LJI308_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description LJI308 perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the LJI308_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.167939
LDHA lactate dehydrogenase A 0.125905
AHNAK AHNAK nucleoprotein 0.124012
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0887126
VIM vimentin 0.0830519
INTS6 integrator complex subunit 6 0.0799398
TPT1 tumor protein, translationally-controlled 1 0.0696871
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0665169
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0649415
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0513964
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0472805
TPI1 triosephosphate isomerase 1 0.046046
SMAD3 SMAD family member 3 0.0454305
ZSWIM6 zinc finger, SWIM-type containing 6 0.0421586
CAVIN1 caveolae associated protein 1 0.0417696
RBM39 RNA binding motif protein 39 0.0408322
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0406806
PTK2 protein tyrosine kinase 2 0.0399349
HSPA8 heat shock 70kDa protein 8 0.0397196
RPS12 ribosomal protein S12 0.0393167
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0384501
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0383473
AKAP13 A kinase (PRKA) anchor protein 13 0.0382372
EEF2 eukaryotic translation elongation factor 2 0.0367256
SDC4 syndecan 4 0.0354952
CLTC clathrin, heavy chain (Hc) 0.0354594
VCL vinculin 0.0339324
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0327211
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0324561
CALR calreticulin 0.0324182
GLS2 glutaminase 2 (liver, mitochondrial) 0.0322968
HLA-B major histocompatibility complex, class I, B 0.0321222
FTL ferritin, light polypeptide 0.0317705
SKP1 S-phase kinase-associated protein 1 0.0311754
PDE8A phosphodiesterase 8A 0.0298632
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0294268
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0292929
SYCP2 synaptonemal complex protein 2 0.0291923
RPS3 ribosomal protein S3 0.0291907
CD44 CD44 molecule (Indian blood group) 0.029128
EPN2 epsin 2 0.0288137
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.028732
SFPQ splicing factor proline/glutamine-rich 0.0281068
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0280974
CANX calnexin 0.0280084
SEC31A SEC31 homolog A (S. cerevisiae) 0.0279527
RAB10 RAB10, member RAS oncogene family 0.0279518
SLC38A2 solute carrier family 38, member 2 0.0272983
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0272765
NBEAL1 neurobeachin-like 1 0.027228
HSPH1 heat shock 105kDa/110kDa protein 1 0.0270995
CPNE1 copine I 0.0270073
SIK3 SIK family kinase 3 0.0268083
LMNA lamin A/C 0.026441
SQSTM1 sequestosome 1 0.0263326
GDI2 GDP dissociation inhibitor 2 0.0262189
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0259583
OSBPL8 oxysterol binding protein-like 8 0.0259187
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0258066
HLA-A major histocompatibility complex, class I, A 0.0257876
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0256615
TNPO1 transportin 1 0.0255802
FNBP4 formin binding protein 4 0.0251533
CD59 CD59 molecule, complement regulatory protein 0.025127
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0250438
IQGAP1 IQ motif containing GTPase activating protein 1 0.0249159
TUBB4B tubulin, beta 4B class IVb 0.0247943
NAP1L1 nucleosome assembly protein 1-like 1 0.0247742
CLIC1 chloride intracellular channel 1 0.024622
CAMTA1 calmodulin binding transcription activator 1 0.0245696
NFE2L1 nuclear factor, erythroid 2-like 1 0.0245573
GPR75-ASB3 GPR75-ASB3 readthrough 0.024542
ARHGAP21 Rho GTPase activating protein 21 0.0243954
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0243742
ANKRD28 ankyrin repeat domain 28 0.0242572
RSAD2 radical S-adenosyl methionine domain containing 2 0.0241714
RBM25 RNA binding motif protein 25 0.0239388
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0237338
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.023564
RPL5 ribosomal protein L5 0.0232229
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0231159
ZEB1 zinc finger E-box binding homeobox 1 0.0231101
NAP1L4 nucleosome assembly protein 1-like 4 0.02292
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0227579
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0226685
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0226684
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0225523
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0224963
GNAS GNAS complex locus 0.0224602
SMYD3 SET and MYND domain containing 3 0.0223168
SP100 SP100 nuclear antigen 0.0222818
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0220328
SON SON DNA binding protein 0.0220306
CEP290 centrosomal protein 290kDa 0.0219828
KTN1 kinectin 1 (kinesin receptor) 0.0219765
TOP2B topoisomerase (DNA) II beta 180kDa 0.0218938
DEK DEK proto-oncogene 0.0216082
GPATCH2L G patch domain containing 2-like 0.0212386
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0211874
CAPRIN2 caprin family member 2 0.0211838

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0977732
ZMYND8 zinc finger, MYND-type containing 8 -0.0765419
FTH1 ferritin, heavy polypeptide 1 -0.0751298
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0601951
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0516256
IGF2 insulin-like growth factor 2 -0.0507472
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0480963
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0450644
DNER delta/notch-like EGF repeat containing -0.0430554
BASP1 brain abundant, membrane attached signal protein 1 -0.0407506
DSCAM Down syndrome cell adhesion molecule -0.0399469
HILPDA hypoxia inducible lipid droplet-associated -0.0372985
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0363037
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0353599
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0342002
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0336616
GPC5 glypican 5 -0.032363
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.031673
DSE dermatan sulfate epimerase -0.0310963
IGFBP3 insulin-like growth factor binding protein 3 -0.030393
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0300616
FAM3C family with sequence similarity 3, member C -0.0296098
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0290672
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0288479
FMN1 formin 1 -0.0282613
AKAP9 A kinase (PRKA) anchor protein 9 -0.0269683
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0269379
SASH1 SAM and SH3 domain containing 1 -0.0266345
PDIA3 protein disulfide isomerase family A, member 3 -0.0262749
ATG7 autophagy related 7 -0.0260558
FAM177A1 family with sequence similarity 177, member A1 -0.0258886
RSRC1 arginine/serine-rich coiled-coil 1 -0.0256098
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0255545
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0246813
NUP98 nucleoporin 98kDa -0.0246208
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0245355
RPLP1 ribosomal protein, large, P1 -0.0243411
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.024194
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0239342
PRR16 proline rich 16 -0.0236236
LRRC49 leucine rich repeat containing 49 -0.023577
IL1RAP interleukin 1 receptor accessory protein -0.0234781
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0231002
MARCKS myristoylated alanine-rich protein kinase C substrate -0.023068
ANO6 anoctamin 6 -0.0229813
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0226963
EGR1 early growth response 1 -0.022255
TMEM41B transmembrane protein 41B -0.0222394
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0221196
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0220738
NBEA neurobeachin -0.0218707
MAML2 mastermind-like 2 (Drosophila) -0.0213657
MYO10 myosin X -0.0212894
PCM1 pericentriolar material 1 -0.0212392
DYNLRB1 dynein, light chain, roadblock-type 1 -0.021199
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0210544
NGLY1 N-glycanase 1 -0.0210278
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0207128
ANKRD11 ankyrin repeat domain 11 -0.0207107
NAMPT nicotinamide phosphoribosyltransferase -0.0204088
TMOD3 tropomodulin 3 (ubiquitous) -0.0202038
HOOK2 hook microtubule-tethering protein 2 -0.0200842
TMEM87A transmembrane protein 87A -0.0200628
RAB5A RAB5A, member RAS oncogene family -0.0200192
CLEC2D C-type lectin domain family 2, member D -0.0199468
RAD51B RAD51 paralog B -0.0199365
MAP4 microtubule-associated protein 4 -0.0197807
TULP4 tubby like protein 4 -0.0196066
KLF4 Kruppel-like factor 4 (gut) -0.0195944
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0195867
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.0195398
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0195107
ATF7IP activating transcription factor 7 interacting protein -0.0194351
OGA O-GlcNAcase -0.0194135
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0193756
MRC2 mannose receptor, C type 2 -0.0193537
KMT5B lysine methyltransferase 5B -0.0192936
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -0.0190586
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0189646
NHSL1 NHS-like 1 -0.0188328
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.0186464
CYFIP1 cytoplasmic FMR1 interacting protein 1 -0.0186399
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0185381
DHX34 DEAH (Asp-Glu-Ala-His) box polypeptide 34 -0.0183855
CCDC88A coiled-coil domain containing 88A -0.018284
RAP1B RAP1B, member of RAS oncogene family -0.0181498
PRKD3 protein kinase D3 -0.0180919
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0180647
PBRM1 polybromo 1 -0.0180514
UBN2 ubinuclein 2 -0.0179298
SKIC3 SKI3 subunit of superkiller complex -0.0179221
ATXN3 ataxin 3 -0.0178461
NDRG1 N-myc downstream regulated 1 -0.0177986
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0177983
UGCG UDP-glucose ceramide glucosyltransferase -0.0177847
BIRC3 baculoviral IAP repeat containing 3 -0.0177599
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) -0.0177136
IGFBP4 insulin-like growth factor binding protein 4 -0.0176387
MECP2 methyl CpG binding protein 2 -0.0176233
LAMB1 laminin, beta 1 -0.0175661