LRAT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)|The protein encoded by this gene localizes to the endoplasmic reticulum, where it catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester. This reaction is an important step in vitamin A metabolism in the visual system. Mutations in this gene have been associated with early-onset severe retinal dystrophy and Leber congenital amaurosis 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014] (NCBI Entrez Gene Database, 9227)
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Genes

338 genes differentially expressed following the LRAT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CLDN5 claudin 5 2.39744
OR52A5 olfactory receptor, family 52, subfamily A, member 5 2.39744
TSGA13 testis specific, 13 2.39744
CD160 CD160 molecule 2.39744
PCDHB6 protocadherin beta 6 2.39744
SOX18 SRY (sex determining region Y)-box 18 2.39744
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 2.39744
NRAP nebulin-related anchoring protein 2.39744
TKTL1 transketolase-like 1 2.39744
FETUB fetuin B 2.39744
ZNF717 zinc finger protein 717 2.39744
ADGRE1 adhesion G protein-coupled receptor E1 2.39744
ADGRE3 adhesion G protein-coupled receptor E3 2.39744
PTPRH protein tyrosine phosphatase, receptor type, H 2.39744
GPR160 G protein-coupled receptor 160 2.39744
TMEM229A transmembrane protein 229A 2.39744
SYCP1 synaptonemal complex protein 1 2.39744
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.39744
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.39744
COLEC10 collectin sub-family member 10 (C-type lectin) 2.39744
SCG2 secretogranin II 2.39744
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 2.39744
CTRL chymotrypsin-like 2.39744
GDNF glial cell derived neurotrophic factor 2.39744
ASB12 ankyrin repeat and SOCS box containing 12 2.39744
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.39744
TTLL8 tubulin tyrosine ligase-like family member 8 2.39744
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 2.39744
COL15A1 collagen, type XV, alpha 1 2.39744
SPINK13 serine peptidase inhibitor, Kazal type 13 (putative) 2.39744
SETSIP SET-like protein 2.39744
GPR101 G protein-coupled receptor 101 2.39744
MUC22 mucin 22 2.39744
LBX2 ladybird homeobox 2 2.39744
ACOT12 acyl-CoA thioesterase 12 2.39744
C9ORF152 chromosome 9 open reading frame 152 2.39744
C2ORF80 chromosome 2 open reading frame 80 2.39744
TUBB1 tubulin, beta 1 class VI 2.39744
MYOM2 myomesin 2 2.39744
PECAM1 platelet/endothelial cell adhesion molecule 1 2.39744
AVPR2 arginine vasopressin receptor 2 2.39744
NCKAP1L NCK-associated protein 1-like 2.39744
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.39744
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.39744
ZNF556 zinc finger protein 556 2.39744
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.39744
TDRD1 tudor domain containing 1 2.39744
MYO1G myosin IG 2.39744
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.39744
LOC107986837 uncharacterized LOC107986837 2.39744
HAO2 hydroxyacid oxidase 2 (long chain) 2.39744
ALDOB aldolase B, fructose-bisphosphate 2.39744
USP3 ubiquitin specific peptidase 3 2.39744
CLEC10A C-type lectin domain family 10, member A 2.39744
AVPR1B arginine vasopressin receptor 1B 2.39744
HTRA4 HtrA serine peptidase 4 2.39744
TCERG1L transcription elongation regulator 1-like 2.39744
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.39744
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.39744
TBC1D3L TBC1 domain family, member 3L 2.39744
TIMM29 translocase of inner mitochondrial membrane 29 2.39744
HTD2 hydroxyacyl-thioester dehydratase type 2 2.39744
OR56B2 olfactory receptor family 56 subfamily B member 2 2.39744
CIMIP2C ciliary microtubule inner protein 2C 2.39744
IRF2-DT IRF2 divergent transcript 2.39744
NOTCH2NLB notch 2 N-terminal like B 2.39744
TMEM270 transmembrane protein 270 2.39744
JAML junction adhesion molecule like 2.39744
TAFA5 TAFA chemokine like family member 5 2.39744
CCN6 cellular communication network factor 6 2.39744
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.39744
MYOCOS myocilin opposite strand 2.39744
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.39744
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.39744
C1QTNF1 C1q and tumor necrosis factor related protein 1 2.39744
SCN7A sodium channel, voltage gated, type VII alpha subunit 2.39744
C1QL2 complement component 1, q subcomponent-like 2 2.39744
TFEC transcription factor EC 2.39744
S1PR1 sphingosine-1-phosphate receptor 1 2.39744
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.39744
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.39744
ULBP1 UL16 binding protein 1 2.39744
CKM creatine kinase, muscle 2.39744
OLAH oleoyl-ACP hydrolase 2.39744
SPDYC speedy/RINGO cell cycle regulator family member C 2.39744
FGFBP1 fibroblast growth factor binding protein 1 2.39744
ADRB3 adrenoceptor beta 3 2.39744
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.39744
TREX2 three prime repair exonuclease 2 2.39744
FCMR Fc fragment of IgM receptor 2.39744
TSPAN1 tetraspanin 1 2.39744
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.39744
GATA5 GATA binding protein 5 2.39744
RNF183 ring finger protein 183 2.39744
DLK1 delta-like 1 homolog (Drosophila) 2.39744
HAL histidine ammonia-lyase 2.39744
HPR haptoglobin-related protein 2.39744
HMX1 H6 family homeobox 1 2.39744
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.39744
LY6G6C lymphocyte antigen 6 complex, locus G6C 2.39744
BRDT bromodomain, testis-specific 2.39744
TTC16 tetratricopeptide repeat domain 16 2.39744
ANKLE2 ankyrin repeat and LEM domain containing 2 2.39744
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.39744
GFI1B growth factor independent 1B transcription repressor 2.39744
SAMD7 sterile alpha motif domain containing 7 2.39744
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 2.39744
IL17REL interleukin 17 receptor E-like 2.39744
NPIPB15 nuclear pore complex interacting protein family, member B15 2.39744
PIP prolactin-induced protein 2.39744
KLHDC8A kelch domain containing 8A 2.39744
GNG8 guanine nucleotide binding protein (G protein), gamma 8 2.39744
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.39744
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.39744
ZMYND12 zinc finger, MYND-type containing 12 2.39744
ECM1 extracellular matrix protein 1 2.39744
NOG noggin 2.39744
RGS18 regulator of G-protein signaling 18 2.39744
APOC2 apolipoprotein C-II 2.39744
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 2.39744
NPBWR1 neuropeptides B/W receptor 1 2.39744
MAMLD1 mastermind-like domain containing 1 2.39744
TRADD TNFRSF1A-associated via death domain 2.39744
FOXE3 forkhead box E3 2.39744
TBC1D10C TBC1 domain family, member 10C 2.39744
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.39744
JAKMIP3 Janus kinase and microtubule interacting protein 3 2.39744
COX7B2 cytochrome c oxidase subunit VIIb2 2.39744
BTNL8 butyrophilin-like 8 2.39744
MAPK9 mitogen-activated protein kinase 9 2.39744
PIH1D2 PIH1 domain containing 2 2.39744
TNR tenascin R 2.39744
IL1B interleukin 1, beta 2.39744
RGSL1 regulator of G-protein signaling like 1 2.39744
HOPX HOP homeobox 2.39744
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.39744
DAND5 DAN domain family member 5, BMP antagonist 2.39744
NBEAL1 neurobeachin-like 1 2.39744
SLN sarcolipin 2.39744
ZC2HC1B zinc finger, C2HC-type containing 1B 2.39744
NFE2 nuclear factor, erythroid 2 2.39744
ZNF658 zinc finger protein 658 2.39744
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 2.39744
SGMS2 sphingomyelin synthase 2 2.39744
C17ORF78 chromosome 17 open reading frame 78 2.39744
IL37 interleukin 37 2.39744
ABI3 ABI family, member 3 2.39744
CD22 CD22 molecule 2.39744
GBX2 gastrulation brain homeobox 2 2.39744
EVPL envoplakin 2.39744
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.39744
TMEM132C transmembrane protein 132C 2.39744
RNASE6 ribonuclease, RNase A family, k6 2.39744
DRC7 dynein regulatory complex subunit 7 2.39744
BTBD17 BTB (POZ) domain containing 17 2.39744
TWIST1 twist family bHLH transcription factor 1 2.39744
TPH1 tryptophan hydroxylase 1 2.39744
XCR1 chemokine (C motif) receptor 1 2.39744
TGM3 transglutaminase 3 2.39744
NOBOX NOBOX oogenesis homeobox 2.39744
PXT1 peroxisomal, testis specific 1 2.39744
USP32 ubiquitin specific peptidase 32 2.39744
LHX2 LIM homeobox 2 2.39744
HMGB4 high mobility group box 4 2.39744
FGF16 fibroblast growth factor 16 2.39744
GCM1 glial cells missing homolog 1 (Drosophila) 2.39744
CHAD chondroadherin 2.39744
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.39744
MSLN mesothelin 2.39744
RTN4RL1 reticulon 4 receptor-like 1 2.39744
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.39744
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.39744
ROM1 retinal outer segment membrane protein 1 2.39744
OSBPL1A oxysterol binding protein-like 1A 2.35398
REEP6 receptor accessory protein 6 2.33629
ZNHIT1 zinc finger, HIT-type containing 1 2.31254
MPZL2 myelin protein zero-like 2 2.3094
PAX7 paired box 7 2.3094
EGFL6 EGF-like-domain, multiple 6 2.3094
MARCHF7 membrane associated ring-CH-type finger 7 2.29583
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 2.28292
ZNF536 zinc finger protein 536 2.2626
CIBAR1 CBY1 interacting BAR domain containing 1 2.2626
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6 2.2626
TP53BP2 tumor protein p53 binding protein 2 2.2626
AP4B1 adaptor-related protein complex 4, beta 1 subunit 2.2626
STRIP1 striatin interacting protein 1 2.25339
FABP6 fatty acid binding protein 6, ileal 2.22198
ESD esterase D 2.18992
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2.18992
ZNF155 zinc finger protein 155 2.18556
PLCL2 phospholipase C-like 2 2.16574
CNPY4 canopy FGF signaling regulator 4 2.16574
KMT5C lysine methyltransferase 5C 2.1379
PEX14 peroxisomal biogenesis factor 14 2.13316
MAST2 microtubule associated serine/threonine kinase 2 2.13196
NPR1 natriuretic peptide receptor 1 2.13196
GANC glucosidase, alpha; neutral C 2.12652
MORC4 MORC family CW-type zinc finger 4 2.11288
ZNF747 zinc finger protein 747 2.11288
TROAP trophinin associated protein 2.11025
PASK PAS domain containing serine/threonine kinase 2.09312
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.06967
UGT3A2 UDP glycosyltransferase 3 family, polypeptide A2 2.06429
ZCCHC14 zinc finger, CCHC domain containing 14 2.06075
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 2.05981
TRIM2 tripartite motif containing 2 2.04074
GALM galactose mutarotase (aldose 1-epimerase) 2.04066
HPCAL4 hippocalcin like 4 2.0402
NLGN3 neuroligin 3 2.0402
ESYT1 extended synaptotagmin-like protein 1 2.03672
STK32C serine/threonine kinase 32C 2.02942
OR2A7 olfactory receptor, family 2, subfamily A, member 7 2.02696
DENND1A DENN/MADD domain containing 1A 2.01994
CLSTN1 calsyntenin 1 2.01994

decreased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) -2.39744
ZNF230 zinc finger protein 230 -2.39744
LZTFL1 leucine zipper transcription factor-like 1 -2.39744
CCT2 chaperonin containing TCP1, subunit 2 (beta) -2.39744
PNP purine nucleoside phosphorylase -2.39744
NLRC5 NLR family, CARD domain containing 5 -2.39744
TMEM175 transmembrane protein 175 -2.39744
EDA2R ectodysplasin A2 receptor -2.39744
GP6 glycoprotein VI (platelet) -2.39744
RAD51C RAD51 paralog C -2.39744
APLN apelin -2.39744
MVK mevalonate kinase -2.39744
LHCGR luteinizing hormone/choriogonadotropin receptor -2.39744
SUSD2 sushi domain containing 2 -2.39744
ZNF672 zinc finger protein 672 -2.39744
DPH6 diphthamine biosynthesis 6 -2.39744
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 -2.39744
GRIK1 glutamate receptor, ionotropic, kainate 1 -2.39744
FBN2 fibrillin 2 -2.39744
ITGB1BP2 integrin beta 1 binding protein (melusin) 2 -2.39744
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.39744
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) -2.39744
SLC30A10 solute carrier family 30, member 10 -2.39744
IFI16 interferon, gamma-inducible protein 16 -2.39744
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 -2.39744
SH2D3C SH2 domain containing 3C -2.39744
AIDA axin interactor, dorsalization associated -2.39744
OAZ3 ornithine decarboxylase antizyme 3 -2.39744
PINK1 PTEN induced putative kinase 1 -2.39744
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -2.39744
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 -2.39744
DOK3 docking protein 3 -2.39744
RASL11B RAS-like, family 11, member B -2.39744
ELFN1 extracellular leucine-rich repeat and fibronectin type III domain containing 1 -2.39744
ATP5PF ATP synthase peripheral stalk subunit F6 -2.39744
ADGRL3 adhesion G protein-coupled receptor L3 -2.39744
NUDT4B nudix hydrolase 4B -2.39744
CSNK1G1 casein kinase 1, gamma 1 -2.39744
SP140L SP140 nuclear body protein-like -2.39744
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1 -2.39744
SNX27 sorting nexin family member 27 -2.39744
MBD1 methyl-CpG binding domain protein 1 -2.39744
TMEM139 transmembrane protein 139 -2.39744
LCAT lecithin-cholesterol acyltransferase -2.39744
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta -2.39744
PCDH19 protocadherin 19 -2.39744
TMEM230 transmembrane protein 230 -2.39744
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a -2.39744
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.39744
ACTL6B actin-like 6B -2.35462
PYY peptide YY -2.35398
RXRB retinoid X receptor, beta -2.35203
ANGEL1 angel homolog 1 (Drosophila) -2.26704
OR52H1 olfactory receptor, family 52, subfamily H, member 1 -2.2626
TLDC2 TBC/LysM-associated domain containing 2 -2.2626
KLHL31 kelch-like family member 31 -2.2626
GPR20 G protein-coupled receptor 20 -2.2626
RUNX3 runt-related transcription factor 3 -2.2626
SLC9C2 solute carrier family 9, member C2 (putative) -2.2626
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.2626
PAX5 paired box 5 -2.2626
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 -2.2626
ARSI arylsulfatase family, member I -2.2626
ASIC4 acid sensing (proton gated) ion channel family member 4 -2.2626
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -2.2626
KCNIP3 Kv channel interacting protein 3, calsenilin -2.2626
PANO1 proapoptotic nucleolar protein 1 -2.2626
ERVV-2 endogenous retrovirus group V, member 2 -2.2626
HLA-DOB major histocompatibility complex, class II, DO beta -2.2626
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -2.2626
HK3 hexokinase 3 (white cell) -2.2626
TIGIT T cell immunoreceptor with Ig and ITIM domains -2.2626
APOB apolipoprotein B -2.2626
SAMD5 sterile alpha motif domain containing 5 -2.2626
SLC22A24 solute carrier family 22, member 24 -2.2626
CLEC4C C-type lectin domain family 4, member C -2.2626
GLOD5 glyoxalase domain containing 5 -2.2626
WFDC1 WAP four-disulfide core domain 1 -2.2626
NTN5 netrin 5 -2.2626
CDH22 cadherin 22, type 2 -2.2626
SNAI2 snail family zinc finger 2 -2.2626
C10ORF90 chromosome 10 open reading frame 90 -2.2626
NMBR neuromedin B receptor -2.2626
DPH1 diphthamide biosynthesis 1 -2.2626
MYL5 myosin, light chain 5, regulatory -2.2626
SLC38A7 solute carrier family 38, member 7 -2.2452
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.22747
SOX9 SRY (sex determining region Y)-box 9 -2.22747
ZMYM6 zinc finger, MYM-type 6 -2.22573
ZNF707 zinc finger protein 707 -2.22573
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) -2.22198
SCARB2 scavenger receptor class B, member 2 -2.19969
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 -2.17657
CYTH3 cytohesin 3 -2.16994
CDHR4 cadherin-related family member 4 -2.15356
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.12792
TSPAN17 tetraspanin 17 -2.12652
MOGS mannosyl-oligosaccharide glucosidase -2.11025
OMA1 OMA1 zinc metallopeptidase -2.10932
GMPPA GDP-mannose pyrophosphorylase A -2.10932
PTEN phosphatase and tensin homolog -2.10423
TRIM25 tripartite motif containing 25 -2.10266
CEP19 centrosomal protein 19kDa -2.09658
MIPOL1 mirror-image polydactyly 1 -2.09643
LDLR low density lipoprotein receptor -2.09227
SLFN5 schlafen family member 5 -2.0889
SYS1 Sys1 golgi trafficking protein -2.0889
THRAP3 thyroid hormone receptor associated protein 3 -2.0889
SMIM11 small integral membrane protein 11 -2.08312
NR4A2 nuclear receptor subfamily 4, group A, member 2 -2.08063
DZIP1 DAZ interacting zinc finger protein 1 -2.07782
THAP5 THAP domain containing 5 -2.07333
RIC8B RIC8 guanine nucleotide exchange factor B -2.06967
RPS7 ribosomal protein S7 -2.05247
TP53INP1 tumor protein p53 inducible nuclear protein 1 -2.04239
FRMD5 FERM domain containing 5 -2.03774
NOX4 NADPH oxidase 4 -2.03234
OSBPL10 oxysterol binding protein-like 10 -2.029
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 -2.02173
NEK6 NIMA-related kinase 6 -2.02101
WIPF1 WAS/WASL interacting protein family, member 1 -2.01994
MED30 mediator complex subunit 30 -2.00095
TMEM101 transmembrane protein 101 -2.00095