LRP5 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description low density lipoprotein receptor-related protein 5|This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 4041)
External Link http://www.ncbi.nlm.nih.gov/gene/4041
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Genes

65 interacting proteins for LRP5 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APCDD1 adenomatosis polyposis coli down-regulated 1
APH1B APH1B gamma secretase subunit
ARR3 arrestin 3, retinal (X-arrestin)
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
AXIN1 axin 1
CAPRIN2 caprin family member 2
CSNK1G2 casein kinase 1, gamma 2
DACT1 dishevelled-binding antagonist of beta-catenin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DKK4 dickkopf WNT signaling pathway inhibitor 4
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
FZD1 frizzled class receptor 1
FZD2 frizzled class receptor 2
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
FZD8 frizzled class receptor 8
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNG8 guanine nucleotide binding protein (G protein), gamma 8
GSK3B glycogen synthase kinase 3 beta
HNF4A hepatocyte nuclear factor 4, alpha
KREMEN1 kringle containing transmembrane protein 1
KREMEN2 kringle containing transmembrane protein 2
MESDC2 mesoderm development candidate 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MMP25 matrix metallopeptidase 25
NCSTN nicastrin
NDP Norrie disease (pseudoglioma)
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
SAG S-antigen; retina and pineal gland (arrestin)
SMAD9 SMAD family member 9
SOST sclerostin
THBS1 thrombospondin 1
TSPAN12 tetraspanin 12
UBC ubiquitin C
USP8 ubiquitin specific peptidase 8
WNT1 wingless-type MMTV integration site family, member 1
WNT3A wingless-type MMTV integration site family, member 3A
WNT8A wingless-type MMTV integration site family, member 8A
WNT8B wingless-type MMTV integration site family, member 8B