LS411N Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description disease: colorectal carcinoma (Cell Line Ontology, CLO_0007406)
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Genes

489 gene knockdowns changing fitness of LS411N relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
ADPRHL1 ADP-ribosylhydrolase like 1 3.19303
GPX4 glutathione peroxidase 4 3.19303
CARD14 caspase recruitment domain family, member 14 3.07398
ST7 suppression of tumorigenicity 7 3.06108
ZNF610 zinc finger protein 610 3.01403
RNF167 ring finger protein 167 2.91807
ADCY3 adenylate cyclase 3 2.66616
AP3M2 adaptor-related protein complex 3, mu 2 subunit 2.58915
UBE2D3 ubiquitin-conjugating enzyme E2D 3 2.47216
SLC16A14 solute carrier family 16, member 14 2.38489
DCX doublecortin 2.36738
TBX4 T-box 4 2.28662
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 2.26397
NPEPPS aminopeptidase puromycin sensitive 2.21858
OR5M1 olfactory receptor, family 5, subfamily M, member 1 2.21802
CDX4 caudal type homeobox 4 2.16975
THOC6 THO complex 6 2.12456
ZNF322P1 zinc finger protein 322 pseudogene 1 2.11184
KRT6A keratin 6A, type II 2.09825
SPNS1 spinster homolog 1 (Drosophila) 2.07313
PRDM7 PR domain containing 7 2.06634
SRRM1 serine/arginine repetitive matrix 1 2.05377
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 2.04824
GFOD2 glucose-fructose oxidoreductase domain containing 2 1.99639
RUVBL1 RuvB-like AAA ATPase 1 1.95662
B4GALT7 xylosylprotein beta 1,4-galactosyltransferase, polypeptide 7 1.9016
B3GAT3 beta-1,3-glucuronyltransferase 3 1.90074
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma 1.89722
CDH7 cadherin 7, type 2 1.87068
POLDIP3 polymerase (DNA-directed), delta interacting protein 3 1.87045
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 1.86036
TWIST1 twist family bHLH transcription factor 1 1.84909
COPZ1 coatomer protein complex, subunit zeta 1 1.82408
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 1.8227
ARG1 arginase 1 1.82268
CIB2 calcium and integrin binding family member 2 1.81977
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 1.81589
ODC1 ornithine decarboxylase 1 1.79678
KRT6C keratin 6C, type II 1.79102
CBR1 carbonyl reductase 1 1.77954
TNP1 transition protein 1 (during histone to protamine replacement) 1.77039
POM121C POM121 transmembrane nucleoporin C 1.75448
PPT1 palmitoyl-protein thioesterase 1 1.75012
PFN1 profilin 1 1.73822
SLC25A18 solute carrier family 25 (glutamate carrier), member 18 1.72921
ZNF525 zinc finger protein 525 1.72257
EPHA4 EPH receptor A4 1.70736
FKBP1A FK506 binding protein 1A, 12kDa 1.67781
FGF3 fibroblast growth factor 3 1.66798
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 1.66108
E4F1 E4F transcription factor 1 1.66099
ZNF845 zinc finger protein 845 1.6569
MBD2 methyl-CpG binding domain protein 2 1.65666
GVINP1 GTPase, very large interferon inducible pseudogene 1 1.65639
KPNA3 karyopherin alpha 3 (importin alpha 4) 1.64667
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 1.64523
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 1.64343
PPP4C protein phosphatase 4, catalytic subunit 1.62908
ADAMTSL4 ADAMTS-like 4 1.62082
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 1.59755
KLRC3 killer cell lectin-like receptor subfamily C, member 3 1.59285
SLC39A7 solute carrier family 39 (zinc transporter), member 7 1.58186
STON1-GTF2A1L STON1-GTF2A1L readthrough 1.57455
REG1B regenerating islet-derived 1 beta 1.57366
KNG1 kininogen 1 1.57031
MMP2 matrix metallopeptidase 2 1.56825
RAX2 retina and anterior neural fold homeobox 2 1.56108
KCTD7 potassium channel tetramerization domain containing 7 1.5552
MED28 mediator complex subunit 28 1.54773
LEP leptin 1.54686
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1.54199
DDX19B DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B 1.53692
RHBDD3 rhomboid domain containing 3 1.52812
PTGR2 prostaglandin reductase 2 1.52376
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 1.51544
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 1.50677
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 1.50481
MEX3B mex-3 RNA binding family member B 1.49433
SLC13A3 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 1.48676
MED9 mediator complex subunit 9 1.48549
GTF2A1L general transcription factor IIA, 1-like 1.48353
ZNF569 zinc finger protein 569 1.47605
SORCS3 sortilin-related VPS10 domain containing receptor 3 1.47008
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 1.46672
PCSK9 proprotein convertase subtilisin/kexin type 9 1.46178
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 1.45106
UGCG UDP-glucose ceramide glucosyltransferase 1.44916
WWOX WW domain containing oxidoreductase 1.43719
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.4323
ZNF322 zinc finger protein 322 1.41854
SGK223 homolog of rat pragma of Rnd2 1.41783
PKN1 protein kinase N1 1.41315
ESRRA estrogen-related receptor alpha 1.40821
TUBB2A tubulin, beta 2A class IIa 1.40585
DMRT3 doublesex and mab-3 related transcription factor 3 1.4041
CLDN3 claudin 3 1.40246
ADGRF1 adhesion G protein-coupled receptor F1 1.39276
SREBF2 sterol regulatory element binding transcription factor 2 1.38521
BST1 bone marrow stromal cell antigen 1 1.38459
CHD2 chromodomain helicase DNA binding protein 2 1.37719
BGLAP bone gamma-carboxyglutamate (gla) protein 1.36867
FZD4 frizzled class receptor 4 1.36697
RIC8B RIC8 guanine nucleotide exchange factor B 1.36696
RTP1 receptor (chemosensory) transporter protein 1 1.36609
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 1.36592
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 1.36082
GMPS guanine monphosphate synthase 1.35428
CHD1 chromodomain helicase DNA binding protein 1 1.35033
EFHB EF-hand domain family, member B 1.34704
GGPS1 geranylgeranyl diphosphate synthase 1 1.34515
ULBP1 UL16 binding protein 1 1.34478
ZNF587 zinc finger protein 587 1.34326
ADGRG5 adhesion G protein-coupled receptor G5 1.33896
IRF8 interferon regulatory factor 8 1.33437
CCL26 chemokine (C-C motif) ligand 26 1.33233
PZP pregnancy-zone protein 1.32124
PHACTR3 phosphatase and actin regulator 3 1.31994
EFCAB3 EF-hand calcium binding domain 3 1.31989
CXORF23 chromosome X open reading frame 23 1.31974
DPP8 dipeptidyl-peptidase 8 1.31961
CLSTN2 calsyntenin 2 1.31544
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 1.31255
PAPOLG poly(A) polymerase gamma 1.30825
CD300C CD300c molecule 1.30699
TUSC2 tumor suppressor candidate 2 1.30689
CST4 cystatin S 1.30595
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 1.30577
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13 1.30486
BCL7C B-cell CLL/lymphoma 7C 1.30416
PDXK pyridoxal (pyridoxine, vitamin B6) kinase 1.301
KRT6B keratin 6B, type II 1.30023
TTC23 tetratricopeptide repeat domain 23 1.28992
HOXD11 homeobox D11 1.28787
CAMK1D calcium/calmodulin-dependent protein kinase ID 1.28161
MINK1 misshapen-like kinase 1 1.27414
IK IK cytokine, down-regulator of HLA II 1.27405
ACSL3 acyl-CoA synthetase long-chain family member 3 1.26803
UBA1 ubiquitin-like modifier activating enzyme 1 1.2618
SLC4A9 solute carrier family 4, sodium bicarbonate cotransporter, member 9 1.25902
RPP38 ribonuclease P/MRP 38kDa subunit 1.25842
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.2576
MTM1 myotubularin 1 1.25387
CDK18 cyclin-dependent kinase 18 1.25281
SLC30A8 solute carrier family 30 (zinc transporter), member 8 1.2512
TRPV3 transient receptor potential cation channel, subfamily V, member 3 1.24485
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 1.24462
WBP11 WW domain binding protein 11 1.24209
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 1.2403
CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 1.23997
FOXB1 forkhead box B1 1.23674
LIPE lipase, hormone-sensitive 1.23567
TPO thyroid peroxidase 1.22838
PHF5A PHD finger protein 5A 1.22779
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 1.22701
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits 1.22372
CASP5 caspase 5, apoptosis-related cysteine peptidase 1.21882
MAPK13 mitogen-activated protein kinase 13 1.21716
SEC23A Sec23 homolog A (S. cerevisiae) 1.21705
MORF4L1 mortality factor 4 like 1 1.21302
TCOF1 Treacher Collins-Franceschetti syndrome 1 1.21301
RAB28 RAB28, member RAS oncogene family 1.21287
EIF3J eukaryotic translation initiation factor 3, subunit J 1.21239
TNFSF12-TNFSF13 TNFSF12-TNFSF13 readthrough 1.21056
ABAT 4-aminobutyrate aminotransferase 1.19985
AOC3 amine oxidase, copper containing 3 1.19733
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 1.19478
TRIP10 thyroid hormone receptor interactor 10 1.19314
ZNF560 zinc finger protein 560 1.19186
TULP3 tubby like protein 3 1.19185
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 1.18987
GLS2 glutaminase 2 (liver, mitochondrial) 1.18512
TRIM23 tripartite motif containing 23 1.1839
TM9SF2 transmembrane 9 superfamily member 2 1.18234
AP4S1 adaptor-related protein complex 4, sigma 1 subunit 1.17923
KDM4A lysine (K)-specific demethylase 4A 1.17453
EGFR epidermal growth factor receptor 1.17221
PCGF6 polycomb group ring finger 6 1.17167
ECEL1 endothelin converting enzyme-like 1 1.17063
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 1.16821
PPME1 protein phosphatase methylesterase 1 1.16312
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta 1.16162
LPP LIM domain containing preferred translocation partner in lipoma 1.16074
COPE coatomer protein complex, subunit epsilon 1.1605
UGP2 UDP-glucose pyrophosphorylase 2 1.1503
KITLG KIT ligand 1.14249
ENAH enabled homolog (Drosophila) 1.14234
RHOV ras homolog family member V 1.14138
HRK harakiri, BCL2 interacting protein 1.13867
EDAR ectodysplasin A receptor 1.13595
ADRM1 adhesion regulating molecule 1 1.13257
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 1.12707
PCDH15 protocadherin-related 15 1.12528
IL17RE interleukin 17 receptor E 1.12457
PPT2-EGFL8 PPT2-EGFL8 readthrough (NMD candidate) 1.1232
NUPL1 nucleoporin like 1 1.12179
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 1.11814
MRPL37 mitochondrial ribosomal protein L37 1.11394
TMX3 thioredoxin-related transmembrane protein 3 1.11361
ZNF207 zinc finger protein 207 1.1076
CSNK1E casein kinase 1, epsilon 1.10663
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 1.10585
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 1.10507
FBXL20 F-box and leucine-rich repeat protein 20 1.10337
DLX1 distal-less homeobox 1 1.10214
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 1.09811
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 1.09037
TRPC4 transient receptor potential cation channel, subfamily C, member 4 1.08811
SLC4A2 solute carrier family 4 (anion exchanger), member 2 1.08707
SP2 Sp2 transcription factor 1.08567
HRASLS HRAS-like suppressor 1.07842
PEX11B peroxisomal biogenesis factor 11 beta 1.07623
PKD2L2 polycystic kidney disease 2-like 2 1.07617
CDC25B cell division cycle 25B 1.07586
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 1.07551
EPX eosinophil peroxidase 1.07193
TONSL tonsoku-like, DNA repair protein 1.06723
MAT1A methionine adenosyltransferase I, alpha 1.06566
ZCCHC9 zinc finger, CCHC domain containing 9 1.06427
ZNF211 zinc finger protein 211 1.06376
UBE2R2 ubiquitin-conjugating enzyme E2R 2 1.06318
DSTYK dual serine/threonine and tyrosine protein kinase 1.06038
CCNL1 cyclin L1 1.05743
FBXO24 F-box protein 24 1.0536
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 1.04425
IL17C interleukin 17C 1.0429
ACVRL1 activin A receptor type II-like 1 1.04265
PRG3 proteoglycan 3 1.04262
FMNL1 formin-like 1 1.03972
CRELD1 cysteine-rich with EGF-like domains 1 1.03901
SPATA8 spermatogenesis associated 8 1.0371
EPS15 epidermal growth factor receptor pathway substrate 15 1.03701
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1 1.03673
ZNF701 zinc finger protein 701 1.03523
B3GAT2 beta-1,3-glucuronyltransferase 2 1.03521
LEFTY1 left-right determination factor 1 1.03487
ADAM21 ADAM metallopeptidase domain 21 1.03465
TRPM1 transient receptor potential cation channel, subfamily M, member 1 1.03411
OR7G2 olfactory receptor, family 7, subfamily G, member 2 1.03351
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 1.03309
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.03112
CLNS1A chloride channel, nucleotide-sensitive, 1A 1.03068
MEF2A myocyte enhancer factor 2A 1.03019
GUCA1A guanylate cyclase activator 1A (retina) 1.02614
DDIT4 DNA-damage-inducible transcript 4 1.02395
TRIP6 thyroid hormone receptor interactor 6 1.0237
CNBP CCHC-type zinc finger, nucleic acid binding protein 1.02368
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3 1.02234
DNTT DNA nucleotidylexotransferase 1.02211
HSF1 heat shock transcription factor 1 1.02118
SOX9 SRY (sex determining region Y)-box 9 1.01628
ORM1 orosomucoid 1 1.01424
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 1.01046
PMF1-BGLAP PMF1-BGLAP readthrough 1.00882
TRPM4 transient receptor potential cation channel, subfamily M, member 4 1.00733
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 1.00561
EPRS glutamyl-prolyl-tRNA synthetase 1.00521
FAM131B family with sequence similarity 131, member B 1.00346
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli) 1.00341
FOXE3 forkhead box E3 1.00128
RPS6KL1 ribosomal protein S6 kinase-like 1 1.00108

decreased fitness

Symbol Name Standardized Value
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -3.06578
GLUL glutamate-ammonia ligase -2.57179
MITF microphthalmia-associated transcription factor -2.51355
NUCB1 nucleobindin 1 -2.50168
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -2.50033
ZADH2 zinc binding alcohol dehydrogenase domain containing 2 -2.50012
CCR1 chemokine (C-C motif) receptor 1 -2.43422
KCTD6 potassium channel tetramerization domain containing 6 -2.41138
FYN FYN proto-oncogene, Src family tyrosine kinase -2.30028
PRKX protein kinase, X-linked -2.25887
MC3R melanocortin 3 receptor -2.19771
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) -2.17379
SORD sorbitol dehydrogenase -2.15772
CLK2P1 CDC-like kinase 2, pseudogene 1 -2.1158
PCYOX1 prenylcysteine oxidase 1 -2.115
IFNGR1 interferon gamma receptor 1 -2.08331
KAT7 K(lysine) acetyltransferase 7 -2.08065
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -2.01776
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 -1.99358
TSPAN17 tetraspanin 17 -1.94882
KRT23 keratin 23, type I -1.91965
SMAD5 SMAD family member 5 -1.91463
TLR4 toll-like receptor 4 -1.88609
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase -1.85235
ZNF479 zinc finger protein 479 -1.81269
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 -1.78355
DDR2 discoidin domain receptor tyrosine kinase 2 -1.77271
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -1.77184
GPR141 G protein-coupled receptor 141 -1.75466
ZNF792 zinc finger protein 792 -1.75316
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -1.72154
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -1.71584
SERHL2 serine hydrolase-like 2 -1.71427
TIPE2 TNF alpha induced protein 8 like 2 -1.70685
CPB1 carboxypeptidase B1 (tissue) -1.69369
NUP107 nucleoporin 107kDa -1.66503
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -1.66344
SFN stratifin -1.65766
ZNF430 zinc finger protein 430 -1.65538
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -1.62079
RDH10 retinol dehydrogenase 10 (all-trans) -1.61698
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -1.61263
MBIP MAP3K12 binding inhibitory protein 1 -1.58792
TARDBP TAR DNA binding protein -1.58613
MCTP1 multiple C2 domains, transmembrane 1 -1.58571
HMGN1 high mobility group nucleosome binding domain 1 -1.58386
CHML choroideremia-like (Rab escort protein 2) -1.57816
SNRPG small nuclear ribonucleoprotein polypeptide G -1.56985
AIF1L allograft inflammatory factor 1-like -1.56495
CELA2A chymotrypsin-like elastase family, member 2A -1.56137
ZNF273 zinc finger protein 273 -1.55179
ZNF420 zinc finger protein 420 -1.54841
MAP7D1 MAP7 domain containing 1 -1.5413
CAB39 calcium binding protein 39 -1.52264
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -1.52239
CALCR calcitonin receptor -1.52109
KLF15 Kruppel-like factor 15 -1.51589
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) -1.50235
UCK1 uridine-cytidine kinase 1 -1.49921
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -1.49816
ZNF432 zinc finger protein 432 -1.49437
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -1.48963
ADSSL1 adenylosuccinate synthase like 1 -1.48564
SPINK6 serine peptidase inhibitor, Kazal type 6 -1.47139
LRFN1 leucine rich repeat and fibronectin type III domain containing 1 -1.4655
DPP6 dipeptidyl-peptidase 6 -1.4522
IL9R interleukin 9 receptor -1.45027
SKAP1 src kinase associated phosphoprotein 1 -1.44329
USP54 ubiquitin specific peptidase 54 -1.44219
SYNJ2 synaptojanin 2 -1.43169
OR1S2 olfactory receptor, family 1, subfamily S, member 2 -1.42909
GCH1 GTP cyclohydrolase 1 -1.42842
ATP8A2 ATPase, aminophospholipid transporter, class I, type 8A, member 2 -1.42442
GOLGA4 golgin A4 -1.40883
VRK3 vaccinia related kinase 3 -1.39648
ZNF689 zinc finger protein 689 -1.39349
OAT ornithine aminotransferase -1.39213
MOGAT1 monoacylglycerol O-acyltransferase 1 -1.3902
ZBTB26 zinc finger and BTB domain containing 26 -1.38674
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -1.38218
CHUK conserved helix-loop-helix ubiquitous kinase -1.37846
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 -1.37489
UBE2F ubiquitin-conjugating enzyme E2F (putative) -1.37358
ACAT1 acetyl-CoA acetyltransferase 1 -1.36843
FAS Fas cell surface death receptor -1.36636
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -1.36417
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene) -1.35859
LRMP lymphoid-restricted membrane protein -1.3522
GRK1 G protein-coupled receptor kinase 1 -1.344
OR5AU1 olfactory receptor, family 5, subfamily AU, member 1 -1.33957
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -1.3375
RNF149 ring finger protein 149 -1.33662
LOXL4 lysyl oxidase-like 4 -1.33527
MLH1 mutL homolog 1 -1.33523
OR2G2 olfactory receptor, family 2, subfamily G, member 2 -1.33383
MDFI MyoD family inhibitor -1.33175
PAPPA2 pappalysin 2 -1.32907
GATA4 GATA binding protein 4 -1.32586
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -1.32395
UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4 -1.3222
LIMK2 LIM domain kinase 2 -1.32186
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 -1.31961
ZNF160 zinc finger protein 160 -1.31784
TBX5 T-box 5 -1.31618
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta -1.31594
HNMT histamine N-methyltransferase -1.31421
ACO1 aconitase 1, soluble -1.31306
ZNF665 zinc finger protein 665 -1.31001
PIAS3 protein inhibitor of activated STAT, 3 -1.3037
PPA1 pyrophosphatase (inorganic) 1 -1.30245
PRTN3 proteinase 3 -1.2915
ESM1 endothelial cell-specific molecule 1 -1.28912
BMP7 bone morphogenetic protein 7 -1.28885
WNK3 WNK lysine deficient protein kinase 3 -1.28856
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 -1.27936
SNAPC3 small nuclear RNA activating complex, polypeptide 3, 50kDa -1.27901
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa -1.27746
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -1.26714
GRAP2 GRB2-related adaptor protein 2 -1.26661
OR7E5P olfactory receptor, family 7, subfamily E, member 5 pseudogene -1.25949
SRSF1 serine/arginine-rich splicing factor 1 -1.25264
CDK13 cyclin-dependent kinase 13 -1.2481
DNAJB11 DnaJ (Hsp40) homolog, subfamily B, member 11 -1.24799
GTF2A1 general transcription factor IIA, 1, 19/37kDa -1.24437
COL14A1 collagen, type XIV, alpha 1 -1.2393
EXOC2 exocyst complex component 2 -1.23635
TAAR2 trace amine associated receptor 2 -1.23232
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -1.23178
WNK1 WNK lysine deficient protein kinase 1 -1.22593
PLAGL1 pleiomorphic adenoma gene-like 1 -1.22565
TMEM241 transmembrane protein 241 -1.22564
TPMT thiopurine S-methyltransferase -1.22554
MPPED1 metallophosphoesterase domain containing 1 -1.2226
MYBPH myosin binding protein H -1.22175
PGM1 phosphoglucomutase 1 -1.22092
BTK Bruton agammaglobulinemia tyrosine kinase -1.22011
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -1.21754
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -1.21191
APC adenomatous polyposis coli -1.21084
NCOA2 nuclear receptor coactivator 2 -1.21041
GPR22 G protein-coupled receptor 22 -1.20995
MMP8 matrix metallopeptidase 8 -1.20539
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 -1.20443
TARBP1 TAR (HIV-1) RNA binding protein 1 -1.20161
C19ORF48 chromosome 19 open reading frame 48 -1.19979
ZNF45 zinc finger protein 45 -1.19836
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 -1.19137
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit -1.19079
ZNF473 zinc finger protein 473 -1.18859
DPCR1 diffuse panbronchiolitis critical region 1 -1.18446
PCDHB4 protocadherin beta 4 -1.18183
PLEKHA5 pleckstrin homology domain containing, family A member 5 -1.17956
FECH ferrochelatase -1.17729
BRD1 bromodomain containing 1 -1.17589
RNF141 ring finger protein 141 -1.17471
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 -1.17043
KIF5B kinesin family member 5B -1.16633
BDH2 3-hydroxybutyrate dehydrogenase, type 2 -1.16457
EPS8 epidermal growth factor receptor pathway substrate 8 -1.16275
KYNU kynureninase -1.16126
SLC39A13 solute carrier family 39 (zinc transporter), member 13 -1.15917
FDPS farnesyl diphosphate synthase -1.1573
DUSP22 dual specificity phosphatase 22 -1.15104
FUBP1 far upstream element (FUSE) binding protein 1 -1.14946
SLCO1B7 solute carrier organic anion transporter family, member 1B7 (non-functional) -1.14928
MEN1 multiple endocrine neoplasia I -1.14915
ALPPL2 alkaline phosphatase, placental-like 2 -1.14871
PLXNA3 plexin A3 -1.14772
LHX8 LIM homeobox 8 -1.13954
CCNG1 cyclin G1 -1.13556
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2 -1.13143
GRM5 glutamate receptor, metabotropic 5 -1.12788
HMOX2 heme oxygenase 2 -1.12779
SUOX sulfite oxidase -1.12562
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -1.12488
ICMT isoprenylcysteine carboxyl methyltransferase -1.1231
CPE carboxypeptidase E -1.12194
LRRK2 leucine-rich repeat kinase 2 -1.12046
FH fumarate hydratase -1.11941
NUP98 nucleoporin 98kDa -1.11792
TCL1A T-cell leukemia/lymphoma 1A -1.11269
ZNF628 zinc finger protein 628 -1.11181
TSPO translocator protein (18kDa) -1.10837
TUSC3 tumor suppressor candidate 3 -1.09833
PECAM1 platelet/endothelial cell adhesion molecule 1 -1.0976
GRK5 G protein-coupled receptor kinase 5 -1.09652
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) -1.0953
PA2G4 proliferation-associated 2G4, 38kDa -1.094
ZNF805 zinc finger protein 805 -1.09096
TSC2 tuberous sclerosis 2 -1.08959
COBL cordon-bleu WH2 repeat protein -1.08834
LYN LYN proto-oncogene, Src family tyrosine kinase -1.08776
ZNF585A zinc finger protein 585A -1.08622
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 -1.08222
EXO1 exonuclease 1 -1.08178
ZNF613 zinc finger protein 613 -1.07969
IL31RA interleukin 31 receptor A -1.07298
HNRNPL heterogeneous nuclear ribonucleoprotein L -1.07146
LMO7 LIM domain 7 -1.06981
CNOT4 CCR4-NOT transcription complex, subunit 4 -1.06665
PABPC1 poly(A) binding protein, cytoplasmic 1 -1.06474
SSBP4 single stranded DNA binding protein 4 -1.06467
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -1.06035
PRF1 perforin 1 (pore forming protein) -1.05897
TAS2R1 taste receptor, type 2, member 1 -1.05627
MRGPRF MAS-related GPR, member F -1.05072
PLAU plasminogen activator, urokinase -1.0497
PTH2R parathyroid hormone 2 receptor -1.04962
RAB7A RAB7A, member RAS oncogene family -1.0478
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene) -1.04109
PTPRF protein tyrosine phosphatase, receptor type, F -1.0394
ACTN4 actinin, alpha 4 -1.03798
SPCS2 signal peptidase complex subunit 2 homolog (S. cerevisiae) -1.03689
PGM5 phosphoglucomutase 5 -1.03531
NEIL2 nei endonuclease VIII-like 2 (E. coli) -1.03459
BAZ1A bromodomain adjacent to zinc finger domain, 1A -1.0337
ATP6V0A4 ATPase, H+ transporting, lysosomal V0 subunit a4 -1.03239
OXSR1 oxidative stress responsive 1 -1.02496
E2F1 E2F transcription factor 1 -1.02463
GUCY2C guanylate cyclase 2C -1.02397
PRPH2 peripherin 2 (retinal degeneration, slow) -1.0222
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -1.01463
OSR2 odd-skipped related transciption factor 2 -1.01055
IFNA14 interferon, alpha 14 -1.00861
MAP3K15 mitogen-activated protein kinase kinase kinase 15 -1.00808
SRRM2 serine/arginine repetitive matrix 2 -1.0053
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -1.00402
PRDM11 PR domain containing 11 -1.0033
BRAF B-Raf proto-oncogene, serine/threonine kinase -1.00076