LRRK2_activemutant_159_GSE36321 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE36321
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Genes

600 genes differentially expressed following the LRRK2_activemutant_159_GSE36321 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
CYR61 cysteine-rich, angiogenic inducer, 61 5.21292
BHLHE41 basic helix-loop-helix family, member e41 4.28595
SLC25A32 solute carrier family 25 (mitochondrial folate carrier), member 32 3.92737
TCL6 T-cell leukemia/lymphoma 6 (non-protein coding) 3.66847
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene 3.64351
ITM2C integral membrane protein 2C 3.546
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 3.41294
HBEGF heparin-binding EGF-like growth factor 3.37566
GYG1 glycogenin 1 3.33843
TPM1 tropomyosin 1 (alpha) 3.32175
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 3.24754
SPON1 spondin 1, extracellular matrix protein 3.19121
NPTX2 neuronal pentraxin II 3.17925
FSTL1 follistatin-like 1 3.1216
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 2.70483
NMB neuromedin B 2.67304
PLS3 plastin 3 2.67115
TRAF3IP2 TRAF3 interacting protein 2 2.66046
KLF5 Kruppel-like factor 5 (intestinal) 2.63932
NID2 nidogen 2 (osteonidogen) 2.61218
FILIP1L filamin A interacting protein 1-like 2.56919
ADAM12 ADAM metallopeptidase domain 12 2.5076
MCAM melanoma cell adhesion molecule 2.47797
TRAF2 TNF receptor-associated factor 2 2.46585
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.41637
DTNA dystrobrevin, alpha 2.39943
CFLAR CASP8 and FADD-like apoptosis regulator 2.36128
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 2.31348
FZD1 frizzled class receptor 1 2.28823
PELO pelota homolog (Drosophila) 2.23456
FOXA2 forkhead box A2 2.21443
SYNDIG1 synapse differentiation inducing 1 2.16834
RAB8A RAB8A, member RAS oncogene family 2.15367
PMP22 peripheral myelin protein 22 2.15272
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 2.14176
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 2.11372
OLFML2A olfactomedin-like 2A 2.10022
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 2.06273
MEIS1 Meis homeobox 1 2.05902
CCT4 chaperonin containing TCP1, subunit 4 (delta) 1.98755
EGLN3 egl-9 family hypoxia-inducible factor 3 1.98708
TOR1A torsin family 1, member A (torsin A) 1.98633
C8ORF4 chromosome 8 open reading frame 4 1.98159
PON2 paraoxonase 2 1.97993
LAMB1 laminin, beta 1 1.97773
MYOF myoferlin 1.96227
SH3BP4 SH3-domain binding protein 4 1.95384
ZHX2 zinc fingers and homeoboxes 2 1.88081
GLIPR1 GLI pathogenesis-related 1 1.87834
ANXA1 annexin A1 1.85934
P3H2 prolyl 3-hydroxylase 2 1.84288
IGFBP3 insulin-like growth factor binding protein 3 1.82229
LYPD1 LY6/PLAUR domain containing 1 1.8116
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 1.81066
CCDC106 coiled-coil domain containing 106 1.78639
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.77311
HK1 hexokinase 1 1.77198
CD36 CD36 molecule (thrombospondin receptor) 1.7657
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 1.76195
PRR13 proline rich 13 1.75091
AFP alpha-fetoprotein 1.74989
CPE carboxypeptidase E 1.73529
CAV1 caveolin 1, caveolae protein, 22kDa 1.7301
NKX2-2 NK2 homeobox 2 1.72611
PANK4 pantothenate kinase 4 1.72511
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 1.72322
BID BH3 interacting domain death agonist 1.67775
FAM114A1 family with sequence similarity 114, member A1 1.67605
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 1.66752
PDGFC platelet derived growth factor C 1.65171
TMEM100 transmembrane protein 100 1.64844
FABP3 fatty acid binding protein 3, muscle and heart 1.64091
MET MET proto-oncogene, receptor tyrosine kinase 1.63259
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 1.62828
TAGLN2 transgelin 2 1.62581
FAM184A family with sequence similarity 184, member A 1.61173
BCL2L1 BCL2-like 1 1.61156
ADM adrenomedullin 1.60461
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 1.60054
TNIP1 TNFAIP3 interacting protein 1 1.60006
LDHB lactate dehydrogenase B 1.59306
RAD51 RAD51 recombinase 1.58549
KIAA1644 KIAA1644 1.58071
STXBP6 syntaxin binding protein 6 (amisyn) 1.5714
TBC1D31 TBC1 domain family, member 31 1.55003
SDC2 syndecan 2 1.54838
PFN2 profilin 2 1.52368
OPTN optineurin 1.52266
PPAP2A phosphatidic acid phosphatase type 2A 1.51724
ECH1 enoyl CoA hydratase 1, peroxisomal 1.51312
RBMS1 RNA binding motif, single stranded interacting protein 1 1.51251
SAMD4A sterile alpha motif domain containing 4A 1.50592
NEFH neurofilament, heavy polypeptide 1.50236
IL13RA2 interleukin 13 receptor, alpha 2 1.50129
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 1.49172
CUL2 cullin 2 1.48503
PLAU plasminogen activator, urokinase 1.48433
UMPS uridine monophosphate synthetase 1.46376
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 1.46359
SAR1B secretion associated, Ras related GTPase 1B 1.44983
SEC61B Sec61 beta subunit 1.44815
HOXA4 homeobox A4 1.44522
FBXL12 F-box and leucine-rich repeat protein 12 1.43748
RCAN2 regulator of calcineurin 2 1.43661
SESN1 sestrin 1 1.43621
PCDH7 protocadherin 7 1.43565
RAI14 retinoic acid induced 14 1.42631
PRC1 protein regulator of cytokinesis 1 1.42096
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.41701
TRIP13 thyroid hormone receptor interactor 13 1.41033
RFTN1 raftlin, lipid raft linker 1 1.40633
IDI1 isopentenyl-diphosphate delta isomerase 1 1.37699
SC5D sterol-C5-desaturase 1.37601
ZNF593 zinc finger protein 593 1.37457
YARS tyrosyl-tRNA synthetase 1.36835
SYNJ2 synaptojanin 2 1.36137
EMP1 epithelial membrane protein 1 1.34518
ADGRG6 adhesion G protein-coupled receptor G6 1.34182
PTX3 pentraxin 3, long 1.34138
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 1.3382
MEST mesoderm specific transcript 1.3373
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.33726
DRAM1 DNA-damage regulated autophagy modulator 1 1.33191
FERMT2 fermitin family member 2 1.3236
PCSK6 proprotein convertase subtilisin/kexin type 6 1.32242
ANXA2 annexin A2 1.31978
HMBS hydroxymethylbilane synthase 1.31562
DOLK dolichol kinase 1.31215
LAMP3 lysosomal-associated membrane protein 3 1.30921
PDLIM2 PDZ and LIM domain 2 (mystique) 1.30199
CANX calnexin 1.29823
SFXN3 sideroflexin 3 1.28623
RBBP7 retinoblastoma binding protein 7 1.28278
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 1.28173
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.28018
LIMCH1 LIM and calponin homology domains 1 1.27738
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 1.2726
FN1 fibronectin 1 1.2691
PDIA6 protein disulfide isomerase family A, member 6 1.26022
RAB31 RAB31, member RAS oncogene family 1.25844
MTMR2 myotubularin related protein 2 1.25831
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 1.25108
NEBL nebulette 1.24169
DOK5 docking protein 5 1.24094
TMEM62 transmembrane protein 62 1.23626
S100A2 S100 calcium binding protein A2 1.23056
SATB2 SATB homeobox 2 1.22992
MN1 meningioma (disrupted in balanced translocation) 1 1.22883
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 1.2273
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 1.22665
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1 1.22558
LDB2 LIM domain binding 2 1.21438
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 1.214
CKLF chemokine-like factor 1.21351
TNS3 tensin 3 1.20134
PTDSS1 phosphatidylserine synthase 1 1.20043
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 1.19762
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.1947
PAPPA pregnancy-associated plasma protein A, pappalysin 1 1.19096
TFPI2 tissue factor pathway inhibitor 2 1.18633
STOM stomatin 1.18428
GPM6B glycoprotein M6B 1.18409
UBC ubiquitin C 1.16774
IQGAP2 IQ motif containing GTPase activating protein 2 1.1616
SLC39A8 solute carrier family 39 (zinc transporter), member 8 1.16146
MSMO1 methylsterol monooxygenase 1 1.15324
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.15072
LDLR low density lipoprotein receptor 1.14619
MAPRE2 microtubule-associated protein, RP/EB family, member 2 1.14491
SQSTM1 sequestosome 1 1.14217
DCTPP1 dCTP pyrophosphatase 1 1.14077
KRT18 keratin 18, type I 1.13498
MYD88 myeloid differentiation primary response 88 1.12606
MAGED1 melanoma antigen family D1 1.12345
COLEC12 collectin sub-family member 12 1.12325
RAB27A RAB27A, member RAS oncogene family 1.11797
ANXA11 annexin A11 1.11763
SYNE1 spectrin repeat containing, nuclear envelope 1 1.11615
NSDHL NAD(P) dependent steroid dehydrogenase-like 1.11598
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 1.11317
C10ORF10 chromosome 10 open reading frame 10 1.11211
ANXA3 annexin A3 1.10988
S100A10 S100 calcium binding protein A10 1.10925
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing 1.1074
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.10664
VIM vimentin 1.10539
PPP1R16B protein phosphatase 1, regulatory subunit 16B 1.1025
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 1.10019
COLGALT2 collagen beta(1-O)galactosyltransferase 2 1.09037
LPAR1 lysophosphatidic acid receptor 1 1.08184
IL17A interleukin 17A 1.08145
DSP desmoplakin 1.07888
IDE insulin-degrading enzyme 1.07877
LUM lumican 1.07867
ENO2 enolase 2 (gamma, neuronal) 1.07537
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.07537
CPS1 carbamoyl-phosphate synthase 1, mitochondrial 1.07462
GULP1 GULP, engulfment adaptor PTB domain containing 1 1.07223
NPR2 natriuretic peptide receptor 2 1.07122
SNX7 sorting nexin 7 1.07037
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 1.06952
GAS7 growth arrest-specific 7 1.06868
NR6A1 nuclear receptor subfamily 6, group A, member 1 1.06641
EFNA5 ephrin-A5 1.0642
RGS1 regulator of G-protein signaling 1 1.06347
LASP1 LIM and SH3 protein 1 1.06128
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.06089
BMP7 bone morphogenetic protein 7 1.06089
PDLIM1 PDZ and LIM domain 1 1.06019
CD300C CD300c molecule 1.05808
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.05529
EPCAM epithelial cell adhesion molecule 1.05103
MYO5C myosin VC 1.05095
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.05021
LIFR leukemia inhibitory factor receptor alpha 1.04171
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 1.03905
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 1.03776
NRG1 neuregulin 1 1.02299
MXRA8 matrix-remodelling associated 8 1.02063
EPB41L2 erythrocyte membrane protein band 4.1-like 2 1.01867
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 1.01783
KIF20A kinesin family member 20A 1.01723
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.01586
EIF5A eukaryotic translation initiation factor 5A 1.01515
MCM6 minichromosome maintenance complex component 6 1.01357
NQO1 NAD(P)H dehydrogenase, quinone 1 1.01238
MSX2 msh homeobox 2 1.01108
STS steroid sulfatase (microsomal), isozyme S 1.00737
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.00669
COL13A1 collagen, type XIII, alpha 1 1.00578
MDFIC MyoD family inhibitor domain containing 1.00552
LAMC1 laminin, gamma 1 (formerly LAMB2) 1.00353
STK32B serine/threonine kinase 32B 1.00207
COL5A1 collagen, type V, alpha 1 1.00154
FJX1 four jointed box 1 (Drosophila) 0.998431
SCG2 secretogranin II 0.994104
BAMBI BMP and activin membrane-bound inhibitor 0.990798
RTN4 reticulon 4 0.990052
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 0.989482
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.98889
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 0.988061
ITGB5 integrin, beta 5 0.987575
LMCD1 LIM and cysteine-rich domains 1 0.984234
RBPMS RNA binding protein with multiple splicing 0.982756
ANAPC13 anaphase promoting complex subunit 13 0.982239
CALCR calcitonin receptor 0.981423
NBL1 neuroblastoma 1, DAN family BMP antagonist 0.981404
PAWR PRKC, apoptosis, WT1, regulator 0.979648
LDLRAP1 low density lipoprotein receptor adaptor protein 1 0.97937
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21 0.977861
STAC SH3 and cysteine rich domain 0.975112
HES1 hes family bHLH transcription factor 1 0.972121
TRIL TLR4 interactor with leucine-rich repeats 0.971484
SORBS2 sorbin and SH3 domain containing 2 0.971447
KEAP1 kelch-like ECH-associated protein 1 0.970351
FBLN1 fibulin 1 0.968075
ELMO1 engulfment and cell motility 1 0.965383
LIMA1 LIM domain and actin binding 1 0.96413
AMOTL2 angiomotin like 2 0.963645
WDR1 WD repeat domain 1 0.96115
ACTN1 actinin, alpha 1 0.960577
LGI1 leucine-rich, glioma inactivated 1 0.95775
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.956115
HRASLS HRAS-like suppressor 0.954863
PTPRM protein tyrosine phosphatase, receptor type, M 0.94468
LAMA5 laminin, alpha 5 0.943882
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.943876
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.943256
RNF6 ring finger protein (C3H2C3 type) 6 0.942541
FAM32A family with sequence similarity 32, member A 0.941835
ACOX2 acyl-CoA oxidase 2, branched chain 0.941811
LPIN1 lipin 1 0.941128
CAPN9 calpain 9 0.938909
PROS1 protein S (alpha) 0.938237
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.937135
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.932929
LRTM1 leucine-rich repeats and transmembrane domains 1 0.930715
ANKRD7 ankyrin repeat domain 7 0.928245
IFI6 interferon, alpha-inducible protein 6 0.926243
TFF3 trefoil factor 3 (intestinal) 0.924809
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 0.924429
PARP2 poly (ADP-ribose) polymerase 2 0.92112
MORC4 MORC family CW-type zinc finger 4 0.918785
FGF13 fibroblast growth factor 13 0.91654
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.915227
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6 0.915066
SEPP1 selenoprotein P, plasma, 1 0.913648
PENK proenkephalin 0.911297
FTL ferritin, light polypeptide 0.910393
SLC35D2 solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 0.90768
AQP4 aquaporin 4 0.907551
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.905607
HNMT histamine N-methyltransferase 0.905179
RITA1 RBPJ interacting and tubulin associated 1 0.90323
JTB jumping translocation breakpoint 0.901844
FANCG Fanconi anemia, complementation group G 0.901662
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.900881
COL18A1 collagen, type XVIII, alpha 1 0.900847
FHL1 four and a half LIM domains 1 0.898717
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.898454

decreased expression

Symbol Name Standardized Value
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein -3.95132
NAALAD2 N-acetylated alpha-linked acidic dipeptidase 2 -3.22124
FBXL15 F-box and leucine-rich repeat protein 15 -3.18173
EPHA3 EPH receptor A3 -3.1392
INPP5F inositol polyphosphate-5-phosphatase F -2.96652
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.72392
TLL2 tolloid-like 2 -2.70737
RNMT RNA (guanine-7-) methyltransferase -2.63865
ZBTB5 zinc finger and BTB domain containing 5 -2.48172
RAD54L2 RAD54-like 2 (S. cerevisiae) -2.46714
HIST1H2BD histone cluster 1, H2bd -2.4564
CDC23 cell division cycle 23 -2.44316
SARAF store-operated calcium entry-associated regulatory factor -2.44079
FKBP1B FK506 binding protein 1B, 12.6 kDa -2.3945
PCDHA2 protocadherin alpha 2 -2.37956
RPL22 ribosomal protein L22 -2.37831
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 -2.29748
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -2.28377
SCAPER S-phase cyclin A-associated protein in the ER -2.21753
GAS1 growth arrest-specific 1 -2.18399
ACSM3 acyl-CoA synthetase medium-chain family member 3 -2.12322
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) -2.11876
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 -2.11294
RPL7A ribosomal protein L7a -2.11154
ODC1 ornithine decarboxylase 1 -2.07356
LMTK2 lemur tyrosine kinase 2 -2.04683
PTCH1 patched 1 -2.01762
AFTPH aftiphilin -1.98895
PSPC1 paraspeckle component 1 -1.96355
FZD10 frizzled class receptor 10 -1.95361
GPR153 G protein-coupled receptor 153 -1.93224
PSRC1 proline/serine-rich coiled-coil 1 -1.91893
BMP5 bone morphogenetic protein 5 -1.9104
STAU1 staufen double-stranded RNA binding protein 1 -1.89674
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) -1.88447
CA4 carbonic anhydrase IV -1.87886
RTN1 reticulon 1 -1.85245
ANOS1 anosmin 1 -1.85233
VAX2 ventral anterior homeobox 2 -1.8298
TLX1 T-cell leukemia homeobox 1 -1.79009
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -1.77687
INTS5 integrator complex subunit 5 -1.76698
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit -1.74274
CCDC47 coiled-coil domain containing 47 -1.74258
ZNF606 zinc finger protein 606 -1.73952
FZD7 frizzled class receptor 7 -1.73741
COL1A2 collagen, type I, alpha 2 -1.73162
ZNF177 zinc finger protein 177 -1.72699
ZFAND1 zinc finger, AN1-type domain 1 -1.7209
GRK5 G protein-coupled receptor kinase 5 -1.70392
SLITRK5 SLIT and NTRK-like family, member 5 -1.69894
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -1.69502
RB1 retinoblastoma 1 -1.69491
AMBRA1 autophagy/beclin-1 regulator 1 -1.6773
H2AFV H2A histone family, member V -1.67482
IL19 interleukin 19 -1.63168
CALM1 calmodulin 1 (phosphorylase kinase, delta) -1.63115
OCEL1 occludin/ELL domain containing 1 -1.63084
DNM3 dynamin 3 -1.61867
GLI3 GLI family zinc finger 3 -1.60976
TRAFD1 TRAF-type zinc finger domain containing 1 -1.60278
HAUS3 HAUS augmin-like complex, subunit 3 -1.59149
TSPAN31 tetraspanin 31 -1.5847
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) -1.58206
DZIP1 DAZ interacting zinc finger protein 1 -1.57424
DCX doublecortin -1.5718
EFNA3 ephrin-A3 -1.56862
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -1.56151
IFITM1 interferon induced transmembrane protein 1 -1.54554
PEX11A peroxisomal biogenesis factor 11 alpha -1.53761
SDHAP1 succinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1 -1.52643
CDK10 cyclin-dependent kinase 10 -1.51695
HIST1H2AC histone cluster 1, H2ac -1.51454
CSAD cysteine sulfinic acid decarboxylase -1.50981
CDKN2A cyclin-dependent kinase inhibitor 2A -1.50825
C18ORF25 chromosome 18 open reading frame 25 -1.49544
AVIL advillin -1.48347
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -1.47552
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -1.46339
NCAM1 neural cell adhesion molecule 1 -1.46233
MPHOSPH9 M-phase phosphoprotein 9 -1.44493
BBS9 Bardet-Biedl syndrome 9 -1.43665
TECPR2 tectonin beta-propeller repeat containing 2 -1.43206
HSDL2 hydroxysteroid dehydrogenase like 2 -1.41601
CCNG1 cyclin G1 -1.40992
PBX3 pre-B-cell leukemia homeobox 3 -1.40257
ING4 inhibitor of growth family, member 4 -1.40019
C14ORF93 chromosome 14 open reading frame 93 -1.39687
ADO 2-aminoethanethiol (cysteamine) dioxygenase -1.39658
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) -1.39196
PGM1 phosphoglucomutase 1 -1.38954
DTX4 deltex 4, E3 ubiquitin ligase -1.38796
ZNF419 zinc finger protein 419 -1.38421
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog -1.37907
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 -1.37794
PCDH8 protocadherin 8 -1.37597
MBD2 methyl-CpG binding domain protein 2 -1.3755
STK39 serine threonine kinase 39 -1.37052
PAX6 paired box 6 -1.36483
PGBD5 piggyBac transposable element derived 5 -1.34642
RPLP1 ribosomal protein, large, P1 -1.34554
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 -1.34379
EDNRB endothelin receptor type B -1.32323
UBE2L6 ubiquitin-conjugating enzyme E2L 6 -1.32163
C14ORF132 chromosome 14 open reading frame 132 -1.31926
CLMN calmin (calponin-like, transmembrane) -1.30618
NSG1 neuron specific gene family member 1 -1.27939
IPO7 importin 7 -1.27812
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -1.27662
ZNF638 zinc finger protein 638 -1.27532
HEXIM1 hexamethylene bis-acetamide inducible 1 -1.27474
MAGEA6 melanoma antigen family A6 -1.26499
NR2F1 nuclear receptor subfamily 2, group F, member 1 -1.26195
FANCF Fanconi anemia, complementation group F -1.25231
ARHGAP32 Rho GTPase activating protein 32 -1.24868
KDM3A lysine (K)-specific demethylase 3A -1.24714
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -1.24296
MLH3 mutL homolog 3 -1.23711
AAK1 AP2 associated kinase 1 -1.23301
STMN2 stathmin 2 -1.21967
MAT2B methionine adenosyltransferase II, beta -1.21529
EFS embryonal Fyn-associated substrate -1.21392
STOML1 stomatin (EPB72)-like 1 -1.20815
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -1.20581
PAN2 PAN2 poly(A) specific ribonuclease subunit -1.20475
FAM8A1 family with sequence similarity 8, member A1 -1.19932
GUSBP11 glucuronidase, beta pseudogene 11 -1.19406
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 -1.19061
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 -1.18911
CCBL2 cysteine conjugate-beta lyase 2 -1.18525
PHF8 PHD finger protein 8 -1.17979
ALK anaplastic lymphoma receptor tyrosine kinase -1.17565
DPYSL2 dihydropyrimidinase-like 2 -1.17294
ENOX2 ecto-NOX disulfide-thiol exchanger 2 -1.17127
ZSCAN26 zinc finger and SCAN domain containing 26 -1.1636
SCN3A sodium channel, voltage gated, type III alpha subunit -1.16253
TSPYL4 TSPY-like 4 -1.16253
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -1.16127
BCAP29 B-cell receptor-associated protein 29 -1.16078
VRK3 vaccinia related kinase 3 -1.16053
DPYSL3 dihydropyrimidinase-like 3 -1.15726
FGFR3 fibroblast growth factor receptor 3 -1.14942
GRSF1 G-rich RNA sequence binding factor 1 -1.14526
DHFR dihydrofolate reductase -1.14498
LRPPRC leucine-rich pentatricopeptide repeat containing -1.14222
SEPT6 septin 6 -1.14009
RFX5 regulatory factor X, 5 (influences HLA class II expression) -1.12916
ZNF254 zinc finger protein 254 -1.12779
IZUMO4 IZUMO family member 4 -1.11997
ERLIN2 ER lipid raft associated 2 -1.11271
ATF2 activating transcription factor 2 -1.11212
COG4 component of oligomeric golgi complex 4 -1.11159
RALGPS1 Ral GEF with PH domain and SH3 binding motif 1 -1.1109
SLN sarcolipin -1.10728
HIST2H2BE histone cluster 2, H2be -1.10651
TAGLN3 transgelin 3 -1.10066
PAQR6 progestin and adipoQ receptor family member VI -1.09526
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -1.08622
SALL2 spalt-like transcription factor 2 -1.08536
ZNF544 zinc finger protein 544 -1.08325
RGS16 regulator of G-protein signaling 16 -1.08074
NMU neuromedin U -1.08032
INSM1 insulinoma-associated 1 -1.08007
AP3S2 adaptor-related protein complex 3, sigma 2 subunit -1.07626
IPO5 importin 5 -1.0699
AGTPBP1 ATP/GTP binding protein 1 -1.06087
SKP1 S-phase kinase-associated protein 1 -1.05643
ACKR3 atypical chemokine receptor 3 -1.05562
PBX1 pre-B-cell leukemia homeobox 1 -1.0545
WHSC1L1 Wolf-Hirschhorn syndrome candidate 1-like 1 -1.05417
STRADA STE20-related kinase adaptor alpha -1.05111
MAML1 mastermind-like 1 (Drosophila) -1.0427
MAP7 microtubule-associated protein 7 -1.03408
FGFR2 fibroblast growth factor receptor 2 -1.03088
VPS33B vacuolar protein sorting 33 homolog B (yeast) -1.0282
ATP9B ATPase, class II, type 9B -1.02462
SEPT2 septin 2 -1.02056
PVRIG poliovirus receptor related immunoglobulin domain containing -1.019
TERF2IP telomeric repeat binding factor 2, interacting protein -1.01164
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) -1.01092
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -1.00374
WDR11 WD repeat domain 11 -1.0008
MKRN1 makorin ring finger protein 1 -0.997663
SOCS2 suppressor of cytokine signaling 2 -0.99588
HOXA2 homeobox A2 -0.995562
KRTAP1-3 keratin associated protein 1-3 -0.995225
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 -0.993488
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -0.992238
IFNA8 interferon, alpha 8 -0.991812
GLDC glycine dehydrogenase (decarboxylating) -0.987895
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like -0.986694
CRTAP cartilage associated protein -0.981017
RPLP0 ribosomal protein, large, P0 -0.979636
DGKI diacylglycerol kinase, iota -0.976584
PRKCB protein kinase C, beta -0.975519
EGR3 early growth response 3 -0.969808
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.969575
TLN2 talin 2 -0.96786
EFR3A EFR3 homolog A (S. cerevisiae) -0.967503
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -0.966895
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.965476
PEX5 peroxisomal biogenesis factor 5 -0.961382
GGPS1 geranylgeranyl diphosphate synthase 1 -0.959897
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.959799
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 -0.957824
ZFYVE26 zinc finger, FYVE domain containing 26 -0.955189
SLC25A44 solute carrier family 25, member 44 -0.954755
ITSN1 intersectin 1 (SH3 domain protein) -0.952871
GSPT2 G1 to S phase transition 2 -0.951224
LINC00599 long intergenic non-protein coding RNA 599 -0.95052
AKR1C1 aldo-keto reductase family 1, member C1 -0.949436
SMC1A structural maintenance of chromosomes 1A -0.949013
PRMT2 protein arginine methyltransferase 2 -0.948744
LMO3 LIM domain only 3 (rhombotin-like 2) -0.939671
PNMA1 paraneoplastic Ma antigen 1 -0.938324
TPT1 tumor protein, translationally-controlled 1 -0.937278
SSR1 signal sequence receptor, alpha -0.937127
ENGASE endo-beta-N-acetylglucosaminidase -0.935806
TTC12 tetratricopeptide repeat domain 12 -0.934514
COPS2 COP9 signalosome subunit 2 -0.933848
ASTN1 astrotactin 1 -0.933199
SFPQ splicing factor proline/glutamine-rich -0.930052
ADGRE1 adhesion G protein-coupled receptor E1 -0.928924
IRX5 iroquois homeobox 5 -0.928882
TOB2 transducer of ERBB2, 2 -0.925405
FNBP4 formin binding protein 4 -0.923879
RORC RAR-related orphan receptor C -0.913358
CTNNBIP1 catenin, beta interacting protein 1 -0.911644
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 -0.909978
MXRA5 matrix-remodelling associated 5 -0.909809
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) -0.908313
SUGP2 SURP and G patch domain containing 2 -0.905104
ZSCAN32 zinc finger and SCAN domain containing 32 -0.904328
IPO9 importin 9 -0.903138
TMEM184B transmembrane protein 184B -0.902483
EIF3L eukaryotic translation initiation factor 3, subunit L -0.901845
GLI2 GLI family zinc finger 2 -0.901839
VWA5A von Willebrand factor A domain containing 5A -0.90132
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7 -0.900852
LYRM9 LYR motif containing 9 -0.898839
MAPT microtubule-associated protein tau -0.895719
CCDC121 coiled-coil domain containing 121 -0.895564
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -0.894536
STMN4 stathmin-like 4 -0.894013
EPHB2 EPH receptor B2 -0.887034
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 -0.885751
GREB1 growth regulation by estrogen in breast cancer 1 -0.882728
PRDM13 PR domain containing 13 -0.882052
INA internexin neuronal intermediate filament protein, alpha -0.881459
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.878152
ARGLU1 arginine and glutamate rich 1 -0.877413
ABAT 4-aminobutyrate aminotransferase -0.87741
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta) -0.876564
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -0.875881
LTA4H leukotriene A4 hydrolase -0.87418
NR2E1 nuclear receptor subfamily 2, group E, member 1 -0.87278
DIDO1 death inducer-obliterator 1 -0.872598
EFR3B EFR3 homolog B (S. cerevisiae) -0.867333
SETBP1 SET binding protein 1 -0.865305
BCL6 B-cell CLL/lymphoma 6 -0.864893
MKNK1 MAP kinase interacting serine/threonine kinase 1 -0.864765
PAPOLA poly(A) polymerase alpha -0.861925
BTG2 BTG family, member 2 -0.861674
ZIC1 Zic family member 1 -0.861574
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.861208
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 -0.860849
SPG11 spastic paraplegia 11 (autosomal recessive) -0.860741
SLTM SAFB-like, transcription modulator -0.860468
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 -0.860174
PSIP1 PC4 and SFRS1 interacting protein 1 -0.860094
CAND1 cullin-associated and neddylation-dissociated 1 -0.859962
JAKMIP2 janus kinase and microtubule interacting protein 2 -0.859242
RAB11B RAB11B, member RAS oncogene family -0.858206
PRSS23 protease, serine, 23 -0.856283
ZNF112 zinc finger protein 112 -0.85618
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase -0.856125
RPGRIP1L RPGRIP1-like -0.855636
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.855136
GOLGA8B golgin A8 family, member B -0.851716
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.851658
GEMIN8 gem (nuclear organelle) associated protein 8 -0.850218
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 -0.84989
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.847707
TCERG1 transcription elongation regulator 1 -0.846096
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.846087
COX5A cytochrome c oxidase subunit Va -0.84605
MUTYH mutY homolog -0.845696
RPL37 ribosomal protein L37 -0.842219
POGZ pogo transposable element with ZNF domain -0.840864
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.83844
MED23 mediator complex subunit 23 -0.837902
TSPAN13 tetraspanin 13 -0.836772
ANKRD6 ankyrin repeat domain 6 -0.835564
CLGN calmegin -0.835296
ANKRD26 ankyrin repeat domain 26 -0.834896
SOX3 SRY (sex determining region Y)-box 3 -0.833333
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.83212
FAM149B1 family with sequence similarity 149, member B1 -0.831863
ADCY1 adenylate cyclase 1 (brain) -0.831116
NR2F2 nuclear receptor subfamily 2, group F, member 2 -0.830451
Funding