| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | leucine-rich repeat kinase 2|This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 120892) |
| External Link | https://ncbi.nlm.nih.gov/gene/120892 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the LRRK2 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LSM5 | LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 0.014833 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | 0.013589 |
| XIC | X chromosome inactivation center | 0.0123121 |
| EPHB2 | EPH receptor B2 | 0.01188 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.0115521 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0111883 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0110395 |
| TRAPPC3 | trafficking protein particle complex 3 | 0.0109584 |
| MMP12 | matrix metallopeptidase 12 | 0.00974729 |
| REG3A | regenerating islet-derived 3 alpha | 0.00960246 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | 0.00957019 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00956918 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.00935878 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.00905089 |
| TNC | tenascin C | 0.00883467 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | 0.00862482 |
| PRDX2 | peroxiredoxin 2 | 0.0085547 |
| CPE | carboxypeptidase E | 0.00844905 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0084128 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | 0.00837645 |
| SRGN | serglycin | 0.00837151 |
| ACOT7 | acyl-CoA thioesterase 7 | 0.00831236 |
| DEFA6 | defensin, alpha 6, Paneth cell-specific | 0.00830189 |
| CCNE2 | cyclin E2 | 0.00815155 |
| TMX1 | thioredoxin-related transmembrane protein 1 | 0.0081314 |
| CCDC47 | coiled-coil domain containing 47 | 0.00807513 |
| FABP1 | fatty acid binding protein 1, liver | 0.00804244 |
| FBN1 | fibrillin 1 | 0.00794279 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.00788401 |
| ZNF395 | zinc finger protein 395 | 0.0078825 |
| H1-0 | H1.0 linker histone | 0.00760821 |
| TIMM9 | translocase of inner mitochondrial membrane 9 homolog (yeast) | 0.00753266 |
| GNG10 | guanine nucleotide binding protein (G protein), gamma 10 | 0.00729585 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.00724099 |
| ERI2 | ERI1 exoribonuclease family member 2 | 0.00723999 |
| MT1E | metallothionein 1E | 0.00721215 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 | 0.00719908 |
| FKBP1B | FK506 binding protein 1B, 12.6 kDa | 0.00710776 |
| MPHOSPH8 | M-phase phosphoprotein 8 | 0.00708617 |
| NMU | neuromedin U | 0.0070835 |
| CNIH1 | cornichon family AMPA receptor auxiliary protein 1 | 0.00702495 |
| TMSB15A | thymosin beta 15a | 0.00697093 |
| LTB | lymphotoxin beta (TNF superfamily, member 3) | 0.00694951 |
| CYBRD1 | cytochrome b reductase 1 | 0.00694461 |
| DPYD | dihydropyrimidine dehydrogenase | 0.00684837 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.00683858 |
| RPS17 | ribosomal protein S17 | 0.0068303 |
| CHI3L1 | chitinase 3-like 1 (cartilage glycoprotein-39) | 0.00680522 |
| DEGS1 | delta(4)-desaturase, sphingolipid 1 | 0.0067713 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.00675399 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00674649 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.00672672 |
| CXCL9 | chemokine (C-X-C motif) ligand 9 | 0.00669727 |
| CD209 | CD209 molecule | 0.00669564 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.00667856 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 0.006671 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | 0.00666821 |
| CD1C | CD1c molecule | 0.00666156 |
| DNASE1L3 | deoxyribonuclease I-like 3 | 0.006649 |
| GPA33 | glycoprotein A33 (transmembrane) | 0.00660444 |
| SEC24A | SEC24 family member A | 0.00660391 |
| ATP10B | ATPase, class V, type 10B | 0.00656276 |
| ARL4A | ADP-ribosylation factor-like 4A | 0.00654894 |
| CHN1 | chimerin 1 | 0.00654021 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0065082 |
| RTN1 | reticulon 1 | 0.0064837 |
| GANAB | glucosidase, alpha; neutral AB | 0.00648258 |
| HOXD1 | homeobox D1 | 0.00647067 |
| NSL1 | NSL1, MIS12 kinetochore complex component | 0.0064635 |
| NUSAP1 | nucleolar and spindle associated protein 1 | 0.00645998 |
| NGFRAP1 | nerve growth factor receptor (TNFRSF16) associated protein 1 | 0.00643507 |
| ARG1 | arginase 1 | 0.0064315 |
| FASTKD3 | FAST kinase domains 3 | 0.00635724 |
| LOXL2 | lysyl oxidase-like 2 | 0.00634607 |
| ACP3 | acid phosphatase 3 | 0.00634243 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.00632788 |
| CD1E | CD1e molecule | 0.00631623 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | 0.00630432 |
| CLU | clusterin | 0.006284 |
| NNMT | nicotinamide N-methyltransferase | 0.00628237 |
| WDR7 | WD repeat domain 7 | 0.00625578 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.00623993 |
| MT1G | metallothionein 1G | 0.00621663 |
| CPOX | coproporphyrinogen oxidase | 0.00619751 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00617894 |
| FGL2 | fibrinogen-like 2 | 0.00616782 |
| LST1 | leukocyte specific transcript 1 | 0.0061183 |
| CPS1 | carbamoyl-phosphate synthase 1, mitochondrial | 0.00611342 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.00611003 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.00610861 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | 0.00609347 |
| CALD1 | caldesmon 1 | 0.00606796 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | 0.00606077 |
| SMARCD2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2 | 0.0060595 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.00596693 |
| CD1B | CD1b molecule | 0.00595598 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | 0.00593826 |
| TRAF5 | TNF receptor-associated factor 5 | 0.00593531 |
| ACP2 | acid phosphatase 2, lysosomal | 0.00590828 |
| HBD | hemoglobin, delta | 0.00590342 |
| DCXR | dicarbonyl/L-xylulose reductase | 0.00589401 |
| TIMM22 | translocase of inner mitochondrial membrane 22 homolog (yeast) | 0.00588034 |
| TFR2 | transferrin receptor 2 | 0.00586089 |
| BCL11A | B-cell CLL/lymphoma 11A (zinc finger protein) | 0.00585136 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00584176 |
| ZNF91 | zinc finger protein 91 | 0.00584076 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | 0.00578173 |
| WIPF1 | WAS/WASL interacting protein family, member 1 | 0.0057739 |
| AZF1 | azoospermia factor 1 | 0.00575815 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.00574862 |
| CLEC10A | C-type lectin domain family 10, member A | 0.00574646 |
| PHTF2 | putative homeodomain transcription factor 2 | 0.00574515 |
| XPNPEP1 | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 0.00573713 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | 0.00571406 |
| GPX1 | glutathione peroxidase 1 | 0.00571367 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.00570805 |
| TMEM14B | transmembrane protein 14B | 0.00570495 |
| CD86 | CD86 molecule | 0.0056961 |
| ATP5MJ | ATP synthase membrane subunit j | 0.00568642 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.00568375 |
| CPVL | carboxypeptidase, vitellogenic-like | 0.00565702 |
| MRPL9 | mitochondrial ribosomal protein L9 | 0.00565681 |
| COMMD8 | COMM domain containing 8 | 0.00565474 |
| UGT2B15 | UDP glucuronosyltransferase 2 family, polypeptide B15 | 0.00563495 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | 0.00563062 |
| CCR7 | chemokine (C-C motif) receptor 7 | 0.00562827 |
| TSPAN6 | tetraspanin 6 | 0.00562373 |
| CHN2 | chimerin 2 | 0.00562087 |
| CBX3 | chromobox homolog 3 | 0.00560185 |
| FABP6 | fatty acid binding protein 6, ileal | 0.0055915 |
| LOX | lysyl oxidase | 0.00556175 |
| LEF1 | lymphoid enhancer-binding factor 1 | 0.00553897 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | 0.00551987 |
| MINPP1 | multiple inositol-polyphosphate phosphatase 1 | 0.00551833 |
| UBE2D1 | ubiquitin-conjugating enzyme E2D 1 | 0.00551319 |
| RNF138 | ring finger protein 138, E3 ubiquitin protein ligase | 0.00550504 |
| ARNT2 | aryl-hydrocarbon receptor nuclear translocator 2 | 0.00548808 |
| CSF2RB | colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 0.00547225 |
| SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 0.00547164 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | 0.00546766 |
| LY96 | lymphocyte antigen 96 | 0.00546481 |
| SNRPD1 | small nuclear ribonucleoprotein D1 polypeptide 16kDa | 0.00546103 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | 0.00545904 |
| NIPSNAP2 | nipsnap homolog 2 | 0.00545171 |
| PIN1 | peptidylprolyl cis/trans isomerase, NIMA-interacting 1 | 0.00542843 |
| PDGFC | platelet derived growth factor C | 0.00542471 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 0.00540593 |
| DSC1 | desmocollin 1 | 0.00540426 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.00540424 |
| CHMP7 | charged multivesicular body protein 7 | 0.00540325 |
| COPS4 | COP9 signalosome subunit 4 | 0.0054008 |
| ITK | IL2-inducible T-cell kinase | 0.00538981 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00538164 |
| TMEM106B | transmembrane protein 106B | 0.00537622 |
| C12ORF29 | chromosome 12 open reading frame 29 | 0.00537537 |
| CBR4 | carbonyl reductase 4 | 0.00537502 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00537251 |
| NDUFA4 | NDUFA4, mitochondrial complex associated | 0.00535304 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | 0.005345 |
| PRPF19 | pre-mRNA processing factor 19 | 0.00533962 |
| HINT1 | histidine triad nucleotide binding protein 1 | 0.00533664 |
| SOX11 | SRY (sex determining region Y)-box 11 | 0.00533352 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.00532692 |
| PENK | proenkephalin | 0.00531585 |
| CCNB2 | cyclin B2 | 0.00530899 |
| RMI1 | RecQ mediated genome instability 1 | 0.00530874 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.00530309 |
| EPHX2 | epoxide hydrolase 2, cytoplasmic | 0.00530295 |
| ACTL6A | actin-like 6A | 0.00530093 |
| GSTO1 | glutathione S-transferase omega 1 | 0.00528682 |
| ANXA6 | annexin A6 | 0.00528561 |
| ANGEL2 | angel homolog 2 (Drosophila) | 0.00526056 |
| MCMBP | minichromosome maintenance complex binding protein | 0.00526039 |
| RPA3 | replication protein A3, 14kDa | 0.00525746 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | 0.00525415 |
| XK | X-linked Kx blood group | 0.00525295 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | 0.00525188 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.00524103 |
| APOC3 | apolipoprotein C-III | 0.00523982 |
| G3BP2 | GTPase activating protein (SH3 domain) binding protein 2 | 0.00523568 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.00522207 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.00522139 |
| ADSL | adenylosuccinate lyase | 0.00521909 |
| FNTA | farnesyltransferase, CAAX box, alpha | 0.00521824 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.00521751 |
| MMP9 | matrix metallopeptidase 9 | 0.00521532 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.00519959 |
| ECI2 | enoyl-CoA delta isomerase 2 | 0.005189 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.00518155 |
| RFC2 | replication factor C (activator 1) 2, 40kDa | 0.00517748 |
| LYRM4 | LYR motif containing 4 | 0.00517294 |
| RNASE6 | ribonuclease, RNase A family, k6 | 0.00516928 |
| EIF1AX | eukaryotic translation initiation factor 1A, X-linked | 0.00516432 |
| PRPS2 | phosphoribosyl pyrophosphate synthetase 2 | 0.0051613 |
| GLS | glutaminase | 0.00515508 |
| APOC2 | apolipoprotein C-II | 0.00515336 |
| LRRC40 | leucine rich repeat containing 40 | 0.00514489 |
| FMO5 | flavin containing monooxygenase 5 | 0.00514385 |
| CAAP1 | caspase activity and apoptosis inhibitor 1 | 0.00514294 |
| SOCS1 | suppressor of cytokine signaling 1 | 0.00513466 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | 0.00513281 |
| PDLIM4 | PDZ and LIM domain 4 | 0.00510943 |
| PHB2 | prohibitin 2 | 0.00510818 |
| CREG1 | cellular repressor of E1A-stimulated genes 1 | 0.00510488 |
| C1R | complement component 1, r subcomponent | 0.00510069 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00509071 |
| ERBIN | erbb2 interacting protein | 0.00508955 |
| TYRP1 | tyrosinase-related protein 1 | 0.0050841 |
| RSBN1 | round spermatid basic protein 1 | 0.00508248 |
| ORC4 | origin recognition complex, subunit 4 | 0.00507667 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | 0.00507333 |
| EXOSC4 | exosome component 4 | 0.0050712 |
| CPA4 | carboxypeptidase A4 | 0.00507015 |
| CNN3 | calponin 3, acidic | 0.00506338 |
| MIOS | missing oocyte, meiosis regulator, homolog (Drosophila) | 0.00505878 |
| MAP3K3 | mitogen-activated protein kinase kinase kinase 3 | 0.0050584 |
| C1ORF54 | chromosome 1 open reading frame 54 | 0.00505623 |
| SLC5A1 | solute carrier family 5 (sodium/glucose cotransporter), member 1 | 0.00505229 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | 0.00504943 |
| FCGR2B | Fc fragment of IgG, low affinity IIb, receptor (CD32) | 0.00504038 |
| NOL11 | nucleolar protein 11 | 0.00503049 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.00502913 |
| PDSS1 | prenyl (decaprenyl) diphosphate synthase, subunit 1 | 0.00502422 |
| NOTCH2 | notch 2 | 0.00501696 |
| EYA1 | EYA transcriptional coactivator and phosphatase 1 | 0.00501622 |
| FERMT2 | fermitin family member 2 | 0.00501618 |
| JADE1 | jade family PHD finger 1 | 0.00501065 |
| PLA2G4A | phospholipase A2, group IVA (cytosolic, calcium-dependent) | 0.00500725 |
| BMI1 | BMI1 proto-oncogene, polycomb ring finger | 0.00500685 |
| RRM1 | ribonucleotide reductase M1 | 0.00500368 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00500282 |
| CISH | cytokine inducible SH2-containing protein | 0.00500208 |
| SCAND1 | SCAN domain containing 1 | 0.00499947 |
| TRMT5 | tRNA methyltransferase 5 | 0.00498464 |
| SPTSSA | serine palmitoyltransferase, small subunit A | 0.00498405 |
| CLCA1 | chloride channel accessory 1 | 0.00497733 |
| NOC3L | nucleolar complex associated 3 homolog (S. cerevisiae) | 0.00497674 |
| HLA-DRB6 | major histocompatibility complex, class II, DR beta 6 (pseudogene) | 0.00497586 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.00497493 |
| HLA-DOB | major histocompatibility complex, class II, DO beta | 0.00496963 |
| PSTPIP2 | proline-serine-threonine phosphatase interacting protein 2 | 0.00496875 |
| SST | somatostatin | 0.00495357 |
| BST2 | bone marrow stromal cell antigen 2 | 0.00495346 |
| MTMR4 | myotubularin related protein 4 | 0.00495132 |
| ANKRD49 | ankyrin repeat domain 49 | 0.00494301 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.00494192 |
| HNMT | histamine N-methyltransferase | 0.0049355 |
| CCL17 | chemokine (C-C motif) ligand 17 | 0.00493161 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | 0.00493153 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.00492201 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KRT19 | keratin 19, type I | -0.0225557 |
| S100A8 | S100 calcium binding protein A8 | -0.0198645 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.0172178 |
| KRT5 | keratin 5, type II | -0.0161252 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.0157818 |
| KRT14 | keratin 14, type I | -0.0156091 |
| KRT15 | keratin 15, type I | -0.0151859 |
| KRT7 | keratin 7, type II | -0.0150567 |
| S100A9 | S100 calcium binding protein A9 | -0.0148339 |
| GABRP | gamma-aminobutyric acid (GABA) A receptor, pi | -0.014053 |
| HSPA1A | heat shock 70kDa protein 1A | -0.0140516 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.0138555 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.0136468 |
| EPCAM | epithelial cell adhesion molecule | -0.0135171 |
| S100P | S100 calcium binding protein P | -0.0134154 |
| KRT6A | keratin 6A, type II | -0.0132077 |
| SPRR3 | small proline-rich protein 3 | -0.0132065 |
| KRT18 | keratin 18, type I | -0.0129887 |
| KRT13 | keratin 13, type I | -0.0126736 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0121531 |
| MAP7 | microtubule-associated protein 7 | -0.0120238 |
| ANXA1 | annexin A1 | -0.0119508 |
| MMP7 | matrix metallopeptidase 7 | -0.0115219 |
| CCN2 | cellular communication network factor 2 | -0.011452 |
| MMP1 | matrix metallopeptidase 1 | -0.0112398 |
| ATF3 | activating transcription factor 3 | -0.0109389 |
| KRT6B | keratin 6B, type II | -0.0108986 |
| PROM1 | prominin 1 | -0.0107497 |
| HSPB8 | heat shock 22kDa protein 8 | -0.0106133 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | -0.0106036 |
| KRT23 | keratin 23, type I | -0.0105486 |
| AQP3 | aquaporin 3 (Gill blood group) | -0.0104845 |
| CDH1 | cadherin 1, type 1, E-cadherin (epithelial) | -0.010427 |
| SFN | stratifin | -0.0103534 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | -0.0102768 |
| HOPX | HOP homeobox | -0.0101543 |
| VLDLR | very low density lipoprotein receptor | -0.0101057 |
| S100A11 | S100 calcium binding protein A11 | -0.0100947 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0100717 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.0100458 |
| FNDC3B | fibronectin type III domain containing 3B | -0.00998886 |
| CRYAB | crystallin, alpha B | -0.0099867 |
| KRT8 | keratin 8, type II | -0.00996397 |
| BHLHE41 | basic helix-loop-helix family, member e41 | -0.0098021 |
| GNAS | GNAS complex locus | -0.00978248 |
| KLF2 | Kruppel-like factor 2 | -0.00966944 |
| PERP | PERP, TP53 apoptosis effector | -0.00948252 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00947459 |
| FABP4 | fatty acid binding protein 4, adipocyte | -0.00945425 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.00945193 |
| RGS5 | regulator of G-protein signaling 5 | -0.00939332 |
| RAB25 | RAB25, member RAS oncogene family | -0.00935914 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.00930597 |
| BEX1 | brain expressed, X-linked 1 | -0.00922868 |
| SIK1 | salt-inducible kinase 1 | -0.00920984 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.00910061 |
| KRT16 | keratin 16, type I | -0.00909261 |
| CRABP2 | cellular retinoic acid binding protein 2 | -0.00907721 |
| NEBL | nebulette | -0.0090245 |
| KLF6 | Kruppel-like factor 6 | -0.00901088 |
| S100A7 | S100 calcium binding protein A7 | -0.00900327 |
| INHBA | inhibin, beta A | -0.00900037 |
| SPRR1B | small proline-rich protein 1B | -0.00896703 |
| JUP | junction plakoglobin | -0.00891069 |
| EFHD1 | EF-hand domain family, member D1 | -0.00887379 |
| KRT17 | keratin 17, type I | -0.00885074 |
| CYBA | cytochrome b-245, alpha polypeptide | -0.00881165 |
| RCAN1 | regulator of calcineurin 1 | -0.00876069 |
| PRNP | prion protein | -0.00875656 |
| MAGEA3 | melanoma antigen family A3 | -0.0087504 |
| MGP | matrix Gla protein | -0.0087336 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | -0.00869736 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0085839 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | -0.00849352 |
| CD9 | CD9 molecule | -0.00848593 |
| CSTA | cystatin A (stefin A) | -0.00846066 |
| YBX3 | Y box binding protein 3 | -0.00843224 |
| EMP1 | epithelial membrane protein 1 | -0.00843089 |
| RHCG | Rh family, C glycoprotein | -0.00840792 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.00840494 |
| CCNA2 | cyclin A2 | -0.00835331 |
| KCNJ15 | potassium channel, inwardly rectifying subfamily J, member 15 | -0.00832506 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | -0.00824112 |
| EPS8L2 | EPS8-like 2 | -0.00823367 |
| S100A2 | S100 calcium binding protein A2 | -0.00823146 |
| CST1 | cystatin SN | -0.00818032 |
| TSPAN13 | tetraspanin 13 | -0.00811423 |
| EGR1 | early growth response 1 | -0.00810827 |
| TRIM29 | tripartite motif containing 29 | -0.00806002 |
| PLPP2 | phospholipid phosphatase 2 | -0.00801194 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | -0.00800046 |
| PEG3 | paternally expressed 3 | -0.00799726 |
| PLAAT3 | phospholipase A and acyltransferase 3 | -0.00798106 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00794417 |
| VPREB1 | pre-B lymphocyte 1 | -0.00790465 |
| C3 | complement component 3 | -0.00787631 |
| DSP | desmoplakin | -0.00786643 |
| MAGEA12 | melanoma antigen family A12 | -0.00786324 |
| PLLP | plasmolipin | -0.00780761 |
| RGCC | regulator of cell cycle | -0.00780153 |
| KCNJ16 | potassium channel, inwardly rectifying subfamily J, member 16 | -0.00778637 |
| BGN | biglycan | -0.00774118 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.00768485 |
| CRISP3 | cysteine-rich secretory protein 3 | -0.0076747 |
| SLC47A1 | solute carrier family 47 (multidrug and toxin extrusion), member 1 | -0.00765392 |
| NPY1R | neuropeptide Y receptor Y1 | -0.00764397 |
| CFD | complement factor D (adipsin) | -0.0075936 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | -0.00758954 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | -0.00754865 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.00753816 |
| HBEGF | heparin-binding EGF-like growth factor | -0.00750835 |
| ZFP36 | ZFP36 ring finger protein | -0.00749055 |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming | -0.00747644 |
| GLDC | glycine dehydrogenase (decarboxylating) | -0.00746781 |
| FN1 | fibronectin 1 | -0.00746256 |
| STK26 | serine/threonine protein kinase 26 | -0.00736014 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.00733005 |
| S100A14 | S100 calcium binding protein A14 | -0.00731672 |
| CYB5R2 | cytochrome b5 reductase 2 | -0.0073013 |
| LCN2 | lipocalin 2 | -0.0072635 |
| CHP1 | calcineurin-like EF-hand protein 1 | -0.00725626 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | -0.00724754 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | -0.00724637 |
| DEFB1 | defensin, beta 1 | -0.00723535 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.00722852 |
| BCAS1 | breast carcinoma amplified sequence 1 | -0.00710363 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.00710144 |
| VIM | vimentin | -0.00707449 |
| QPCT | glutaminyl-peptide cyclotransferase | -0.00702111 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0070082 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | -0.00699364 |
| AEBP1 | AE binding protein 1 | -0.0069869 |
| GALNT14 | polypeptide N-acetylgalactosaminyltransferase 14 | -0.00693899 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | -0.00692965 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.00692912 |
| MAGEA1 | melanoma antigen family A1 | -0.00690701 |
| MBL2 | mannose-binding lectin (protein C) 2, soluble | -0.0068482 |
| CTSZ | cathepsin Z | -0.00681908 |
| CLDN10 | claudin 10 | -0.00681841 |
| TGFA | transforming growth factor, alpha | -0.00681825 |
| PABPC4 | poly(A) binding protein, cytoplasmic 4 (inducible form) | -0.0068012 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.00679045 |
| DSG3 | desmoglein 3 | -0.00677996 |
| FAM107A | family with sequence similarity 107, member A | -0.00675406 |
| TNNC1 | troponin C type 1 (slow) | -0.00673764 |
| LAMB1 | laminin, beta 1 | -0.00671842 |
| CPM | carboxypeptidase M | -0.00670686 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.00667851 |
| LTF | lactotransferrin | -0.00667588 |
| RASA4 | RAS p21 protein activator 4 | -0.00664671 |
| APOD | apolipoprotein D | -0.00664308 |
| INAVA | innate immunity activator | -0.00663943 |
| CX3CL1 | chemokine (C-X3-C motif) ligand 1 | -0.00663422 |
| SCPEP1 | serine carboxypeptidase 1 | -0.00659619 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | -0.00659602 |
| UPK1B | uroplakin 1B | -0.00659166 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.00656134 |
| CTSD | cathepsin D | -0.00655742 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.00652228 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.00651138 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0065041 |
| DDX21 | DEAD (Asp-Glu-Ala-Asp) box helicase 21 | -0.00648344 |
| USP9Y | ubiquitin specific peptidase 9, Y-linked | -0.00648046 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.00647599 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.00646028 |
| RBM34 | RNA binding motif protein 34 | -0.00646023 |
| ZSCAN18 | zinc finger and SCAN domain containing 18 | -0.00645751 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | -0.00645707 |
| MGLL | monoglyceride lipase | -0.00642578 |
| SMAGP | small cell adhesion glycoprotein | -0.00642378 |
| CHMP2A | charged multivesicular body protein 2A | -0.0064092 |
| TNFAIP6 | tumor necrosis factor, alpha-induced protein 6 | -0.00638345 |
| AMIGO2 | adhesion molecule with Ig-like domain 2 | -0.00637781 |
| TGFBR3 | transforming growth factor, beta receptor III | -0.00636384 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00633633 |
| CTSE | cathepsin E | -0.00631342 |
| AZU1 | azurocidin 1 | -0.00631285 |
| LAMA2 | laminin, alpha 2 | -0.00630606 |
| AGTPBP1 | ATP/GTP binding protein 1 | -0.00629955 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.00629913 |
| EIF6 | eukaryotic translation initiation factor 6 | -0.00629575 |
| S100A10 | S100 calcium binding protein A10 | -0.00629439 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.00627385 |
| IGLL1 | immunoglobulin lambda-like polypeptide 1 | -0.00626474 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.00625949 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.00623471 |
| SFRP1 | secreted frizzled-related protein 1 | -0.00623271 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.00622043 |
| IRS1 | insulin receptor substrate 1 | -0.00621431 |
| XPO7 | exportin 7 | -0.00617884 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | -0.00617798 |
| TMPRSS11E | transmembrane protease, serine 11E | -0.00614741 |
| ALDH3B1 | aldehyde dehydrogenase 3 family, member B1 | -0.0061023 |
| IFI44L | interferon-induced protein 44-like | -0.00608156 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | -0.00607696 |
| SCGB2A2 | secretoglobin, family 2A, member 2 | -0.00607062 |
| GNLY | granulysin | -0.00604023 |
| PEBP1 | phosphatidylethanolamine binding protein 1 | -0.00603046 |
| PITX1 | paired-like homeodomain 1 | -0.00598676 |
| CXADR | coxsackie virus and adenovirus receptor | -0.00598221 |
| EEF1A2 | eukaryotic translation elongation factor 1 alpha 2 | -0.00597813 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0059259 |
| BMP2 | bone morphogenetic protein 2 | -0.00591955 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0059122 |
| TUFT1 | tuftelin 1 | -0.00590991 |
| PLK2 | polo-like kinase 2 | -0.00589675 |
| ERMP1 | endoplasmic reticulum metallopeptidase 1 | -0.00587937 |
| FOXC1 | forkhead box C1 | -0.00586461 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.00585504 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | -0.00585052 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.00584445 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | -0.00584292 |
| DTX4 | deltex 4, E3 ubiquitin ligase | -0.00584289 |
| PSCA | prostate stem cell antigen | -0.00584069 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.00583448 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | -0.0058155 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.00580718 |
| STX3 | syntaxin 3 | -0.00577604 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.00577469 |
| A2M | alpha-2-macroglobulin | -0.00576781 |
| BPGM | 2,3-bisphosphoglycerate mutase | -0.00576222 |
| OSTF1 | osteoclast stimulating factor 1 | -0.00576164 |
| NFASC | neurofascin | -0.00574528 |
| PDZK1 | PDZ domain containing 1 | -0.0057345 |
| SPRR2B | small proline-rich protein 2B | -0.00573248 |
| NPEPL1 | aminopeptidase-like 1 | -0.00571065 |
| CMAS | cytidine monophosphate N-acetylneuraminic acid synthetase | -0.0057094 |
| TUBB6 | tubulin, beta 6 class V | -0.00570371 |
| MYO6 | myosin VI | -0.00568777 |
| CALR | calreticulin | -0.00568724 |
| HGF | hepatocyte growth factor (hepapoietin A; scatter factor) | -0.00568129 |
| MX1 | MX dynamin-like GTPase 1 | -0.00565971 |
| ITM2C | integral membrane protein 2C | -0.00565631 |
| STK24 | serine/threonine kinase 24 | -0.00564717 |
| INSR | insulin receptor | -0.00563186 |
| AK1 | adenylate kinase 1 | -0.00562278 |
| CNPY3 | canopy FGF signaling regulator 3 | -0.00560712 |
| PLAUR | plasminogen activator, urokinase receptor | -0.00560117 |
| BRD2 | bromodomain containing 2 | -0.0055958 |
| PI3 | peptidase inhibitor 3, skin-derived | -0.00557891 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0055604 |
| IPO13 | importin 13 | -0.00556006 |
| TSPAN1 | tetraspanin 1 | -0.00556004 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.00555256 |
| AACS | acetoacetyl-CoA synthetase | -0.00553184 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.00553115 |
| SQLE | squalene epoxidase | -0.00552561 |
| HEBP2 | heme binding protein 2 | -0.00552039 |
| LAMP5 | lysosomal-associated membrane protein family, member 5 | -0.00550515 |
