LLGL2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description lethal giant larvae homolog 2 (Drosophila)|The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 3993)
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Genes

323 genes differentially expressed following the LLGL2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PITX3 paired-like homeodomain 3 3.38227
TPPP2 tubulin polymerization-promoting protein family member 2 3.38227
PCDHA3 protocadherin alpha 3 3.38227
RNF183 ring finger protein 183 3.38227
PDE7B phosphodiesterase 7B 3.38227
BMP8B bone morphogenetic protein 8b 3.38227
SOX30 SRY (sex determining region Y)-box 30 3.38227
LRRC43 leucine rich repeat containing 43 3.38227
SAMD15 sterile alpha motif domain containing 15 3.38227
PLAAT4 phospholipase A and acyltransferase 4 3.38227
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 3.38227
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 3.38227
CIMIP4 ciliary microtubule inner protein 4 3.38227
TRIML1 tripartite motif family-like 1 3.38227
STAP1 signal transducing adaptor family member 1 3.38227
SHCBP1L SHC SH2-domain binding protein 1-like 3.38227
TAS2R46 taste receptor, type 2, member 46 3.38227
SELPLG selectin P ligand 3.38227
EPHX4 epoxide hydrolase 4 3.36294
CEP295NL CEP295 N-terminal like 3.36294
SIGLEC7 sialic acid binding Ig-like lectin 7 3.36294
TMEM191B transmembrane protein 191B 3.36294
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 3.36294
SLC26A1 solute carrier family 26 (anion exchanger), member 1 3.36294
IL22RA1 interleukin 22 receptor, alpha 1 3.36294
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 3.36294
TMEM151A transmembrane protein 151A 3.36294
PCDHGB3 protocadherin gamma subfamily B, 3 3.36294
NRAP nebulin-related anchoring protein 3.36294
SLC25A45 solute carrier family 25, member 45 3.36294
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 3.36294
GPR26 G protein-coupled receptor 26 3.36294
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 3.36294
TRAT1 T cell receptor associated transmembrane adaptor 1 3.36294
AVP arginine vasopressin 3.36294
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 3.36294
SPACA5 sperm acrosome associated 5 3.36294
NMUR2 neuromedin U receptor 2 3.36294
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 3.36294
OR6J1 olfactory receptor, family 6, subfamily J, member 1 (gene/pseudogene) 3.36294
MUC22 mucin 22 3.36294
GNRH2 gonadotropin-releasing hormone 2 3.36294
OTUD6A OTU deubiquitinase 6A 3.36294
NLRP10 NLR family, pyrin domain containing 10 3.36294
CRX cone-rod homeobox 3.36294
KIF2B kinesin family member 2B 3.36294
TCP11 t-complex 11, testis-specific 3.36294
DLL4 delta-like 4 (Drosophila) 3.36294
S100A5 S100 calcium binding protein A5 3.36294
TMEM121 transmembrane protein 121 3.36294
FAM9B family with sequence similarity 9, member B 3.36294
LOC124909439 uncharacterized LOC124909439 3.36294
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 3.36294
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 3.36294
CCDC42 coiled-coil domain containing 42 3.36294
NPIPB7 nuclear pore complex interacting protein family, member B7 3.36294
GPR84 G protein-coupled receptor 84 3.36294
PNPLA1 patatin-like phospholipase domain containing 1 3.36294
LRRC71 leucine rich repeat containing 71 3.36294
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 3.36294
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.36294
TMOD4 tropomodulin 4 (muscle) 3.36294
H2BC1 H2B clustered histone 1 3.36294
SPMIP1 sperm microtubule inner protein 1 3.36294
LITAFD LITAF domain containing 3.36294
SPMIP3 sperm microtubule inner protein 3 3.36294
TMEM273 transmembrane protein 273 3.36294
DUSP29 dual specificity phosphatase 29 3.36294
DNAAF8 dynein axonemal assembly factor 8 3.36294
DERPC DERPC proline and glycine rich nuclear protein 3.36294
CCDC9B coiled-coil domain containing 9B 3.36294
FGFBP2 fibroblast growth factor binding protein 2 3.36294
SAA1 serum amyloid A1 3.36294
PTTG2 pituitary tumor-transforming 2 3.36294
FPR3 formyl peptide receptor 3 3.36294
ZNF98 zinc finger protein 98 3.36294
HBA2 hemoglobin, alpha 2 3.36294
TSSK4 testis-specific serine kinase 4 3.36294
TMPRSS11F transmembrane protease, serine 11F 3.36294
HLX H2.0-like homeobox 3.36294
MYBPHL myosin binding protein H-like 3.36294
RS1 retinoschisin 1 3.36294
GGT5 gamma-glutamyltransferase 5 3.36294
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 3.36294
UTS2 urotensin 2 3.36294
TSPO2 translocator protein 2 3.36294
SBSN suprabasin 3.36294
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 3.36294
TMEM235 transmembrane protein 235 3.36294
CKM creatine kinase, muscle 3.36294
CLIP4 CAP-GLY domain containing linker protein family, member 4 3.36294
THPO thrombopoietin 3.36294
RELL2 RELT-like 2 3.36294
GOLGA8T golgin A8 family, member T 3.36294
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 3.36294
HOXD1 homeobox D1 3.36294
ERICH6B glutamate-rich 6B 3.36294
BPIFB4 BPI fold containing family B, member 4 3.36294
IL21R interleukin 21 receptor 3.36294
OR5H14 olfactory receptor, family 5, subfamily H, member 14 3.36294
GCOM1 GRINL1A complex locus 1 3.36294
AQP9 aquaporin 9 3.36294
C6ORF163 chromosome 6 open reading frame 163 3.36294
ZNF541 zinc finger protein 541 3.36294
NXNL1 nucleoredoxin-like 1 3.36294
MRLN myoregulin 3.36294
MR1 major histocompatibility complex, class I-related 3.36294
HBE1 hemoglobin, epsilon 1 3.36294
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.36294
PHOSPHO1 phosphatase, orphan 1 3.36294
SMIM22 small integral membrane protein 22 3.36294
TRIM55 tripartite motif containing 55 3.36294
C2CD4B C2 calcium-dependent domain containing 4B 3.36294
PCDHGA4 protocadherin gamma subfamily A, 4 3.36294
GOLGA8O golgin A8 family, member O 3.36294
ZNF831 zinc finger protein 831 3.36294
LMX1B LIM homeobox transcription factor 1, beta 3.36294
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.36294
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 3.36294
CLEC1A C-type lectin domain family 1, member A 3.36294
GPR61 G protein-coupled receptor 61 3.36294
NT5C1B 5'-nucleotidase, cytosolic IB 3.36294
DLX3 distal-less homeobox 3 3.36294
DCTN2 dynactin 2 (p50) 3.36294
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 3.36294
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.36294
PABPN1L poly(A) binding protein, nuclear 1-like (cytoplasmic) 3.36294
TTC16 tetratricopeptide repeat domain 16 3.36294
C8ORF89 chromosome 8 open reading frame 89 3.36294
TEKT2 tektin 2 (testicular) 3.36294
MUC16 mucin 16, cell surface associated 3.36294
TBPL2 TATA box binding protein like 2 3.36294
ABRA actin binding Rho activating protein 3.36294
PTCRA pre T-cell antigen receptor alpha 3.36294
TBC1D28 TBC1 domain family, member 28 3.36294
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.36294
ANKRD30A ankyrin repeat domain 30A 3.36294
ZBED6 zinc finger, BED-type containing 6 3.36294
ITPKA inositol-trisphosphate 3-kinase A 3.36294
GPBAR1 G protein-coupled bile acid receptor 1 3.36294
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 3.36294
CHRM4 cholinergic receptor, muscarinic 4 3.36294
FZD1 frizzled class receptor 1 3.36294
DHRS7C dehydrogenase/reductase (SDR family) member 7C 3.36294
OXER1 oxoeicosanoid (OXE) receptor 1 3.36294
WDFY4 WDFY family member 4 3.36294
ZMYND10 zinc finger, MYND-type containing 10 3.36294
HSPB7 heat shock 27kDa protein family, member 7 (cardiovascular) 3.36294
TMEM184A transmembrane protein 184A 3.36294
CCNO cyclin O 3.36294
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 3.36294
RSAD2 radical S-adenosyl methionine domain containing 2 3.36294
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 3.36294
CHRM1 cholinergic receptor, muscarinic 1 3.36294
ETV2 ets variant 2 3.32649
RFX8 RFX family member 8, lacking RFX DNA binding domain 3.32649
DENND2D DENN/MADD domain containing 2D 3.1325
PEX12 peroxisomal biogenesis factor 12 2.96905
ZIK1 zinc finger protein interacting with K protein 1 2.88743
DGAT1 diacylglycerol O-acyltransferase 1 2.86464
CPB2 carboxypeptidase B2 (plasma) 2.86015
OSGEP O-sialoglycoprotein endopeptidase 2.6036
GPR20 G protein-coupled receptor 20 2.56554
FREM3 FRAS1 related extracellular matrix 3 2.51822
NINJ2 ninjurin 2 2.51822
CBR1 carbonyl reductase 1 2.48705
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase 2.48025
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 2.42516
UPK1B uroplakin 1B 2.39075
FBH1 F-box DNA helicase 1 2.37358
CTSF cathepsin F 2.36621
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 2.35495
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.3501
CNTN2 contactin 2 (axonal) 2.3501
ABI3 ABI family, member 3 2.3501
CFAP73 cilia and flagella associated protein 73 2.3501
MAT1A methionine adenosyltransferase I, alpha 2.3501
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.3501
OR2A14 olfactory receptor, family 2, subfamily A, member 14 2.3501
HSDL2 hydroxysteroid dehydrogenase like 2 2.34905
MEX3C mex-3 RNA binding family member C 2.29491
CFAP54 cilia and flagella associated 54 2.28606
DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13 2.28241
JAG1 jagged 1 2.26292
UBA6 ubiquitin-like modifier activating enzyme 6 2.26292
LHCGR luteinizing hormone/choriogonadotropin receptor 2.24712
COL8A1 collagen, type VIII, alpha 1 2.24053
LZTS1 leucine zipper, putative tumor suppressor 1 2.24053
SYNE1 spectrin repeat containing, nuclear envelope 1 2.24053
TTC9 tetratricopeptide repeat domain 9 2.23887
GPC6 glypican 6 2.23364
ACAA2 acetyl-CoA acyltransferase 2 2.18119
SAP130 Sin3A-associated protein, 130kDa 2.1317
PLSCR2 phospholipid scramblase 2 2.1317
TRIM38 tripartite motif containing 38 2.12187
KMT5B lysine methyltransferase 5B 2.11381
RYR3 ryanodine receptor 3 2.07035
TRNAU1AP tRNA selenocysteine 1 associated protein 1 2.06941
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 2.06696
TMEM106A transmembrane protein 106A 2.05928
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 2.05585
IMP4 IMP4, U3 small nucleolar ribonucleoprotein 2.03979
SKI SKI proto-oncogene 2.0316
NUTF2 nuclear transport factor 2 2.01579
BCL2L2 BCL2-like 2 2.01579
C8ORF33 chromosome 8 open reading frame 33 2.01576
C22ORF23 chromosome 22 open reading frame 23 2.01162
PXDN peroxidasin 2.01162
DERL3 derlin 3 2.00872
MYORG myogenesis regulating glycosidase (putative) 2.00647

decreased expression

Symbol Name Standardized Value
ZNF597 zinc finger protein 597 -3.38227
LRRC19 leucine rich repeat containing 19 -3.38227
TMEM272 transmembrane protein 272 -3.38227
ANPEP alanyl (membrane) aminopeptidase -3.38227
CCDC68 coiled-coil domain containing 68 -3.38227
SOWAHD sosondowah ankyrin repeat domain family member D -3.38227
LLGL2 lethal giant larvae homolog 2 (Drosophila) -3.38227
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 -3.36294
VASH2 vasohibin 2 -3.36294
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa -3.36294
SPINT4 serine peptidase inhibitor, Kunitz type 4 -3.36294
TSHZ1 teashirt zinc finger homeobox 1 -3.36294
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -3.36294
GMCL1 germ cell-less, spermatogenesis associated 1 -3.36294
FARSB phenylalanyl-tRNA synthetase, beta subunit -3.36294
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 -3.36294
UPK3A uroplakin 3A -3.36294
KLRF1 killer cell lectin-like receptor subfamily F, member 1 -3.36294
C1QTNF2 C1q and tumor necrosis factor related protein 2 -3.36294
ZEB2 zinc finger E-box binding homeobox 2 -3.36294
LOC114841035 uncharacterized LOC114841035 -3.36294
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 -3.36294
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 -3.36294
WNT9B wingless-type MMTV integration site family, member 9B -3.36294
GPR22 G protein-coupled receptor 22 -3.36294
MYL10 myosin, light chain 10, regulatory -3.36294
PELI3 pellino E3 ubiquitin protein ligase family member 3 -3.36294
MUC20 mucin 20, cell surface associated -3.36294
APOB apolipoprotein B -3.36294
BHLHA15 basic helix-loop-helix family, member a15 -3.36294
CTXND1 cortexin domain containing 1 -3.36294
COL9A2 collagen, type IX, alpha 2 -3.36294
MPIG6B megakaryocyte and platelet inhibitory receptor G6b -3.36294
SMIM41 small integral membrane protein 41 -3.36294
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -3.36294
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 -3.36294
PCDHGA7 protocadherin gamma subfamily A, 7 -3.36294
LINC02798 long intergenic non-protein coding RNA 2798 -3.36294
KLHL10 kelch-like family member 10 -3.36294
PLA2G5 phospholipase A2, group V -3.36294
TIGD3 tigger transposable element derived 3 -3.36294
CPXM1 carboxypeptidase X (M14 family), member 1 -3.26463
VSTM2B V-set and transmembrane domain containing 2B -3.26463
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -3.0636
FERMT3 fermitin family member 3 -2.99559
C11ORF52 chromosome 11 open reading frame 52 -2.93238
SHISAL2A shisa like 2A -2.86919
MFF mitochondrial fission factor -2.84448
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.78212
MMRN2 multimerin 2 -2.73978
SMIM19 small integral membrane protein 19 -2.65185
HFM1 HFM1, ATP-dependent DNA helicase homolog (S. cerevisiae) -2.64705
MRPL2 mitochondrial ribosomal protein L2 -2.63601
APOLD1 apolipoprotein L domain containing 1 -2.62666
CLDN15 claudin 15 -2.60644
WIPF3 WAS/WASL interacting protein family, member 3 -2.60264
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.59903
MEAK7 MTOR associated protein, eak-7 homolog -2.51822
KMT5A lysine methyltransferase 5A -2.50924
ASPH aspartate beta-hydroxylase -2.49576
PBK PDZ binding kinase -2.42715
WIPI2 WD repeat domain, phosphoinositide interacting 2 -2.37358
FUNDC1 FUN14 domain containing 1 -2.37358
CIDEB cell death-inducing DFFA-like effector b -2.36351
CRABP2 cellular retinoic acid binding protein 2 -2.36351
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.35504
TMED9 transmembrane emp24 protein transport domain containing 9 -2.3501
GIPR gastric inhibitory polypeptide receptor -2.34759
MOG myelin oligodendrocyte glycoprotein -2.29491
FGF4 fibroblast growth factor 4 -2.29491
OR2A42 olfactory receptor, family 2, subfamily A, member 42 -2.29491
CYFIP2 cytoplasmic FMR1 interacting protein 2 -2.26332
CHGB chromogranin B -2.24912
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 -2.24678
SGMS2 sphingomyelin synthase 2 -2.24678
C1ORF202 chromosome 1 open reading frame 202 -2.24053
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.24053
CLUL1 clusterin-like 1 (retinal) -2.24053
TRIM56 tripartite motif containing 56 -2.24053
KIRREL2 kin of IRRE like 2 (Drosophila) -2.24053
MYH3 myosin, heavy chain 3, skeletal muscle, embryonic -2.24053
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -2.24053
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3 -2.24053
CCDC25 coiled-coil domain containing 25 -2.23718
SNRPN small nuclear ribonucleoprotein polypeptide N -2.23076
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.20121
RPL3 ribosomal protein L3 -2.19466
MLYCD malonyl-CoA decarboxylase -2.18319
DDB1 damage-specific DNA binding protein 1, 127kDa -2.18272
MXD3 MAX dimerization protein 3 -2.15433
ADCK1 aarF domain containing kinase 1 -2.15337
RPL27 ribosomal protein L27 -2.14686
ZNF121 zinc finger protein 121 -2.13667
NFYC nuclear transcription factor Y, gamma -2.08286
DISC1 disrupted in schizophrenia 1 -2.08178
NDUFAF2 NADH dehydrogenase (ubiquinone) complex I, assembly factor 2 -2.08178
CLSPN claspin -2.07035
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6 -2.0597
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) -2.05095
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.05095
LSM1 LSM1, U6 small nuclear RNA associated -2.04976
ZMYM3 zinc finger, MYM-type 3 -2.04358
DOHH deoxyhypusine hydroxylase/monooxygenase -2.0182
LAMA5 laminin, alpha 5 -2.01579
PHB1 prohibitin 1 -2.01579
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -2.01579
OSBPL11 oxysterol binding protein-like 11 -2.01041
PRKAG1 protein kinase, AMP-activated, gamma 1 non-catalytic subunit -2.00646
WDR48 WD repeat domain 48 -2.00419
INTS4 integrator complex subunit 4 -2.00114
ALKAL2 ALK and LTK ligand 2 -2.00055
FUOM fucose mutarotase -2.00055
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.00055