8 zinc finger, MYND-type containing 8 -0.0216227
CDCP1 CUB domain containing protein 1 -0.0211159
SFRP1 secreted frizzled-related protein 1 -0.020985
UBC ubiquitin C -0.0204517
FAM20C family with sequence similarity 20, member C -0.019761
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0187916
COL1A2 collagen, type I, alpha 2 -0.0187514
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0182484
NAV1 neuron navigator 1 -0.0177321
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0176591
STC1 stanniocalcin 1 -0.017458
SAMD3 sterile alpha motif domain containing 3 -0.0171419
ARHGAP22 Rho GTPase activating protein 22 -0.0170052
ELL2 elongation factor, RNA polymerase II, 2 -0.0167501
NT5E 5'-nucleotidase, ecto (CD73) -0.0164395
ZBTB38 zinc finger and BTB domain containing 38 -0.0159596
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0153453
TMSB4X thymosin beta 4, X-linked -0.0150532
ASPH aspartate beta-hydroxylase -0.0147818
ADAM12 ADAM metallopeptidase domain 12 -0.0147766
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0144951
PDE10A phosphodiesterase 10A -0.0144572
EXOC4 exocyst complex component 4 -0.0143293
EHBP1 EH domain binding protein 1 -0.0141738
COL1A1 collagen, type I, alpha 1 -0.0141576
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0139189
MMP12 matrix metallopeptidase 12 -0.0139046
COL4A2 collagen, type IV, alpha 2 -0.0133487
ZBTB20 zinc finger and BTB domain containing 20 -0.0133076
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0132201
DIAPH2 diaphanous-related formin 2 -0.013035
TOX2 TOX high mobility group box family member 2 -0.0127867
ADNP activity-dependent neuroprotector homeobox -0.0123328
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0123042
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0121649
CLMP CXADR-like membrane protein -0.0118805
MAML2 mastermind-like 2 (Drosophila) -0.0116604
THBS2 thrombospondin 2 -0.0116051
NRN1 neuritin 1 -0.0115616
MSN moesin -0.0114774
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0113437
ABTB3 ankyrin repeat and BTB domain containing 3 -0.011335
IQCJ IQ motif containing J -0.0113129
NRP1 neuropilin 1 -0.0110663
PTH2R parathyroid hormone 2 receptor -0.0109684
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0109012
OSMR oncostatin M receptor -0.0108869
SOX5 SRY (sex determining region Y)-box 5 -0.010879
SLC35F3 solute carrier family 35, member F3 -0.0108244
ATG7 autophagy related 7 -0.0107907
RPL14 ribosomal protein L14 -0.0107081
GREM1 gremlin 1, DAN family BMP antagonist -0.0107001
SLF2 SMC5-SMC6 complex localization factor 2 -0.0106088
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0104677
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0104298
RGS17 regulator of G-protein signaling 17 -0.0102677
MKI67 marker of proliferation Ki-67 -0.0101661
PSD3 pleckstrin and Sec7 domain containing 3 -0.0101599
ZNF217 zinc finger protein 217 -0.0100828
TPM4 tropomyosin 4 -0.0100337
PHF10 PHD finger protein 10 -0.010032
ANLN anillin, actin binding protein -0.00997533
LAMB1 laminin, beta 1 -0.00996026
NF1 neurofibromin 1 -0.00989607
PRICKLE2 prickle homolog 2 (Drosophila) -0.00986403
APP amyloid beta (A4) precursor protein -0.00984792
PPARD peroxisome proliferator-activated receptor delta -0.0097493
FMN1 formin 1 -0.0097084
RASA2 RAS p21 protein activator 2 -0.00970729
CEP112 centrosomal protein 112kDa -0.00955611
DNAAF9 dynein axonemal assembly factor 9 -0.00955434
NCKAP5 NCK-associated protein 5 -0.00951488
RRBP1 ribosome binding protein 1 -0.00943239
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.00942642