LTF Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description lactotransferrin|This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014] (NCBI Entrez Gene Database, 4057)
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Genes

323 genes differentially expressed following the LTF gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ASB17 ankyrin repeat and SOCS box containing 17 2.91972
C1ORF141 chromosome 1 open reading frame 141 2.91972
IL1RN interleukin 1 receptor antagonist 2.91972
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 2.91972
TTLL2 tubulin tyrosine ligase-like family member 2 2.91972
CX3CR1 chemokine (C-X3-C motif) receptor 1 2.91972
BRICD5 BRICHOS domain containing 5 2.91972
ATOH1 atonal homolog 1 (Drosophila) 2.91972
DIO1 deiodinase, iodothyronine, type I 2.91972
PLB1 phospholipase B1 2.91972
UTS2 urotensin 2 2.91972
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.91972
MUSK muscle, skeletal, receptor tyrosine kinase 2.91972
OPRL1 opiate receptor-like 1 2.91972
CCL3L3 chemokine (C-C motif) ligand 3-like 3 2.91972
TNIP3 TNFAIP3 interacting protein 3 2.91972
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.91972
SPRR1B small proline-rich protein 1B 2.91972
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.91972
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.91972
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.91972
MYO1A myosin IA 2.91972
FXYD2 FXYD domain containing ion transport regulator 2 2.91972
ACADL acyl-CoA dehydrogenase, long chain 2.91972
PITX1 paired-like homeodomain 1 2.91972
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 2.91972
SHISA3 shisa family member 3 2.91972
CNTN6 contactin 6 2.91972
SLC35G5 solute carrier family 35, member G5 2.91972
SYT15 synaptotagmin XV 2.91972
ANXA2R annexin A2 receptor 2.91972
ASIC4 acid sensing (proton gated) ion channel family member 4 2.91972
TMC8 transmembrane channel-like 8 2.91972
TMC3 transmembrane channel-like 3 2.91972
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.91972
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.91972
PMCH pro-melanin-concentrating hormone 2.91972
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.91972
TPRX1 tetra-peptide repeat homeobox 1 2.91972
LGSN lengsin, lens protein with glutamine synthetase domain 2.91972
SPDYE2B speedy/RINGO cell cycle regulator family member E2B 2.91972
TBR1 T-box, brain, 1 2.91972
IL31RA interleukin 31 receptor A 2.91972
KLF17 Kruppel-like factor 17 2.91972
TAS2R39 taste receptor, type 2, member 39 2.91972
FPR1 formyl peptide receptor 1 2.91972
SYCP2 synaptonemal complex protein 2 2.91972
SIM2 single-minded family bHLH transcription factor 2 2.91972
IL6 interleukin 6 2.91972
SIX2 SIX homeobox 2 2.91972
GZMM granzyme M (lymphocyte met-ase 1) 2.91972
CAPN14 calpain 14 2.91972
PCDHA3 protocadherin alpha 3 2.91972
LIX1 Lix1 homolog (chicken) 2.91972
ARL5C ADP-ribosylation factor-like 5C 2.91972
GOLGA7B golgin A7 family, member B 2.91972
GDA guanine deaminase 2.91972
KLHL30 kelch-like family member 30 2.91972
OASL 2'-5'-oligoadenylate synthetase-like 2.91972
NKX2-2 NK2 homeobox 2 2.91972
ZIC4 Zic family member 4 2.91972
SOX1 SRY (sex determining region Y)-box 1 2.91972
MYBPHL myosin binding protein H-like 2.91972
UIMC1 ubiquitin interaction motif containing 1 2.91972
MYBPC3 myosin binding protein C, cardiac 2.91972
TMEM179 transmembrane protein 179 2.91972
AMTN amelotin 2.91972
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.91972
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 2.91972
GJA10 gap junction protein, alpha 10, 62kDa 2.91972
SBSN suprabasin 2.91972
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.91972
CCNB3 cyclin B3 2.91972
OSGIN1 oxidative stress induced growth inhibitor 1 2.91972
SCG2 secretogranin II 2.91972
SERPINA11 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11 2.91972
HEATR9 HEAT repeat containing 9 2.91972
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.91972
ADRB2 adrenoceptor beta 2, surface 2.91972
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.91972
TCF23 transcription factor 23 2.91972
PKP1 plakophilin 1 2.91972
BMP8B bone morphogenetic protein 8b 2.91972
AMDHD1 amidohydrolase domain containing 1 2.91972
PMIS2 PMIS2 transmembrane protein 2.91972
SPATA9 spermatogenesis associated 9 2.91972
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.91972
OCM oncomodulin 2.91972
PCARE photoreceptor cilium actin regulator 2.91972
CRYBA1 crystallin, beta A1 2.91972
CFAP157 cilia and flagella associated protein 157 2.91972
TPPP2 tubulin polymerization-promoting protein family member 2 2.91972
CBY2 chibby family member 2 2.91972
MUC7 mucin 7, secreted 2.91972
C20ORF144 chromosome 20 open reading frame 144 2.91972
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.91972
DRD5 dopamine receptor D5 2.91972
PCDHGA4 protocadherin gamma subfamily A, 4 2.91972
MCCD1 mitochondrial coiled-coil domain 1 2.91972
MUC17 mucin 17, cell surface associated 2.91972
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 2.91972
SMIM38 small integral membrane protein 38 2.91972
MINAR2 membrane integral NOTCH2 associated receptor 2 2.91972
NTN5 netrin 5 2.91972
DLX3 distal-less homeobox 3 2.91972
PRSS33 protease, serine, 33 2.91972
GAS2L2 growth arrest-specific 2 like 2 2.91972
ACSS1 acyl-CoA synthetase short-chain family member 1 2.91972
LOC124906010 uncharacterized LOC124906010 2.91972
ZNF831 zinc finger protein 831 2.91972
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.91972
C17ORF113 chromosome 17 open reading frame 113 2.91972
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.91972
SPMAP2L sperm microtubule associated protein 2 like 2.91972
ESPNL espin-like 2.91972
RASA4 RAS p21 protein activator 4 2.91972
GPR62 G protein-coupled receptor 62 2.91972
PGR progesterone receptor 2.91972
GARIN6 golgi associated RAB2 interactor family member 6 2.91972
LHX2 LIM homeobox 2 2.91972
TMPPE transmembrane protein with metallophosphoesterase domain 2.91972
OR52P1 olfactory receptor family 52 subfamily P member 1 (gene/pseudogene) 2.91972
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.91972
TSPAN16 tetraspanin 16 2.91972
TNR tenascin R 2.91972
FRMPD1 FERM and PDZ domain containing 1 2.91972
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.91972
ERMN ermin, ERM-like protein 2.91972
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.91972
LRRC32 leucine rich repeat containing 32 2.91972
SCEL sciellin 2.91972
VAX2 ventral anterior homeobox 2 2.91972
PCDHGB4 protocadherin gamma subfamily B, 4 2.91972
LTB4R2 leukotriene B4 receptor 2 2.91972
NIM1K NIM1 serine/threonine protein kinase 2.91972
OR3A1 olfactory receptor, family 3, subfamily A, member 1 2.91972
PKD2L1 polycystic kidney disease 2-like 1 2.91972
MLANA melan-A 2.91972
CCDC166 coiled-coil domain containing 166 2.91972
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.91972
TRPA1 transient receptor potential cation channel, subfamily A, member 1 2.91972
LY6K lymphocyte antigen 6 complex, locus K 2.91972
CARD9 caspase recruitment domain family, member 9 2.91972
OR51M1 olfactory receptor, family 51, subfamily M, member 1 2.91972
MYEOV myeloma overexpressed 2.91972
ZNF471 zinc finger protein 471 2.91972
SHOX2 short stature homeobox 2 2.91972
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 2.91972
CLRN1 clarin 1 2.91972
PTH1R parathyroid hormone 1 receptor 2.91972
TBX1 T-box 1 2.91972
TBC1D10C TBC1 domain family, member 10C 2.91972
HTD2 hydroxyacyl-thioester dehydratase type 2 2.91972
WFDC9 WAP four-disulfide core domain 9 2.91972
NKX1-2 NK1 homeobox 2 2.91972
ADAM8 ADAM metallopeptidase domain 8 2.91972
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.91972
DEFB107B defensin, beta 107B 2.91972
AQP7 aquaporin 7 2.91972
CST1 cystatin SN 2.91972
RAD21L1 RAD21-like 1 (S. pombe) 2.91972
C3AR1 complement component 3a receptor 1 2.91972
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.91972
EDN3 endothelin 3 2.91972
CNKSR1 connector enhancer of kinase suppressor of Ras 1 2.91288
CALR3 calreticulin 3 2.87598
MMP26 matrix metallopeptidase 26 2.84164
NCF2 neutrophil cytosolic factor 2 2.84164
ITPRID1 ITPR interacting domain containing 1 2.84164
RBPMS2 RNA binding protein with multiple splicing 2 2.79989
ANGPTL2 angiopoietin-like 2 2.77384
TMED9 transmembrane emp24 protein transport domain containing 9 2.72453
SLC35G2 solute carrier family 35, member G2 2.66291
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 2.61258
INO80E INO80 complex subunit E 2.59879
PDK1 pyruvate dehydrogenase kinase, isozyme 1 2.59374
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 2.42374
A1CF APOBEC1 complementation factor 2.41743
ARHGAP23 Rho GTPase activating protein 23 2.41743
AGAP4 ArfGAP with GTPase domain, ankyrin repeat and PH domain 4 2.4024
TTC17 tetratricopeptide repeat domain 17 2.39455
TSPO translocator protein (18kDa) 2.38155
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 2.37338
CXCR2 chemokine (C-X-C motif) receptor 2 2.37338
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.37338
PROB1 proline-rich basic protein 1 2.37338
BSX brain-specific homeobox 2.37338
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 2.36578
TMLHE trimethyllysine hydroxylase, epsilon 2.36144
FBL fibrillarin 2.33697
PKDCC protein kinase domain containing, cytoplasmic 2.31811
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 2.29024
TRHR thyrotropin-releasing hormone receptor 2.28735
ZNF66 zinc finger protein 66 2.27817
RAB3D RAB3D, member RAS oncogene family 2.25795
SCN1B sodium channel, voltage gated, type I beta subunit 2.2553
STK4 serine/threonine kinase 4 2.25256
TARS3 threonyl-tRNA synthetase 3 2.19196
SRP54 signal recognition particle 54kDa 2.18961
PDE11A phosphodiesterase 11A 2.18003
DTX3 deltex 3, E3 ubiquitin ligase 2.16919
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 2.16214
AUNIP aurora kinase A and ninein interacting protein 2.1468
PTPRU protein tyrosine phosphatase, receptor type, U 2.13276
WTIP Wilms tumor 1 interacting protein 2.11755
HRH2 histamine receptor H2 2.1088
SNED1 sushi, nidogen and EGF-like domains 1 2.10874
FDX1 ferredoxin 1 2.10761
MBD4 methyl-CpG binding domain protein 4 2.10512
LRFN3 leucine rich repeat and fibronectin type III domain containing 3 2.10466
MYCBP MYC binding protein 2.10189
TRAF3 TNF receptor-associated factor 3 2.07515
RPL7 ribosomal protein L7 2.07219
ZNF660-ZNF197 ZNF660-ZNF197 readthrough 2.06983
PDZD11 PDZ domain containing 11 2.05915
CD177 CD177 molecule 2.0327
CDH22 cadherin 22, type 2 2.0327
P2RY2 purinergic receptor P2Y, G-protein coupled, 2 2.0327
CIMAP2 ciliary microtubule associated protein 2 2.0327
CHCT1 CHD1 helical C-terminal domain containing 1 2.0327
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.0327
C2ORF80 chromosome 2 open reading frame 80 2.0327
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.0327
ANXA6 annexin A6 2.0327
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.0327
SLC14A2 solute carrier family 14 (urea transporter), member 2 2.0327
SLC1A2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 2.0327
FBXO32 F-box protein 32 2.0327
KBTBD7 kelch repeat and BTB (POZ) domain containing 7 2.02114

decreased expression

Symbol Name Standardized Value
GRAMD2A GRAM domain containing 2A -2.91972
EFHB EF-hand domain family, member B -2.91972
CAGE1 cancer antigen 1 -2.91972
INSM1 insulinoma-associated 1 -2.91972
IGSF23 immunoglobulin superfamily, member 23 -2.91972
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled -2.91972
MAFA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A -2.91972
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 -2.83624
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3 -2.77362
NWD2 NACHT and WD repeat domain containing 2 -2.77362
TM4SF1 transmembrane 4 L six family member 1 -2.77362
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 -2.77362
TNNI1 troponin I type 1 (skeletal, slow) -2.77362
SMYD1 SET and MYND domain containing 1 -2.77362
CACNA2D4 calcium channel, voltage-dependent, alpha 2/delta subunit 4 -2.77362
PTPN7 protein tyrosine phosphatase, non-receptor type 7 -2.77362
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.77362
CIITA class II, major histocompatibility complex, transactivator -2.77362
CPB2 carboxypeptidase B2 (plasma) -2.77362
LBP lipopolysaccharide binding protein -2.77362
SPDEF SAM pointed domain containing ETS transcription factor -2.77362
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.77362
VWC2L von Willebrand factor C domain containing protein 2-like -2.77362
SOX30 SRY (sex determining region Y)-box 30 -2.77362
PDZD9 PDZ domain containing 9 -2.77362
AHSG alpha-2-HS-glycoprotein -2.77362
CHADL chondroadherin-like -2.77362
PCDHGB2 protocadherin gamma subfamily B, 2 -2.77362
TTLL13 tubulin tyrosine ligase like 13 -2.77362
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 -2.77362
ALX4 ALX homeobox 4 -2.77362
C10ORF67 chromosome 10 open reading frame 67 -2.77362
TSGA10IP testis specific, 10 interacting protein -2.77362
CFAP47 cilia and flagella associated protein 47 -2.77362
MDGA1 MAM domain containing glycosylphosphatidylinositol anchor 1 -2.77362
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.77362
ATP13A4 ATPase type 13A4 -2.77362
PCDHGA7 protocadherin gamma subfamily A, 7 -2.77362
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) -2.77362
KLF4 Kruppel-like factor 4 (gut) -2.77362
LOC124904542 uncharacterized LOC124904542 -2.77362
BTNL8 butyrophilin-like 8 -2.77362
CTCF CCCTC-binding factor (zinc finger protein) -2.71582
ZNF185 zinc finger protein 185 (LIM domain) -2.6758
DAGLB diacylglycerol lipase, beta -2.66926
UBAC1 UBA domain containing 1 -2.66291
KDM7A lysine (K)-specific demethylase 7A -2.63107
CS citrate synthase -2.56371
GLB1L2 galactosidase, beta 1-like 2 -2.55602
RASD2 RASD family, member 2 -2.55602
TNS2 tensin 2 -2.55602
ADGRE3 adhesion G protein-coupled receptor E3 -2.55602
DDR2 discoidin domain receptor tyrosine kinase 2 -2.53468
CDC42SE2 CDC42 small effector 2 -2.52828
TEDC1 tubulin epsilon and delta complex 1 -2.45822
RGPD6 RANBP2-like and GRIP domain containing 6 -2.45822
EXOSC3 exosome component 3 -2.45583
FBLL1 fibrillarin-like 1 -2.4052
WASL Wiskott-Aldrich syndrome-like -2.35893
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -2.35851
ABAT 4-aminobutyrate aminotransferase -2.35203
AP3M2 adaptor-related protein complex 3, mu 2 subunit -2.34945
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1 -2.31407
HTRA3 HtrA serine peptidase 3 -2.29539
HSPB11 heat shock protein family B (small), member 11 -2.28986
IRS1 insulin receptor substrate 1 -2.28909
AP3B1 adaptor-related protein complex 3, beta 1 subunit -2.25545
MAP7 microtubule-associated protein 7 -2.2521
CPNE4 copine IV -2.22669
IST1 increased sodium tolerance 1 homolog (yeast) -2.17631
NUP62 nucleoporin 62kDa -2.17194
SETDB1 SET domain, bifurcated 1 -2.15659
SH3PXD2B SH3 and PX domains 2B -2.14847
PP2D1 protein phosphatase 2C-like domain containing 1 -2.1388
LAG3 lymphocyte-activation gene 3 -2.1388
KLC2 kinesin light chain 2 -2.13659
CPNE8 copine VIII -2.12795
IL3RA interleukin 3 receptor, alpha (low affinity) -2.12019
CA1 carbonic anhydrase I -2.11968
CCR10 chemokine (C-C motif) receptor 10 -2.11968
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -2.10761
RPP38 ribonuclease P/MRP 38kDa subunit -2.10761
SEC14L4 SEC14-like 4 (S. cerevisiae) -2.09823
BCL7C B-cell CLL/lymphoma 7C -2.08892
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) -2.06875
PECR peroxisomal trans-2-enoyl-CoA reductase -2.05915
MROH1 maestro heat-like repeat family member 1 -2.05915
EMILIN2 elastin microfibril interfacer 2 -2.05915
ACYP1 acylphosphatase 1, erythrocyte (common) type -2.05255
IPO5 importin 5 -2.03664
GRID2 glutamate receptor, ionotropic, delta 2 -2.0327
SPATS2L spermatogenesis associated, serine-rich 2-like -2.0327
CABP1 calcium binding protein 1 -2.02092
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 -2.01313