Dataset | PhosphoSitePlus Substrates of Kinases |
Category | physical interactions |
Type | kinase |
Description | lemur tyrosine kinase 2|The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009] (NCBI Entrez Gene Database, 22853) |
External Link | http://www.ncbi.nlm.nih.gov/gene/22853 |
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3 substrates of the kinase LMTK2 from the curated PhosphoSitePlus Substrates of Kinases dataset.