LS180 Gene Set

Dataset CCLE Cell Line Gene Expression Profiles
Category transcriptomics
Type cell line
Description Human, Caucasian, colon, adenocarcinoma, colorectal, cell line. Morphology: epithelial; Species: human, Caucasian female 58 year old; Tissue: colon; Tumor: adenocarcinoma, colorectal. (BRENDA Tissue and Enzyme Source Ontology, BTO_0001609)
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Genes

343 genes with high or low expression in LS180 relative to other cell lines from the CCLE Cell Line Gene Expression Profiles dataset.

high expression

Symbol Name Standardized Value
CES3 carboxylesterase 3 2.65504
MYH13 myosin, heavy chain 13, skeletal muscle 2.65492
LINC00238 long intergenic non-protein coding RNA 238 2.61002
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 2.59288
GIPC2 GIPC PDZ domain containing family, member 2 2.57957
EPHB3 EPH receptor B3 2.50359
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.40919
MYH4 myosin, heavy chain 4, skeletal muscle 2.40872
LOC113230 uncharacterized protein LOC113230 2.33578
MT1G metallothionein 1G 2.31161
MRPL16 mitochondrial ribosomal protein L16 2.26113
PTGDR prostaglandin D2 receptor (DP) 2.25291
MUC6 mucin 6, oligomeric mucus/gel-forming 2.25266
MLEC malectin 2.24866
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.21768
CASP6 caspase 6, apoptosis-related cysteine peptidase 2.21444
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 2.18567
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) 2.16268
PIGR polymeric immunoglobulin receptor 2.13802
XKRX XK, Kell blood group complex subunit-related, X-linked 2.13772
MYH1 myosin, heavy chain 1, skeletal muscle, adult 2.13763
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.07896
FFAR4 free fatty acid receptor 4 2.073
ARHGAP44 Rho GTPase activating protein 44 2.06914
DPEP1 dipeptidase 1 (renal) 2.06507
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.04755
OR51E1 olfactory receptor, family 51, subfamily E, member 1 2.04754
TUBAL3 tubulin, alpha-like 3 2.04744
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 2.04038
APEH acylaminoacyl-peptide hydrolase 2.02741
TRABD2A TraB domain containing 2A 2.011
GPA33 glycoprotein A33 (transmembrane) 1.99506
TNS4 tensin 4 1.9874
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3 1.97719
IL33 interleukin 33 1.96974
IGFL2 IGF-like family member 2 1.96844
LOC100506125 uncharacterized LOC100506125 1.96428
ZG16 zymogen granule protein 16 1.95393
ASCL2 achaete-scute family bHLH transcription factor 2 1.92885
GSTK1 glutathione S-transferase kappa 1 1.91916
RETNLB resistin like beta 1.91847
NKX2-3 NK2 homeobox 3 1.89964
NXPE1 neurexophilin and PC-esterase domain family, member 1 1.89921
FAM3D family with sequence similarity 3, member D 1.89166
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 1.88947
EPHB2 EPH receptor B2 1.8817
FAIM2 Fas apoptotic inhibitory molecule 2 1.88029
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 1.87041
ASB4 ankyrin repeat and SOCS box containing 4 1.86325
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.8625
KCNRG potassium channel regulator 1.83739
PHGR1 proline/histidine/glycine-rich 1 1.83702
ABHD12B abhydrolase domain containing 12B 1.82819
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 1.79839
FCAMR Fc receptor, IgA, IgM, high affinity 1.79747
TMEM35 transmembrane protein 35 1.79735
ATOH1 atonal homolog 1 (Drosophila) 1.78292
LRRC75A leucine rich repeat containing 75A 1.78286
NOS3 nitric oxide synthase 3 (endothelial cell) 1.7672
RABL6 RAB, member RAS oncogene family-like 6 1.75766
TTPA tocopherol (alpha) transfer protein 1.74715
SLCO1B3 solute carrier organic anion transporter family, member 1B3 1.73548
PEX7 peroxisomal biogenesis factor 7 1.73369
SAMD5 sterile alpha motif domain containing 5 1.72869
NOXO1 NADPH oxidase organizer 1 1.7243
NOX1 NADPH oxidase 1 1.71342
C9ORF152 chromosome 9 open reading frame 152 1.7132
ECT2 epithelial cell transforming 2 1.68363
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 1.67938
TRPM2 transient receptor potential cation channel, subfamily M, member 2 1.67712
MUC5B mucin 5B, oligomeric mucus/gel-forming 1.66872
RIPK3 receptor-interacting serine-threonine kinase 3 1.66306
TRIM54 tripartite motif containing 54 1.65804
GGT6 gamma-glutamyltransferase 6 1.65046
AP2B1 adaptor-related protein complex 2, beta 1 subunit 1.64642
EPHA1 EPH receptor A1 1.64499
MUC2 mucin 2, oligomeric mucus/gel-forming 1.64478
EN1 engrailed homeobox 1 1.64399
ZDHHC6 zinc finger, DHHC-type containing 6 1.61045
DEFA6 defensin, alpha 6, Paneth cell-specific 1.60716
FCGBP Fc fragment of IgG binding protein 1.60699
UBXN10 UBX domain protein 10 1.60548
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 1.6041
ZNF511 zinc finger protein 511 1.59941
SOD3 superoxide dismutase 3, extracellular 1.59484
AAA1 aortic aneurysm, familial abdominal 1 1.58356
LOC100505938 uncharacterized LOC100505938 1.58078
GLCE glucuronic acid epimerase 1.57931
GCAT glycine C-acetyltransferase 1.57603
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.56258
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 1.56214
RAMP1 receptor (G protein-coupled) activity modifying protein 1 1.56051
GMDS GDP-mannose 4,6-dehydratase 1.55558
KRT75 keratin 75, type II 1.55033
TTC19 tetratricopeptide repeat domain 19 1.54206
GTF2A2 general transcription factor IIA, 2, 12kDa 1.54102
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 1.53184
LOC100652770 1.53129
GCC2 GRIP and coiled-coil domain containing 2 1.52943
RASL11A RAS-like, family 11, member A 1.5284
IL20RA interleukin 20 receptor, alpha 1.52269
TPRN taperin 1.52189
BBS2 Bardet-Biedl syndrome 2 1.52155
FAM131B family with sequence similarity 131, member B 1.52001
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.51659
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 1.51418
LGALS4 lectin, galactoside-binding, soluble, 4 1.50805
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 1.50368
C6ORF203 chromosome 6 open reading frame 203 1.50216
MRPL50 mitochondrial ribosomal protein L50 1.49758
REG4 regenerating islet-derived family, member 4 1.49714
CMTR2 cap methyltransferase 2 1.49542
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 1.48682
TRIM2 tripartite motif containing 2 1.48631
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 1.48581
NRN1 neuritin 1 1.48274
COX18 COX18 cytochrome c oxidase assembly factor 1.48212
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5 1.4788
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 1.47837
SPINK4 serine peptidase inhibitor, Kazal type 4 1.47802
PARM1 prostate androgen-regulated mucin-like protein 1 1.4778
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 1.47722
PRR15L proline rich 15-like 1.47186
TMEM52 transmembrane protein 52 1.47011
MUC17 mucin 17, cell surface associated 1.46873
HHLA2 HERV-H LTR-associating 2 1.46629
ZDHHC3 zinc finger, DHHC-type containing 3 1.46488
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 1.46321
CDX1 caudal type homeobox 1 1.45467
EHF ets homologous factor 1.45281
RPL31 ribosomal protein L31 1.45257
CCDC170 coiled-coil domain containing 170 1.45161
HOTTIP HOXA distal transcript antisense RNA 1.44745
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 1.4413
KLK15 kallikrein-related peptidase 15 1.4394
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.4337
PTPRB protein tyrosine phosphatase, receptor type, B 1.4315
PAH phenylalanine hydroxylase 1.43113
SMIM20 small integral membrane protein 20 1.43081
CDX2 caudal type homeobox 2 1.43062
FAAH fatty acid amide hydrolase 1.42846
KLK1 kallikrein 1 1.42844
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 1.42532
MUC3A mucin 3A, cell surface associated 1.42371
DEGS2 delta(4)-desaturase, sphingolipid 2 1.42336
SIAE sialic acid acetylesterase 1.42224
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 1.42208
RPL22L1 ribosomal protein L22-like 1 1.416
BTC betacellulin 1.41548
ZSWIM5 zinc finger, SWIM-type containing 5 1.41528
NRARP NOTCH-regulated ankyrin repeat protein 1.41515
TMEM54 transmembrane protein 54 1.4139
PAQR8 progestin and adipoQ receptor family member VIII 1.41089
STAMBPL1 STAM binding protein-like 1 1.40733
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 1.39856
FUOM fucose mutarotase 1.39622
CLRN3 clarin 3 1.39579
GPR35 G protein-coupled receptor 35 1.39564
LRRC19 leucine rich repeat containing 19 1.39282
CLCN3 chloride channel, voltage-sensitive 3 1.3908
NKD1 naked cuticle homolog 1 (Drosophila) 1.39053
KIF9 kinesin family member 9 1.38804
TMEM144 transmembrane protein 144 1.38624
FAM136A family with sequence similarity 136, member A 1.37806
CRB3 crumbs family member 3 1.37805
ANKRD22 ankyrin repeat domain 22 1.37607
STARD5 StAR-related lipid transfer (START) domain containing 5 1.37247
NPDC1 neural proliferation, differentiation and control, 1 1.36611
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 1.36453
LRP4 low density lipoprotein receptor-related protein 4 1.35817
TXN thioredoxin 1.35437
TMEM141 transmembrane protein 141 1.35326
AXIN2 axin 2 1.35087
HOXA11-AS HOXA11 antisense RNA 1.34881

low expression

Symbol Name Standardized Value
POT1 protection of telomeres 1 -3.96878
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -3.32293
CBX6 chromobox homolog 6 -3.122
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 -3.09642
CYLC1 cylicin, basic protein of sperm head cytoskeleton 1 -2.90308
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -2.83057
RGS19 regulator of G-protein signaling 19 -2.6574
FXR1 fragile X mental retardation, autosomal homolog 1 -2.62244
NPY1R neuropeptide Y receptor Y1 -2.57405
OGFRL1 opioid growth factor receptor-like 1 -2.51954
C11ORF84 chromosome 11 open reading frame 84 -2.49958
CDH9 cadherin 9, type 2 (T1-cadherin) -2.49193
MMRN1 multimerin 1 -2.34795
ANKRD65 ankyrin repeat domain 65 -2.33665
LONRF1 LON peptidase N-terminal domain and ring finger 1 -2.30439
NCAM1 neural cell adhesion molecule 1 -2.30189
ZNF625 zinc finger protein 625 -2.27457
DPF1 D4, zinc and double PHD fingers family 1 -2.25976
C16ORF54 chromosome 16 open reading frame 54 -2.23155
SCN8A sodium channel, voltage gated, type VIII alpha subunit -2.22649
CA6 carbonic anhydrase VI -2.2252
TMEM108 transmembrane protein 108 -2.21353
RUSC2 RUN and SH3 domain containing 2 -2.20542
IL10 interleukin 10 -2.20507
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -2.20281
BPIFA3 BPI fold containing family A, member 3 -2.19982
BTN2A1 butyrophilin, subfamily 2, member A1 -2.19788
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -2.18004
LOC100505498 uncharacterized LOC100505498 -2.17188
EPHX3 epoxide hydrolase 3 -2.11003
HS3ST3B1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1 -2.07763
CCDC65 coiled-coil domain containing 65 -2.05163
ZNF304 zinc finger protein 304 -2.05035
CRNDE colorectal neoplasia differentially expressed (non-protein coding) -2.0453
RDX radixin -2.02615
EMX1 empty spiracles homeobox 1 -1.99399
DMXL2 Dmx-like 2 -1.98362
FGF5 fibroblast growth factor 5 -1.97104
FAM205A family with sequence similarity 205, member A -1.96327
DEGS1 delta(4)-desaturase, sphingolipid 1 -1.96146
LHCGR luteinizing hormone/choriogonadotropin receptor -1.94783
UHMK1 U2AF homology motif (UHM) kinase 1 -1.94084
APCS amyloid P component, serum -1.93762
PDPN podoplanin -1.93622
EFCAB6 EF-hand calcium binding domain 6 -1.92941
NFE2L1 nuclear factor, erythroid 2-like 1 -1.91688
LOC100506790 uncharacterized LOC100506790 -1.9162
KRT72 keratin 72, type II -1.90817
BAX BCL2-associated X protein -1.90279
CTRL chymotrypsin-like -1.90059
FBXO15 F-box protein 15 -1.8878
VN1R1 vomeronasal 1 receptor 1 -1.88539
C5ORF47 chromosome 5 open reading frame 47 -1.87398
NRD1 nardilysin (N-arginine dibasic convertase) -1.87378
WDTC1 WD and tetratricopeptide repeats 1 -1.87238
RBMS1 RNA binding motif, single stranded interacting protein 1 -1.86903
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 -1.85361
C2ORF73 chromosome 2 open reading frame 73 -1.84616
DNAJC18 DnaJ (Hsp40) homolog, subfamily C, member 18 -1.84283
LOC100506113 uncharacterized LOC100506113 -1.82347
TCEAL7 transcription elongation factor A (SII)-like 7 -1.81681
ZNF512B zinc finger protein 512B -1.81659
SOX6 SRY (sex determining region Y)-box 6 -1.81477
FAM162B family with sequence similarity 162, member B -1.81106
PLD4 phospholipase D family, member 4 -1.79826
BTN2A2 butyrophilin, subfamily 2, member A2 -1.79561
LOC100506844 uncharacterized LOC100506844 -1.78793
TXNDC9 thioredoxin domain containing 9 -1.77601
CUTC cutC copper transporter -1.77076
CR1 complement component (3b/4b) receptor 1 (Knops blood group) -1.76942
SOAT1 sterol O-acyltransferase 1 -1.75846
PRR11 proline rich 11 -1.75826
TRPV5 transient receptor potential cation channel, subfamily V, member 5 -1.75378
VSTM4 V-set and transmembrane domain containing 4 -1.7365
RASGEF1C RasGEF domain family, member 1C -1.73417
AIM2 absent in melanoma 2 -1.73105
ZNF10 zinc finger protein 10 -1.72836
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 -1.71436
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 -1.71156
CNPY1 canopy FGF signaling regulator 1 -1.71072
PDE3A phosphodiesterase 3A, cGMP-inhibited -1.70176
C20ORF194 chromosome 20 open reading frame 194 -1.69673
SMAP1 small ArfGAP 1 -1.69623
MMP16 matrix metallopeptidase 16 (membrane-inserted) -1.69389
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 -1.68877
TMPRSS15 transmembrane protease, serine 15 -1.68328
CPNE2 copine II -1.68187
LOC728485 uncharacterized LOC728485 -1.68003
SEZ6 seizure related 6 homolog (mouse) -1.67558
NHLH1 nescient helix loop helix 1 -1.67214
NKX2-2 NK2 homeobox 2 -1.66999
MYH10 myosin, heavy chain 10, non-muscle -1.66687
ADGRF1 adhesion G protein-coupled receptor F1 -1.66634
PABPC4L poly(A) binding protein, cytoplasmic 4-like -1.65741
AVPR1A arginine vasopressin receptor 1A -1.65588
ZBTB10 zinc finger and BTB domain containing 10 -1.6551
DBN1 drebrin 1 -1.65424
C2ORF81 chromosome 2 open reading frame 81 -1.65071
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 -1.64871
C10ORF90 chromosome 10 open reading frame 90 -1.63752
IK IK cytokine, down-regulator of HLA II -1.63533
ADAM28 ADAM metallopeptidase domain 28 -1.63228
DACT3 dishevelled-binding antagonist of beta-catenin 3 -1.6315
GIP gastric inhibitory polypeptide -1.62645
C9ORF50 chromosome 9 open reading frame 50 -1.62329
NTF3 neurotrophin 3 -1.6228
CDR1 cerebellar degeneration-related protein 1, 34kDa -1.61672
ZNF140 zinc finger protein 140 -1.61295
F13B coagulation factor XIII, B polypeptide -1.60696
CCT8L2 chaperonin containing TCP1, subunit 8 (theta)-like 2 -1.60466
CPAMD8 C3 and PZP-like, alpha-2-macroglobulin domain containing 8 -1.6029
GAB1 GRB2-associated binding protein 1 -1.58659
MYO5A myosin VA (heavy chain 12, myoxin) -1.58365
RRAGC Ras-related GTP binding C -1.57632
STARD3NL STARD3 N-terminal like -1.57234
HYLS1 hydrolethalus syndrome 1 -1.57038
RAD21L1 RAD21-like 1 (S. pombe) -1.56982
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 -1.56898
CAPN14 calpain 14 -1.56852
SMC1B structural maintenance of chromosomes 1B -1.5652
SPAG16 sperm associated antigen 16 -1.56457
MYO15A myosin XVA -1.56402
VPS9D1 VPS9 domain containing 1 -1.56359
IGHV3-23 immunoglobulin heavy variable 3-23 -1.56131
ZNF605 zinc finger protein 605 -1.55984
FMR1NB fragile X mental retardation 1 neighbor -1.55725
APH1B APH1B gamma secretase subunit -1.55545
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled -1.55212
TAF1B TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa -1.54956
MGC45922 uncharacterized LOC284365 -1.54663
C3ORF80 chromosome 3 open reading frame 80 -1.54311
SEC14L4 SEC14-like 4 (S. cerevisiae) -1.53763
APOL2 apolipoprotein L, 2 -1.53556
THSD7A thrombospondin, type I, domain containing 7A -1.52743
CYTH4 cytohesin 4 -1.52736
ZDHHC19 zinc finger, DHHC-type containing 19 -1.52658
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -1.52568
CEP85L centrosomal protein 85kDa-like -1.51519
NXPE3 neurexophilin and PC-esterase domain family, member 3 -1.51312
MAP7D1 MAP7 domain containing 1 -1.51151
TNF tumor necrosis factor -1.50747
PRR29 proline rich 29 -1.50656
FAM179B family with sequence similarity 179, member B -1.50515
KRTAP9-9 keratin associated protein 9-9 -1.50452
QKI QKI, KH domain containing, RNA binding -1.50254
LHX3 LIM homeobox 3 -1.49859
TEX15 testis expressed 15 -1.4964
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) -1.49444
ZNF548 zinc finger protein 548 -1.49362
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1 -1.48788
GPHA2 glycoprotein hormone alpha 2 -1.48704
RASL11B RAS-like, family 11, member B -1.48634
PBX3 pre-B-cell leukemia homeobox 3 -1.48572
SCN2A sodium channel, voltage gated, type II alpha subunit -1.48556
CNBP CCHC-type zinc finger, nucleic acid binding protein -1.48234
SP7 Sp7 transcription factor -1.48022
GPN1 GPN-loop GTPase 1 -1.47922
PAX2 paired box 2 -1.47868
MRVI1 murine retrovirus integration site 1 homolog -1.47843
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -1.47439
TMEM71 transmembrane protein 71 -1.47136
ZMAT1 zinc finger, matrin-type 1 -1.46809
WDR54 WD repeat domain 54 -1.46692
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -1.46591
MARCH4 membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase -1.46283
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 -1.46202
ZNF470 zinc finger protein 470 -1.45499
GSC2 goosecoid homeobox 2 -1.45424
SGCE sarcoglycan, epsilon -1.45402