LMNA Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description lamin A/C|The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012] (NCBI Entrez Gene Database, 4000)
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Genes

313 genes differentially expressed following the LMNA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 3.52991
SOX18 SRY (sex determining region Y)-box 18 3.52991
GRXCR2 glutaredoxin, cysteine rich 2 3.52991
CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 3.52991
SKOR1 SKI family transcriptional corepressor 1 3.52991
GJB1 gap junction protein, beta 1, 32kDa 3.52991
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 3.52991
GFAP glial fibrillary acidic protein 3.52991
OLIG1 oligodendrocyte transcription factor 1 3.52991
LRG1 leucine-rich alpha-2-glycoprotein 1 3.52991
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 3.52991
CD209 CD209 molecule 3.52991
CABP4 calcium binding protein 4 3.52991
CFHR5 complement factor H-related 5 3.52991
HRH4 histamine receptor H4 3.52991
CD6 CD6 molecule 3.52991
ZACN zinc activated ligand-gated ion channel 3.52991
FGF21 fibroblast growth factor 21 3.52991
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 3.52991
CELF3 CUGBP, Elav-like family member 3 3.52991
CD1A CD1a molecule 3.52991
ANKRD22 ankyrin repeat domain 22 3.52991
RSPO3 R-spondin 3 3.52991
C19ORF67 chromosome 19 open reading frame 67 3.52991
MYO1G myosin IG 3.52991
GALR3 galanin receptor 3 3.52991
MYL2 myosin, light chain 2, regulatory, cardiac, slow 3.52991
CCDC83 coiled-coil domain containing 83 3.52991
AMELX amelogenin, X-linked 3.52991
RHOJ ras homolog family member J 3.52991
IRX1 iroquois homeobox 1 3.52991
MYOZ2 myozenin 2 3.52991
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.52991
NMS neuromedin S 3.52991
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 3.52991
OSGIN1 oxidative stress induced growth inhibitor 1 3.52991
C12ORF71 chromosome 12 open reading frame 71 3.52991
C11ORF87 chromosome 11 open reading frame 87 3.52991
LCN15 lipocalin 15 3.52991
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 3.52991
CCDC38 coiled-coil domain containing 38 3.52991
PNOC prepronociceptin 3.52991
OR5V1 olfactory receptor, family 5, subfamily V, member 1 3.52991
KRT72 keratin 72, type II 3.52991
ATOH7 atonal homolog 7 (Drosophila) 3.52991
IL33 interleukin 33 3.52991
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.52991
NOTCH2NLB notch 2 N-terminal like B 3.52991
IMPG1 interphotoreceptor matrix proteoglycan 1 3.52991
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 3.52991
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.52991
TBX10 T-box 10 3.52991
FAM228A family with sequence similarity 228, member A 3.52991
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.52991
DYNAP dynactin associated protein 3.52991
DLK2 delta-like 2 homolog (Drosophila) 3.52991
ZAR1L zygote arrest 1-like 3.52991
ZNF441 zinc finger protein 441 3.52991
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.52991
TRAPPC3L trafficking protein particle complex 3-like 3.52991
TEX54 testis expressed 54 3.52991
LOC122526780 uncharacterized LOC122526780 3.52991
H3C13 H3 clustered histone 13 3.52991
IHO1 interactor of HORMAD1 1 3.52991
CCDC190 coiled-coil domain containing 190 3.52991
AJM1 apical junction component 1 homolog 3.52991
DERPC DERPC proline and glycine rich nuclear protein 3.52991
MISP3 MISP family member 3 3.52991
HAO2 hydroxyacid oxidase 2 (long chain) 3.52991
LRRC72 leucine rich repeat containing 72 3.52991
DDTL D-dopachrome tautomerase-like 3.52991
IL4 interleukin 4 3.52991
DMBX1 diencephalon/mesencephalon homeobox 1 3.52991
HAPLN2 hyaluronan and proteoglycan link protein 2 3.52991
OR2A12 olfactory receptor, family 2, subfamily A, member 12 3.52991
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 3.52991
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 3.52991
EDAR ectodysplasin A receptor 3.52991
MAGEB1 melanoma antigen family B1 3.52991
HHEX hematopoietically expressed homeobox 3.52991
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.52991
RNF113B ring finger protein 113B 3.52991
RUNX3 runt-related transcription factor 3 3.52991
PTH parathyroid hormone 3.52991
PGA4 pepsinogen 4, group I (pepsinogen A) 3.52991
CSN2 casein beta 3.52991
CCR9 chemokine (C-C motif) receptor 9 3.52991
PIWIL1 piwi-like RNA-mediated gene silencing 1 3.52991
MYOG myogenin (myogenic factor 4) 3.52991
C1QL2 complement component 1, q subcomponent-like 2 3.52991
OAF OAF homolog (Drosophila) 3.52991
C12ORF54 chromosome 12 open reading frame 54 3.52991
ZNF99 zinc finger protein 99 3.52991
MMP10 matrix metallopeptidase 10 3.52991
CNTF ciliary neurotrophic factor 3.52991
TTC9B tetratricopeptide repeat domain 9B 3.52991
DRD2 dopamine receptor D2 3.52991
MUCL1 mucin-like 1 3.52991
EVPLL envoplakin-like 3.52991
VWA7 von Willebrand factor A domain containing 7 3.52991
DNTT DNA nucleotidylexotransferase 3.52991
THBD thrombomodulin 3.52991
MTUS2 microtubule associated tumor suppressor candidate 2 3.52991
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 3.52991
SLC22A24 solute carrier family 22, member 24 3.52991
CLEC4D C-type lectin domain family 4, member D 3.52991
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.52991
CLDN34 claudin 34 3.52991
CST7 cystatin F (leukocystatin) 3.52991
SMIM23 small integral membrane protein 23 3.52991
KLHL41 kelch-like family member 41 3.52991
IL21R interleukin 21 receptor 3.52991
RNASE11 ribonuclease, RNase A family, 11 (non-active) 3.52991
CALHM3 calcium homeostasis modulator 3 3.52991
TNP1 transition protein 1 (during histone to protamine replacement) 3.52991
LRRK2 leucine-rich repeat kinase 2 3.52991
PABPN1L poly(A) binding protein, nuclear 1-like (cytoplasmic) 3.52991
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 3.52991
POU4F1 POU class 4 homeobox 1 3.52991
GBX1 gastrulation brain homeobox 1 3.52991
CNGB1 cyclic nucleotide gated channel beta 1 3.52991
TEX26 testis expressed 26 3.52991
MB myoglobin 3.52991
VMO1 vitelline membrane outer layer 1 homolog (chicken) 3.52991
PDK4 pyruvate dehydrogenase kinase, isozyme 4 3.52991
CCDC170 coiled-coil domain containing 170 3.52991
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 3.52991
GPR150 G protein-coupled receptor 150 3.52991
RGS8 regulator of G-protein signaling 8 3.52991
TBX1 T-box 1 3.52991
SLCO2B1 solute carrier organic anion transporter family, member 2B1 3.52991
FGG fibrinogen gamma chain 3.52991
ITGB7 integrin, beta 7 3.52991
ARL13A ADP-ribosylation factor-like 13A 3.52991
VWF von Willebrand factor 3.52991
ADGRD1 adhesion G protein-coupled receptor D1 3.52991
F13B coagulation factor XIII, B polypeptide 3.52991
CD27 CD27 molecule 3.52991
DGCR6 DiGeorge syndrome critical region gene 6 3.52991
GBA3 glucosidase, beta, acid 3 (gene/pseudogene) 3.52991
DUOXA1 dual oxidase maturation factor 1 3.52991
DES desmin 3.52991
IFITM10 interferon induced transmembrane protein 10 3.52991
PRR15L proline rich 15-like 3.52991
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 3.52991
KRT16 keratin 16, type I 3.52991
SLFN12L schlafen family member 12-like 3.52991
CIDEA cell death-inducing DFFA-like effector a 3.52991
BPIFC BPI fold containing family C 3.52991
PLGLB1 plasminogen-like B1 3.52991
NUTM2A NUT family member 2A 3.52991
DCAF8L2 DDB1 and CUL4 associated factor 8-like 2 3.52991
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 3.52991
GAL3ST2 galactose-3-O-sulfotransferase 2 3.52991
HHIPL2 HHIP-like 2 3.52991
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 3.52991
KCNC2 potassium channel, voltage gated Shaw related subfamily C, member 2 3.52991
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 3.52991
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 3.52991
SLITRK6 SLIT and NTRK-like family, member 6 3.52991
TTC13 tetratricopeptide repeat domain 13 3.4809
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 3.45612
PAPLN papilin, proteoglycan-like sulfated glycoprotein 3.17193
CHD8 chromodomain helicase DNA binding protein 8 3.17193
H3-3A H3.3 histone A 3.13816
OOEP oocyte expressed protein 3.13754
APOO apolipoprotein O 3.01971
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 2.95471
FAM163B family with sequence similarity 163, member B 2.81443
NOM1 nucleolar protein with MIF4G domain 1 2.72352
MESP2 mesoderm posterior basic helix-loop-helix transcription factor 2 2.60193
NPHP3 nephronophthisis 3 (adolescent) 2.50382
C2CD2L C2CD2-like 2.49762
PREB prolactin regulatory element binding 2.43988
PLD5 phospholipase D family, member 5 2.42559
CRB3 crumbs family member 3 2.42559
LTB lymphotoxin beta (TNF superfamily, member 3) 2.42314
C11ORF42 chromosome 11 open reading frame 42 2.42314
EFCAB12 EF-hand calcium binding domain 12 2.42314
NPPA natriuretic peptide A 2.42314
BMP8B bone morphogenetic protein 8b 2.42314
CORO6 coronin 6 2.42314
FAM50A family with sequence similarity 50, member A 2.42314
SPACDR sperm acrosome developmental regulator 2.42314
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.42314
KCNIP3 Kv channel interacting protein 3, calsenilin 2.42314
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.40252
UTRN utrophin 2.39161
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2.38566
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.33839
FLOT2 flotillin 2 2.32907
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 2.3139
IL1RAP interleukin 1 receptor accessory protein 2.3044
DOCK9 dedicator of cytokinesis 9 2.3044
TEKTIP1 tektin bundle interacting protein 1 2.30274
ACTR10 actin-related protein 10 homolog (S. cerevisiae) 2.29633
ITGA8 integrin, alpha 8 2.29348
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.29348
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 2.2891
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae) 2.23751
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein) 2.2085
TMEM160 transmembrane protein 160 2.2085
NEURL4 neuralized E3 ubiquitin protein ligase 4 2.18938
SGPP1 sphingosine-1-phosphate phosphatase 1 2.1785
RAB5C RAB5C, member RAS oncogene family 2.16763
APEH acylaminoacyl-peptide hydrolase 2.16763
TMEM120A transmembrane protein 120A 2.16647
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) 2.16235
AP1S2 adaptor-related protein complex 1, sigma 2 subunit 2.15164
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 2.14095
C11ORF24 chromosome 11 open reading frame 24 2.13626
EXOC5 exocyst complex component 5 2.12199
VEGFA vascular endothelial growth factor A 2.12178
SLX4IP SLX4 interacting protein 2.1052
RBIS ribosomal biogenesis factor 2.1052
EXOSC5 exosome component 5 2.10029
ARF4 ADP-ribosylation factor 4 2.07959
KCTD21 potassium channel tetramerization domain containing 21 2.07959
MACF1 microtubule-actin crosslinking factor 1 2.07808
PHKA2 phosphorylase kinase, alpha 2 (liver) 2.06502
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 2.04482
SPDYE1 speedy/RINGO cell cycle regulator family member E1 2.04482
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 2.04482
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.04136
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.03566
INSIG1 insulin induced gene 1 2.03383
SYT11 synaptotagmin XI 2.03147
DDAH2 dimethylarginine dimethylaminohydrolase 2 2.01539

decreased expression

Symbol Name Standardized Value
NPIPA2 nuclear pore complex interacting protein family, member A2 -3.52991
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 -3.52991
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 -3.52991
ZMYND12 zinc finger, MYND-type containing 12 -3.52991
ACP7 acid phosphatase 7, tartrate resistant (putative) -3.52991
MUC6 mucin 6, oligomeric mucus/gel-forming -3.52991
KIF12 kinesin family member 12 -3.52991
ABHD1 abhydrolase domain containing 1 -3.52991
PGBDF plakoglobin binding and degradation factor -3.52991
TMPRSS15 transmembrane protease, serine 15 -3.52991
TTLL2 tubulin tyrosine ligase-like family member 2 -3.52991
AHSG alpha-2-HS-glycoprotein -3.52991
KIF19 kinesin family member 19 -3.52991
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -3.52991
CYGB cytoglobin -3.52991
IZUMO4 IZUMO family member 4 -3.52991
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 -3.52991
DEFB131B defensin beta 131B -3.52991
TSPAN16 tetraspanin 16 -3.52991
PLA2G2C phospholipase A2, group IIC -3.52991
GPRC6A G protein-coupled receptor, class C, group 6, member A -3.52991
CTSK cathepsin K -3.52991
C22ORF31 chromosome 22 open reading frame 31 -3.52991
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide -3.52991
FIMP1 fertilization-influencing membrane protein 1 -3.52991
CTSO cathepsin O -3.52991
TEX12 testis expressed 12 -3.52991
GRK7 G protein-coupled receptor kinase 7 -3.44067
RASL11B RAS-like, family 11, member B -3.17193
STX19 syntaxin 19 -3.08319
STAG3 stromal antigen 3 -3.03474
CCDC171 coiled-coil domain containing 171 -2.91124
FAM194C family with sequence similarity 149 member C -2.86249
CCDC180 coiled-coil domain containing 180 -2.76623
ZNF281 zinc finger protein 281 -2.73326
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -2.70968
CCAR1 cell division cycle and apoptosis regulator 1 -2.60193
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.56368
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa -2.53169
TXK TXK tyrosine kinase -2.4725
C17ORF78 chromosome 17 open reading frame 78 -2.4496
CCDC178 coiled-coil domain containing 178 -2.4496
KLHL31 kelch-like family member 31 -2.42213
FBP2 fructose-1,6-bisphosphatase 2 -2.42213
DYDC1 DPY30 domain containing 1 -2.42213
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -2.42213
RAB8A RAB8A, member RAS oncogene family -2.35943
NSUN5 NOP2/Sun domain family, member 5 -2.34107
CA9 carbonic anhydrase IX -2.33555
SLC30A10 solute carrier family 30, member 10 -2.33555
PFN2 profilin 2 -2.32214
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -2.30036
PROC protein C (inactivator of coagulation factors Va and VIIIa) -2.30036
MARCHF7 membrane associated ring-CH-type finger 7 -2.29488
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) -2.29185
MIF4GD MIF4G domain containing -2.24591
MRRF mitochondrial ribosome recycling factor -2.23646
ELMO3 engulfment and cell motility 3 -2.2121
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -2.20683
PDLIM7 PDZ and LIM domain 7 (enigma) -2.18247
FLRT2 fibronectin leucine rich transmembrane protein 2 -2.1785
MSH3 mutS homolog 3 -2.16235
HPSE heparanase -2.15425
BIN2 bridging integrator 2 -2.15164
PRSS53 protease, serine, 53 -2.15164
CCDC74B coiled-coil domain containing 74B -2.15164
CHERP calcium homeostasis endoplasmic reticulum protein -2.15122
MDC1 mediator of DNA-damage checkpoint 1 -2.14095
PBLD phenazine biosynthesis-like protein domain containing -2.12133
ARL17A ADP-ribosylation factor-like 17A -2.12133
RASGEF1A RasGEF domain family, member 1A -2.10758
FOXRED2 FAD-dependent oxidoreductase domain containing 2 -2.1052
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.1052
BLTP2 bridge-like lipid transfer protein family member 2 -2.10083
CDK2AP1 cyclin-dependent kinase 2 associated protein 1 -2.07799
BCAR3 breast cancer anti-estrogen resistance 3 -2.06632
EGF epidermal growth factor -2.06446
SPATA6L spermatogenesis associated 6-like -2.04482
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) -2.04136
PIDD1 p53-induced death domain protein 1 -2.03147
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.03147
DDR1 discoidin domain receptor tyrosine kinase 1 -2.02085
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -2.02055
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 -2.0049
CDKN2AIP CDKN2A interacting protein -2.00451