| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/157920 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in LUBIPROSTONE relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | 1.17 |
| PEX7 | peroxisomal biogenesis factor 7 | 0.96 |
| FAM193B | family with sequence similarity 193, member B | 0.62 |
| ENO1 | enolase 1, (alpha) | 0.62 |
| LSM1 | LSM1, U6 small nuclear RNA associated | 0.62 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.6 |
| PLK1 | polo-like kinase 1 | 0.59 |
| SYTL3 | synaptotagmin-like 3 | 0.59 |
| MED12L | mediator complex subunit 12-like | 0.59 |
| ODC1 | ornithine decarboxylase 1 | 0.59 |
| CBLL1 | Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase | 0.58 |
| CDC20 | cell division cycle 20 | 0.56 |
| HYLS1 | hydrolethalus syndrome 1 | 0.55 |
| CADPS | Ca++-dependent secretion activator | 0.54 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | 0.51 |
| BFAR | bifunctional apoptosis regulator | 0.51 |
| LONP2 | lon peptidase 2, peroxisomal | 0.5 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.49 |
| KNSTRN | kinetochore-localized astrin/SPAG5 binding protein | 0.48 |
| POLR3H | polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) | 0.48 |
| PPME1 | protein phosphatase methylesterase 1 | 0.48 |
| TTN | titin | 0.48 |
| PROSER3 | proline and serine rich 3 | 0.47 |
| RFWD3 | ring finger and WD repeat domain 3 | 0.47 |
| RGN | regucalcin | 0.47 |
| ZBTB44 | zinc finger and BTB domain containing 44 | 0.47 |
| PTPRU | protein tyrosine phosphatase, receptor type, U | 0.47 |
| TYMS | thymidylate synthetase | 0.46 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.45 |
| NDUFA3 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa | 0.43 |
| STX1A | syntaxin 1A (brain) | 0.43 |
| FBXO45 | F-box protein 45 | 0.43 |
| RFLNB | refilin B | 0.43 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | 0.42 |
| SHQ1 | SHQ1, H/ACA ribonucleoprotein assembly factor | 0.42 |
| TEX15 | testis expressed 15 | 0.41 |
| FABP6 | fatty acid binding protein 6, ileal | 0.41 |
| DEPDC1 | DEP domain containing 1 | 0.41 |
| PIGX | phosphatidylinositol glycan anchor biosynthesis, class X | 0.41 |
| PCLAF | PCNA clamp associated factor | 0.41 |
| PITX1 | paired-like homeodomain 1 | 0.4 |
| HSF2 | heat shock transcription factor 2 | 0.4 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | 0.4 |
| MRFAP1 | Morf4 family associated protein 1 | 0.4 |
| ACOX1 | acyl-CoA oxidase 1, palmitoyl | 0.4 |
| TMEM131L | transmembrane 131 like | 0.4 |
| HOXA7 | homeobox A7 | 0.39 |
| ZNF724 | zinc finger protein 724 | 0.39 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.39 |
| RBIS | ribosomal biogenesis factor | 0.39 |
| ZBED1 | zinc finger, BED-type containing 1 | 0.39 |
| KPNA2 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) | 0.39 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.39 |
| ZMYND19 | zinc finger, MYND-type containing 19 | 0.39 |
| PRAME | preferentially expressed antigen in melanoma | 0.39 |
| ASTE1 | asteroid homolog 1 (Drosophila) | 0.38 |
| ANTKMT | adenine nucleotide translocase lysine methyltransferase | 0.38 |
| TTK | TTK protein kinase | 0.38 |
| MPHOSPH9 | M-phase phosphoprotein 9 | 0.38 |
| UCK2 | uridine-cytidine kinase 2 | 0.37 |
| MSMO1 | methylsterol monooxygenase 1 | 0.37 |
| EXO1 | exonuclease 1 | 0.37 |
| METTL18 | methyltransferase like 18 | 0.37 |
| DENND5B | DENN/MADD domain containing 5B | 0.37 |
| THAP4 | THAP domain containing 4 | 0.37 |
| SP100 | SP100 nuclear antigen | 0.37 |
| CDCA7 | cell division cycle associated 7 | 0.37 |
| ITGB1BP1 | integrin beta 1 binding protein 1 | 0.36 |
| EPOP | elongin BC and polycomb repressive complex 2 associated protein | 0.36 |
| CCDC170 | coiled-coil domain containing 170 | 0.36 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.36 |
| GLUL | glutamate-ammonia ligase | 0.36 |
| HOXA9 | homeobox A9 | 0.36 |
| E2F7 | E2F transcription factor 7 | 0.36 |
| FEM1A | fem-1 homolog a (C. elegans) | 0.36 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | 0.35 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 0.35 |
| PIAS4 | protein inhibitor of activated STAT, 4 | 0.35 |
| RNF220 | ring finger protein 220 | 0.35 |
| SIVA1 | SIVA1, apoptosis-inducing factor | 0.35 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.35 |
| DGKH | diacylglycerol kinase, eta | 0.35 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | 0.35 |
| MKX | mohawk homeobox | 0.35 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 0.34 |
| REX1BD | required for excision 1-B domain containing | 0.34 |
| MCM10 | minichromosome maintenance complex component 10 | 0.34 |
| AMD1 | adenosylmethionine decarboxylase 1 | 0.34 |
| KLHL25 | kelch-like family member 25 | 0.34 |
| ARMC4 | armadillo repeat containing 4 | 0.34 |
| CHEK1 | checkpoint kinase 1 | 0.34 |
| TTPA | tocopherol (alpha) transfer protein | 0.33 |
| AEBP2 | AE binding protein 2 | 0.33 |
| PIGH | phosphatidylinositol glycan anchor biosynthesis, class H | 0.33 |
| HELLS | helicase, lymphoid-specific | 0.33 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | 0.32 |
| CDC25B | cell division cycle 25B | 0.32 |
| COA5 | cytochrome c oxidase assembly factor 5 | 0.32 |
| CENPE | centromere protein E, 312kDa | 0.32 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMEM263 | transmembrane protein 263 | -1.61 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -1.21 |
| VGF | VGF nerve growth factor inducible | -1.01 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.99 |
| RPL18 | ribosomal protein L18 | -0.95 |
| H1-4 | H1.4 linker histone, cluster member | -0.86 |
| PCBD1 | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | -0.81 |
| KMT2B | lysine (K)-specific methyltransferase 2B | -0.8 |
| GPATCH4 | G patch domain containing 4 | -0.76 |
| B3GNT3 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 | -0.7 |
| GDF15 | growth differentiation factor 15 | -0.69 |
| CD3EAP | CD3e molecule, epsilon associated protein | -0.68 |
| AKNA | AT-hook transcription factor | -0.68 |
| NRP1 | neuropilin 1 | -0.67 |
| PYGM | phosphorylase, glycogen, muscle | -0.66 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | -0.66 |
| HMGN4 | high mobility group nucleosomal binding domain 4 | -0.64 |
| PLAU | plasminogen activator, urokinase | -0.63 |
| H1-0 | H1.0 linker histone | -0.63 |
| H1-3 | H1.3 linker histone, cluster member | -0.61 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.61 |
| SESN2 | sestrin 2 | -0.6 |
| CCDC71L | coiled-coil domain containing 71-like | -0.57 |
| KSR2 | kinase suppressor of ras 2 | -0.56 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.56 |
| AP3D1 | adaptor-related protein complex 3, delta 1 subunit | -0.55 |
| PDE2A | phosphodiesterase 2A, cGMP-stimulated | -0.55 |
| ZCCHC17 | zinc finger, CCHC domain containing 17 | -0.54 |
| PLAUR | plasminogen activator, urokinase receptor | -0.54 |
| KNOP1 | lysine-rich nucleolar protein 1 | -0.53 |
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -0.52 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.52 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | -0.51 |
| S100PBP | S100P binding protein | -0.5 |
| NKAP | NFKB activating protein | -0.5 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.49 |
| RPL37 | ribosomal protein L37 | -0.49 |
| RBBP6 | retinoblastoma binding protein 6 | -0.49 |
| TET1 | tet methylcytosine dioxygenase 1 | -0.48 |
| ADCY10 | adenylate cyclase 10 (soluble) | -0.48 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | -0.48 |
| TP53 | tumor protein p53 | -0.47 |
| LAMC2 | laminin, gamma 2 | -0.47 |
| FHIT | fragile histidine triad | -0.47 |
| CDA | cytidine deaminase | -0.47 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | -0.46 |
| ATG2A | autophagy related 2A | -0.45 |
| NDRG1 | N-myc downstream regulated 1 | -0.45 |
| CUL9 | cullin 9 | -0.45 |
| ATP9A | ATPase, class II, type 9A | -0.45 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.45 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | -0.45 |
| KDM6B | lysine (K)-specific demethylase 6B | -0.44 |
| JUN | jun proto-oncogene | -0.44 |
| RRBP1 | ribosome binding protein 1 | -0.44 |
| GLRX | glutaredoxin (thioltransferase) | -0.44 |
| GPATCH8 | G patch domain containing 8 | -0.43 |
| RNASE4 | ribonuclease, RNase A family, 4 | -0.43 |
| NUDT6 | nudix (nucleoside diphosphate linked moiety X)-type motif 6 | -0.43 |
| ZNF768 | zinc finger protein 768 | -0.43 |
| RPL6 | ribosomal protein L6 | -0.42 |
| H1-2 | H1.2 linker histone, cluster member | -0.42 |
| PRG4 | proteoglycan 4 | -0.42 |
| RETREG1 | reticulophagy regulator 1 | -0.42 |
| ZNF76 | zinc finger protein 76 | -0.41 |
| TLCD4 | TLC domain containing 4 | -0.41 |
| SEMG2 | semenogelin II | -0.41 |
| COL14A1 | collagen, type XIV, alpha 1 | -0.41 |
| DOP1A | DOP1 leucine zipper like protein A | -0.4 |
| SLC41A3 | solute carrier family 41, member 3 | -0.4 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.4 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.4 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.4 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.4 |
| ZC3H10 | zinc finger CCCH-type containing 10 | -0.39 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.39 |
| CBR1 | carbonyl reductase 1 | -0.39 |
| CMPK2 | cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial | -0.39 |
| TMEM106B | transmembrane protein 106B | -0.39 |
| HECA | headcase homolog (Drosophila) | -0.38 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.38 |
| ZBTB4 | zinc finger and BTB domain containing 4 | -0.38 |
| UQCR10 | ubiquinol-cytochrome c reductase, complex III subunit X | -0.38 |
| CELSR1 | cadherin, EGF LAG seven-pass G-type receptor 1 | -0.38 |
| F2 | coagulation factor II (thrombin) | -0.38 |
| LAMB3 | laminin, beta 3 | -0.38 |
| BLOC1S1 | biogenesis of lysosomal organelles complex-1, subunit 1 | -0.37 |
| RPL19 | ribosomal protein L19 | -0.37 |
| STARD3NL | STARD3 N-terminal like | -0.37 |
| PRR36 | proline rich 36 | -0.37 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.37 |
| PLIN2 | perilipin 2 | -0.37 |
| R3HDM4 | R3H domain containing 4 | -0.37 |
| HMGA1 | high mobility group AT-hook 1 | -0.37 |
| MCF2L | MCF.2 cell line derived transforming sequence-like | -0.36 |
| HMGN1 | high mobility group nucleosome binding domain 1 | -0.36 |
| HMGA2 | high mobility group AT-hook 2 | -0.36 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.36 |
| H1-5 | H1.5 linker histone, cluster member | -0.36 |
