LMO2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description LIM domain only 2 (rhombotin-like 1)|LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008] (NCBI Entrez Gene Database, 4005)
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Genes

353 genes differentially expressed following the LMO2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COL19A1 collagen, type XIX, alpha 1 3.65476
FAM180A family with sequence similarity 180, member A 3.65476
EPAS1 endothelial PAS domain protein 1 3.65476
IGFL2 IGF-like family member 2 3.65476
SPINK4 serine peptidase inhibitor, Kazal type 4 3.65476
TEX13B testis expressed 13B 3.65476
TM4SF1 transmembrane 4 L six family member 1 3.65476
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 3.65476
OLFM4 olfactomedin 4 3.65476
GRIA2 glutamate receptor, ionotropic, AMPA 2 3.65476
FGD2 FYVE, RhoGEF and PH domain containing 2 3.65476
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 3.65476
EQTN equatorin, sperm acrosome associated 3.65476
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.65476
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.65476
LOX lysyl oxidase 3.65476
NDRG1 N-myc downstream regulated 1 3.65476
SBK3 SH3 domain binding kinase family, member 3 3.65476
HRH4 histamine receptor H4 3.65476
AGTR1 angiotensin II receptor, type 1 3.65476
ALB albumin 3.65476
CLEC12A C-type lectin domain family 12, member A 3.65476
GPR26 G protein-coupled receptor 26 3.65476
GIMAP4 GTPase, IMAP family member 4 3.65476
SPINT3 serine peptidase inhibitor, Kunitz type, 3 3.65476
TMC2 transmembrane channel-like 2 3.65476
OR4D9 olfactory receptor, family 4, subfamily D, member 9 3.65476
GYS2 glycogen synthase 2 (liver) 3.65476
EVPL envoplakin 3.65476
NR4A3 nuclear receptor subfamily 4, group A, member 3 3.65476
BTBD16 BTB (POZ) domain containing 16 3.65476
HIGD1C HIG1 hypoxia inducible domain family, member 1C 3.65476
RBP4 retinol binding protein 4, plasma 3.65476
PSD2 pleckstrin and Sec7 domain containing 2 3.65476
GALR3 galanin receptor 3 3.65476
TSHZ1 teashirt zinc finger homeobox 1 3.65476
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.65476
TGFB3 transforming growth factor, beta 3 3.65476
RFPL2 ret finger protein-like 2 3.65476
F7 coagulation factor VII (serum prothrombin conversion accelerator) 3.65476
KCNIP3 Kv channel interacting protein 3, calsenilin 3.65476
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.65476
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 3.65476
DLL4 delta-like 4 (Drosophila) 3.65476
LRRIQ4 leucine-rich repeats and IQ motif containing 4 3.65476
HES7 hes family bHLH transcription factor 7 3.65476
R3HDML R3H domain containing-like 3.65476
CSNK2A2IP casein kinase 2 subunit alpha' interacting protein 3.65476
PLG plasminogen 3.65476
ACER1 alkaline ceramidase 1 3.65476
FMO2 flavin containing monooxygenase 2 (non-functional) 3.65476
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 3.65476
TREX2 three prime repair exonuclease 2 3.65476
TMEM196 transmembrane protein 196 3.65476
LY6K lymphocyte antigen 6 complex, locus K 3.65476
MAGIX MAGI family member, X-linked 3.65476
ZNF705D zinc finger protein 705D 3.65476
TMOD4 tropomodulin 4 (muscle) 3.65476
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 3.65476
H1-6 H1.6 linker histone, cluster member 3.65476
SPMIP11 sperm microtubule inner protein 11 3.65476
SMIM45 small integral membrane protein 45 3.65476
EZHIP EZH inhibitory protein 3.65476
H2BW1 H2B.W histone 1 3.65476
SPATA46 spermatogenesis associated 46 3.65476
CBLIF cobalamin binding intrinsic factor 3.65476
TBXT T-box transcription factor T 3.65476
EOLA1 endothelium and lymphocyte associated ASCH domain 1 3.65476
SMIM38 small integral membrane protein 38 3.65476
OR2F2 olfactory receptor, family 2, subfamily F, member 2 3.65476
TAF1L TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like 3.65476
FAM107A family with sequence similarity 107, member A 3.65476
PCDHB11 protocadherin beta 11 3.65476
ARL5C ADP-ribosylation factor-like 5C 3.65476
GGT6 gamma-glutamyltransferase 6 3.65476
FOXD1 forkhead box D1 3.65476
ACTL10 actin-like 10 3.65476
OR2A25 olfactory receptor, family 2, subfamily A, member 25 3.65476
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 3.65476
KLF17 Kruppel-like factor 17 3.65476
PRB1 proline-rich protein BstNI subfamily 1 3.65476
CFAP99 cilia and flagella associated protein 99 3.65476
CD48 CD48 molecule 3.65476
CBLN3 cerebellin 3 precursor 3.65476
GDF6 growth differentiation factor 6 3.65476
CAPN8 calpain 8 3.65476
C9 complement component 9 3.65476
RUNX3 runt-related transcription factor 3 3.65476
OVOL3 ovo-like zinc finger 3 3.65476
IL5 interleukin 5 3.65476
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.65476
NPIPB9 nuclear pore complex interacting protein family, member B9 3.65476
PTP4A1 protein tyrosine phosphatase type IVA, member 1 3.65476
TAS2R3 taste receptor, type 2, member 3 3.65476
CALML6 calmodulin-like 6 3.65476
EFCAB9 EF-hand calcium binding domain 9 3.65476
BTNL3 butyrophilin-like 3 3.65476
ARR3 arrestin 3, retinal (X-arrestin) 3.65476
KRT222 keratin 222, type II 3.65476
GLOD5 glyoxalase domain containing 5 3.65476
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 3.65476
CDHR5 cadherin-related family member 5 3.65476
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 3.65476
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.65476
GP2 glycoprotein 2 (zymogen granule membrane) 3.65476
PLAT plasminogen activator, tissue 3.65476
PRSS55 protease, serine, 55 3.65476
APOC2 apolipoprotein C-II 3.65476
KPNA7 karyopherin alpha 7 (importin alpha 8) 3.65476
CIDEA cell death-inducing DFFA-like effector a 3.65476
LRRC46 leucine rich repeat containing 46 3.65476
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.65476
KRTAP19-5 keratin associated protein 19-5 3.65476
NIM1K NIM1 serine/threonine protein kinase 3.65476
CT55 cancer/testis antigen 55 3.65476
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.65476
POU2AF1 POU class 2 associating factor 1 3.65476
C2CD4D C2 calcium-dependent domain containing 4D 3.65476
PRAC1 prostate cancer susceptibility candidate 1 3.65476
CSF1R colony stimulating factor 1 receptor 3.65476
LGALS14 lectin, galactoside-binding, soluble, 14 3.65476
IGIP IgA-inducing protein 3.65476
REG1A regenerating islet-derived 1 alpha 3.65476
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.65476
GAS2L2 growth arrest-specific 2 like 2 3.65476
GBX1 gastrulation brain homeobox 1 3.65476
BTG4 B-cell translocation gene 4 3.65476
TMPPE transmembrane protein with metallophosphoesterase domain 3.65476
BCL2L15 BCL2-like 15 3.65476
BCO1 beta-carotene oxygenase 1 3.65476
RRH retinal pigment epithelium-derived rhodopsin homolog 3.65476
CLEC18C C-type lectin domain family 18, member C 3.65476
TBX10 T-box 10 3.65476
LRRC19 leucine rich repeat containing 19 3.65476
PRR35 proline rich 35 3.65476
TH tyrosine hydroxylase 3.65476
SPHKAP SPHK1 interactor, AKAP domain containing 3.65476
NOBOX NOBOX oogenesis homeobox 3.65476
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 3.65476
CAPSL calcyphosine-like 3.65476
CYP4Z1 cytochrome P450, family 4, subfamily Z, polypeptide 1 3.65476
IL33 interleukin 33 3.65476
IL37 interleukin 37 3.65476
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 3.65476
GPRC5A G protein-coupled receptor, class C, group 5, member A 3.65476
FGF10 fibroblast growth factor 10 3.65476
CIB4 calcium and integrin binding family member 4 3.65476
ANXA8 annexin A8 3.65476
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.65476
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 3.65476
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 3.65476
SLC51B solute carrier family 51, beta subunit 3.65476
TGM5 transglutaminase 5 3.65476
TGM1 transglutaminase 1 3.65476
CHRM4 cholinergic receptor, muscarinic 4 3.65476
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 3.65476
OR14A2 olfactory receptor, family 14, subfamily A, member 2 3.65476
DEFB134 defensin, beta 134 3.65476
PRR15L proline rich 15-like 3.65476
GCSAML germinal center-associated, signaling and motility-like 3.65476
TMPRSS5 transmembrane protease, serine 5 3.6215
MROH6 maestro heat-like repeat family member 6 3.6215
ETNPPL ethanolamine-phosphate phospho-lyase 3.6215
RPS25 ribosomal protein S25 3.41077
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.20575
RIBC1 RIB43A domain with coiled-coils 1 3.12213
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 2.94832
RPL36 ribosomal protein L36 2.84774
UBE2J1 ubiquitin-conjugating enzyme E2, J1 2.8438
SALL2 spalt-like transcription factor 2 2.7889
MICOS10 mitochondrial contact site and cristae organizing system subunit 10 2.71137
HLA-A major histocompatibility complex, class I, A 2.70106
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.70106
TXLNB taxilin beta 2.61409
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.61409
TTC29 tetratricopeptide repeat domain 29 2.61409
PODNL1 podocan-like 1 2.61409
FAM13C family with sequence similarity 13, member C 2.61409
KLHDC8A kelch domain containing 8A 2.61409
CLPSL1 colipase-like 1 2.5156
CSRP2 cysteine and glycine-rich protein 2 2.51446
KRT18 keratin 18, type I 2.50795
SLC44A1 solute carrier family 44 (choline transporter), member 1 2.49086
COL9A1 collagen, type IX, alpha 1 2.48967
TACR2 tachykinin receptor 2 2.38444
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 2.37139
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 2.35541
SLC35B2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 2.34047
CDC40 cell division cycle 40 2.33945
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.32455
RPL4 ribosomal protein L4 2.31467
NEK10 NIMA-related kinase 10 2.29021
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.28742
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 2.26866
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.25582
UBC ubiquitin C 2.24267
TBKBP1 TBK1 binding protein 1 2.22472
ANKFY1 ankyrin repeat and FYVE domain containing 1 2.20459
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 2.20134
CNTROB centrobin, centrosomal BRCA2 interacting protein 2.20099
RMDN2 regulator of microtubule dynamics 2 2.19431
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 2.17911
MSI1 musashi RNA-binding protein 1 2.17867
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 2.1501
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 2.1501
ZNF577 zinc finger protein 577 2.14014
ART3 ADP-ribosyltransferase 3 2.13626
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 2.12149
ZNF594 zinc finger protein 594 2.12149
KIF27 kinesin family member 27 2.12118
RPLP2 ribosomal protein, large, P2 2.09885
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae) 2.09653
NEFH neurofilament, heavy polypeptide 2.09162
EIF5A eukaryotic translation initiation factor 5A 2.0829
EFCAB7 EF-hand calcium binding domain 7 2.08191
ZNF224 zinc finger protein 224 2.07712
C1ORF122 chromosome 1 open reading frame 122 2.06804
ARFIP2 ADP-ribosylation factor interacting protein 2 2.06602
SAMD8 sterile alpha motif domain containing 8 2.05478
PRMT1 protein arginine methyltransferase 1 2.04716
MFSD1 major facilitator superfamily domain containing 1 2.03399
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.01946
CDC14A cell division cycle 14A 2.01705
USP54 ubiquitin specific peptidase 54 2.01463
PPT2 palmitoyl-protein thioesterase 2 2.00338
CAVIN3 caveolae associated protein 3 2.00066

decreased expression

Symbol Name Standardized Value
TMEM238L transmembrane protein 238 like -3.65476
MCHR1 melanin-concentrating hormone receptor 1 -3.65476
B3GALT2 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 2 -3.65476
LCN10 lipocalin 10 -3.65476
GCC1 GRIP and coiled-coil domain containing 1 -3.65476
CENPN centromere protein N -3.65476
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -3.65476
KIF12 kinesin family member 12 -3.65476
C2CD2L C2CD2-like -3.65476
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -3.65476
HEPACAM hepatic and glial cell adhesion molecule -3.65476
RNF222 ring finger protein 222 -3.65476
POTEI POTE ankyrin domain family, member I -3.65476
CD300A CD300a molecule -3.65476
DUSP10 dual specificity phosphatase 10 -3.65476
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 -3.65476
DUSP29 dual specificity phosphatase 29 -3.65476
RTL5 retrotransposon Gag like 5 -3.65476
FGFBP1 fibroblast growth factor binding protein 1 -3.65476
CCR3 chemokine (C-C motif) receptor 3 -3.65476
C1QTNF2 C1q and tumor necrosis factor related protein 2 -3.65476
SPAG17 sperm associated antigen 17 -3.65476
FER1L6 fer-1-like family member 6 -3.65476
FOLR1 folate receptor 1 (adult) -3.65476
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 -3.65476
PARP3 poly (ADP-ribose) polymerase family, member 3 -3.65476
USP26 ubiquitin specific peptidase 26 -3.65476
ALOX15 arachidonate 15-lipoxygenase -3.65476
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -3.65476
UPK1A uroplakin 1A -3.65476
KRTAP5-11 keratin associated protein 5-11 -3.65476
CERKL ceramide kinase-like -3.65476
LYG1 lysozyme G-like 1 -3.65476
IL21R interleukin 21 receptor -3.65476
ADAM8 ADAM metallopeptidase domain 8 -3.65476
PACRG PARK2 co-regulated -3.65476
KISS1 KiSS-1 metastasis-suppressor -3.65476
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) -3.65476
SHANK1 SH3 and multiple ankyrin repeat domains 1 -3.62906
BCL7A B-cell CLL/lymphoma 7A -3.57593
C19ORF84 chromosome 19 open reading frame 84 -3.55446
RAB37 RAB37, member RAS oncogene family -3.42923
WRN Werner syndrome, RecQ helicase-like -3.34189
ABHD17B abhydrolase domain containing 17B -3.19724
DPYSL3 dihydropyrimidinase-like 3 -3.11154
CORIN corin, serine peptidase -2.9701
MOB3B MOB kinase activator 3B -2.94352
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -2.93954
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -2.90031
IL23A interleukin 23, alpha subunit p19 -2.89561
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 -2.88546
E2F5 E2F transcription factor 5, p130-binding -2.86772
BORCS7 BLOC-1 related complex subunit 7 -2.77218
H2AZ2 H2A.Z variant histone 2 -2.72522
RETREG2 reticulophagy regulator family member 2 -2.70027
CNOT6L CCR4-NOT transcription complex, subunit 6-like -2.69487
MELK maternal embryonic leucine zipper kinase -2.61409
ZBED5 zinc finger, BED-type containing 5 -2.59773
SLIT2 slit homolog 2 (Drosophila) -2.59687
L3MBTL4 l(3)mbt-like 4 (Drosophila) -2.59687
WDR46 WD repeat domain 46 -2.59202
NFASC neurofascin -2.56325
SMAD1 SMAD family member 1 -2.54029
IQANK1 IQ motif and ankyrin repeat containing 1 -2.5239
SIK3 SIK family kinase 3 -2.52113
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 -2.51446
H4C11 H4 clustered histone 11 -2.50795
PPP1R36 protein phosphatase 1, regulatory subunit 36 -2.50795
DNAJB7 DnaJ (Hsp40) homolog, subfamily B, member 7 -2.50795
LRRC36 leucine rich repeat containing 36 -2.50795
HCN2 hyperpolarization activated cyclic nucleotide gated potassium channel 2 -2.50795
TES testin LIM domain protein -2.49265
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -2.49086
SMC3 structural maintenance of chromosomes 3 -2.48824
SERTAD2 SERTA domain containing 2 -2.48634
COL12A1 collagen, type XII, alpha 1 -2.45631
TMCC3 transmembrane and coiled-coil domain family 3 -2.42687
DOP1B DOP1 leucine zipper like protein B -2.39182
GNS glucosamine (N-acetyl)-6-sulfatase -2.38885
PHETA1 PH domain containing endocytic trafficking adaptor 1 -2.36945
ASPH aspartate beta-hydroxylase -2.36538
PAN3 PAN3 poly(A) specific ribonuclease subunit -2.36093
OR2H2 olfactory receptor, family 2, subfamily H, member 2 -2.33945
PATL2 protein associated with topoisomerase II homolog 2 (yeast) -2.33945
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -2.33945
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.33945
KAZN kazrin, periplakin interacting protein -2.32804
SPATA16 spermatogenesis associated 16 -2.32519
CAPN3 calpain 3, (p94) -2.32519
DLG2 discs, large homolog 2 (Drosophila) -2.32519
FAM193B family with sequence similarity 193, member B -2.30097
GID8 GID complex subunit 8 -2.29908
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -2.29547
LHFPL6 LHFPL tetraspan subfamily member 6 -2.29132
SLC75A1 solute carrier family 75 member 1 -2.28677
TMEM19 transmembrane protein 19 -2.2844
MYH9 myosin, heavy chain 9, non-muscle -2.28067
GOLGA1 golgin A1 -2.25186
PARD6A par-6 family cell polarity regulator alpha -2.25186
SRSF1 serine/arginine-rich splicing factor 1 -2.25186
SHISA4 shisa family member 4 -2.23637
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.23521
SWT1 SWT1 RNA endoribonuclease homolog (S. cerevisiae) -2.23308
ACTA2 actin, alpha 2, smooth muscle, aorta -2.23308
TRIM65 tripartite motif containing 65 -2.23308
ADARB1 adenosine deaminase, RNA-specific, B1 -2.22915
EPB41 erythrocyte membrane protein band 4.1 -2.21794
ATP2A3 ATPase, Ca++ transporting, ubiquitous -2.21517
GADD45B growth arrest and DNA-damage-inducible, beta -2.21068
SLC61A1 solute carrier family 61 member 1 -2.18905
RAB6A RAB6A, member RAS oncogene family -2.17032
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -2.15563
LRP2BP LRP2 binding protein -2.15309
PCNX4 pecanex 4 -2.14178
CCDC110 coiled-coil domain containing 110 -2.13272
COLGALT2 collagen beta(1-O)galactosyltransferase 2 -2.12642
TPP2 tripeptidyl peptidase II -2.10215
SLC35A5 solute carrier family 35, member A5 -2.09885
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -2.09653
NDUFAF1 NADH dehydrogenase (ubiquinone) complex I, assembly factor 1 -2.09653
KCTD10 potassium channel tetramerization domain containing 10 -2.06921
SPICE1 spindle and centriole associated protein 1 -2.06067
ANKRD28 ankyrin repeat domain 28 -2.05891
MED27 mediator complex subunit 27 -2.04824
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.0453
SGSM3 small G protein signaling modulator 3 -2.01553
SLC7A6OS solute carrier family 7, member 6 opposite strand -2.00498