LRRK2 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description leucine-rich repeat kinase 2|This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 120892)
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100 substrates of the kinase LRRK2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
TBC1D3 TBC1 domain family, member 3
MICALL1 MICAL-like 1
RNPS1 RNA binding protein S1, serine-rich domain
UTP15 UTP15, U3 small nucleolar ribonucleoprotein, homolog (S. cerevisiae)
NCF4 neutrophil cytosolic factor 4, 40kDa
TNNI3 troponin I type 3 (cardiac)
KIAA1671 KIAA1671
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
TOR4A torsin family 4, member A
SACK1H scaffolding CK1 anchoring protein H
AKAP12 A kinase (PRKA) anchor protein 12
CABLES1 Cdk5 and Abl enzyme substrate 1
LRCH2 leucine-rich repeats and calponin homology (CH) domain containing 2
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit
TBC1D4 TBC1 domain family, member 4
MKI67 marker of proliferation Ki-67
TRA2B transformer 2 beta homolog (Drosophila)
IRS4 insulin receptor substrate 4
TRPV6 transient receptor potential cation channel, subfamily V, member 6
CCDC85C coiled-coil domain containing 85C
CORO1A coronin, actin binding protein, 1A
CNN1 calponin 1, basic, smooth muscle
KMT2B lysine (K)-specific methyltransferase 2B
MSN moesin
EGFR epidermal growth factor receptor
FGD3 FYVE, RhoGEF and PH domain containing 3
ILK integrin-linked kinase
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
PRR15 proline rich 15
STK26 serine/threonine protein kinase 26
CD3EAP CD3e molecule, epsilon associated protein
ARHGAP17 Rho GTPase activating protein 17
FRK fyn-related Src family tyrosine kinase
FRMD4A FERM domain containing 4A
MYH9 myosin, heavy chain 9, non-muscle
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
PRKCD protein kinase C, delta
S1PR1 sphingosine-1-phosphate receptor 1
MSX2 msh homeobox 2
PLEK pleckstrin
HRH1 histamine receptor H1
SRSF2 serine/arginine-rich splicing factor 2
AKAP5 A kinase (PRKA) anchor protein 5
ERBB2 erb-b2 receptor tyrosine kinase 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
RAB44 RAB44, member RAS oncogene family
RDX radixin
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
PA2G4 proliferation-associated 2G4, 38kDa
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
LPAR1 lysophosphatidic acid receptor 1
DRD2 dopamine receptor D2
CBX3 chromobox homolog 3
C16ORF78 chromosome 16 open reading frame 78
HNRNPF heterogeneous nuclear ribonucleoprotein F
PRM2 protamine 2
RB1 retinoblastoma 1
DAPK3 death-associated protein kinase 3
MAP3K11 mitogen-activated protein kinase kinase kinase 11
RAP1GAP RAP1 GTPase activating protein
NUP93 nucleoporin 93kDa
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
PCM1 pericentriolar material 1
DFNA5 deafness, autosomal dominant 5
ADAM10 ADAM metallopeptidase domain 10
VPRBP Vpr (HIV-1) binding protein
RASA1 RAS p21 protein activator (GTPase activating protein) 1
EZR ezrin
CYTH2 cytohesin 2
HIST1H1C histone cluster 1, H1c
NLGN4X neuroligin 4, X-linked
TICRR TOPBP1-interacting checkpoint and replication regulator
DROSHA drosha, ribonuclease type III
MYOD1 myogenic differentiation 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
ZNF318 zinc finger protein 318
BRAF B-Raf proto-oncogene, serine/threonine kinase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
FOXG1 forkhead box G1
SCNM1 sodium channel modifier 1
FXYD1 FXYD domain containing ion transport regulator 1
NUMA1 nuclear mitotic apparatus protein 1
MYL9 myosin, light chain 9, regulatory
MAP2K1 mitogen-activated protein kinase kinase 1
CHD1L chromodomain helicase DNA binding protein 1-like
DGAT1 diacylglycerol O-acyltransferase 1
CGN cingulin
LIMK2 LIM domain kinase 2
MEPCE methylphosphate capping enzyme
CLK2 CDC-like kinase 2
PRPF4B pre-mRNA processing factor 4B
LIG1 ligase I, DNA, ATP-dependent
PDCD11 programmed cell death 11
JUP junction plakoglobin
CTNND1 catenin (cadherin-associated protein), delta 1
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12
PUM2 pumilio RNA-binding family member 2
PUM1 pumilio RNA-binding family member 1
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1