LS-123 Gene Set

Dataset GDSC Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
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Genes

287 genes with high or low expression in LS-123 relative to other cell lines from the GDSC Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 3.44636
CST5 cystatin D 2.78725
BTG4 B-cell translocation gene 4 2.66931
UBE2A ubiquitin-conjugating enzyme E2A 2.64625
ABHD3 abhydrolase domain containing 3 2.57376
GABARAPL1 GABA(A) receptor-associated protein like 1 2.52766
C4BPB complement component 4 binding protein, beta 2.49463
PANX1 pannexin 1 2.44549
RGS7 regulator of G-protein signaling 7 2.44536
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 2.42058
RBM7 RNA binding motif protein 7 2.41608
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 2.37229
MTM1 myotubularin 1 2.35615
EDAR ectodysplasin A receptor 2.33235
ATP4B ATPase, H+/K+ exchanging, beta polypeptide 2.30348
FOXJ2 forkhead box J2 2.2719
FMR1 fragile X mental retardation 1 2.20134
ACE2 angiotensin I converting enzyme 2 2.17063
UBE2L6 ubiquitin-conjugating enzyme E2L 6 2.15979
PICALM phosphatidylinositol binding clathrin assembly protein 2.15593
SAV1 salvador family WW domain containing protein 1 2.14524
RSAD2 radical S-adenosyl methionine domain containing 2 2.11463
UST uronyl-2-sulfotransferase 2.11229
TMEM123 transmembrane protein 123 2.09724
IFIH1 interferon induced with helicase C domain 1 2.09091
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 2.08268
BLZF1 basic leucine zipper nuclear factor 1 2.04086
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.038
MYD88 myeloid differentiation primary response 88 2.03518
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.01522
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15 2.01465
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 1.98021
KLK10 kallikrein-related peptidase 10 1.96591
MOSPD1 motile sperm domain containing 1 1.96477
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin) 1.94223
LY6G6C lymphocyte antigen 6 complex, locus G6C 1.93328
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit 1.92451
NMU neuromedin U 1.90798
TLR4 toll-like receptor 4 1.89961
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 1.87091
TNNC1 troponin C type 1 (slow) 1.86858
RALB v-ral simian leukemia viral oncogene homolog B 1.85478
ANKRD10 ankyrin repeat domain 10 1.85012
IL20RA interleukin 20 receptor, alpha 1.84043
KISS1 KiSS-1 metastasis-suppressor 1.83741
DOCK9 dedicator of cytokinesis 9 1.83709
FBXO31 F-box protein 31 1.83684
KDM6A lysine (K)-specific demethylase 6A 1.82975
TCHH trichohyalin 1.80037
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 1.79979
SCEL sciellin 1.78885
ZW10 zw10 kinetochore protein 1.78309
SOSTDC1 sclerostin domain containing 1 1.77504
RP2 retinitis pigmentosa 2 (X-linked recessive) 1.77105
KLK6 kallikrein-related peptidase 6 1.76902
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.76734
IL36RN interleukin 36 receptor antagonist 1.75186
KLK5 kallikrein-related peptidase 5 1.74847
TDRD7 tudor domain containing 7 1.74824
EXPH5 exophilin 5 1.74681
PLSCR1 phospholipid scramblase 1 1.73952
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 1.73933
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.73475
TSN translin 1.73449
UPK2 uroplakin 2 1.72961
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 1.71685
ANKRD49 ankyrin repeat domain 49 1.71578
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 1.70427
STS steroid sulfatase (microsomal), isozyme S 1.70348
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 1.70237
NSDHL NAD(P) dependent steroid dehydrogenase-like 1.69806
ANO1 anoctamin 1, calcium activated chloride channel 1.69574
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 1.69371
MBNL2 muscleblind-like splicing regulator 2 1.69294
JRKL JRK-like 1.68899
SIX5 SIX homeobox 5 1.67749
CEP76 centrosomal protein 76kDa 1.67521
HIST1H4H histone cluster 1, H4h 1.67477
ZNF185 zinc finger protein 185 (LIM domain) 1.66089
KRT20 keratin 20, type I 1.64351
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 1.61979
UNC50 unc-50 homolog (C. elegans) 1.61934
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 1.61763
FBXL14 F-box and leucine-rich repeat protein 14 1.60906
MCTS1 malignant T cell amplified sequence 1 1.60802
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 1.59674
KIF18A kinesin family member 18A 1.58646
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 1.58313
RNF39 ring finger protein 39 1.58237
C1GALT1C1 C1GALT1-specific chaperone 1 1.5714
VPS35 vacuolar protein sorting 35 homolog (S. cerevisiae) 1.56311
ENDOD1 endonuclease domain containing 1 1.55997
TSPAN2 tetraspanin 2 1.55389
INSIG2 insulin induced gene 2 1.55383
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 1.55316
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 1.55025
TREML2 triggering receptor expressed on myeloid cells-like 2 1.55005
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) 1.54577
PDE5A phosphodiesterase 5A, cGMP-specific 1.54007
HIST1H2AG histone cluster 1, H2ag 1.5389
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 1.53473
OXSR1 oxidative stress responsive 1 1.53461
PHKB phosphorylase kinase, beta 1.53174
CD9 CD9 molecule 1.53098
SCML1 sex comb on midleg-like 1 (Drosophila) 1.52945
TMEM47 transmembrane protein 47 1.5258
PKP2 plakophilin 2 1.5152
SAP30L SAP30-like 1.51484
ANO2 anoctamin 2, calcium activated chloride channel 1.50908
MUC4 mucin 4, cell surface associated 1.5041
SRCAP Snf2-related CREBBP activator protein 1.49063
STYK1 serine/threonine/tyrosine kinase 1 1.48927
TRPV6 transient receptor potential cation channel, subfamily V, member 6 1.48464
JPH2 junctophilin 2 1.48416
OR7A5 olfactory receptor, family 7, subfamily A, member 5 1.48166
KLF4 Kruppel-like factor 4 (gut) 1.4801
CLIC5 chloride intracellular channel 5 1.47604
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 1.46284
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 1.46103
ITFG1 integrin alpha FG-GAP repeat containing 1 1.45569
SGPL1 sphingosine-1-phosphate lyase 1 1.45526
RIOK3 RIO kinase 3 1.45205
CXCL10 chemokine (C-X-C motif) ligand 10 1.45068
PCDHA10 protocadherin alpha 10 1.44914
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 1.4479
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae) 1.44773
HIST1H3E histone cluster 1, H3e 1.44595
RTP4 receptor (chemosensory) transporter protein 4 1.43737
MX2 MX dynamin-like GTPase 2 1.43654
CUL4B cullin 4B 1.43426
CST2 cystatin SA 1.42691
GCC1 GRIP and coiled-coil domain containing 1 1.4215
IL3 interleukin 3 1.41753

low expression

Symbol Name Standardized Value
PPAT phosphoribosyl pyrophosphate amidotransferase -3.34244
DCAKD dephospho-CoA kinase domain containing -3.07242
HIPK2 homeodomain interacting protein kinase 2 -3.03089
PCGF1 polycomb group ring finger 1 -2.97697
SRP72 signal recognition particle 72kDa -2.97596
MED24 mediator complex subunit 24 -2.95062
DTX3 deltex 3, E3 ubiquitin ligase -2.90853
LIMK1 LIM domain kinase 1 -2.70029
CCNT1 cyclin T1 -2.68032
ZNF271P zinc finger protein 271, pseudogene -2.59845
GRB2 growth factor receptor-bound protein 2 -2.52314
PNKP polynucleotide kinase 3'-phosphatase -2.52117
TMEM121 transmembrane protein 121 -2.37862
DROSHA drosha, ribonuclease type III -2.29703
MPV17 MpV17 mitochondrial inner membrane protein -2.26883
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 -2.2276
THY1 Thy-1 cell surface antigen -2.2254
IER3IP1 immediate early response 3 interacting protein 1 -2.22365
PTCD1 pentatricopeptide repeat domain 1 -2.22169
DSPP dentin sialophosphoprotein -2.21192
HOMER2 homer scaffolding protein 2 -2.20714
SUCLG1 succinate-CoA ligase, alpha subunit -2.18894
ATHL1 ATH1, acid trehalase-like 1 (yeast) -2.15445
GFOD2 glucose-fructose oxidoreductase domain containing 2 -2.14932
GRK4 G protein-coupled receptor kinase 4 -2.12692
ATL2 atlastin GTPase 2 -2.08848
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) -2.07617
EGR4 early growth response 4 -2.05082
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) -2.02982
RPL39L ribosomal protein L39-like -2.00312
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 -1.99947
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle -1.99131
KIAA0513 KIAA0513 -1.98842
FAM160B2 family with sequence similarity 160, member B2 -1.97486
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit -1.96744
CASC1 cancer susceptibility candidate 1 -1.95801
MAGEB2 melanoma antigen family B2 -1.94294
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 -1.93981
SPAG4 sperm associated antigen 4 -1.93904
MTIF2 mitochondrial translational initiation factor 2 -1.93089
WNT8B wingless-type MMTV integration site family, member 8B -1.92664
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 -1.92479
TXN2 thioredoxin 2 -1.9188
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -1.89463
NACA2 nascent polypeptide-associated complex alpha subunit 2 -1.89384
MCTP1 multiple C2 domains, transmembrane 1 -1.89357
ZNF41 zinc finger protein 41 -1.88952
NARF nuclear prelamin A recognition factor -1.87773
PPP1R10 protein phosphatase 1, regulatory subunit 10 -1.87192
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -1.86301
UNC45A unc-45 homolog A (C. elegans) -1.85164
KLHL11 kelch-like family member 11 -1.84568
COL9A2 collagen, type IX, alpha 2 -1.84254
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -1.82202
CASC3 cancer susceptibility candidate 3 -1.82135
TRAPPC8 trafficking protein particle complex 8 -1.82089
DCTN1 dynactin 1 -1.81348
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -1.80328
PCDH11X protocadherin 11 X-linked -1.79147
BIRC7 baculoviral IAP repeat containing 7 -1.78951
SCUBE3 signal peptide, CUB domain, EGF-like 3 -1.77869
TRAP1 TNF receptor-associated protein 1 -1.77332
POLG polymerase (DNA directed), gamma -1.76756
SUB1 SUB1 homolog (S. cerevisiae) -1.76274
MEIS1 Meis homeobox 1 -1.75319
MRPS27 mitochondrial ribosomal protein S27 -1.74541
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -1.74225
BASP1 brain abundant, membrane attached signal protein 1 -1.7414
TIPIN TIMELESS interacting protein -1.72594
MYRIP myosin VIIA and Rab interacting protein -1.72217
GCAT glycine C-acetyltransferase -1.72008
OCLM oculomedin -1.7086
CCDC28B coiled-coil domain containing 28B -1.69031
EDC4 enhancer of mRNA decapping 4 -1.68863
METTL16 methyltransferase like 16 -1.6842
GPS1 G protein pathway suppressor 1 -1.68104
STX10 syntaxin 10 -1.67447
TTLL3 tubulin tyrosine ligase-like family member 3 -1.67276
NLE1 notchless homolog 1 (Drosophila) -1.65466
RING1 ring finger protein 1 -1.64839
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa -1.64607
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) -1.64355
SRRM2 serine/arginine repetitive matrix 2 -1.63483
NRSN2 neurensin 2 -1.63436
PLEKHO2 pleckstrin homology domain containing, family O member 2 -1.63431
MAPT microtubule-associated protein tau -1.62902
PWWP2A PWWP domain containing 2A -1.62831
MLX MLX, MAX dimerization protein -1.61832
UBE4B ubiquitination factor E4B -1.61819
NME3 NME/NM23 nucleoside diphosphate kinase 3 -1.61786
THAP7 THAP domain containing 7 -1.61188
ENO1 enolase 1, (alpha) -1.61116
THRA thyroid hormone receptor, alpha -1.60904
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 -1.60617
USP19 ubiquitin specific peptidase 19 -1.60267
IGSF9B immunoglobulin superfamily, member 9B -1.59568
BCL2 B-cell CLL/lymphoma 2 -1.58341
ARNT aryl hydrocarbon receptor nuclear translocator -1.57432
RNGTT RNA guanylyltransferase and 5'-phosphatase -1.5668
DUS2 dihydrouridine synthase 2 -1.5646
TOM1 target of myb1 (chicken) -1.55847
GUSB glucuronidase, beta -1.55059
ANAPC5 anaphase promoting complex subunit 5 -1.54853
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 -1.54764
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 -1.54324
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome -1.54019
STAB1 stabilin 1 -1.53667
OAZ3 ornithine decarboxylase antizyme 3 -1.53421
COX4I1 cytochrome c oxidase subunit IV isoform 1 -1.53077
SF3A1 splicing factor 3a, subunit 1, 120kDa -1.52977
EIF3L eukaryotic translation initiation factor 3, subunit L -1.52158
RSAD1 radical S-adenosyl methionine domain containing 1 -1.51886
IL2 interleukin 2 -1.51321
WDR3 WD repeat domain 3 -1.50939
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F -1.50392
B4GALT3 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3 -1.50312
NOP10 NOP10 ribonucleoprotein -1.49707
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -1.49642
SIRPA signal-regulatory protein alpha -1.49379
COPS6 COP9 signalosome subunit 6 -1.49296
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) -1.49265
XYLT2 xylosyltransferase II -1.48911
INTS12 integrator complex subunit 12 -1.48768
DOCK10 dedicator of cytokinesis 10 -1.48721
MAPKBP1 mitogen-activated protein kinase binding protein 1 -1.48598
NEK1 NIMA-related kinase 1 -1.48132
ADM2 adrenomedullin 2 -1.47799
NCDN neurochondrin -1.47793
AHCYL1 adenosylhomocysteinase-like 1 -1.47583
GPR135 G protein-coupled receptor 135 -1.47553
TTLL12 tubulin tyrosine ligase-like family member 12 -1.47541
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 -1.47379
PRKDC protein kinase, DNA-activated, catalytic polypeptide -1.47346
DPYSL4 dihydropyrimidinase-like 4 -1.47342
LTBP4 latent transforming growth factor beta binding protein 4 -1.47327
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -1.47086
AQP7 aquaporin 7 -1.46977
TBCE tubulin folding cofactor E -1.46325
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4) -1.46317
NR2E1 nuclear receptor subfamily 2, group E, member 1 -1.45423
ATP5G2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) -1.44747
TLL2 tolloid-like 2 -1.44647
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 -1.44464
PACS1 phosphofurin acidic cluster sorting protein 1 -1.44328
GMPR2 guanosine monophosphate reductase 2 -1.44189
WDR43 WD repeat domain 43 -1.44094
FGF5 fibroblast growth factor 5 -1.43718
SGCE sarcoglycan, epsilon -1.43555
OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain containing 2 -1.43468
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -1.43401
MPPE1 metallophosphoesterase 1 -1.42655
TTC27 tetratricopeptide repeat domain 27 -1.42088
AAAS achalasia, adrenocortical insufficiency, alacrimia -1.41967
GOLPH3 golgi phosphoprotein 3 (coat-protein) -1.41836