LM-1685-253 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the LM-1685-253 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ABLIM3 actin binding LIM protein family, member 3
ACAA2 acetyl-CoA acyltransferase 2
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACSM3 acyl-CoA synthetase medium-chain family member 3
ALPK1 alpha-kinase 1
ANGPT4 angiopoietin 4
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ATXN8OS ATXN8 opposite strand (non-protein coding)
AXIN1 axin 1
BEST2 bestrophin 2
BIN1 bridging integrator 1
C17ORF59 chromosome 17 open reading frame 59
CAPN9 calpain 9
CARTPT CART prepropeptide
CASR calcium-sensing receptor
CD101 CD101 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHAT choline O-acetyltransferase
CIB2 calcium and integrin binding family member 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COX4I1 cytochrome c oxidase subunit IV isoform 1
CSH2 chorionic somatomammotropin hormone 2
CXXC4 CXXC finger protein 4
ENOX2 ecto-NOX disulfide-thiol exchanger 2
FAM107A family with sequence similarity 107, member A
FBXO31 F-box protein 31
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGR FGR proto-oncogene, Src family tyrosine kinase
FOXRED2 FAD-dependent oxidoreductase domain containing 2
G0S2 G0/G1 switch 2
GLI2 GLI family zinc finger 2
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GRM8 glutamate receptor, metabotropic 8
GYPB glycophorin B (MNS blood group)
HEMK1 HemK methyltransferase family member 1
HIST1H2AB histone cluster 1, H2ab
HNF1A HNF1 homeobox A
HRASLS2 HRAS-like suppressor 2
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
ICAM1 intercellular adhesion molecule 1
ING4 inhibitor of growth family, member 4
KLHL35 kelch-like family member 35
LAMA2 laminin, alpha 2
LAPTM5 lysosomal protein transmembrane 5
LGALS9 lectin, galactoside-binding, soluble, 9
LMF1 lipase maturation factor 1
MAPK8 mitogen-activated protein kinase 8
MASP2 mannan-binding lectin serine peptidase 2
MSRB2 methionine sulfoxide reductase B2
MT1G metallothionein 1G
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
NUP160 nucleoporin 160kDa
NUP214 nucleoporin 214kDa
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PHOX2B paired-like homeobox 2b
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
PLXNB3 plexin B3
PNMA3 paraneoplastic Ma antigen 3
POM121L9P POM121 transmembrane nucleoporin-like 9, pseudogene
PON3 paraoxonase 3
PPP1R10 protein phosphatase 1, regulatory subunit 10
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like
RAB3A RAB3A, member RAS oncogene family
RNASE3 ribonuclease, RNase A family, 3
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RPAIN RPA interacting protein
RPL14 ribosomal protein L14
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
S100A3 S100 calcium binding protein A3
S1PR4 sphingosine-1-phosphate receptor 4
SGSH N-sulfoglucosamine sulfohydrolase
SH2B1 SH2B adaptor protein 1
SLC14A2 solute carrier family 14 (urea transporter), member 2
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNX1 sorting nexin 1
SPDEF SAM pointed domain containing ETS transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SYT2 synaptotagmin II
TAS2R13 taste receptor, type 2, member 13
TEK TEK tyrosine kinase, endothelial
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast)
TMEM140 transmembrane protein 140
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TSPAN32 tetraspanin 32
UBE2I ubiquitin-conjugating enzyme E2I
ULBP2 UL16 binding protein 2
USP20 ubiquitin specific peptidase 20
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
VCX2 variable charge, X-linked 2

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACBD4 acyl-CoA binding domain containing 4
ACVRL1 activin A receptor type II-like 1
ANKRD40 ankyrin repeat domain 40
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ART3 ADP-ribosyltransferase 3
ASIP agouti signaling protein
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
C7ORF43 chromosome 7 open reading frame 43
CA5BP1 carbonic anhydrase VB pseudogene 1
CEP97 centrosomal protein 97kDa
CHKB choline kinase beta
CHML choroideremia-like (Rab escort protein 2)
CLDN14 claudin 14
CLEC2B C-type lectin domain family 2, member B
CUEDC1 CUE domain containing 1
CYSLTR2 cysteinyl leukotriene receptor 2
DCSTAMP dendrocyte expressed seven transmembrane protein
DIO3 deiodinase, iodothyronine, type III
DPEP1 dipeptidase 1 (renal)
DRP2 dystrophin related protein 2
ENAH enabled homolog (Drosophila)
EPHA4 EPH receptor A4
EPX eosinophil peroxidase
FAM110B family with sequence similarity 110, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FBXO22 F-box protein 22
FGFR3 fibroblast growth factor receptor 3
FKBP10 FK506 binding protein 10, 65 kDa
FOLR3 folate receptor 3 (gamma)
FOXD1 forkhead box D1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GEMIN7 gem (nuclear organelle) associated protein 7
GK2 glycerol kinase 2
GLMN glomulin, FKBP associated protein
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GSTT1 glutathione S-transferase theta 1
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3
IFT22 intraflagellar transport 22
IL10RA interleukin 10 receptor, alpha
JOSD1 Josephin domain containing 1
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KCNMB3 potassium channel subfamily M regulatory beta subunit 3
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR3DS1 killer cell immunoglobulin-like receptor, three domains, short cytoplasmic tail, 1
KRBOX4 KRAB box domain containing 4
LBR lamin B receptor
LHX6 LIM homeobox 6
LMTK1 lemur tail kinase 1
LOC100127972 uncharacterized LOC100127972
LOC441601 septin 7 pseudogene
LRRC42 leucine rich repeat containing 42
MAGEB2 melanoma antigen family B2
MAGOHB mago-nashi homolog B (Drosophila)
MICU2 mitochondrial calcium uptake 2
MTERF4 mitochondrial transcription termination factor 4
MVP major vault protein
NCS1 neuronal calcium sensor 1
NOD1 nucleotide-binding oligomerization domain containing 1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NRGN neurogranin (protein kinase C substrate, RC3)
PARM1 prostate androgen-regulated mucin-like protein 1
PDZD8 PDZ domain containing 8
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIP prolactin-induced protein
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein
PPP1R17 protein phosphatase 1, regulatory subunit 17
PRDM14 PR domain containing 14
PRMT7 protein arginine methyltransferase 7
PRMT8 protein arginine methyltransferase 8
RAB23 RAB23, member RAS oncogene family
RANBP6 RAN binding protein 6
RNF186 ring finger protein 186
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SAMHD1 SAM domain and HD domain 1
SEC24B SEC24 family member B
SETD1A SET domain containing 1A
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SPIB Spi-B transcription factor (Spi-1/PU.1 related)
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TFB2M transcription factor B2, mitochondrial
TGM5 transglutaminase 5
TMSB4Y thymosin beta 4, Y-linked
TRAC T cell receptor alpha constant
TUBGCP5 tubulin, gamma complex associated protein 5
UGT8 UDP glycosyltransferase 8
VEGFC vascular endothelial growth factor C
VSIG10 V-set and immunoglobulin domain containing 10
ZBTB44 zinc finger and BTB domain containing 44
ZC4H2 zinc finger, C4H2 domain containing
ZNF211 zinc finger protein 211
ZNF35 zinc finger protein 35
ZNF536 zinc finger protein 536
ZNF623 zinc finger protein 623
ZNF675 zinc finger protein 675