LMBR1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description limb development membrane protein 1|This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 64327)
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Genes

352 genes differentially expressed following the LMBR1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRB4 proline-rich protein BstNI subfamily 4 2.23871
EQTN equatorin, sperm acrosome associated 2.23871
USP26 ubiquitin specific peptidase 26 2.23871
SLC46A3 solute carrier family 46, member 3 2.23871
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.23871
MN1 meningioma (disrupted in balanced translocation) 1 2.23871
PLIN4 perilipin 4 2.23871
TRIM15 tripartite motif containing 15 2.23871
SLC35G5 solute carrier family 35, member G5 2.23871
SOX10 SRY (sex determining region Y)-box 10 2.23871
ACVR1C activin A receptor, type IC 2.23871
HORMAD1 HORMA domain containing 1 2.23871
HORMAD2 HORMA domain containing 2 2.23871
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.23871
CLEC12A C-type lectin domain family 12, member A 2.23871
ZACN zinc activated ligand-gated ion channel 2.23871
RALGDS ral guanine nucleotide dissociation stimulator 2.23871
PYCR2 pyrroline-5-carboxylate reductase family, member 2 2.23871
GRXCR1 glutaredoxin, cysteine rich 1 2.23871
KLK1 kallikrein 1 2.23871
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.23871
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 2.23871
USH1G Usher syndrome 1G (autosomal recessive) 2.23871
KLHL34 kelch-like family member 34 2.23871
PLVAP plasmalemma vesicle associated protein 2.23871
TMPRSS11A transmembrane protease, serine 11A 2.23871
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3 2.23871
UPK3A uroplakin 3A 2.23871
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.23871
RASSF10 Ras association (RalGDS/AF-6) domain family (N-terminal) member 10 2.23871
MRPL57 mitochondrial ribosomal protein L57 2.23871
HCST hematopoietic cell signal transducer 2.23871
CD164L2 CD164 sialomucin-like 2 2.23871
LCN15 lipocalin 15 2.23871
CD68 CD68 molecule 2.23871
CPB2 carboxypeptidase B2 (plasma) 2.23871
CRIP2 cysteine-rich protein 2 2.23871
CRIP1 cysteine-rich protein 1 (intestinal) 2.23871
DPPA3 developmental pluripotency associated 3 2.23871
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.23871
NPIPA5 nuclear pore complex interacting protein family, member A5 2.23871
HEPHL1 hephaestin-like 1 2.23871
SETSIP SET-like protein 2.23871
CACNG1 calcium channel, voltage-dependent, gamma subunit 1 2.23871
CA4 carbonic anhydrase IV 2.23871
THRSP thyroid hormone responsive 2.23871
GSTM2 glutathione S-transferase mu 2 (muscle) 2.23871
TMEM191C transmembrane protein 191C 2.23871
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.23871
GJB5 gap junction protein, beta 5, 31.1kDa 2.23871
GFAP glial fibrillary acidic protein 2.23871
SIGLEC9 sialic acid binding Ig-like lectin 9 2.23871
SPOCD1 SPOC domain containing 1 2.23871
KDM6B lysine (K)-specific demethylase 6B 2.23871
PBOV1 prostate and breast cancer overexpressed 1 2.23871
FCRL5 Fc receptor-like 5 2.23871
HCRTR2 hypocretin (orexin) receptor 2 2.23871
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa 2.23871
NT5E 5'-nucleotidase, ecto (CD73) 2.23871
CIMIP2B ciliary microtubule inner protein 2B 2.23871
SMIM41 small integral membrane protein 41 2.23871
CCDC9B coiled-coil domain containing 9B 2.23871
CARMIL2 capping protein regulator and myosin 1 linker 2 2.23871
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.23871
PCDHGA9 protocadherin gamma subfamily A, 9 2.23871
SAPCD1 suppressor APC domain containing 1 2.23871
YIPF7 Yip1 domain family, member 7 2.23871
AVPR1A arginine vasopressin receptor 1A 2.23871
AANAT aralkylamine N-acetyltransferase 2.23871
CEP170B centrosomal protein 170B 2.23871
ALX1 ALX homeobox 1 2.23871
PNLIPRP2 pancreatic lipase-related protein 2 2.23871
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.23871
RTL9 retrotransposon Gag like 9 2.23871
CPLANE2 ciliogenesis and planar polarity effector complex subunit 2 2.23871
LOC114841035 uncharacterized LOC114841035 2.23871
FAM240C family with sequence similarity 240 member C 2.23871
STRIT1 small transmembrane regulator of ion transport 1 2.23871
TOP6BL TOP6B like initiator of meiotic double strand breaks 2.23871
DUSP13B dual specificity phosphatase 13B 2.23871
C17ORF113 chromosome 17 open reading frame 113 2.23871
CFAP97D2 CFAP97 domain containing 2 2.23871
GREP1 glycine rich extracellular protein 1 2.23871
H3-7 H3.7 histone (putative) 2.23871
IQCN IQ motif containing N 2.23871
H2BW1 H2B.W histone 1 2.23871
H2BC3 H2B clustered histone 3 2.23871
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 2.23871
ACTA2 actin, alpha 2, smooth muscle, aorta 2.23871
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.23871
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 2.23871
IL6 interleukin 6 2.23871
ZNF575 zinc finger protein 575 2.23871
C1ORF162 chromosome 1 open reading frame 162 2.23871
CXCL14 chemokine (C-X-C motif) ligand 14 2.23871
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.23871
MSX1 msh homeobox 1 2.23871
AXDND1 axonemal dynein light chain domain containing 1 2.23871
MAG myelin associated glycoprotein 2.23871
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.23871
ITK IL2-inducible T-cell kinase 2.23871
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.23871
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 2.23871
CFAP45 cilia and flagella associated protein 45 2.23871
SBSN suprabasin 2.23871
DUSP9 dual specificity phosphatase 9 2.23871
KRT86 keratin 86, type II 2.23871
PDC phosducin 2.23871
LMNTD1 lamin tail domain containing 1 2.23871
TMPRSS5 transmembrane protease, serine 5 2.23871
GCSAM germinal center-associated, signaling and motility 2.23871
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.23871
IL16 interleukin 16 2.23871
BEST3 bestrophin 3 2.23871
PNPLA1 patatin-like phospholipase domain containing 1 2.23871
ZAR1L zygote arrest 1-like 2.23871
PGLYRP1 peptidoglycan recognition protein 1 2.23871
PTPRB protein tyrosine phosphatase, receptor type, B 2.23871
NGB neuroglobin 2.23871
TMEM139 transmembrane protein 139 2.23871
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 2.23871
RRH retinal pigment epithelium-derived rhodopsin homolog 2.23871
PDZRN4 PDZ domain containing ring finger 4 2.23871
GTF2A1L general transcription factor IIA, 1-like 2.23871
TEX12 testis expressed 12 2.23871
ILDR2 immunoglobulin-like domain containing receptor 2 2.23871
SVOP SV2 related protein homolog (rat) 2.23871
SPEF2 sperm flagellar 2 2.23871
IST1 increased sodium tolerance 1 homolog (yeast) 2.23871
VSTM1 V-set and transmembrane domain containing 1 2.23871
CFAP61 cilia and flagella associated protein 61 2.23871
TMED6 transmembrane emp24 protein transport domain containing 6 2.23871
GOLGA6B golgin A6 family, member B 2.23871
PDCL2 phosducin-like 2 2.23871
OAZ3 ornithine decarboxylase antizyme 3 2.23871
RGS17 regulator of G-protein signaling 17 2.23871
POF1B premature ovarian failure, 1B 2.23871
KLRG2 killer cell lectin-like receptor subfamily G, member 2 2.23871
PABPC4L poly(A) binding protein, cytoplasmic 4-like 2.23871
CXCR5 chemokine (C-X-C motif) receptor 5 2.23871
CPSF4L cleavage and polyadenylation specific factor 4-like 2.23871
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.23871
GLOD5 glyoxalase domain containing 5 2.23871
IL21R interleukin 21 receptor 2.23871
ERICH6B glutamate-rich 6B 2.23871
RBM24 RNA binding motif protein 24 2.23871
PLD6 phospholipase D family, member 6 2.23871
SP140L SP140 nuclear body protein-like 2.23871
LRRN4 leucine rich repeat neuronal 4 2.23871
PDE11A phosphodiesterase 11A 2.23871
TEX29 testis expressed 29 2.23871
ZPBP zona pellucida binding protein 2.23871
BTG4 B-cell translocation gene 4 2.23871
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 2.23871
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.23871
GSDMA gasdermin A 2.23871
B3GAT3 beta-1,3-glucuronyltransferase 3 2.23871
SEZ6L seizure related 6 homolog (mouse)-like 2.23871
CFB complement factor B 2.23871
CASQ2 calsequestrin 2 (cardiac muscle) 2.23871
PCDHAC1 protocadherin alpha subfamily C, 1 2.23871
OTOP2 otopetrin 2 2.23871
CPXM1 carboxypeptidase X (M14 family), member 1 2.23871
CTSH cathepsin H 2.23871
BCL2L15 BCL2-like 15 2.23871
CCNI2 cyclin I family, member 2 2.23871
TPSAB1 tryptase alpha/beta 1 2.23871
MYLK2 myosin light chain kinase 2 2.23871
IGIP IgA-inducing protein 2.23871
GPR150 G protein-coupled receptor 150 2.23871
HLA-G major histocompatibility complex, class I, G 2.23871
GPR142 G protein-coupled receptor 142 2.23871
PLA2G2C phospholipase A2, group IIC 2.23871
AKR1B15 aldo-keto reductase family 1, member B15 2.23871
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 2.23871
ANXA2R annexin A2 receptor 2.23871
TTC36 tetratricopeptide repeat domain 36 2.23871
GRWD1 glutamate-rich WD repeat containing 1 2.23871
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.23871
TICAM1 toll-like receptor adaptor molecule 1 2.23871
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 2.23871
EPN3 epsin 3 2.23871
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.23871
NOS2 nitric oxide synthase 2, inducible 2.23871
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.23871
XCR1 chemokine (C motif) receptor 1 2.23871
PPP1R36 protein phosphatase 1, regulatory subunit 36 2.23871
SSX1 synovial sarcoma, X breakpoint 1 2.23871
LOXL4 lysyl oxidase-like 4 2.23871
LPO lactoperoxidase 2.23871
STOML3 stomatin (EPB72)-like 3 2.23871
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 2.23871
VPREB3 pre-B lymphocyte 3 2.23871
IL33 interleukin 33 2.23871
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.23871
NFE2 nuclear factor, erythroid 2 2.23871
IL32 interleukin 32 2.23871
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.23871
FGF10 fibroblast growth factor 10 2.23871
RNF224 ring finger protein 224 2.23871
RBPMS2 RNA binding protein with multiple splicing 2 2.23871
PTGDR prostaglandin D2 receptor (DP) 2.23871
NWD2 NACHT and WD repeat domain containing 2 2.23871
FAM181B family with sequence similarity 181, member B 2.23871
HSPB8 heat shock 22kDa protein 8 2.23871
CHRNB4 cholinergic receptor, nicotinic, beta 4 (neuronal) 2.23871
KRT17 keratin 17, type I 2.23871
GYS2 glycogen synthase 2 (liver) 2.23871
SPHK1 sphingosine kinase 1 2.23871
TGM1 transglutaminase 1 2.23871
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.23871
PLGLB1 plasminogen-like B1 2.23871
PSORS1C1 psoriasis susceptibility 1 candidate 1 2.23871
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.23871
NPAS4 neuronal PAS domain protein 4 2.23871
IRF2BP1 interferon regulatory factor 2 binding protein 1 2.23871
PDCD1 programmed cell death 1 2.23871
NWD1 NACHT and WD repeat domain containing 1 2.23871
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.23871
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 2.23871
MAS1 MAS1 proto-oncogene, G protein-coupled receptor 2.23871
PSORS1C2 psoriasis susceptibility 1 candidate 2 2.23871
ZNF721 zinc finger protein 721 2.22004
TIGD1 tigger transposable element derived 1 2.20237
LLGL2 lethal giant larvae homolog 2 (Drosophila) 2.1979
COPS7A COP9 signalosome subunit 7A 2.1979
FAM184A family with sequence similarity 184, member A 2.18719
CAPN2 calpain 2, (m/II) large subunit 2.17727
PCLO piccolo presynaptic cytomatrix protein 2.16439
FMNL2 formin-like 2 2.16236
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 2.14272
CYB5D1 cytochrome b5 domain containing 1 2.11006
PLSCR4 phospholipid scramblase 4 2.11006
NEK5 NIMA-related kinase 5 2.1068
GTF2A2 general transcription factor IIA, 2, 12kDa 2.1068
ARHGAP32 Rho GTPase activating protein 32 2.10048
SIN3B SIN3 transcription regulator family member B 2.07306
SLCO1A2 solute carrier organic anion transporter family, member 1A2 2.05846
PMPCB peptidase (mitochondrial processing) beta 2.05135
RNFT1 ring finger protein, transmembrane 1 2.04166
ART3 ADP-ribosyltransferase 3 2.04166
XIRP2 xin actin binding repeat containing 2 2.03844
RNFT2 ring finger protein, transmembrane 2 2.03168
NSRP1 nuclear speckle splicing regulatory protein 1 2.02944
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20 2.02679
ZNF780A zinc finger protein 780A 2.02104
RPA3 replication protein A3, 14kDa 2.0181

decreased expression

Symbol Name Standardized Value
SPATA5L1 spermatogenesis associated 5-like 1 -2.23871
ARRDC1 arrestin domain containing 1 -2.23871
TJP2 tight junction protein 2 -2.23871
HAPLN4 hyaluronan and proteoglycan link protein 4 -2.23871
LMBR1 limb development membrane protein 1 -2.23871
DSG2 desmoglein 2 -2.23871
VSTM2B V-set and transmembrane domain containing 2B -2.23871
PNMA2 paraneoplastic Ma antigen 2 -2.23871
DEGS1 delta(4)-desaturase, sphingolipid 1 -2.23871
OXCT2 3-oxoacid CoA transferase 2 -2.23871
CHL1 cell adhesion molecule L1-like -2.23871
CHD5 chromodomain helicase DNA binding protein 5 -2.23871
HELZ2 helicase with zinc finger 2, transcriptional coactivator -2.23871
MED4 mediator complex subunit 4 -2.23871
SNAI2 snail family zinc finger 2 -2.23871
SCIN scinderin -2.23871
GALK2 galactokinase 2 -2.23871
BLOC1S3 biogenesis of lysosomal organelles complex-1, subunit 3 -2.23871
OVOL3 ovo-like zinc finger 3 -2.23871
PBDC1 polysaccharide biosynthesis domain containing 1 -2.23871
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 -2.23871
WNT3A wingless-type MMTV integration site family, member 3A -2.23871
PON3 paraoxonase 3 -2.23871
C2ORF69 chromosome 2 open reading frame 69 -2.23871
SCP2 sterol carrier protein 2 -2.23871
VASN vasorin -2.23871
GTF2B general transcription factor IIB -2.23871
LPIN2 lipin 2 -2.23871
COL24A1 collagen, type XXIV, alpha 1 -2.23871
CLDN18 claudin 18 -2.23871
TIMM29 translocase of inner mitochondrial membrane 29 -2.23871
RASAL1 RAS protein activator like 1 (GAP1 like) -2.23871
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.23871
CRLF2 cytokine receptor-like factor 2 -2.23871
TRIM17 tripartite motif containing 17 -2.23871
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C -2.23871
NIPSNAP3A nipsnap homolog 3A (C. elegans) -2.23871
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -2.23871
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase -2.23871
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 -2.23871
PLCXD2 phosphatidylinositol-specific phospholipase C, X domain containing 2 -2.23871
IRF9 interferon regulatory factor 9 -2.23871
TMEM269 transmembrane protein 269 -2.23871
MYOZ1 myozenin 1 -2.23871
PRSS53 protease, serine, 53 -2.23871
TMEM54 transmembrane protein 54 -2.23871
VMAC vimentin-type intermediate filament associated coiled-coil protein -2.23871
CCDC177 coiled-coil domain containing 177 -2.23871
DDHD1 DDHD domain containing 1 -2.23871
VWA1 von Willebrand factor A domain containing 1 -2.23871
FBXO32 F-box protein 32 -2.23871
CCDC181 coiled-coil domain containing 181 -2.23871
SHISA9 shisa family member 9 -2.23871
IGFBP7 insulin-like growth factor binding protein 7 -2.23871
F10 coagulation factor X -2.23871
HSPA1L heat shock 70kDa protein 1-like -2.23871
CNKSR1 connector enhancer of kinase suppressor of Ras 1 -2.23871
ANKRD54 ankyrin repeat domain 54 -2.23871
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 -2.23871
TM4SF18 transmembrane 4 L six family member 18 -2.23871
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 -2.23871
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.23871
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -2.23871
NOL11 nucleolar protein 11 -2.23871
MXD4 MAX dimerization protein 4 -2.23871
CD24 CD24 molecule -2.23871
PAQR9 progestin and adipoQ receptor family member IX -2.23871
SNAP91 synaptosomal-associated protein, 91kDa -2.23871
KCMF1 potassium channel modulatory factor 1 -2.23538
ADGRL1 adhesion G protein-coupled receptor L1 -2.22271
LARS2 leucyl-tRNA synthetase 2, mitochondrial -2.2197
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.20562
HDAC2 histone deacetylase 2 -2.18902
FAR1 fatty acyl CoA reductase 1 -2.18359
ST7 suppression of tumorigenicity 7 -2.16622
CABLES1 Cdk5 and Abl enzyme substrate 1 -2.15847
BIK BCL2-interacting killer (apoptosis-inducing) -2.1388
MSH6 mutS homolog 6 -2.11225
DSCAML1 Down syndrome cell adhesion molecule like 1 -2.11006
ZIC1 Zic family member 1 -2.11006
TFF3 trefoil factor 3 (intestinal) -2.11006
CCDC60 coiled-coil domain containing 60 -2.11006
PCDHGA12 protocadherin gamma subfamily A, 12 -2.11006
ZNF470 zinc finger protein 470 -2.11006
ACAN aggrecan -2.11006
TRIL TLR4 interactor with leucine-rich repeats -2.11006
DSTYK dual serine/threonine and tyrosine protein kinase -2.11006
CHD4 chromodomain helicase DNA binding protein 4 -2.11006
DLG3 discs, large homolog 3 (Drosophila) -2.10486
HSF2 heat shock transcription factor 2 -2.10291
WNT5B wingless-type MMTV integration site family, member 5B -2.0914
NCKAP5 NCK-associated protein 5 -2.08614
MOB1B MOB kinase activator 1B -2.08481
ALDH6A1 aldehyde dehydrogenase 6 family, member A1 -2.08448
NOL12 nucleolar protein 12 -2.08448
PLXDC1 plexin domain containing 1 -2.07475
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit -2.06246
PDE8B phosphodiesterase 8B -2.05867
SNTG1 syntrophin, gamma 1 -2.04845
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 -2.04731
ROR2 receptor tyrosine kinase-like orphan receptor 2 -2.02944
NSUN4 NOP2/Sun domain family, member 4 -2.02002
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.0181
UBE3A ubiquitin protein ligase E3A -2.0181
AKAP8L A kinase (PRKA) anchor protein 8-like -2.00516