LRP6 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description low density lipoprotein receptor-related protein 6|This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009] (NCBI Entrez Gene Database, 4040)
External Link http://www.ncbi.nlm.nih.gov/gene/4040
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Genes

95 interacting proteins for LRP6 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
ANTXR1 anthrax toxin receptor 1
ANTXR2 anthrax toxin receptor 2
APC adenomatous polyposis coli
APH1B APH1B gamma secretase subunit
APOB apolipoprotein B
ARR3 arrestin 3, retinal (X-arrestin)
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
ATP13A2 ATPase type 13A2
AXIN1 axin 1
BAMBI BMP and activin membrane-bound inhibitor
CAPRIN2 caprin family member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CSNK1A1 casein kinase 1, alpha 1
CSNK1E casein kinase 1, epsilon
CSNK1G1 casein kinase 1, gamma 1
CSNK1G2 casein kinase 1, gamma 2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DACT1 dishevelled-binding antagonist of beta-catenin 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK2 dickkopf WNT signaling pathway inhibitor 2
DKK4 dickkopf WNT signaling pathway inhibitor 4
DVL1 dishevelled segment polarity protein 1
DVL2 dishevelled segment polarity protein 2
DVL3 dishevelled segment polarity protein 3
EEA1 early endosome antigen 1
FBXW11 F-box and WD repeat domain containing 11
FZD1 frizzled class receptor 1
FZD2 frizzled class receptor 2
FZD4 frizzled class receptor 4
FZD5 frizzled class receptor 5
FZD6 frizzled class receptor 6
FZD8 frizzled class receptor 8
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GNG10 guanine nucleotide binding protein (G protein), gamma 10
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GNG13 guanine nucleotide binding protein (G protein), gamma 13
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GNG3 guanine nucleotide binding protein (G protein), gamma 3
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG5 guanine nucleotide binding protein (G protein), gamma 5
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GNG8 guanine nucleotide binding protein (G protein), gamma 8
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
IGFBP4 insulin-like growth factor binding protein 4
IQGAP1 IQ motif containing GTPase activating protein 1
KREMEN1 kringle containing transmembrane protein 1
KREMEN2 kringle containing transmembrane protein 2
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LRRK2 leucine-rich repeat kinase 2
MESDC1 mesoderm development candidate 1
MESDC2 mesoderm development candidate 2
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MMP25 matrix metallopeptidase 25
NCSTN nicastrin
NPC1 Niemann-Pick disease, type C1
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITPNA phosphatidylinositol transfer protein, alpha
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PSEN1 presenilin 1
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
RAB11A RAB11A, member RAS oncogene family
RPS27A ribosomal protein S27a
RSPO1 R-spondin 1
SAG S-antigen; retina and pineal gland (arrestin)
SOST sclerostin
UBC ubiquitin C
USP8 ubiquitin specific peptidase 8
WIF1 WNT inhibitory factor 1
WNT1 wingless-type MMTV integration site family, member 1
WNT3A wingless-type MMTV integration site family, member 3A
WNT5A wingless-type MMTV integration site family, member 5A
WNT8A wingless-type MMTV integration site family, member 8A
WNT8B wingless-type MMTV integration site family, member 8B
ZNRF3 zinc and ring finger 3