LKB1 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description serine/threonine kinase 11|This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 6794)
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100 substrates of the kinase LKB1 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
AGFG1 ArfGAP with FG repeats 1
KIAA1671 KIAA1671
ATXN2L ataxin 2-like
SIK3 SIK family kinase 3
SIK2 salt-inducible kinase 2
CCDC88A coiled-coil domain containing 88A
NUAK2 NUAK family, SNF1-like kinase, 2
FGD4 FYVE, RhoGEF and PH domain containing 4
FBRSL1 fibrosin-like 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELF1 E74-like factor 1 (ets domain transcription factor)
TMEM245 transmembrane protein 245
PDLIM7 PDZ and LIM domain 7 (enigma)
MICALL1 MICAL-like 1
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2
TACC3 transforming, acidic coiled-coil containing protein 3
IRS1 insulin receptor substrate 1
HAUS6 HAUS augmin-like complex, subunit 6
MYCT1 myc target 1
ATN1 atrophin 1
EP300 E1A binding protein p300
AP3D1 adaptor-related protein complex 3, delta 1 subunit
EP400 E1A binding protein p400
NF1 neurofibromin 1
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
MECP2 methyl CpG binding protein 2
TRIP12 thyroid hormone receptor interactor 12
SFPQ splicing factor proline/glutamine-rich
RBMS1 RNA binding motif, single stranded interacting protein 1
TUBA4A tubulin, alpha 4a
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa
PELI2 pellino E3 ubiquitin protein ligase family member 2
LPIN2 lipin 2
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
YAP1 Yes-associated protein 1
MKL2 MKL/myocardin-like 2
CEP135 centrosomal protein 135kDa
PHLDB1 pleckstrin homology-like domain, family B, member 1
ORC1 origin recognition complex, subunit 1
AAK1 AP2 associated kinase 1
TUBA3E tubulin, alpha 3e
TUBA3D tubulin, alpha 3d
KIAA1429 KIAA1429
BICD2 bicaudal D homolog 2 (Drosophila)
ARGLU1 arginine and glutamate rich 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
FLJ22184
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
KNOP1 lysine-rich nucleolar protein 1
TCOF1 Treacher Collins-Franceschetti syndrome 1
EPHA3 EPH receptor A3
PLCL2 phospholipase C-like 2
CDCA8 cell division cycle associated 8
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
ZNF148 zinc finger protein 148
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
C5ORF24 chromosome 5 open reading frame 24
PRKDC protein kinase, DNA-activated, catalytic polypeptide
ESYT2 extended synaptotagmin-like protein 2
ZC3H13 zinc finger CCCH-type containing 13
RLTPR RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing
CXORF49B chromosome X open reading frame 49B
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
SYT6 synaptotagmin VI
SORBS3 sorbin and SH3 domain containing 3
EOMES eomesodermin
CCDC71 coiled-coil domain containing 71
ABI1 abl-interactor 1
TUBA1C tubulin, alpha 1c
TUBA1B tubulin, alpha 1b
TUBA1A tubulin, alpha 1a
RBBP8NL RBBP8 N-terminal like
SRRM1 serine/arginine repetitive matrix 1
SRRM2 serine/arginine repetitive matrix 2
PPIP5K1 diphosphoinositol pentakisphosphate kinase 1
IRX2 iroquois homeobox 2
MED1 mediator complex subunit 1
TSC2 tuberous sclerosis 2
CTTN cortactin
MELK maternal embryonic leucine zipper kinase
TENM4 teneurin transmembrane protein 4
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
MANEAL mannosidase, endo-alpha-like
NUMB numb homolog (Drosophila)
DMWD dystrophia myotonica, WD repeat containing
TARDBP TAR DNA binding protein
RAI1 retinoic acid induced 1
AURKB aurora kinase B
CASS4 Cas scaffolding protein family member 4
TRRAP transformation/transcription domain-associated protein
NAV2 neuron navigator 2
PRPF6 pre-mRNA processing factor 6
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
GSK3A glycogen synthase kinase 3 alpha
ITPKB inositol-trisphosphate 3-kinase B
CDC25B cell division cycle 25B
C15ORF52 chromosome 15 open reading frame 52