LTK Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description leukocyte receptor tyrosine kinase|The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 4058)
External Link https://ncbi.nlm.nih.gov/gene/4058
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Genes

500 genes differentially expressed following the LTK gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 0.0167651
KRT14 keratin 14, type I 0.0165428
S100A8 S100 calcium binding protein A8 0.0160332
FABP4 fatty acid binding protein 4, adipocyte 0.0157133
SLPI secretory leukocyte peptidase inhibitor 0.0148107
TM4SF1 transmembrane 4 L six family member 1 0.0147719
CRABP2 cellular retinoic acid binding protein 2 0.0136964
S100A2 S100 calcium binding protein A2 0.0129109
GAS1 growth arrest-specific 1 0.012691
CHRDL1 chordin-like 1 0.0126247
FLNA filamin A, alpha 0.0122033
LCP1 lymphocyte cytosolic protein 1 (L-plastin) 0.012124
NXN nucleoredoxin 0.012041
LIMCH1 LIM and calponin homology domains 1 0.0119871
GSTA4 glutathione S-transferase alpha 4 0.0118704
ADGRG6 adhesion G protein-coupled receptor G6 0.0117862
PTGER4 prostaglandin E receptor 4 (subtype EP4) 0.0117144
S100A7 S100 calcium binding protein A7 0.011647
TMEM45A transmembrane protein 45A 0.0116401
C3 complement component 3 0.0112879
SFRP4 secreted frizzled-related protein 4 0.0112397
S100A9 S100 calcium binding protein A9 0.0111464
CLCA2 chloride channel accessory 2 0.0109505
CLEC2B C-type lectin domain family 2, member B 0.0109149
CFB complement factor B 0.0108642
AQP3 aquaporin 3 (Gill blood group) 0.010802
TGFBR3 transforming growth factor, beta receptor III 0.0105498
ZNF185 zinc finger protein 185 (LIM domain) 0.0105256
PSCA prostate stem cell antigen 0.0102541
PALMD palmdelphin 0.0101851
GBP2 guanylate binding protein 2, interferon-inducible 0.0101106
RNPS1 RNA binding protein S1, serine-rich domain 0.0100168
HOPX HOP homeobox 0.00991811
NID1 nidogen 1 0.00978298
KRT17 keratin 17, type I 0.00974148
CRISP3 cysteine-rich secretory protein 3 0.00973512
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) 0.00958519
FBLN1 fibulin 1 0.0095735
MIA melanoma inhibitory activity 0.0095368
CCNB2 cyclin B2 0.0095127
HOXC6 homeobox C6 0.00947475
FBLN5 fibulin 5 0.00946752
NFIB nuclear factor I/B 0.00935828
KIF20A kinesin family member 20A 0.00928793
KRT13 keratin 13, type I 0.00924576
LEF1 lymphoid enhancer-binding factor 1 0.00917896
MGP matrix Gla protein 0.00907953
TGM2 transglutaminase 2 0.00904566
CCL2 chemokine (C-C motif) ligand 2 0.00892784
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1 0.00888454
CALML3 calmodulin-like 3 0.00884413
NUPR1 nuclear protein, transcriptional regulator, 1 0.00875943
LAMA5 laminin, alpha 5 0.00875198
SFRP1 secreted frizzled-related protein 1 0.00873853
EMP2 epithelial membrane protein 2 0.00864922
PPP1R3C protein phosphatase 1, regulatory subunit 3C 0.0085679
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2 0.00853636
LAPTM4B lysosomal protein transmembrane 4 beta 0.00852431
C1R complement component 1, r subcomponent 0.00849966
COL14A1 collagen, type XIV, alpha 1 0.00846597
CLU clusterin 0.00845653
SYNM synemin, intermediate filament protein 0.00842764
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 0.00841902
PDZK1IP1 PDZK1 interacting protein 1 0.00840036
RET ret proto-oncogene 0.00833133
PODXL podocalyxin-like 0.00830717
CRIP2 cysteine-rich protein 2 0.00826422
SPRR1B small proline-rich protein 1B 0.00823815
TENT5A terminal nucleotidyltransferase 5A 0.00820264
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00819999
MFAP5 microfibrillar associated protein 5 0.00816983
WDR61 WD repeat domain 61 0.00813111
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 0.00812599
RUNX3 runt-related transcription factor 3 0.00809619
TGM1 transglutaminase 1 0.00807313
KRT15 keratin 15, type I 0.00804214
AEBP1 AE binding protein 1 0.00798805
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.0079831
PLK1 polo-like kinase 1 0.00795221
PDZRN3 PDZ domain containing ring finger 3 0.00794515
AOC3 amine oxidase, copper containing 3 0.0079092
PDGFRL platelet-derived growth factor receptor-like 0.00789463
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.00786605
NSG1 neuron specific gene family member 1 0.00784585
SORBS1 sorbin and SH3 domain containing 1 0.0078299
CST6 cystatin E/M 0.00781081
TP63 tumor protein p63 0.00779632
TRIM29 tripartite motif containing 29 0.00778608
BCHE butyrylcholinesterase 0.00775239
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 0.00772645
PIP prolactin-induced protein 0.00771347
LY6D lymphocyte antigen 6 complex, locus D 0.00770831
CD99 CD99 molecule 0.00770106
PEG10 paternally expressed 10 0.00765995
KLK11 kallikrein-related peptidase 11 0.00764657
RARRES3 retinoic acid receptor responder (tazarotene induced) 3 0.00764512
KLK7 kallikrein-related peptidase 7 0.00758308
LY6E lymphocyte antigen 6 complex, locus E 0.00755777
TMEM255A transmembrane protein 255A 0.0075387
SPRR1A small proline-rich protein 1A 0.00752159
CALD1 caldesmon 1 0.00750276
IFI16 interferon, gamma-inducible protein 16 0.00748167
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.00747865
IFI44 interferon-induced protein 44 0.00746426
BST2 bone marrow stromal cell antigen 2 0.00745771
LTBP2 latent transforming growth factor beta binding protein 2 0.00744999
SELL selectin L 0.00743117
STON1 stonin 1 0.00741305
ELOVL5 ELOVL fatty acid elongase 5 0.00738655
BTN3A3 butyrophilin, subfamily 3, member A3 0.00738332
ASPN asporin 0.00737119
DCN decorin 0.00736858
KLK8 kallikrein-related peptidase 8 0.00734869
REEP1 receptor accessory protein 1 0.00730557
ABLIM1 actin binding LIM protein 1 0.00729433
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast) 0.00728039
XPO7 exportin 7 0.00726539
KRT6B keratin 6B, type II 0.00723289
PAN2 PAN2 poly(A) specific ribonuclease subunit 0.00722561
WWTR1 WW domain containing transcription regulator 1 0.00719858
FGFBP1 fibroblast growth factor binding protein 1 0.00717964
NSDHL NAD(P) dependent steroid dehydrogenase-like 0.00716585
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.00714797
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F 0.00713291
MCAM melanoma cell adhesion molecule 0.00702675
NOTCH2 notch 2 0.00701916
KLK10 kallikrein-related peptidase 10 0.00700283
E2F2 E2F transcription factor 2 0.00699895
CETN2 centrin, EF-hand protein, 2 0.00699269
APOD apolipoprotein D 0.00698526
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.00698223
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 0.00697547
BHLHE41 basic helix-loop-helix family, member e41 0.00697442
TMED3 transmembrane emp24 protein transport domain containing 3 0.00696718
MSLN mesothelin 0.00696431
PIGB phosphatidylinositol glycan anchor biosynthesis, class B 0.00696167
RAPSN receptor-associated protein of the synapse 0.00694211
DPYD dihydropyrimidine dehydrogenase 0.00694175
MGST2 microsomal glutathione S-transferase 2 0.00688183
UBE2I ubiquitin-conjugating enzyme E2I 0.0068684
ACLY ATP citrate lyase 0.00686356
LTA4H leukotriene A4 hydrolase 0.00685324
CSTA cystatin A (stefin A) 0.00683704
ESYT1 extended synaptotagmin-like protein 1 0.00682862
LOX lysyl oxidase 0.0067394
KRT5 keratin 5, type II 0.00673811
IL7R interleukin 7 receptor 0.00672463
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 0.00671721
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.00671089
CD93 CD93 molecule 0.00670589
MATN2 matrilin 2 0.00662597
LYPD1 LY6/PLAUR domain containing 1 0.00662398
ADIRF adipogenesis regulatory factor 0.00662378
EPPK1 epiplakin 1 0.00660345
TNS1 tensin 1 0.0065986
LPAR6 lysophosphatidic acid receptor 6 0.00659679
LAMA4 laminin, alpha 4 0.00659589
CCR2 chemokine (C-C motif) receptor 2 0.0065862
TMEM204 transmembrane protein 204 0.00658151
ASB9 ankyrin repeat and SOCS box containing 9 0.00657697
TIMP3 TIMP metallopeptidase inhibitor 3 0.00657125
PLAT plasminogen activator, tissue 0.00655663
SNCG synuclein, gamma (breast cancer-specific protein 1) 0.00655583
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 0.00654114
PDZD2 PDZ domain containing 2 0.00651432
CASP4 caspase 4, apoptosis-related cysteine peptidase 0.00650316
ADIPOQ adiponectin, C1Q and collagen domain containing 0.00648015
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.00647146
CLGN calmegin 0.0064637
SRPX sushi-repeat containing protein, X-linked 0.00646237
CAVIN1 caveolae associated protein 1 0.00645765
PIR pirin (iron-binding nuclear protein) 0.0064481
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.00644216
CFD complement factor D (adipsin) 0.00642322
RHCG Rh family, C glycoprotein 0.00641929
CXCL12 chemokine (C-X-C motif) ligand 12 0.00641424
C7 complement component 7 0.00641227
ADGRG2 adhesion G protein-coupled receptor G2 0.00640845
PCP4 Purkinje cell protein 4 0.00640259
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 0.00637663
IVL involucrin 0.00636349
RGS1 regulator of G-protein signaling 1 0.00636333
ZNF750 zinc finger protein 750 0.00633414
KRT16 keratin 16, type I 0.00632026
GNAS GNAS complex locus 0.00628617
GIMAP6 GTPase, IMAP family member 6 0.00627987
CAVIN3 caveolae associated protein 3 0.00626319
ACKR1 atypical chemokine receptor 1 (Duffy blood group) 0.00625125
GIMAP4 GTPase, IMAP family member 4 0.00624374
COL10A1 collagen, type X, alpha 1 0.00624371
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 0.00623938
SOX11 SRY (sex determining region Y)-box 11 0.00622651
DSC2 desmocollin 2 0.00622564
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 0.00619842
SMTN smoothelin 0.00619686
DSG3 desmoglein 3 0.00617352
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.00616252
RAP2C RAP2C, member of RAS oncogene family 0.00616136
VLDLR very low density lipoprotein receptor 0.00616015
RASIP1 Ras interacting protein 1 0.0061556
LMOD1 leiomodin 1 (smooth muscle) 0.0061537
NNMT nicotinamide N-methyltransferase 0.00615059
FASN fatty acid synthase 0.00614715
SUCO SUN domain containing ossification factor 0.00613204
IL18 interleukin 18 0.00612358
LDOC1 leucine zipper, down-regulated in cancer 1 0.00610646
MAL mal, T-cell differentiation protein 0.00608974
SCRIB scribbled planar cell polarity protein 0.00608081
SSR2 signal sequence receptor, beta (translocon-associated protein beta) 0.00607351
BCAP31 B-cell receptor-associated protein 31 0.00606534
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0060548
PARP1 poly (ADP-ribose) polymerase 1 0.00604072
CD69 CD69 molecule 0.00603733
ELP1 elongator acetyltransferase complex subunit 1 0.00602534
MEIS2 Meis homeobox 2 0.00598704
PMP22 peripheral myelin protein 22 0.00598382
PIEZO1 piezo-type mechanosensitive ion channel component 1 0.00597482
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.00596989
SSPN sarcospan 0.00596895
UBXN7 UBX domain protein 7 0.0059443
FGFR1 fibroblast growth factor receptor 1 0.00594149
MMP2 matrix metallopeptidase 2 0.00592533
TYRP1 tyrosinase-related protein 1 0.00592137
SCGB1D2 secretoglobin, family 1D, member 2 0.0059166
PSME4 proteasome (prosome, macropain) activator subunit 4 0.00590672
PRSS21 protease, serine, 21 (testisin) 0.00588528
RAB4A RAB4A, member RAS oncogene family 0.00588425
KLK5 kallikrein-related peptidase 5 0.00587701
CDH5 cadherin 5, type 2 (vascular endothelium) 0.0058758
CXCL14 chemokine (C-X-C motif) ligand 14 0.00585697
COL9A3 collagen, type IX, alpha 3 0.00580936
PPL periplakin 0.00578874
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.00577884
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.00577784
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00577335
PI3 peptidase inhibitor 3, skin-derived 0.00574664
ANOS1 anosmin 1 0.00573898
NR2F1 nuclear receptor subfamily 2, group F, member 1 0.00573734
SRP72 signal recognition particle 72kDa 0.00572804
DDR2 discoidin domain receptor tyrosine kinase 2 0.00572112
PDE4B phosphodiesterase 4B, cAMP-specific 0.00571884
FDPS farnesyl diphosphate synthase 0.00571579
PLN phospholamban 0.00570035
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.00569451
KRT6A keratin 6A, type II 0.00568483
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 0.0056763
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.00566795
PUF60 poly-U binding splicing factor 60KDa 0.0056638
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.00565975
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.00565503

decreased expression

Symbol Name Standardized Value
SEPP1 selenoprotein P, plasma, 1 -0.0149162
CA2 carbonic anhydrase II -0.0145695
AOC1 amine oxidase, copper containing 1 -0.0140959
BASP1 brain abundant, membrane attached signal protein 1 -0.0128778
S100P S100 calcium binding protein P -0.0124022
RTN2 reticulon 2 -0.012334
WSB1 WD repeat and SOCS box containing 1 -0.0123286
FUCA1 fucosidase, alpha-L- 1, tissue -0.011717
SATB2 SATB homeobox 2 -0.0116572
CCNB1 cyclin B1 -0.0112422
KRT19 keratin 19, type I -0.0112202
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) -0.0110663
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) -0.0110549
CLCA1 chloride channel accessory 1 -0.010929
PTPRD protein tyrosine phosphatase, receptor type, D -0.0109104
PCNA proliferating cell nuclear antigen -0.0107984
LGALS4 lectin, galactoside-binding, soluble, 4 -0.0105625
STC2 stanniocalcin 2 -0.0105475
TMEM176B transmembrane protein 176B -0.0104991
TMEM176A transmembrane protein 176A -0.0104955
BMP2 bone morphogenetic protein 2 -0.0104186
TUBB2A tubulin, beta 2A class IIa -0.0103354
CXCL13 chemokine (C-X-C motif) ligand 13 -0.0101669
SIRT3 sirtuin 3 -0.0101633
EREG epiregulin -0.00997632
SLC26A3 solute carrier family 26 (anion exchanger), member 3 -0.00971951
EFHD1 EF-hand domain family, member D1 -0.00969613
EIF5A eukaryotic translation initiation factor 5A -0.00963102
CLDN7 claudin 7 -0.00962304
SHTN1 shootin 1 -0.00962293
HMGA1 high mobility group AT-hook 1 -0.00962265
HIST1H2AC histone cluster 1, H2ac -0.00942902
CYBA cytochrome b-245, alpha polypeptide -0.00925044
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 -0.00899317
ANPEP alanyl (membrane) aminopeptidase -0.00895808
ZBTB38 zinc finger and BTB domain containing 38 -0.00888104
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme -0.00885132
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) -0.00884689
EVI2A ecotropic viral integration site 2A -0.00877749
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -0.00877375
CKS2 CDC28 protein kinase regulatory subunit 2 -0.00874896
SALL1 spalt-like transcription factor 1 -0.00867159
SCG5 secretogranin V -0.00855137
AKR1C1 aldo-keto reductase family 1, member C1 -0.00853907
TGIF1 TGFB-induced factor homeobox 1 -0.00842974
TPBG trophoblast glycoprotein -0.00842142
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 -0.00839477
MUC2 mucin 2, oligomeric mucus/gel-forming -0.00835725
BLNK B-cell linker -0.00830439
MYBPC1 myosin binding protein C, slow type -0.00827822
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 -0.00820954
CHN2 chimerin 2 -0.0081763
DMTF1 cyclin D binding myb-like transcription factor 1 -0.00817547
VEGFA vascular endothelial growth factor A -0.00816218
LEFTY1 left-right determination factor 1 -0.00813427
ANKRD36 ankyrin repeat domain 36 -0.00804263
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -0.00802242
TCL1A T-cell leukemia/lymphoma 1A -0.00801999
IL17RB interleukin 17 receptor B -0.0079827
RAP2A RAP2A, member of RAS oncogene family -0.00786084
TDP2 tyrosyl-DNA phosphodiesterase 2 -0.00785428
CALB1 calbindin 1, 28kDa -0.00777605
IL1R1 interleukin 1 receptor, type I -0.00774322
TRAF4 TNF receptor-associated factor 4 -0.00770408
CLC Charcot-Leyden crystal galectin -0.00769846
PADI2 peptidyl arginine deiminase, type II -0.00769511
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.00761649
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -0.00759926
HBD hemoglobin, delta -0.00755758
COL6A3 collagen, type VI, alpha 3 -0.00751224
CLDN3 claudin 3 -0.00749108
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.00747132
MMP1 matrix metallopeptidase 1 -0.00746631
DHDDS dehydrodolichyl diphosphate synthase -0.00746177
F2RL1 coagulation factor II (thrombin) receptor-like 1 -0.00745342
NAMPT nicotinamide phosphoribosyltransferase -0.00742964
TGFA transforming growth factor, alpha -0.00742427
PLS1 plastin 1 -0.0074141
RBM47 RNA binding motif protein 47 -0.00741062
JAG1 jagged 1 -0.00729886
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0072949
ZIC1 Zic family member 1 -0.00728591
VNN1 vanin 1 -0.00727778
TPST2 tyrosylprotein sulfotransferase 2 -0.00725265
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) -0.00723617
AKR1C2 aldo-keto reductase family 1, member C2 -0.00722776
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 -0.00720682
CCK cholecystokinin -0.00720531
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.00719879
KLF4 Kruppel-like factor 4 (gut) -0.00715648
CDH17 cadherin 17, LI cadherin (liver-intestine) -0.00715546
NFIL3 nuclear factor, interleukin 3 regulated -0.00713724
ZBTB18 zinc finger and BTB domain containing 18 -0.00707281
AKR1C3 aldo-keto reductase family 1, member C3 -0.00706638
CNOT4 CCR4-NOT transcription complex, subunit 4 -0.0069486
WASL Wiskott-Aldrich syndrome-like -0.00693908
CSNK1A1 casein kinase 1, alpha 1 -0.00693783
CREB3L1 cAMP responsive element binding protein 3-like 1 -0.00693062
H1-2 H1.2 linker histone, cluster member -0.00692996
LSR lipolysis stimulated lipoprotein receptor -0.00689794
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.00682236
SDC4 syndecan 4 -0.00680906
KIAA0100 KIAA0100 -0.00677369
TP53 tumor protein p53 -0.00677002
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.00673476
GFAP glial fibrillary acidic protein -0.0067294
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.00669459
GOT1 glutamic-oxaloacetic transaminase 1, soluble -0.00669346
ZG16 zymogen granule protein 16 -0.00668474
WEE1 WEE1 G2 checkpoint kinase -0.00667337
KIAA0226L KIAA0226-like -0.00666251
SAT1 spermidine/spermine N1-acetyltransferase 1 -0.00666104
NECTIN3 nectin cell adhesion molecule 3 -0.0066328
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0066209
IGSF6 immunoglobulin superfamily, member 6 -0.00661633
BAMBI BMP and activin membrane-bound inhibitor -0.00659892
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide -0.00650446
RAB40B RAB40B, member RAS oncogene family -0.00648233
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 -0.00645828
BIK BCL2-interacting killer (apoptosis-inducing) -0.00645661
CDCA4 cell division cycle associated 4 -0.00642766
PTPRK protein tyrosine phosphatase, receptor type, K -0.0064244
ZNF91 zinc finger protein 91 -0.00641842
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -0.00641247
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0064035
RAB2A RAB2A, member RAS oncogene family -0.00639996
ANKRD10 ankyrin repeat domain 10 -0.00637843
MICU2 mitochondrial calcium uptake 2 -0.0063585
ERBIN erbb2 interacting protein -0.00635664
XBP1 X-box binding protein 1 -0.00634484
ADM adrenomedullin -0.00631943
ENC1 ectodermal-neural cortex 1 (with BTB domain) -0.0063141
PTPRO protein tyrosine phosphatase, receptor type, O -0.00630472
CXCL3 chemokine (C-X-C motif) ligand 3 -0.00628534
PARM1 prostate androgen-regulated mucin-like protein 1 -0.00627766
TRIP6 thyroid hormone receptor interactor 6 -0.00627737
ELL2 elongation factor, RNA polymerase II, 2 -0.00624998
CCDC88A coiled-coil domain containing 88A -0.006222
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -0.00621716
SLC26A2 solute carrier family 26 (anion exchanger), member 2 -0.00616389
GPI glucose-6-phosphate isomerase -0.00616326
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -0.00615911
CDC20 cell division cycle 20 -0.00614648
TMEM106B transmembrane protein 106B -0.00614422
GSTO1 glutathione S-transferase omega 1 -0.00612891
ARMCX1 armadillo repeat containing, X-linked 1 -0.00611709
DST dystonin -0.00608976
TMEM260 transmembrane protein 260 -0.00608604
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0060753
ITM2C integral membrane protein 2C -0.00604798
HOMER3 homer scaffolding protein 3 -0.00602822
RAB25 RAB25, member RAS oncogene family -0.00600304
SLC22A18 solute carrier family 22, member 18 -0.00599811
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.00599526
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2 -0.00598937
NOX1 NADPH oxidase 1 -0.00598451
UGCG UDP-glucose ceramide glucosyltransferase -0.00597964
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -0.00597055
MT1F metallothionein 1F -0.00596903
RABEP1 rabaptin, RAB GTPase binding effector protein 1 -0.00596628
ADCY1 adenylate cyclase 1 (brain) -0.00596533
GSTT1 glutathione S-transferase theta 1 -0.00592086
COL1A2 collagen, type I, alpha 2 -0.00591108
BCL2L1 BCL2-like 1 -0.0059099
HSPA2 heat shock 70kDa protein 2 -0.00589528
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 -0.00588703
SH3GL3 SH3-domain GRB2-like 3 -0.00588215
MEF2C myocyte enhancer factor 2C -0.00587342
NEK3 NIMA-related kinase 3 -0.00586837
AK5 adenylate kinase 5 -0.00585765
TMEM38B transmembrane protein 38B -0.00584768
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) -0.0058427
IPO5 importin 5 -0.00583024
PF4 platelet factor 4 -0.00581897
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 -0.00581448
S100A6 S100 calcium binding protein A6 -0.00581215
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.00580895
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase -0.00580879
TUBB2B tubulin, beta 2B class IIb -0.00580624
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -0.00579308
ZSCAN18 zinc finger and SCAN domain containing 18 -0.00579106
FOSL1 FOS-like antigen 1 -0.00578852
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1 -0.00576413
NFE2L2 nuclear factor, erythroid 2-like 2 -0.00576116
F3 coagulation factor III (thromboplastin, tissue factor) -0.0057481
KRT20 keratin 20, type I -0.00574788
FABP1 fatty acid binding protein 1, liver -0.00574212
TLK2 tousled-like kinase 2 -0.00572873
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) -0.00572344
ST18 suppression of tumorigenicity 18, zinc finger -0.00572141
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0057119
FAM3C family with sequence similarity 3, member C -0.00570661
H2AX H2A.X variant histone -0.00568881
CEMIP cell migration inducing protein, hyaluronan binding -0.00568689
BEX4 brain expressed, X-linked 4 -0.00568599
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 -0.00568589
SUCLA2 succinate-CoA ligase, ADP-forming, beta subunit -0.00568178
HAL histidine ammonia-lyase -0.00567021
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -0.00566537
CGGBP1 CGG triplet repeat binding protein 1 -0.00565194
CADM1 cell adhesion molecule 1 -0.00564876
MT1M metallothionein 1M -0.00564609
MCF2L MCF.2 cell line derived transforming sequence-like -0.00563678
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6 -0.00562602
CPE carboxypeptidase E -0.00562467
HTRA1 HtrA serine peptidase 1 -0.00560792
KLF10 Kruppel-like factor 10 -0.00559487
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0055944
BEX1 brain expressed, X-linked 1 -0.00559071
ABHD11 abhydrolase domain containing 11 -0.00557835
CTBP2 C-terminal binding protein 2 -0.00557818
TXNIP thioredoxin interacting protein -0.00557748
MINK1 misshapen-like kinase 1 -0.0055728
NPIPB3 nuclear pore complex interacting protein family, member B3 -0.0055662
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -0.00556005
ECM1 extracellular matrix protein 1 -0.00555899
HMGB2 high mobility group box 2 -0.00555682
ARHGAP22 Rho GTPase activating protein 22 -0.00555422
TSPAN8 tetraspanin 8 -0.00555316
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.00555018
CDX1 caudal type homeobox 1 -0.00553271
WIPI1 WD repeat domain, phosphoinositide interacting 1 -0.00552514
LAT2 linker for activation of T cells family, member 2 -0.0055203
ADAP1 ArfGAP with dual PH domains 1 -0.00549992
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -0.00548407
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.00544592
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 -0.00544275
CTH cystathionine gamma-lyase -0.00542863
MMP9 matrix metallopeptidase 9 -0.00542287
SNAP25 synaptosomal-associated protein, 25kDa -0.00541138
EZR ezrin -0.00540141
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.00539874
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -0.00538026
ZNF423 zinc finger protein 423 -0.00537052
COLEC12 collectin sub-family member 12 -0.00535566
FBXL5 F-box and leucine-rich repeat protein 5 -0.00535044
MAOA monoamine oxidase A -0.0053336
CCNE1 cyclin E1 -0.00532868
QPCT glutaminyl-peptide cyclotransferase -0.0053238
UGDH UDP-glucose 6-dehydrogenase -0.00532078
POU2AF1 POU class 2 associating factor 1 -0.00530679
PCLO piccolo presynaptic cytomatrix protein -0.00528708
AARS1 alanyl-tRNA synthetase 1 -0.00528662
HMGB1 high mobility group box 1 -0.00527223
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.00526896
BCAS1 breast carcinoma amplified sequence 1 -0.00526656
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -0.00525866
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa -0.00525806
MAPK13 mitogen-activated protein kinase 13 -0.00524902
GRM3 glutamate receptor, metabotropic 3 -0.00524198