LJI308_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.107922
B2M beta-2-microglobulin 0.0995586
VIM vimentin 0.0901641
TIMP3 TIMP metallopeptidase inhibitor 3 0.084838
FTL ferritin, light polypeptide 0.0837159
HLA-B major histocompatibility complex, class I, B 0.0771671
TPT1 tumor protein, translationally-controlled 1 0.0740764
AHNAK AHNAK nucleoprotein 0.0651515
DSCAM Down syndrome cell adhesion molecule 0.0587976
SDC4 syndecan 4 0.0560178
KYNU kynureninase 0.0514558
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0510087
RPS12 ribosomal protein S12 0.0499174
CADM1 cell adhesion molecule 1 0.0493679
RPS8 ribosomal protein S8 0.0486551
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0465935
LDHA lactate dehydrogenase A 0.046587
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.045812
RPL37A ribosomal protein L37a 0.045475
NDRG1 N-myc downstream regulated 1 0.0454617
SQSTM1 sequestosome 1 0.0433307
ADM adrenomedullin 0.0431115
PTMA prothymosin, alpha 0.0416381
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0403104
RPS3 ribosomal protein S3 0.0403097
HLA-A major histocompatibility complex, class I, A 0.0402076
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0392243
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0386331
ENO1 enolase 1, (alpha) 0.0383548
RPS16 ribosomal protein S16 0.0378142
SOD2 superoxide dismutase 2, mitochondrial 0.0373053
H3-3B H3.3 histone B 0.0370041
RPS19 ribosomal protein S19 0.0363158
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0362946
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0356661
TPI1 triosephosphate isomerase 1 0.0354577
IGFBP7 insulin-like growth factor binding protein 7 0.0350533
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0335981
CALR calreticulin 0.0335793
SFTPA2 surfactant protein A2 0.0330593
ASPH aspartate beta-hydroxylase 0.0330529
RPS17 ribosomal protein S17 0.0329026
RPL12 ribosomal protein L12 0.0317369
FNDC3B fibronectin type III domain containing 3B 0.0316556
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0315636
ZNF292 zinc finger protein 292 0.0310005
RPL28 ribosomal protein L28 0.0305002
MYH9 myosin, heavy chain 9, non-muscle 0.030373
SLC38A2 solute carrier family 38, member 2 0.0301299
INTS6 integrator complex subunit 6 0.0299877
RACK1 receptor for activated C kinase 1 0.0298974
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0292971
CANX calnexin 0.0289405
RPL31 ribosomal protein L31 0.0287685
ZNF395 zinc finger protein 395 0.0287568
FGFR1 fibroblast growth factor receptor 1 0.0281899
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.027842
RPS27A ribosomal protein S27a 0.0278135
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0275294
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.027479
ZSWIM6 zinc finger, SWIM-type containing 6 0.0274672
ZFAND3 zinc finger, AN1-type domain 3 0.0273812
APLP2 amyloid beta (A4) precursor-like protein 2 0.0273682
MCFD2 multiple coagulation factor deficiency 2 0.0271586
EEF2 eukaryotic translation elongation factor 2 0.0267725
CTNND1 catenin (cadherin-associated protein), delta 1 0.0258634
PCBP2 poly(rC) binding protein 2 0.0251808
FAM13A family with sequence similarity 13, member A 0.0251792
RPL11 ribosomal protein L11 0.0251286
RPS6 ribosomal protein S6 0.0249023
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0248258
SMAD3 SMAD family member 3 0.0246444
RPL35A ribosomal protein L35a 0.0239833
SCFD1 sec1 family domain containing 1 0.0237984
RPL26 ribosomal protein L26 0.02367
RPL37 ribosomal protein L37 0.0234058
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0232065
UBE2H ubiquitin-conjugating enzyme E2H 0.0230116
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0229609
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0226609
LGALS3 lectin, galactoside-binding, soluble, 3 0.0223669
TXNIP thioredoxin interacting protein 0.022318
NFE2L1 nuclear factor, erythroid 2-like 1 0.0223027
ARID4B AT rich interactive domain 4B (RBP1-like) 0.022285
SSBP2 single-stranded DNA binding protein 2 0.0219799
ARHGAP24 Rho GTPase activating protein 24 0.0219326
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.0219186
PALLD palladin, cytoskeletal associated protein 0.0217205
RYBP RING1 and YY1 binding protein 0.0215687
UBC ubiquitin C 0.0215392
RPLP1 ribosomal protein, large, P1 0.0215266
TNRC6B trinucleotide repeat containing 6B 0.0214975
RPS24 ribosomal protein S24 0.0213363
RPLP2 ribosomal protein, large, P2 0.0209505
FLNB filamin B, beta 0.020796
CLIC4 chloride intracellular channel 4 0.0206529
BASP1 brain abundant, membrane attached signal protein 1 0.0206365
RPS4X ribosomal protein S4, X-linked 0.0205881
PDE4D phosphodiesterase 4D, cAMP-specific 0.0204851
PERP PERP, TP53 apoptosis effector 0.0203626

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.0889985
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0858856
F3 coagulation factor III (thromboplastin, tissue factor) -0.0829225
IGFBP3 insulin-like growth factor binding protein 3 -0.0823794
CDH13 cadherin 13 -0.0768194
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0751436
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0717033
FN1 fibronectin 1 -0.0700087
PRSS23 protease, serine, 23 -0.0679993
MT1X metallothionein 1X -0.0589379
GLIS3 GLIS family zinc finger 3 -0.0524643
HMGA2 high mobility group AT-hook 2 -0.0508511
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0423817
TMEM165 transmembrane protein 165 -0.0412866
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0411542
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0409542
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0396831
RTN4 reticulon 4 -0.0327798
NAV1 neuron navigator 1 -0.0319074
COL5A1 collagen, type V, alpha 1 -0.031701
FRMD4A FERM domain containing 4A -0.0303135
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0299204
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0285512
COL6A2 collagen, type VI, alpha 2 -0.0281551
CAV1 caveolin 1, caveolae protein, 22kDa -0.0269688
MAP1B microtubule-associated protein 1B -0.0267991
TPM1 tropomyosin 1 (alpha) -0.0260836
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0259103
NAMPT nicotinamide phosphoribosyltransferase -0.0257386
RRBP1 ribosome binding protein 1 -0.025143
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0246055
RAI14 retinoic acid induced 14 -0.0241321
RIN2 Ras and Rab interactor 2 -0.0233388
POTEF POTE ankyrin domain family, member F -0.0231128
CALD1 caldesmon 1 -0.0226115
NRXN3 neurexin 3 -0.0224248
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0223748
ZMYND8 zinc finger, MYND-type containing 8 -0.0222316
PSD3 pleckstrin and Sec7 domain containing 3 -0.0221912
SYNPO synaptopodin -0.0200751
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0200212
AKAP12 A kinase (PRKA) anchor protein 12 -0.0194476
THBS1 thrombospondin 1 -0.0192379
CLMP CXADR-like membrane protein -0.0192097
VEGFC vascular endothelial growth factor C -0.0189861
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0189621
TPM4 tropomyosin 4 -0.0189
MYADM myeloid-associated differentiation marker -0.0185411
KAZN kazrin, periplakin interacting protein -0.0184215
CHD9 chromodomain helicase DNA binding protein 9 -0.0179937
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0179767
ARHGAP22 Rho GTPase activating protein 22 -0.017766
DPYD dihydropyrimidine dehydrogenase -0.0177257
TRIO trio Rho guanine nucleotide exchange factor -0.0174046
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0171866
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0167857
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0167275
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0165375
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0165307
ANTXR2 anthrax toxin receptor 2 -0.0164509
SDK1 sidekick cell adhesion molecule 1 -0.0163929
AFF3 AF4/FMR2 family, member 3 -0.0163074
CSMD2 CUB and Sushi multiple domains 2 -0.0162314
LAMB1 laminin, beta 1 -0.0161375
CBX3 chromobox homolog 3 -0.0160849
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0160138
FMNL2 formin-like 2 -0.0160009
LOX lysyl oxidase -0.0158686
HIPK2 homeodomain interacting protein kinase 2 -0.0156479
JAZF1 JAZF zinc finger 1 -0.0154335
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.015419
MON2 MON2 homolog (S. cerevisiae) -0.0151936
NRP1 neuropilin 1 -0.0151805
FNIP1 folliculin interacting protein 1 -0.0151162
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0149107
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0148086
MGLL monoglyceride lipase -0.0146675
NT5E 5'-nucleotidase, ecto (CD73) -0.0145361
AAK1 AP2 associated kinase 1 -0.0144428
CCND1 cyclin D1 -0.0143223
NF1 neurofibromin 1 -0.0142501
COL7A1 collagen, type VII, alpha 1 -0.0142501
SEPTIN11 septin 11 -0.0141008
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0140977
SMIM44 small integral membrane protein 44 -0.0140836
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0140828
DNAAF9 dynein axonemal assembly factor 9 -0.013939
TNS3 tensin 3 -0.013935
CCM2 cerebral cavernous malformation 2 -0.0139329
VEGFA vascular endothelial growth factor A -0.0138853
ZEB2 zinc finger E-box binding homeobox 2 -0.0138403
SCFD2 sec1 family domain containing 2 -0.0138101
SBF2 SET binding factor 2 -0.0137342
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -0.0136459
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0135924
EGFR epidermal growth factor receptor -0.0135265
OXR1 oxidation resistance 1 -0.0135009
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0132836
ADAM10 ADAM metallopeptidase domain 10 -0.0132522
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0132303