LS513 Gene Set

Dataset Achilles Cell Line Gene Essentiality Profiles
Category disease or phenotype associations
Type cell line
Description disease: colorectal carcinoma (Cell Line Ontology, CLO_0007407)
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Genes

429 gene knockdowns changing fitness of LS513 relative to other cell lines from the Achilles Cell Line Gene Essentiality Profiles dataset.

increased fitness

Symbol Name Standardized Value
IGF1 insulin-like growth factor 1 (somatomedin C) 3.19303
MKRN1 makorin ring finger protein 1 3.17447
ZNF493 zinc finger protein 493 3.15889
AGBL2 ATP/GTP binding protein-like 2 3.10513
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 2.96687
ZNF737 zinc finger protein 737 2.88155
SMS spermine synthase 2.71243
WIF1 WNT inhibitory factor 1 2.67055
BAG4 BCL2-associated athanogene 4 2.6328
MBNL1 muscleblind-like splicing regulator 1 2.60897
DCTN4 dynactin 4 (p62) 2.59358
ZNF600 zinc finger protein 600 2.56515
PDF peptide deformylase (mitochondrial) 2.56382
ZNF43 zinc finger protein 43 2.49903
SATL1 spermidine/spermine N1-acetyl transferase-like 1 2.49851
FGF3 fibroblast growth factor 3 2.47876
SPINK6 serine peptidase inhibitor, Kazal type 6 2.44935
WNT1 wingless-type MMTV integration site family, member 1 2.43267
SERPINB12 serpin peptidase inhibitor, clade B (ovalbumin), member 12 2.40724
ZNF254 zinc finger protein 254 2.39736
QKI QKI, KH domain containing, RNA binding 2.39696
ZNF253 zinc finger protein 253 2.37666
PDILT protein disulfide isomerase-like, testis expressed 2.31594
ZNF92 zinc finger protein 92 2.27312
NUPL1 nucleoporin like 1 2.21916
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 2.16855
ZEB2 zinc finger E-box binding homeobox 2 2.1616
PEX11B peroxisomal biogenesis factor 11 beta 2.14735
ZNF729 zinc finger protein 729 2.11062
FGFR3 fibroblast growth factor receptor 3 2.10379
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.06887
MAPK13 mitogen-activated protein kinase 13 2.06657
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.05412
MBL2 mannose-binding lectin (protein C) 2, soluble 2.04223
GLRX2 glutaredoxin 2 1.96413
SHOX2 short stature homeobox 2 1.93037
ZC3HC1 zinc finger, C3HC-type containing 1 1.92977
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 1.91403
ZNF93 zinc finger protein 93 1.8957
IFT54 intraflagellar transport 54 1.89118
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 1.88195
SPEN spen family transcriptional repressor 1.82722
ABR active BCR-related 1.82116
FBN2 fibrillin 2 1.82071
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) 1.81256
ZNF681 zinc finger protein 681 1.80598
PGM3 phosphoglucomutase 3 1.79741
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 1.78914
PAWR PRKC, apoptosis, WT1, regulator 1.78869
INHBC inhibin, beta C 1.78137
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 1.77532
ZNF676 zinc finger protein 676 1.77491
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 1.77265
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.73519
TSLP thymic stromal lymphopoietin 1.70899
GABRR3 gamma-aminobutyric acid (GABA) A receptor, rho 3 (gene/pseudogene) 1.70436
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 1.70083
RNPEP arginyl aminopeptidase (aminopeptidase B) 1.69917
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 1.6962
TAS2R4 taste receptor, type 2, member 4 1.69289
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 1.68489
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 1.68471
C17ORF85 chromosome 17 open reading frame 85 1.68062
CENPJ centromere protein J 1.67345
NANP N-acetylneuraminic acid phosphatase 1.65564
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa 1.64261
ADAM22 ADAM metallopeptidase domain 22 1.63372
B3GAT3 beta-1,3-glucuronyltransferase 3 1.61496
GAL3ST4 galactose-3-O-sulfotransferase 4 1.58863
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein 1.58771
RXRB retinoid X receptor, beta 1.56357
SLC16A4 solute carrier family 16, member 4 1.55943
GPR15 G protein-coupled receptor 15 1.55108
ARF4 ADP-ribosylation factor 4 1.53749
KRT6A keratin 6A, type II 1.52905
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial 1.52501
DMRT3 doublesex and mab-3 related transcription factor 3 1.52423
VPREB1 pre-B lymphocyte 1 1.50596
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled 1.49777
TATDN2 TatD DNase domain containing 2 1.48818
RARS arginyl-tRNA synthetase 1.47537
F2RL1 coagulation factor II (thrombin) receptor-like 1 1.47093
IL2RB interleukin 2 receptor, beta 1.46984
CIITA class II, major histocompatibility complex, transactivator 1.4692
HRASLS HRAS-like suppressor 1.46484
MTM1 myotubularin 1 1.4629
EFCAB2 EF-hand calcium binding domain 2 1.4588
TLR6 toll-like receptor 6 1.45825
TRIB3 tribbles pseudokinase 3 1.44693
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 1.43802
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1 1.42443
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 1.4103
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 1.40756
CHEK2 checkpoint kinase 2 1.39168
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 1.38927
PHF5A PHD finger protein 5A 1.37972
AADAC arylacetamide deacetylase 1.36747
A2ML1 alpha-2-macroglobulin-like 1 1.3581
TMED7 transmembrane emp24 protein transport domain containing 7 1.35616
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 1.356
ZNF141 zinc finger protein 141 1.34865
EBF1 early B-cell factor 1 1.34676
SIM2 single-minded family bHLH transcription factor 2 1.33927
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.33735
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 1.33534
RBBP7 retinoblastoma binding protein 7 1.33339
HDGFRP3 hepatoma-derived growth factor, related protein 3 1.32976
IL7R interleukin 7 receptor 1.32903
CCR8 chemokine (C-C motif) receptor 8 1.32659
AKNA AT-hook transcription factor 1.32078
HYAL1 hyaluronoglucosaminidase 1 1.31414
DHRS4L2 dehydrogenase/reductase (SDR family) member 4 like 2 1.31297
EXOSC8 exosome component 8 1.30951
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 1.30935
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.30429
RAN RAN, member RAS oncogene family 1.29661
BMP6 bone morphogenetic protein 6 1.29528
DCP1B decapping mRNA 1B 1.29487
ADGRD1 adhesion G protein-coupled receptor D1 1.29142
CIR1 corepressor interacting with RBPJ, 1 1.28551
RPP38 ribonuclease P/MRP 38kDa subunit 1.2833
PGK2 phosphoglycerate kinase 2 1.28283
MRGPRD MAS-related GPR, member D 1.27916
OGFR opioid growth factor receptor 1.27261
THBS1 thrombospondin 1 1.27071
SPDEF SAM pointed domain containing ETS transcription factor 1.26943
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2 1.25791
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 1.25761
LGSN lengsin, lens protein with glutamine synthetase domain 1.25173
IL31RA interleukin 31 receptor A 1.24998
STX1B syntaxin 1B 1.24685
ATP10A ATPase, class V, type 10A 1.24342
KRT6C keratin 6C, type II 1.24204
TPM2 tropomyosin 2 (beta) 1.24005
TMEM14A transmembrane protein 14A 1.23387
SLC35B4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 1.23231
IRF8 interferon regulatory factor 8 1.23177
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 1.22668
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.22562
AFF4 AF4/FMR2 family, member 4 1.21903
ZNF407 zinc finger protein 407 1.21753
SRSF7 serine/arginine-rich splicing factor 7 1.21297
ANAPC16 anaphase promoting complex subunit 16 1.19528
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 1.19218
ATM ATM serine/threonine kinase 1.18918
ZNF329 zinc finger protein 329 1.18891
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 1.18783
ZNF362 zinc finger protein 362 1.18291
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 1.1804
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 1.178
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma 1.17649
HIST3H3 histone cluster 3, H3 1.17342
ZNF37A zinc finger protein 37A 1.17088
RAB28 RAB28, member RAS oncogene family 1.16801
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 1.16564
MMP28 matrix metallopeptidase 28 1.16309
IFNGR1 interferon gamma receptor 1 1.1621
PTPN12 protein tyrosine phosphatase, non-receptor type 12 1.1597
ADAM28 ADAM metallopeptidase domain 28 1.15875
TXN thioredoxin 1.15591
KPNA3 karyopherin alpha 3 (importin alpha 4) 1.15517
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 1.153
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.1523
PRB4 proline-rich protein BstNI subfamily 4 1.14748
NUP54 nucleoporin 54kDa 1.14729
FUS FUS RNA binding protein 1.14671
GIPR gastric inhibitory polypeptide receptor 1.14539
ACTR3B ARP3 actin-related protein 3 homolog B (yeast) 1.14333
CPA1 carboxypeptidase A1 (pancreatic) 1.14121
IL10RB interleukin 10 receptor, beta 1.13831
DGCR2 DiGeorge syndrome critical region gene 2 1.12873
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 1.12849
H2BFM H2B histone family, member M 1.12722
EFHD1 EF-hand domain family, member D1 1.12203
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 1.11938
SDR9C7 short chain dehydrogenase/reductase family 9C, member 7 1.11234
PGF placental growth factor 1.10619
SENP5 SUMO1/sentrin specific peptidase 5 1.10453
DLX6 distal-less homeobox 6 1.10037
POU3F4 POU class 3 homeobox 4 1.09673
DHRS4L1 dehydrogenase/reductase (SDR family) member 4 like 1 1.09463
RBM5 RNA binding motif protein 5 1.09414
MAP3K13 mitogen-activated protein kinase kinase kinase 13 1.09217
SRPK1 SRSF protein kinase 1 1.09207
USP10 ubiquitin specific peptidase 10 1.09048
COX7C cytochrome c oxidase subunit VIIc 1.09029
GH2 growth hormone 2 1.08677
CTRL chymotrypsin-like 1.08257
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 1.08019
PRMT1 protein arginine methyltransferase 1 1.07661
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein 1.07513
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 1.06819
CCKBR cholecystokinin B receptor 1.06555
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 1.06433
LPAR1 lysophosphatidic acid receptor 1 1.05792
HOXC5 homeobox C5 1.05661
HDAC8 histone deacetylase 8 1.05636
PCDHB14 protocadherin beta 14 1.05604
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 1.0545
PAX8 paired box 8 1.05264
ICOS inducible T-cell co-stimulator 1.04894
HS6ST1 heparan sulfate 6-O-sulfotransferase 1 1.04613
IDH3B isocitrate dehydrogenase 3 (NAD+) beta 1.04322
CHUK conserved helix-loop-helix ubiquitous kinase 1.04271
TPO thyroid peroxidase 1.0414
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 1.04079
ZNF77 zinc finger protein 77 1.03995
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.03787
PPME1 protein phosphatase methylesterase 1 1.03535
GJA4 gap junction protein, alpha 4, 37kDa 1.0327
ASF1B anti-silencing function 1B histone chaperone 1.0301
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 1.02882
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8 1.02759
EED embryonic ectoderm development 1.02743
GJA9-MYCBP GJA9-MYCBP readthrough 1.02408
SGK223 homolog of rat pragma of Rnd2 1.01486
BCAR3 breast cancer anti-estrogen resistance 3 1.01144
UBTF upstream binding transcription factor, RNA polymerase I 1.01133
XAB2 XPA binding protein 2 1.00522
SP3 Sp3 transcription factor 1.00487
POLM polymerase (DNA directed), mu 1.00342
DLG2 discs, large homolog 2 (Drosophila) 1.00254

decreased fitness

Symbol Name Standardized Value
CENPN centromere protein N -2.87881
HIST1H3F histone cluster 1, H3f -2.8785
HSDL2 hydroxysteroid dehydrogenase like 2 -2.77377
SRPRB signal recognition particle receptor, B subunit -2.67067
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -2.62546
OR1S1 olfactory receptor, family 1, subfamily S, member 1 (gene/pseudogene) -2.55567
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.35438
TRIP6 thyroid hormone receptor interactor 6 -2.34447
AIPL1 aryl hydrocarbon receptor interacting protein-like 1 -2.34151
ADGRE2 adhesion G protein-coupled receptor E2 -2.33577
YES1 YES proto-oncogene 1, Src family tyrosine kinase -2.29453
ARID1A AT rich interactive domain 1A (SWI-like) -2.20377
SPOCK3 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 -2.09099
PCDH11Y protocadherin 11 Y-linked -2.07996
ZKSCAN4 zinc finger with KRAB and SCAN domains 4 -2.05201
RGSL1 regulator of G-protein signaling like 1 -2.04931
GBX1 gastrulation brain homeobox 1 -2.03262
CD8B CD8b molecule -2.01602
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -1.99075
IQGAP1 IQ motif containing GTPase activating protein 1 -1.96768
RHAG Rh-associated glycoprotein -1.86698
DCHS1 dachsous cadherin-related 1 -1.84307
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -1.83929
GUCY1A2 guanylate cyclase 1, soluble, alpha 2 -1.83163
TRPM5 transient receptor potential cation channel, subfamily M, member 5 -1.82266
EGR1 early growth response 1 -1.81792
SSBP2 single-stranded DNA binding protein 2 -1.78379
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 -1.77789
BCORL1 BCL6 corepressor-like 1 -1.73476
CLSTN2 calsyntenin 2 -1.68882
SLC35E4 solute carrier family 35, member E4 -1.68206
PLXNC1 plexin C1 -1.68056
EMP2 epithelial membrane protein 2 -1.67809
MMP15 matrix metallopeptidase 15 (membrane-inserted) -1.67681
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -1.66189
RAB10 RAB10, member RAS oncogene family -1.63446
SKA2 spindle and kinetochore associated complex subunit 2 -1.63425
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) -1.62018
ZNF81 zinc finger protein 81 -1.61517
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -1.60624
GATA6 GATA binding protein 6 -1.60066
ZNF273 zinc finger protein 273 -1.60061
MECP2 methyl CpG binding protein 2 -1.5935
TLR4 toll-like receptor 4 -1.58761
PDE12 phosphodiesterase 12 -1.58235
AFP alpha-fetoprotein -1.56257
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 -1.56251
RAP2A RAP2A, member of RAS oncogene family -1.55362
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide -1.54822
PAPL iron/zinc purple acid phosphatase-like protein -1.54267
TUBD1 tubulin, delta 1 -1.54255
HOXC10 homeobox C10 -1.52833
IRF4 interferon regulatory factor 4 -1.52424
FOXR1 forkhead box R1 -1.52169
M6PR mannose-6-phosphate receptor (cation dependent) -1.49962
FERMT1 fermitin family member 1 -1.49026
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit -1.48229
RHD Rh blood group, D antigen -1.48159
S1PR3 sphingosine-1-phosphate receptor 3 -1.47652
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) -1.4708
RXFP4 relaxin/insulin-like family peptide receptor 4 -1.46261
DPM2 dolichyl-phosphate mannosyltransferase polypeptide 2, regulatory subunit -1.45376
WDR33 WD repeat domain 33 -1.45237
TRIM33 tripartite motif containing 33 -1.44126
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -1.43945
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -1.43768
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -1.43749
FBP2 fructose-1,6-bisphosphatase 2 -1.41996
ZNF793 zinc finger protein 793 -1.38697
RPS15A ribosomal protein S15a -1.36378
GADD45G growth arrest and DNA-damage-inducible, gamma -1.35974
FAM212B family with sequence similarity 212, member B -1.35923
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -1.35279
CAPN11 calpain 11 -1.35192
UCK2 uridine-cytidine kinase 2 -1.34059
MLEC malectin -1.33324
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced -1.31921
BCL9L B-cell CLL/lymphoma 9-like -1.31883
RABIF RAB interacting factor -1.31375
CALB1 calbindin 1, 28kDa -1.31254
HSDL1 hydroxysteroid dehydrogenase like 1 -1.30984
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa -1.30886
NAA20 N(alpha)-acetyltransferase 20, NatB catalytic subunit -1.30869
EIF2D eukaryotic translation initiation factor 2D -1.30548
RNASET2 ribonuclease T2 -1.28572
HPGDS hematopoietic prostaglandin D synthase -1.28526
TFCP2L1 transcription factor CP2-like 1 -1.28372
SEC22C SEC22 vesicle trafficking protein homolog C (S. cerevisiae) -1.28295
TSC1 tuberous sclerosis 1 -1.28011
FZD4 frizzled class receptor 4 -1.27978
MAP2K6 mitogen-activated protein kinase kinase 6 -1.27756
MMP23A matrix metallopeptidase 23A (pseudogene) -1.27448
MPG N-methylpurine-DNA glycosylase -1.26707
KRT1 keratin 1, type II -1.25972
SLC16A6 solute carrier family 16, member 6 -1.25312
EPHA5 EPH receptor A5 -1.24875
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -1.2426
TRIM60 tripartite motif containing 60 -1.23085
OR2T4 olfactory receptor, family 2, subfamily T, member 4 -1.22862
SENP8 SUMO/sentrin specific peptidase family member 8 -1.22766
SLC35E1 solute carrier family 35, member E1 -1.22655
CLEC4F C-type lectin domain family 4, member F -1.22194
PCDH11X protocadherin 11 X-linked -1.21758
EHMT2 euchromatic histone-lysine N-methyltransferase 2 -1.21666
IRF2BP2 interferon regulatory factor 2 binding protein 2 -1.2161
SIRT7 sirtuin 7 -1.21345
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) -1.21337
PDCD6IP programmed cell death 6 interacting protein -1.2133
ZMIZ1 zinc finger, MIZ-type containing 1 -1.21272
ADRB3 adrenoceptor beta 3 -1.21058
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -1.20781
HSPA2 heat shock 70kDa protein 2 -1.20023
VPS13B vacuolar protein sorting 13 homolog B (yeast) -1.19404
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble -1.19278
RSG1 REM2 and RAB-like small GTPase 1 -1.19162
RBM15 RNA binding motif protein 15 -1.18874
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) -1.18809
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 -1.18776
SCARF1 scavenger receptor class F, member 1 -1.18728
EAF2 ELL associated factor 2 -1.18589
HBG1 hemoglobin, gamma A -1.18511
RNASE6 ribonuclease, RNase A family, k6 -1.18235
LTB lymphotoxin beta (TNF superfamily, member 3) -1.18048
AMDHD1 amidohydrolase domain containing 1 -1.17488
SCRT1 scratch family zinc finger 1 -1.17304
GSTP1 glutathione S-transferase pi 1 -1.17204
DOCK5 dedicator of cytokinesis 5 -1.17155
IGF1R insulin-like growth factor 1 receptor -1.1707
APBB1 amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65) -1.16591
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -1.15804
MMP23B matrix metallopeptidase 23B -1.1572
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -1.14749
MEX3D mex-3 RNA binding family member D -1.14733
RFC1 replication factor C (activator 1) 1, 145kDa -1.14538
SENP3-EIF4A1 SENP3-EIF4A1 readthrough (NMD candidate) -1.14309
MAN2B2 mannosidase, alpha, class 2B, member 2 -1.14273
RORA RAR-related orphan receptor A -1.14022
KRT17 keratin 17, type I -1.13722
IRS2 insulin receptor substrate 2 -1.13338
MS4A14 membrane-spanning 4-domains, subfamily A, member 14 -1.13155
CST3 cystatin C -1.13015
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -1.13014
EIF4A1 eukaryotic translation initiation factor 4A1 -1.12612
ERCC2 excision repair cross-complementation group 2 -1.12402
ZNF117 zinc finger protein 117 -1.11992
IRF1 interferon regulatory factor 1 -1.11861
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -1.1154
AFF1 AF4/FMR2 family, member 1 -1.11403
SEPHS1 selenophosphate synthetase 1 -1.11229
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -1.11132
KLK8 kallikrein-related peptidase 8 -1.10919
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 -1.10892
ACSL6 acyl-CoA synthetase long-chain family member 6 -1.10777
PPARD peroxisome proliferator-activated receptor delta -1.10422
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -1.10184
LYN LYN proto-oncogene, Src family tyrosine kinase -1.09614
GH1 growth hormone 1 -1.09608
PCSK4 proprotein convertase subtilisin/kexin type 4 -1.09453
ZNF835 zinc finger protein 835 -1.09068
RAB35 RAB35, member RAS oncogene family -1.0856
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 -1.0856
EXOSC2 exosome component 2 -1.08506
AQP3 aquaporin 3 (Gill blood group) -1.08481
FAM207A family with sequence similarity 207, member A -1.08209
DRD4 dopamine receptor D4 -1.08082
FAM35A family with sequence similarity 35, member A -1.08026
HHAT hedgehog acyltransferase -1.07841
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 -1.07663
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 -1.0751
ADCY2 adenylate cyclase 2 (brain) -1.07298
TBX3 T-box 3 -1.06748
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -1.06401
MXD4 MAX dimerization protein 4 -1.06302
LAMP1 lysosomal-associated membrane protein 1 -1.05756
RAB23 RAB23, member RAS oncogene family -1.05709
GNS glucosamine (N-acetyl)-6-sulfatase -1.05415
STRN3 striatin, calmodulin binding protein 3 -1.05342
STX4 syntaxin 4 -1.04903
PCDHGA5 protocadherin gamma subfamily A, 5 -1.04897
TP53RK TP53 regulating kinase -1.04818
SREBF1 sterol regulatory element binding transcription factor 1 -1.04477
RUNDC3A RUN domain containing 3A -1.04
HSPA8 heat shock 70kDa protein 8 -1.035
MED13L mediator complex subunit 13-like -1.03458
IFNK interferon, kappa -1.02544
GVINP1 GTPase, very large interferon inducible pseudogene 1 -1.02414
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha -1.02377
PFN4 profilin family, member 4 -1.02236
GPR22 G protein-coupled receptor 22 -1.02223
OR1S2 olfactory receptor, family 1, subfamily S, member 2 -1.0202
ECH1 enoyl CoA hydratase 1, peroxisomal -1.01852
DCTN1 dynactin 1 -1.01787
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 -1.01666
UBE3B ubiquitin protein ligase E3B -1.01588
OCRL oculocerebrorenal syndrome of Lowe -1.01541
MEF2C myocyte enhancer factor 2C -1.01537
PLXNB2 plexin B2 -1.01293
GHSR growth hormone secretagogue receptor -1.01203
PNPLA8 patatin-like phospholipase domain containing 8 -1.01126
UBAP2 ubiquitin associated protein 2 -1.01031
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae) -1.00881
NRF1 nuclear respiratory factor 1 -1.00869
DSG1 desmoglein 1 -1.00842
MED12 mediator complex subunit 12 -1.00736
FGF8 fibroblast growth factor 8 (androgen-induced) -1.00506
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 -1.00172
DPF2 D4, zinc and double PHD fingers family 2 -1.00092